Experiences With Glutathion

[Chrissven]

Hello everyone, how are your experiences with glutathione. And in what quantities did you dose it? I would be happy about experiences and opinions.

 

[Ennya]

I used it for a while, but I didn't see any visible results. Something might have changed or improved, but I didn't notice it. I won't buy it again.

 

[MikeyMike]

I've used it off and on for a bit. Typically dose 100mg IM. I feel like post workout works best and does boost recovery. Especially hard days I try to prioritize using it. Haven't really noticed any other benefits besides recovery. Did order some Pink Korean Gluta and planning on trying 200mg doses when I get it.

 

[downtherabbithole1]

Personally, I’ve only felt the effects of glutathione after I inject IM after a night out drinking. The hangovers are nearly nonexistent.

 

[N Sharp]

Personally, I’ve only felt the effects of glutathione after I inject IM after a night out drinking. The hangovers are nearly nonexistent.

I've never been curious about gluta... until now! May I ask how often you drink, how much, and relatively how old you are? Also, are you researching glps at this time?

 

[miameow]

It is by far my favorite compound. I take 200 mg per shot, and honestly, I’m nervous about the thought of cycling off because I just want to continue forever.

It has done more for my energy levels and general well-being than anything else I’ve tried.

 

[GrandmaJ]

It is by far my favorite compound. I take 200 mg per shot, and honestly, I’m nervous about the thought of cycling off because I just want to continue forever.

It has done more for my energy levels and general well-being than anything else I’ve tried.

I just ordered some before realizing it is supposed to be taken IM not subq. I am not sure I can do IM on myself. Makes me nervous.

 

[AlexSilver]

I just ordered some before realizing it is supposed to be taken IM not subq. I am not sure I can do IM on myself. Makes me nervous.

Sub-Q works. Major antioxidant, really good for you even if you don’t feel it.
Like you, I am also unwilling, so far, to go IM.

But to quote a friend “it just doesn’t hit the same if you don’t put it in the muscle”

 

[Clavicular's Hammer]

Just ordered NAC and Glycine supplements to get my body to make its own.

Be interested to try a shot as well but I’ll stick with the supplements first

 

[miameow]

Just ordered NAC and Glycine supplements to get my body to make its own.

Be interested to try a shot as well but I’ll stick with the supplements first

That makes sense. NAC and glycine are precursors, so they do give your body the building blocks to make more of its own (although it won't feel the same as a direct gluta hit).

Injectable gluta, esp, is more of a direct gluta pulse, so people (inc. myself) feel it more acutely. NAC/glycine tends to be more of a gradual support approach.

So I’d think of it as two different categories:

Direct glutathione delivery (hierarchy of efficacy / bioavailability):
IV > IM/SQ > liposomal oral > standard oral

Glutathione production support:
NAC + glycine/cysteine precursors

Starting with NAC and glycine first is a totally reasonable approach. It just may feel more subtle than a shot and it will take a while until you start feeling a difference. I personally prefer IM shots; it's not that bad once you get used to it and you feel an instant boost.

 

[Clavicular's Hammer]

That makes sense. NAC and glycine are precursors, so they do give your body the building blocks to make more of its own (although it won't feel the same as a direct gluta hit).

Injectable gluta, esp, is more of a direct gluta pulse, so people (inc. myself) feel it more acutely. NAC/glycine tends to be more of a gradual support approach.

So I’d think of it as two different categories:

Direct glutathione delivery (hierarchy of efficacy / bioavailability):
IV > IM/SQ > liposomal oral > standard oral

Glutathione production support:
NAC + glycine/cysteine precursors

Starting with NAC and glycine first is a totally reasonable approach. It just may feel more subtle than a shot and it will take a while until you start feeling a difference. I personally prefer IM shots; it's not that bad once you get used to it and you feel an instant boost.

Both methods your body has to build its own.

The cells can’t take in glutathione whole. So both ways the body has to build it

A shot only has a few minute half life in the body and we don’t know if it down regulates our bodies natural production over time

 

[Brandon556]

I attempted it and it burned like hell. Only got around .2ml in before I pulled it out. It was extremely painful and like a shock. I was not expecting that much pain and im debating if I should try it again.

 

[Calm Logic]

I attempted it and it burned like hell. Only got around .2ml in before I pulled it out. It was extremely painful and like a shock. I was not expecting that much pain and im debating if I should try it again.

The Korean gluta comes in large vials that allow more dilution. Or one can just add to a syringe of BAC, saline, or saline BAC. Even then, I can get ISRs, so I inject IM.

 

[miameow]

Both methods your body has to build its own.

The cells can’t take in glutathione whole. So both ways the body has to build it

A shot only has a few minute half life in the body and we don’t know if it down regulates our bodies natural production over time

The shots and precursors still have different effects.

• NAC and glycine are precursors, so they give your body the building blocks to make GSH later.
• Injected glutathione gives you GSH directly first, so it can enter the glutathione redox cycle immediately: GSH neutralizes oxidants, becomes GSSG, and then gets recycled back into GSH.

• GSH = reduced glutathione, the active antioxidant form.
• GSSG = oxidized glutathione, the “used” form after GSH has done antioxidant work.

That immediate redox-cycle activity is the key difference, and that is what people, including myself, are likely feeling from shots. With NAC/glycine, your body still has to build GSH first, so the effect is more gradual.

I agree that injectable glutathione has a short half-life and that cells may not simply absorb it whole, but short half-life does not mean no effect. It just means the direct redox window is brief. Downstream effects from the pulse can still matter, as with HGH.

Also, oral precursors like NAC/glycine are not absorbed whole or converted into intracellular glutathione immediately either.

As for down-regulating natural production over time, I have seen people raise that concern, similar to how they talk about suppression with other exogenous compounds, including HGH, but I have not seen concrete evidence proving this to be true with glutathione.

Also, glutathione is often cycled rather than run continuously, which would theoretically reduce any concern around long-term suppression.