From Reta to Survo

[dogmom]

I have been on Reta for over a year. I had been on about 10mg. I am at essentially goal but still would like to lose 10lbs. If I lost weight I'd be happy but I'm not transitioning for weight loss.

I like Reta overall. However, my heart rate went up when I started taking it and it never went down to a normal level. I never felt bad. No doctors ever mentioned anything wrong either. But still I never had that on Tirz or Sema. So hear I go with experimenting with Survo to see how that does.

I started Survo at .6mg just to see how it feels. I think Survo goes up to 4.8mg. I don't really feel anything but I didn't expect to. Survo has GIP and Glucagon, which I have been on with Reta. I plan on taking 1.2mg next week.

 

[byefatlicia]

Please tell us how it goes🙂

 

[Peotidethrowaway]

I maybe wouldn’t jump up that fast but you do you

 

[dogmom]

I maybe wouldn’t jump up that fast but you do you

Yeah I'm still debating about doubling it. I may go up to .9mg instead. But in the trials the next step up from .6mg is 1.2mg. I just figured I'd be ok to ramp up fast since I've been on Reta for a year and I've been taking a higher dose of reta for months now.

I have not seen many people talk about Survo. So I'm not sure what side effects may be like.

 

[Calm Logic]

I am on survo now too. I plan to just take it by itself (for a little while at least) to get familiar with it. Just increased the dose to 1 mg this morning.

The only side effect I may have experienced at lower doses like 0.3 mg was diarrhea, but that could have been from another GLP. So another reason I am trying survo by itself.

 

[conzopiriani]

Oh me too me too! Just started a .6mg dose and lowered my Tz to 5mg from 10mg. Almost to goal and feeling antsy about it. Got a single vial to try; problem is I travel internationally quite a bit so need a domestic source. Can't risk any love letters from "de gubamint" so this may be a one of experiment.

 

[Calm Logic]

Can't risk any love letters from "de gubamint"

Amino Lair has their survo 10 kit on sale for $200 ($10 less than usual, as well as singles for $30). There are other affordable single-vial resellers of survo like Grey Axis Research, but Grey is currently sold out. There is also a TG community just for survo and maz users. And survo is becoming more popular for group buys too.

 

[GLP1Pharmacist]

Would titrate slower

 

[lemon lady]

is survo supposed to be better than reta or just as good but works differently? There both still in trials and I haven't found much feedback on survo

 

[conzopiriani]

Amino Lair sells a survo 10 kit for $210 (as well as singles for $30). There are other affordable single-vial resellers of survo like Grey Axis Research, but Grey is currently sold out. There is also a TG community just for survo and maz users. And survo is becoming more popular for group buys too.

Thank you for the info, off to riffle through TG to research.

 

[Peptidase]

I have been on Reta for over a year. I had been on about 10mg. I am at essentially goal but still would like to lose 10lbs. If I lost weight I'd be happy but I'm not transitioning for weight loss.

I like Reta overall. However, my heart rate went up when I started taking it and it never went down to a normal level. I never felt bad. No doctors ever mentioned anything wrong either. But still I never had that on Tirz or Sema. So hear I go with experimenting with Survo to see how that does.

I started Survo at .6mg just to see how it feels. I think Survo goes up to 4.8mg. I don't really feel anything but I didn't expect to. Survo has GIP and Glucagon, which I have been on with Reta. I plan on taking 1.2mg next week.

GLP and glucagon. No GIP activity.

 

[Calm Logic]

And survo is designed with a 8:1 activity ratio, so eight times more potent for the GLP-1 receptor than for the glucagon receptor.

Both reta and tirz are more potent for GIP than anything else.

From the TG survo group, regarding dose strengths:

 

[Calm Logic]

is survo supposed to be better than reta or just as good but works differently? There both still in trials and I haven't found much feedback on survo

A comparison table from a recent article, with the weight loss being faster for the triple-agonist reta (almost 15% weight loss for survo or maz vs. 24.2% for reta). Maz is already approved in China.

Summary of GCGR-based multi-agonists in development for the treatment of obesity.

Drug	Mechanism of action	Percent weight loss	Safety	Key obesity clinical trial programme
Mazdutide	Glucagon and GLP1 receptor co-agonist	−12 (4mg) and −14.8 (6mg) vs −0.5 with placebo at 48 weeks (phase III trial)	GI side-effects (nausea, vomiting, diarrhoea) common	GLORY, phase III
Pemvidutide	Glucagon and GLP1 receptor co-agonist	−10.3 (1.2 mg), −11.2 (1.8 mg) and −15.6% (2.4 mg) vs −2.2 with placebo at 48 weeks (phase II trial)	GI side-effects (nausea, vomiting) noted in phase II study in patients with MASH	VELOCITY, phase III
Survodutide	Glucagon and GLP1 receptor co-agonist	−6.2 (0.6 mg), −12.5 (2.4 mg), −13.2 (3.6 mg), −14.9 (4.8 mg) vs −2.8 with placebo at 46 weeks (phase II trial)	GI side-effects (nausea, vomiting, diarrhoea) common	SYNCHRONIZE, phase III
Retatrutide	Glucagon, GLP1 and GIP receptor co-agonist	−8.7 (1 mg), −17.1 (combined 4 mg group), −22.8 (combined 8 mg group), −24.2 (combined 12 mg group) vs −2.1 with placebo at 48 weeks	GI side-effects (nausea, vomiting, diarrhoea, constipation) common	TRIUMPH, phase III

But most people who use survo or maz do so for stacking, especially with tirz since tirz + (survo or maz) = "ghetto reta."

