Has anybody plotted out serum concentrations of tirz over time based on overlapping dosage at different spacing intervals?

[Glp1judd]

Like the title says, I’m curious what the effect of dosing tirz on a 5 or maybe 4 day interval will be on cumulative serum concentration.

It should be pretty basic math based on below chart, but I’m too lazy to do it at the moment, and hoping someone else has done the work for me.

 

[scarywood75]

Like the title says, I’m curious what the effect of dosing tirz on a 5 or maybe 4 day interval will be on cumulative serum concentration.

It should be pretty basic math based on below chart, but I’m too lazy to do it at the moment, and hoping someone else has done the work for me.

There's a website specifically to calculate this - https://glp1plotter.com/

 

[Glp1judd]

Haha. Amazing.

Thx.

 

[Glp1judd]

So here’s a plot of t15 on a 7 days schedule vs t12 on a 5 day’s schedule.

I think it’s obvious 5 days schedule of 80% dosage is far more desirable.

 

[scarywood75]

So here’s a plot of t15 on a 7 days schedule vs t12 on a 5 day’s schedule.

I think it’s obvious 5 days schedule of 80% dosage is far more desirable.

I wouldn't say, in general our body will take more time to get used to peaks, which in turn may help for tolerance.

That's not specifically for peptide, it's just how our body adapts in general.

 

[TooBigtoFail]

Excellent link. Tks. So much better than an Excel spreadsheet. Great for not overdosing and for stacking. Now, I wonder how would my rat's body react if I microdose Triz 2.0-2.5mg every day? The residual seems to be pretty constant and the peak about the same as 15mg every 7 days. Is that an option to get around a plateau? Like shortening the dosing period by one day each month and adjusting the dose down?

 

[scarywood75]

Excellent link. Tks. So much better than an Excel spreadsheet. Great for not overdosing and for stacking. Now, I wonder how would my rat's body react if I microdose Triz 2.0-2.5mg every day? The residual seems to be pretty constant and the peak about the same as 15mg every 7 days. Is that an option to get around a plateau? Like shortening the dosing period by one day each month and adjusting the dose down?

No, you want those peaks, there's a reason why they didn't do that in the study.

 

[Glp1judd]

No, you want those peaks, there's a reason why they didn't do that in the study.

Not sure im following you. You’re saying the peaks are helpful in staving off tolerance (and reduced effectiveness)?

Based on what data?

I’d imagine we are studying a weekly dosing schedule because people are stupid and afraid of needles generally, so the goal is to make it as idiot proof as possible for the masses this is intended for.

 

[Glp1judd]

FYI, I did a bunch of research yesterday (instead of all the pre Xmas stuff I need to do - another rabbit hole of distraction).

Anyways, from what I learned, it seems peptide are typically sealed with a vacuum of about 70-80%.

I’m not sure how much my chamber vac is capable of, but the dial goes lower than that. I will test it today and of course try to keep well below.

 

[nonyabizznez]

Not sure im following you. You’re saying the peaks are helpful in staving off tolerance (and reduced effectiveness)?

Based on what data?

I’d imagine we are studying a weekly dosing schedule because people are stupid and afraid of needles generally, so the goal is to make it as idiot proof as possible for the masses this is intended for.

There's many ways to look at it. I'm on Prograf (anti rejection medication) and a stable level is desired to prevent rejection. This might not be as effective with GLP medications and may cause the user to need ever increasing dosages to be effective. There's always been the argument that periods of feast and famine trick the metabolism which might be behind the dosing schedule or that the peaks and valleys help with efficacy. Intermittent fasting and the rationale there.

Weekly injections are life changing for those dealing with diabetes. Living life with a weekly GLP remedy instead of living by the moment with insulin shots, a CGM or finger sticks is transformative.

 

[YoYoFat]

Yes, I plotted out the difference between 7, 5, and 3.5 days.

For now, I think I like 3.5 days best, twice a week to match the change of my estrogen patch.

It keeps the serum levels high enough that I have all of the benefits, without the extreme peaks that cause bad side effects.