GLP1 GRAND TOUR: Current RETA Experience

dionysos said:
@Sheldor
I would be very interested to hear your response to stacking Semaglutide with Retatrutide.
Click to expand...
Made Friday 10mg Reta and Sunday 0.25 Semaglutide for food noise.
Today in the morning scales showed 113.5kg. I weighed myself before every day for few weeks and scale was never under 115kg.
Lets wait for Friday to see the one week result
 
So, its Friday and next update is here:
Scale showed today 112.9KG.
I even had a few bad meals during the week like wienerschnitzel, Pizza, french frys. Just went only once to training. I think its still a good result
 
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dionysos said:
My condolences @clevesand.
As a 72yo Atrial Fibrillation patient with a pacemaker I am very interested in this side effect and monitor it closely ie Apple Watch and Medtronics 24/7 cellphone link.

In the sixteen months I’ve taken GLP1s I’ve experienced Tachycardia/palpitations on 6 (six) occasions: 3 notable events while on Semaglutide, 2 notable events while on Tirzepatide, and, 1 less significant event while on Retatrutide+Cagrilintide stack.

The Sema/Tirz events (128bpm) were associated with times of significant emotional stress. The more recent and less signigficant event (120bpm) was not stress/related and did not seem to have a likely cause.

My cardiac care team after analyzing my Apple ECG and Medtronix Pacemaker report said these events, while disconcerting and reportable, were not serious or lengthy; that Afib patients experience these occasionally without apparent cause, that they were ‘expected and not concerning’.

My take on this is that in my case the GLP1s are not causing any unusual cardiac activity. Your own mileage may vary @clevesand

WITHOUT DOUBT YOU SHOULD CONSULT YOUR MD FOR ADVICE.
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Do you disclose to your cardiac care team exactly what you are taking and in what doses?
 
Reta has been amazing.
started Last week of July, SW: 216lb
today sep 17: cw: 196

Goal, low double digit bf%. I am 5’10 with a good build, probably should be getting close to that with another 10lbs.

I started towards the end of July using 2mg/week from Skye. Reta initially obliterated my appetite. I had to force myself to eat, and even then could only eat a few bites. This lasted about 3 weeks. I quickly lost about 10lbs but I bet that was mostly water weight from glycogen depletion. I started taking creatine everyday, so that water weight should be back.

At week 4 I started 4mg/week and at week 5 switched from skye to Amo R10. Some of my hunger is back but still controlled with getting satisfied quickly. I don’t know if the appetite is due to changing to Amo or just my body getting use to reta. I am still losing weight though and I am very happy that strength has not been impacted that much.

Reta is doing a great job for body recomposition.
 
runawayjim123 said:
Do you disclose to your cardiac care team exactly what you are taking and in what doses?
Click to expand...
@runawayjim123
I'm not entirely a fool to myself, Jim!

Not wanting the obligatory lecture (or an entry into my widely available medical record), I had an off-the-record-conversation with the Cardiac Clinic's staff pharmacist. She managed my initial Wegovy therapy for 10-11 months and was super helpful in sourcing through the shortages.

She upheld her professional ethical standards. She also let me know clearly that, as yet, there were no known negative interactions of the three major peptides with the drugs I am currently taking.

Obviously she will not acknowledge this conversation as medical advice for me or for anyone else.
I'm fine with that.
 
I am 31 days in. Reta being my first peptide (technically I took one 2.5 mg dose of tirz one week prior to starting Reta but am not counting that).

My dosing schedule has been a bit unconventional, but am taking a tapered approach:

Day 0: 2mg
Day 7: 2mg
Day 12: 2mg
Day 17: 2mg
Day 22: 2mg
Day 26: 2mg
Day 30: 2mg

This essentially works out to a 7-day titration schedule of 2mg, 2.8mg, 3.5mg (I am here now) throughout the first month.

My next titration will be 3mg every 5 days, starting on day 35 (which will be the equivalent of 4.2mg on a 7 day schedule).

