From Reta to Survo

[dogmom]

I have been on Reta for over a year. I had been on about 10mg. I am at essentially goal but still would like to lose 10lbs. If I lost weight I'd be happy but I'm not transitioning for weight loss.

I like Reta overall. However, my heart rate went up when I started taking it and it never went down to a normal level. I never felt bad. No doctors ever mentioned anything wrong either. But still I never had that on Tirz or Sema. So hear I go with experimenting with Survo to see how that does.

I started Survo at .6mg just to see how it feels. I think Survo goes up to 4.8mg. I don't really feel anything but I didn't expect to. Survo has GIP and Glucagon, which I have been on with Reta. I plan on taking 1.2mg next week.

 

[byefatlicia]

Please tell us how it goes🙂

 

[Peotidethrowaway]

I maybe wouldn’t jump up that fast but you do you

 

[dogmom]

I maybe wouldn’t jump up that fast but you do you

Yeah I'm still debating about doubling it. I may go up to .9mg instead. But in the trials the next step up from .6mg is 1.2mg. I just figured I'd be ok to ramp up fast since I've been on Reta for a year and I've been taking a higher dose of reta for months now.

I have not seen many people talk about Survo. So I'm not sure what side effects may be like.

 

[Calm Logic]

I am on survo now too. I plan to just take it by itself (for a little while at least) to get familiar with it. Just increased the dose to 1 mg this morning.

The only side effect I may have experienced at lower doses like 0.3 mg was diarrhea, but that could have been from another GLP. So another reason I am trying survo by itself.

 

[conzopiriani]

Oh me too me too! Just started a .6mg dose and lowered my Tz to 5mg from 10mg. Almost to goal and feeling antsy about it. Got a single vial to try; problem is I travel internationally quite a bit so need a domestic source. Can't risk any love letters from "de gubamint" so this may be a one of experiment.

 

[Calm Logic]

Can't risk any love letters from "de gubamint"

Amino Lair has their survo 10 kit on sale for $200 ($10 less than usual, as well as singles for $30). There are other affordable single-vial resellers of survo like Grey Axis Research, but Grey is currently sold out. There is also a TG community just for survo and maz users. And survo is becoming more popular for group buys too.

 

[GLP1Pharmacist]

Would titrate slower

 

[lemon lady]

is survo supposed to be better than reta or just as good but works differently? There both still in trials and I haven't found much feedback on survo

 

[conzopiriani]

Amino Lair sells a survo 10 kit for $210 (as well as singles for $30). There are other affordable single-vial resellers of survo like Grey Axis Research, but Grey is currently sold out. There is also a TG community just for survo and maz users. And survo is becoming more popular for group buys too.

Thank you for the info, off to riffle through TG to research.

 

[Peptidase]

I have been on Reta for over a year. I had been on about 10mg. I am at essentially goal but still would like to lose 10lbs. If I lost weight I'd be happy but I'm not transitioning for weight loss.

I like Reta overall. However, my heart rate went up when I started taking it and it never went down to a normal level. I never felt bad. No doctors ever mentioned anything wrong either. But still I never had that on Tirz or Sema. So hear I go with experimenting with Survo to see how that does.

I started Survo at .6mg just to see how it feels. I think Survo goes up to 4.8mg. I don't really feel anything but I didn't expect to. Survo has GIP and Glucagon, which I have been on with Reta. I plan on taking 1.2mg next week.

GLP and glucagon. No GIP activity.

 

[Calm Logic]

And survo is designed with a 8:1 activity ratio, so eight times more potent for the GLP-1 receptor than for the glucagon receptor.

Both reta and tirz are more potent for GIP than anything else.

From the TG survo group, regarding dose strengths:

 

[Calm Logic]

is survo supposed to be better than reta or just as good but works differently? There both still in trials and I haven't found much feedback on survo

A comparison table from a recent article, with the weight loss being faster for the triple-agonist reta (almost 15% weight loss for survo or maz vs. 24.2% for reta). Maz is already approved in China.

Summary of GCGR-based multi-agonists in development for the treatment of obesity.

Drug	Mechanism of action	Percent weight loss	Safety	Key obesity clinical trial programme
Mazdutide	Glucagon and GLP1 receptor co-agonist	−12 (4mg) and −14.8 (6mg) vs −0.5 with placebo at 48 weeks (phase III trial)	GI side-effects (nausea, vomiting, diarrhoea) common	GLORY, phase III
Pemvidutide	Glucagon and GLP1 receptor co-agonist	−10.3 (1.2 mg), −11.2 (1.8 mg) and −15.6% (2.4 mg) vs −2.2 with placebo at 48 weeks (phase II trial)	GI side-effects (nausea, vomiting) noted in phase II study in patients with MASH	VELOCITY, phase III
Survodutide	Glucagon and GLP1 receptor co-agonist	−6.2 (0.6 mg), −12.5 (2.4 mg), −13.2 (3.6 mg), −14.9 (4.8 mg) vs −2.8 with placebo at 46 weeks (phase II trial)	GI side-effects (nausea, vomiting, diarrhoea) common	SYNCHRONIZE, phase III
Retatrutide	Glucagon, GLP1 and GIP receptor co-agonist	−8.7 (1 mg), −17.1 (combined 4 mg group), −22.8 (combined 8 mg group), −24.2 (combined 12 mg group) vs −2.1 with placebo at 48 weeks	GI side-effects (nausea, vomiting, diarrhoea, constipation) common	TRIUMPH, phase III

But most/many people who use survo or maz do so for stacking, especially with tirz (tirz + survo = ghetto reta).