First Reta Phase III Results

[keangkong]

The reta weight loss results were about what I would have expected from the phase 2 trials. Yes, the weight loss was greater but the study lasted longer. The side effects similarly seemed to be about the same as in the phase 2 trials. Still this is very good news. The phase 2 results were excellent. I'm glad that the phase 3 results, which involve a longer study with more people, were similarly impressive.

 

[bogardbilla]

One interesting tidbit about how these studies work in the background, from the patient's point of view, is this comment I found on Reddit from a guy who participated in the study and then decided to silently start skipping doses because he felt he lost too much weight:

https://www.reddit.com/r/RetatrutideTrial/comments/1pk86cs/comment/ntkkdgo

View: https://www.reddit.com/r/RetatrutideTrial/comments/1pk86cs/comment/ntkkdgo/

 

[ThatNextGril]

I just received my first Reta kit - I've been on the fence about switching from Tirz to Reta since my Tirz isn't really Tirzing for me anymore (9 weeks at 12.5mg and I keep gaining and losing the same 7 pounds and the sides are getting brutal).

This helped solidify that decision and I'll be interested to get underway with Reta soon.

Just curious why you didn't opt to up to the clinical dose of 15 with the tirz before switching? Was just due to the sides you were getting at 12.5? I mainly ask because I recently went up to 14-14.5 (depends on what I actually pull that pin day) and have definitely had more sides. I had the usual when I started with sema 2.5 years ago, but when I moved to tirz last Dec, I had almost no sides at all. It's been amazingly smooth this whole time until I went up from 12.5 just before Thanksgiving. I'm debating going back down to 12.5-13 my next pin, to see if the effects go away, but then I'm left not feeling like my beloved tirz is tirzing, either.

 

[PAPoots]

I had to look up Dysesthesia to see how it was different than Allodynia. They are so similar that I wonder if you can have a touch of both at the same time.

Allodynia is the experience of pain from stimuli that are not normally painful, while dysesthesia refers to abnormal, often unpleasant sensations that may occur without an external stimulus.

Definitions​

• Allodynia: This condition involves experiencing pain from stimuli that typically do not cause pain, such as light touch or mild temperature changes. For example, a person with allodynia may feel pain when their skin is lightly brushed or when they wear clothing.
  https://www.bing.com/ck/a?!&&p=78ba...WVuLWFsbG9keW5pYS1hbmQtZHlzZXN0aGVzaWEv&ntb=1
• Dysesthesia: Dysesthesia is characterized by abnormal sensations that can be unpleasant or painful. These sensations may include burning, tingling, or a feeling of something crawling on the skin. Dysesthesia can occur spontaneously or in response to stimuli that usually do not provoke such sensations.