This approach has been a smooth and steady acquaintance with Reta. My biggest SE has been some acid reflux at night on days I have eaten fattier meats for my OMAD meal. And while I don't have a crazy amount of appetite suppression, I find OMAD much easier than without Reta. Once I reach a more therapeutic dose, I will drop the OMAD and space my meals out more evenly throughout the day.

Because I went OMAD just prior to starting Reta, I have lost weight regardless, so it's hard to say whether Reta has had any impact other than making it slightly easier to OMAD. I've tested a couple days off of OMAD and was able to eat quite a lot, so feeling my weight loss is mostly due to a restricted eating window that Reta is aiding (which I'm very happy about!).

I'm down ten pounds over the last 5 weeks, but the scale hasn't moved in a week or so (even went up for a couple days). I attribute that to introducing creatine, much like peppers. I'm sitting a hair under 250. While I do only have a two hour eating window each day, I drink three protein shakes outside of that window, and get 250g of protein in me per day.

My goal is to get down to about 180 with minimal muscle loss. A long road ahead, but off to a good start.
 
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dionysos said:
Gwen,
My wife and I have used peptides from three (3) of the eight high QA vendors vendors shown below. I would happily use Cagrilintide from any one of them.

Through error I began with a 0.600mg dose. No unfortunate side effects, however I do not seem to need that much. My second and third doses have been 0.300mg and that is the Phase Three Study's starting dosage.

My process has been to dose 10mg Retatrutide on Saturday then the small Cagrilintide dose on Wednesday. It is still early days to make firm statements but for me Cagrilintide's half life is longer than the 6-7 days of other GLP1s.

The appetite suppression of Cagri for me could be as much as 10 (ten) days.

Whatever you discover in your Cagrilintide trial let us all know please 🙂
- Dennis

View attachment 1486
Click to expand...


What is the typical titration schedule for cargi? Is it 0.25mg-2.5mg? Thank you!

P.S.Your spreadsheets are awesome! I am sure I would still be overpaying if not for finding your Reddit account.
 
dionysos said:
The story arc in my Grand Tour has been from “easy, long-term weight-loss with full appetite supression and no calorie-counting on Sema TO a stalling-out fall-from-bliss TO six months of effortful-three-different-peptides-uphill-both directions struggle to regain weight-loss Heaven”.
Soon to be made into a major motion picture!

I have pretty well kept the peptide transitions distinct and can accurately distinguish their contributions.

I was hoping to delay publishing about this until I had more experience to report on.

BRIEFLY stated with the minimum of detail:
After 10-11 months successful Semaglutide weight loss I stalled out.

How can you keep on movin' unless you migrate too.
For me the difference in appetite suppression between Semaglutide and Tirzepatide was considerable and stimulated me to titrate rapidly to 7.5mg weekly. It wasn’t enough. Migrating to Tirzepatide reduced side effects but 10mg weekly dosage was required to approach the appetite suppression of Sema. More than 10mg weekly would have been needed to actually equal 2.5mg of Sema weekly.

Stack, stack, stack... they call him The Stacker.
Began stacking 2.5mg of Reta mid-week atop 10mg of TIrzepatide to assist with suppression.
It assisted well! Reta does have somewhat better appetite suppression than Tirzepatide. It soon became clear that the mid-week Reta was doing the heavy lifting and I quick-migrated to 7.5mg of Retatrutide dosage in about three weeks

Rinse and repeat.
Retatrutide is better in every way than Tirzepatide is - for me. Explaining the subtle whys becomes difficult. Certainly there are fewer side effects with Retatrutide than with Tirzepatide; my persistent side is constipation which I treat with Magnesium Citrate gelcaps. Fairly soon the 7.5mg dosage was not sufficient to quell my appetite and I needed to upgrade the dose. Reta unfortunately has the same difficulty for me that Tirzepatide does but not to the same degree - not quite adequate appetite suppression at 10mg weekly.

