Half-Life of GLPs and Other Peptides

[5byfive]

The Peptide List just published a really interesting article on the half-life of GLPs and peptides in general. It gets into how the GLP meds are able to be effective which also has implications for the effectiveness of other peptides. I think its definitely worth a read.

https://thepeptidelist.substack.com/p/the-half-life-is-the-whole-game

Edit: I had to break the link becuse the spam filter is killing the word sub stack now. I don't know why. I did a search and there are plenty of active links to that sub stack. I know there is one person the board doesn't like on there and it seems like the whole site got nuked as a result.

2nd Edit: I should have thought about this in the first place and used a link shortened.

https://shorturl.at/44gCK

 

[eidos]

A very, very good article. Well-written, with no obvious AI slop. The explanations of how GLP-1 agonists work are precise, and it includes a bit of history about their discovery, citing and honouring the researchers, which is really honest. I didn’t know the story about the lizard before, but now I do. It uses metaphors to explain things clearly. There are some very useful FAQs and explanations of why it works or doesn’t work.
It takes a little time and concentration, but it's worth it.
Thanks @5byfive

 

[BrightCandle]

It's spot on, the targets of peptides are usually validated but the real question is do they survive Long enough to have an impact. It is that Long survival that has made glps into what they are.

 

[ishactive18]

The Peptide List just published a really interesting article on the half-life of GLPs and peptides in general. It gets into how the GLP meds are able to be effective which also has implications for the effectiveness of other peptides. I think its definitely worth a read.

https://thepeptidelist.substack.com/p/the-half-life-is-the-whole-game

Edit: I had to break the link becuse the spam filter is killing the word sub stack now. I don't know why. I did a search and there are plenty of active links to that sub stack. I know there is one person the board doesn't like on there and it seems like the whole site got nuked as a result.

Great article and thanks for sharing.

 

[CNCCurrency]

The Peptide List just published a really interesting article on the half-life of GLPs and peptides in general. It gets into how the GLP meds are able to be effective which also has implications for the effectiveness of other peptides. I think its definitely worth a read.

https://thepeptidelist.substack.com/p/the-half-life-is-the-whole-game

Edit: I had to break the link becuse the spam filter is killing the word sub stack now. I don't know why. I did a search and there are plenty of active links to that sub stack. I know there is one person the board doesn't like on there and it seems like the whole site got nuked as a result.

https://thepeptidelist.suspicious-link-removed.com/p/the-half-life-is-the-whole-game

 

[BNLFL]

Neither link work for me.

 

[UpDownLeftRightAS*]

Very cool! Great post!!!

 

[BNLFL]

Neither link work for me.

I got it.

 

[Flash-BCR]

Neither link work for me.

I copied the whole string in the OP and pasted it in and it came up....

Might be a 'florida' thing if that don't work...😎

 

[CNCCurrency]

Very cool! Great post!!! View attachment 27954

Nothing ground breaking in this article.

 

[CSM-101]

Great article - thank you for posting. My big question is: why hasn't some entity created new versions of common gray market peptides such as BPC-157, such that the peptide chain sequence has a fatty acid tail and so forth, in order to extend half-life? Is there any information out there that this has been attempted?

 

[RetCurious]

Neither link work for me.

I was able to copy the text of the url and paste it into another window to get it to work.
If that doesn't work search for the title "The Half-Life Is the Whole Game".

 

[Flash-BCR]

Nothing ground breaking in this article.

...unless you've never broke that ground before... 😎 ...I personally, was today's-years-old before I knew most/all of what was talked about in the article...good stuff!...

 

[indolent]

Much has been said about the effectiveness of split-dosing for tirzepatide, due to its 5-day half life and 7-day official protocol.

But I wonder about eloralintide's once-weekly expected official protocol, given its ~2 week half-life.

Anyone? Anyone? Buehler?

 

[eidos]

Anyone? Anyone? Buehler?

🤣 Haven't seen it in a long time...

 

[Neurogroot]

Great article - thank you for posting. My big question is: why hasn't some entity created new versions of common gray market peptides such as BPC-157, such that the peptide chain sequence has a fatty acid tail and so forth, in order to extend half-life? Is there any information out there that this has been attempted?

I may be mistaken, but some peptides, simply increasing the stability could decrease efficacy, or just fundamentally change how they work.

Works for some though! Example: Semax > N-Acetyl Semax > Adamax.

I’m sure as this sector opens up more and more, we will see some changes. At least, I hope so!