Im luckily still happy with Sema effects, had no reason to switch to more expensive drugs yet, just sharing what I have learned from the experiences of others ...The feeling is the same on Reta for me, does it help you? I’ve tried B12 doesn’t seem to help, from what I saw commented on peppys is to use methylene blue.
I had a little bit of fatigue (among others mild side effects) on Sema, but B12 oral + B complex + multivitamins with mineral + electrolytes was enough for me to feel OK. But injectable form of B12 is something worth trying if your fatigue is really bad as many users have reported it helps them a lot!