Enter the Dragon.
At risk of appearing a weak and needy addict, I admit to now stacking Cagrilintide mid-week atop 10mg of Retatrutide. This is strictly to stop the onset of significant hunger which was stalling me out AGAIN.

I decided on the addition of Cagrilintide mid-week
My intention was to start with 0.300mg but I fumbled the dose calculation or draw. Thankfully I experienced no strong side effects.

The main effect however was substantial - Appetite Suppression At Last!

Cagrilintide ELIMINATED my hunger for 7 days:
I lost 5lbs from Wednesday through end-of-day Sunday!

Based on my recent experience some things seem to be true:
a) Stacking Reta atop Tirz is not efficient or particularly effective.
This seems evident in hindsight as 2/3 of Retatrutide's agonists
duplicate Tirzepatid's agonists;

b) Both peptides have the same "weakness" - they don't suppress appetite nearly so well as Semaglutide.

c) Initial response to Cagrilintide is that its appetite suppression is equal to that of Semaglutide if not greater.

d) If your appetite breaks through while taking high dosages of Tirzepatide adding Cagrilintide is a far better solution than adding Retatrutide.

This data is of course only true for me. Your Mileage May WILL Vary!
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Oh wow I didn’t know sema had better hunger suppression than tirz
 
LumpySpace said:
Have you any experienced any "gelling" of peps from the US vendors? Is there a max amount of time you keep using your vial?
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Peptide Gelling
I’ve read about “gelling” and odd non-dissolving peptides but I have no direct experience of it. My impression, possibly incorrect, is that this phenomenon is much more likely to occur with non-GLP1 peptides.

GLP1 Use Before Date
Addressing this ‘issue’ and a similar question about Bacteriostatic Water have occupied a BIG percentage of my time since I started publishing my datasheets.

To answer directly: there is no time limit I impose on my reconstituted peptides. I have successfully used a reconned GLP1 that was beyond 90 days since first puncture. I experienced no loss of efficacy when comparing this aged (refrigerated) vial with a newly reconned vial from the same batch.

I’ve studied the subject closely and answered all concerns sufficiently well to consider it settled for myself. I’ve chatted/DM’d hundreds of peptiders thousands of words about this; it takes a good deal of verbiage to address all the related issues.

Probably I should compile my chats and create a boilerplate response 🤷🏻‍♂️
 
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I have mixed many vials of 6 different peptides over the last six months.

The only one I had any gelling issues with is AOD-9604. This appears to be a common issue with AOD and where I bought it even warns you on the website about the issue before allowing you to buy it.
This is really not an issue anymore for me because I didn't find it effective anyhow and have no plans to purchase AOD in the future. At the time I was stacking it with Tirz to see if it added anything so I could keep my dosage of Tirz lower because of side effects.
 
PepOhio said:
I have mixed many vials of 6 different peptides over the last six months.

The only one I had any gelling issues with is AOD-9604. This appears to be a common issue with AOD and where I bought it even warns you on the website about the issue before allowing you to buy it.
This is really not an issue anymore for me because I didn't find it effective anyhow and have no plans to purchase AOD in the future. At the time I was stacking it with Tirz to see if it added anything so I could keep my dosage of Tirz lower because of side effects.
Click to expand...
THANKS Pep! Timely, detailed, and useful information 🙂
 
dionysos said:
Peptide Gelling
I’ve read about “gelling” and odd non-dissolving peptides but I have no direct experience of it. My impression, possibly incorrect, is that this phenomenon is much more likely to occur with non-GLP1 peptides.

GLP1 Use Before Date
Addressing this ‘issue’ and a similar question about Bacteriostatic Water have occupied a BIG percentage of my time since I started publishing my datasheets.

To answer directly: there is no time limit I impose on my reconstituted peptides. I have successfully used a reconned GLP1 that was beyond 90 days since first puncture. I experienced no loss of efficacy when comparing this aged (refrigerated) vial with a newly reconned vial from the same batch.