 

[lessthanhalf]

Isn't one of the benefits of tirzepatide or retatrutide the GIP agonism, as it counteracts the nausea and food aversion of GLP-1 at least to some degree. As survo does not have this does it cause more nausea? I know everyone has somewhat different reactions to the different medications, but wouldn't it be cheaper and easier to add a little bit of semaglutide to reta if you wanted more GLP-1 activation?

 

[Calm Logic]

but wouldn't it be cheaper and easier to add a little bit of semaglutide to reta if you wanted more GLP-1 activation?

Right, or stack with cagri instead.

The big appeal of survo is stacking with tirz. Survo and tirz would compete for GLP-1, increasing GLP-1 activation. This could result in more weight loss but also more side effects like nausea:

Tirzepatide and survodutide would indeed compete for the GLP-1 receptor. This competition would not "block" the effect of either drug in the way an antagonist would. Instead, it would lead to a state of heightened GLP-1 receptor activation, potentially resulting in a more pronounced GLP-1-driven therapeutic effect.

However, the overall outcome would be a combination of the effects of all three hormones, which could lead to enhanced weight loss and metabolic control but also potentially increased side effects like nausea and vomiting, which are common with GLP-1 receptor activation.

 

[Peotidethrowaway]

Amino Lair has their survo 10 kit on sale for $200 ($10 less than usual, as well as singles for $30). There are other affordable single-vial resellers of survo like Grey Axis Research, but Grey is currently sold out. There is also a TG community just for survo and maz users. And survo is becoming more popular for group buys too.

Johnny five has some 12mg for 225 or so shipped. They tested about 15mg

On hand in the us. Is the point I was trying to make and just kind of forgot 😂

 

[Calm Logic]

A new study shows high-dose mazdutide (16 mg) resulted in 21 percent weight loss in 20 weeks. That seems promising for high-dose survo as well, which is being studied at 6 mg.

 

[rsmith]

Johnny five has some 12mg for 225 or so shipped. They tested about 15mg

On hand in the us. Is the point I was trying to make and just kind of forgot 😂

They tested about 15mg

Actually, right at 16mg. average over 3 tested vials.

I saw that and thought about picking some up until I read that it shouldn't be stored beyond 30 days. Thus for weekly dosing, we're talking 4mg. per week. Does anyone have any experience storing reconstituted Survo longer than 30 days?

 

[rsmith]

Right, or stack with cagri instead.

The big appeal of survo is stacking with tirz. Survo and tirz would compete for GLP-1, increasing GLP-1 activation. This could result in more weight loss but also more side effects like nausea:

The big appeal of survo is stacking with tirz. Survo and tirz would compete for GLP-1, increasing GLP-1 activation.

If appetite suppression is already adequate, what additional benefit would increased GLP-1 activation from Survo + Tirz produce beyond straight Tirz or Reta?

 

[Peotidethrowaway]

They tested about 15mg

Actually, right at 16mg. average over 3 tested vials.

I saw that and thought about picking some up until I read that it shouldn't be stored beyond 30 days. Thus for weekly dosing, we're talking 4mg. per week. Does anyone have any experience storing reconstituted Survo longer than 30 days?

Then buy 6mg 🤷‍♂️

Or split the vials and freeze half. Idk dude. Do whatever.

Two tested at 16. One tested at 15. I use the lower number when I plan my dose.

 

[Calm Logic]

I read that it shouldn't be stored beyond 30 days.

Not a concern for me, nor something I have read. I sometimes use the phenol in my injectable B-12 as an alternative to BAC. So I plan to use B-12 the next time I recon HGH, which can be visibly fragile during and after recon (very prone to foaming).

If appetite suppression is already adequate

Yes, there are other benefits, and that is a great point that I forgot about. While more GLP-1 activation would have diminishing returns at some point for things like inflammation and bloodwork results, adding glucagon activation (by taking reta or adding survo or maz) would help independently:

If appetite suppression is already adequate, the primary benefit of adding a glucagon agonist like Survodutide (or using a tri-agonist like Retatrutide) would come from the glucagon component itself. Glucagon activation has several distinct advantages beyond what you'd get from just GLP-1/GIP:

Increased Energy Expenditure: Glucagon plays a role in regulating metabolism and can increase the body's energy expenditure. This means you are burning more calories, even at rest. This effect is a different mechanism for weight loss than simply eating less, and it can be particularly helpful for breaking through a weight-loss plateau.

Targeting Liver Fat (Hepatic Steatosis): Glucagon agonism is very effective at reducing fat in the liver. This is a significant health benefit, especially for people with metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD).

Improved Lipid Profiles: While GLP-1 and GIP improve blood markers, glucagon can independently help with fat metabolism, leading to a further reduction in triglycerides and improvements in cholesterol levels.

This is why Survodutide is an attractive option, and why it's a key part of the mechanism for Retatrutide.