I’ve studied the subject closely and answered all concerns sufficiently well to consider it settled for myself. I’ve chatted/DM’d hundreds of peptiders thousands of words about this; it takes a good deal of verbiage to address all the related issues.

Probably I should compile my chats and create a boilerplate response 🤷🏻‍♂️
Click to expand...

Thank you! I appreciate taking your time to reply!

Some users reported gelling on other platforms so I was curious about your experience. It does not look like it is an issue.

As for reconstituted pep/BAC it was only in relation to cargi. I use my recon peps till the last drop so whether it is 1 month or 12 months, it does not really bother me. The same goes for BAC water, I will use it till all 30ml are gone (which might take years at this point 🙂 ).

Again, thank you so much for sharing!
 
SLZRdad said:
Oh wow I didn’t know sema had better hunger suppression than tirz
Click to expand...
It certainly didn't for my RS! Quickly went from sema .25 to the full 1 mg within 3 months trying to get appetite under control. Lost about 10 lbs during that 3 months but it was a constant struggle with appetite and food noise returning at only about a month in no matter how much I upped the dose! Gave up and went to tirz as soon as the sema was gone. Subject has been on tirz 5 mg for 8 weeks with very good appetite control, losing about 1 lb per week and currently seeing no need to titrate up.
 
My endocrinologist told me I could use the original sample Ozempic pen he gave me as long as the liquid was not cloudy despite Novo’s recommendation.

Anecdotally I gave my dear husband multiple 7 year expired Zofran ( for days ) when he had Covid. Personally I never throw out expired medication. It may or may not lose potency but it won’t hurt you.
 
TroyLPN said:
It certainly didn't for my RS! Quickly went from sema .25 to the full 1 mg within 3 months trying to get appetite under control. Lost about 10 lbs during that 3 months but it was a constant struggle with appetite and food noise returning at only about a month in no matter how much I upped the dose! Gave up and went to tirz as soon as the sema was gone. Subject has been on tirz 5 mg for 8 weeks with very good appetite control, losing about 1 lb per week and currently seeing no need to titrate up.
Click to expand...
That’s my experience with Tirz. Just took my 12.5 mg shot of (SRY) Tirz this past Saturday and feeling hungry today :’(
 
SLZRdad said:
That’s my experience with Tirz. Just took my 12.5 mg shot of (SRY) Tirz this past Saturday and feeling hungry today :’(
Click to expand...
Semaglutide at 1mg per week is not considered an effective "therapeutic" dose for weight loss. My comments about relative appetite suppression are based upon 2.4mg per week of Wegovy or research Semaglutide.

For me, a Sema dose at 2.4mg weekly is slightly MORE effective at suppressing my appetite than Tirzepatide at 12.5 mg weekly - call it 5X the effectiveness of Tirz by Volume. Reta is somewhat better with 2. 4mg Sema equal to 8-10mg Tirz - the ratio equal to about 1:4 or 4X as effective by volume. YMMV

What works very well for me is a mid-week dose of 0.300mg of Cagrilintide stacked atop my Reta 10-12mg weekly injection.
 
TroyLPN said:
It certainly didn't for my RS! Quickly went from sema .25 to the full 1 mg within 3 months trying to get appetite under control. Lost about 10 lbs during that 3 months but it was a constant struggle with appetite and food noise returning at only about a month in no matter how much I upped the dose! Gave up and went to tirz as soon as the sema was gone. Subject has been on tirz 5 mg for 8 weeks with very good appetite control, losing about 1 lb per week and currently seeing no need to titrate up.
Click to expand...
Here’s the thing everybody reacts differently. I felt no appetite suppression until my third dose of Wegovy 1 mg, but I lost 30 lbs those first three months. Now I have been on Zepbound since the first week in July started a month of 12.5 now 15 mg this week is literally the first week I am like nope can’t eat one more bite and I delayed my shot by 36 hours cause insurance is cutting me off. I normally do OMAD and eat what I want.

So I maxed out on Sema at 2.4, now maxed at Tirz at 15 mg. Planning on adding Reta low dose see if I can get the last pounds off. Personally I don’t think anyone should stop a medication until they are at max dose, it may not be the peptide but the dose. YMMV
 
Vacation4us said:
Here’s the thing everybody reacts differently. I felt no appetite suppression until my third dose of Wegovy 1 mg, but I lost 30 lbs those first three months. Now I have been on Zepbound since the first week in July started a month of 12.5 now 15 mg this week is literally the first week I am like nope can’t eat one more bite and I delayed my shot by 36 hours cause insurance is cutting me off. I normally do OMAD and eat what I want.

So I maxed out on Sema at 2.4, now maxed at Tirz at 15 mg. Planning on adding Reta low dose see if I can get the last pounds off. Personally I don’t think anyone should stop a medication until they are at max dose, it may not be the peptide but the dose. YMMV
Click to expand...
I agree about the near maximum doses - that’s where I’ve lost the most weight.
 
dionysos said:
Peptide Gelling
I’ve read about “gelling” and odd non-dissolving peptides but I have no direct experience of it. My impression, possibly incorrect, is that this phenomenon is much more likely to occur with non-GLP1 peptides.

GLP1 Use Before Date
Addressing this ‘issue’ and a similar question about Bacteriostatic Water have occupied a BIG percentage of my time since I started publishing my datasheets.

To answer directly: there is no time limit I impose on my reconstituted peptides. I have successfully used a reconned GLP1 that was beyond 90 days since first puncture. I experienced no loss of efficacy when comparing this aged (refrigerated) vial with a newly reconned vial from the same batch.

I’ve studied the subject closely and answered all concerns sufficiently well to consider it settled for myself. I’ve chatted/DM’d hundreds of peptiders thousands of words about this; it takes a good deal of verbiage to address all the related issues.

Probably I should compile my chats and create a boilerplate response 🤷🏻‍♂️
Click to expand...
My thoughts on this topic are that the Eli Lilly reconstituted peptides in their injectable pens have a "discard by" date that is a full year after the prescription is filled. Now, I know generally their stuff is flying out of pharmacies, but there has to be a few weeks between reconstitution, packaging, shipping, and dispensing. So that's easily a year plus...
 
TarHeelPeptideUser said:
My thoughts on this topic are that the Eli Lilly reconstituted peptides in their injectable pens have a "discard by" date that is a full year after the prescription is filled. Now, I know generally their stuff is flying out of pharmacies, but there has to be a few weeks between reconstitution, packaging, shipping, and dispensing. So that's easily a year plus...
Click to expand...
And I think there is good reason to believe a properly refrigerated reconned research peptide would be effective at one year as well, TarHeel 👍
 
dionysos said:
Semaglutide at 1mg per week is not considered an effective "therapeutic" dose for weight loss. My comments about relative appetite suppression are based upon 2.4mg per week of Wegovy or research Semaglutide.

For me, a Sema dose at 2.4mg weekly is slightly MORE effective at suppressing my appetite than Tirzepatide at 12.5 mg weekly - call it 5X the effectiveness of Tirz by Volume. Reta is somewhat better with 2. 4mg Sema equal to 8-10mg Tirz - the ratio equal to about 1:4 or 4X as effective by volume. YMMV

What works very well for me is a mid-week dose of 0.300mg of Cagrilintide stacked atop my Reta 10-12mg weekly injection.
Click to expand...
Sorry, it's been a couple months since I was on Sema. I started at the usual 2.5 mg and gave up on it at 10.
 
I started my stack of Reta 1.5mg + Cagri 0.3mg alternating every 3 days.

So far so good, I'll increase in a month since it's a pretty low dose.
 
Thank you for sharing, this is absolutely GOLD!!
dionysos said:
The story arc in my Grand Tour has been from “easy, long-term weight-loss with full appetite supression and no calorie-counting on Sema TO a stalling-out fall-from-bliss TO six months of effortful-three-different-peptides-uphill-both directions struggle to regain weight-loss Heaven”.
Soon to be made into a major motion picture!

I have pretty well kept the peptide transitions distinct and can accurately distinguish their contributions.

I was hoping to delay publishing about this until I had more experience to report on.

BRIEFLY stated with the minimum of detail:
After 10-11 months successful Semaglutide weight loss I stalled out.

How can you keep on movin' unless you migrate too.
For me the difference in appetite suppression between Semaglutide and Tirzepatide was considerable and stimulated me to titrate rapidly to 7.5mg weekly. It wasn’t enough. Migrating to Tirzepatide reduced side effects but 10mg weekly dosage was required to approach the appetite suppression of Sema. More than 10mg weekly would have been needed to actually equal 2.5mg of Sema weekly.

Stack, stack, stack... they call him The Stacker.
Began stacking 2.5mg of Reta mid-week atop 10mg of TIrzepatide to assist with suppression.
It assisted well! Reta does have somewhat better appetite suppression than Tirzepatide. It soon became clear that the mid-week Reta was doing the heavy lifting and I quick-migrated to 7.5mg of Retatrutide dosage in about three weeks

Rinse and repeat.
Retatrutide is better in every way than Tirzepatide is - for me. Explaining the subtle whys becomes difficult. Certainly there are fewer side effects with Retatrutide than with Tirzepatide; my persistent side is constipation which I treat with Magnesium Citrate gelcaps. Fairly soon the 7.5mg dosage was not sufficient to quell my appetite and I needed to upgrade the dose. Reta unfortunately has the same difficulty for me that Tirzepatide does but not to the same degree - not quite adequate appetite suppression at 10mg weekly.

Enter the Dragon.
At risk of appearing a weak and needy addict, I admit to now stacking Cagrilintide mid-week atop 10mg of Retatrutide. This is strictly to stop the onset of significant hunger which was stalling me out AGAIN.

I decided on the addition of Cagrilintide mid-week
My intention was to start with 0.300mg but I fumbled the dose calculation or draw. Thankfully I experienced no strong side effects.

The main effect however was substantial - Appetite Suppression At Last!

Cagrilintide ELIMINATED my hunger for 7 days:
I lost 5lbs from Wednesday through end-of-day Sunday!

Based on my recent experience some things seem to be true:
a) Stacking Reta atop Tirz is not efficient or particularly effective.
This seems evident in hindsight as 2/3 of Retatrutide's agonists
duplicate Tirzepatid's agonists;

b) Both peptides have the same "weakness" - they don't suppress appetite nearly so well as Semaglutide.

c) Initial response to Cagrilintide is that its appetite suppression is equal to that of Semaglutide if not greater.

d) If your appetite breaks through while taking high dosages of Tirzepatide adding Cagrilintide is a far better solution than adding Retatrutide.

This data is of course only true for me. Your Mileage May WILL Vary!
Click to expand...

scarywood75 said:
I started my stack of Reta 1.5mg + Cagri 0.3mg alternating every 3 days.

So far so good, I'll increase in a month since it's a pretty low dose.
Click to expand...
I was about to tag you here, this info is gold, I see why you stacking cargi, I need to follow suit 🤜🏽🤛🏽 this forum is great, can’t even buy this info 😂
 
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touringsedan said:
Started Reta on 07/01/24 ID:4mg, titrated to 10mg.
Almost no side effects except for Cold/hot shifting in the day (Cold in first half of day, hot other half)

HR rose slowly from 50 to 60.

Losing about 4-5 lbs/wk. No food noise, hunger mostly wiped out around 6+ mg

Will hold on 10 as the Phase 2 clinical showed 8-10 was the best compromise.

I don't think I could ask for anything better.
Click to expand...
It has been a couple months since my last post. Continuing on Reta 12 mg. Weight loss after my prior post has been slowing from 4/wk, 3/wk, 2/wk and now bouncing around 0-2/wk.
Lost 55 lbs. so far in the 15 weeks and very happy and hopefully I can keep losing 1lb/wk until goal.
 
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