MrsRoper_1977
GLP-1 Specialist
While he may be a vendor he never pushes his product. Nothing in that post suggests he’s trying to sell. You’re just trying to stir things up.
I'm going to shoot for losing 100 pounds in 6 months
- Thread starter raw_oyster_eater
- Start date
IMO The three things that can be dangerous in rapid weight loss include :
1) gallbladder : gallstones worsening. If you are obese you probably have gallstones. Rapid weight loss can worsen this and require a cholecystectomy. You can take actigal to prevent this
2) dehydration: this can cause kidney issues. I monitior specific gravity of urine to monitor this.
3) electrolyte loss - cardiac Arrhythmias - due to rapid weight loss and loss of sodium, potassium , etc always take a supplement for this .
I am down 85 lbs since mid April . I have maintained a 1200 calorie diet. Limit added sugar, ensure 75-80 grams of protein a day and balanced ……. I have 45 to make 100 lbs but I was 352 when I started.
Steroids have many, many more issues than peptides and need to be monitor by a provider for safe use.
1) gallbladder : gallstones worsening. If you are obese you probably have gallstones. Rapid weight loss can worsen this and require a cholecystectomy. You can take actigal to prevent this
2) dehydration: this can cause kidney issues. I monitior specific gravity of urine to monitor this.
3) electrolyte loss - cardiac Arrhythmias - due to rapid weight loss and loss of sodium, potassium , etc always take a supplement for this .
I am down 85 lbs since mid April . I have maintained a 1200 calorie diet. Limit added sugar, ensure 75-80 grams of protein a day and balanced ……. I have 45 to make 100 lbs but I was 352 when I started.
Steroids have many, many more issues than peptides and need to be monitor by a provider for safe use.
It's a completely fair point to make, I do have a vendor tag after all 🙂 That said, I think any advice given by strangers online should be carefully considered whether they are from a vendor or not.
And I would hope that people do their own research and read up before injecting anything into their body.
Appreciate the kind words 😍
As for my motive, I would be lying if I said I'm not on here to sell products. But the products I'm selling here is weight loss peptides, not steroids - And the vendor section is the place to do that.
Other places on the board I just read and engage in order to learn and share knowledge/experience (Whether you agree with what I say or not is up to you). Long term I believe that's more beneficial than pushing products.
When it comes to steroids, they do have quite a bad rep because they are more often abused than used, usually without proper management - But that doesn't mean they don't have upsides if used correctly.
Steroid use is probably a lot more common than you think, it's just that everyone using them doesn't look like the hulk - quite few steroid users do actually.
Not saying abusing steroids for bigger muscles is a good thing, I'm no fan of the fitness industry, but it is what it is and some of us are happy to take that risk. Objectively that's a silly decision, but that can be said for a lot of things people do 🙂
I specifically mentioned a low dosage, testosterone since it's one of the safer options for maintaining muscle mass on a prolonged calorie deficit. I could argue that anavar and hgh (debatable) might serve the purpose too with a low chance of side effects - If the dosing isn't stupid.
Does that mean I think everyone should start taking testosterone?
Definitely not (well, depends - but that's off topic for this discussion)...
There are several potential complications, and overweight can increase those risks, antiatherogenic lipid profile, blood pressure, sleep apnea, aromatase and estrogen related side effects etc.
"Also testosterone is known to stimulate growth of prostate cancer in men diagnosed with the condition. Recent clinical trials, which provide more accurate information compared to observational studies, have provided some comfort around both the heart and prostate cancer risks. For men who clearly have testosterone deficiency, there is no apparent increased risk of heart attack or stroke or greater chance of developing a new prostate cancer from testosterone replacement therapy."
Is testosterone therapy safe? Take a breath before you take the plunge - Harvard Health
The marketing of therapy for low testosterone highlights the short-term benefits, like increased energy, mental sharpness, and improved sexual function. But serious concerns remain about potential ...
www.health.harvard.edu
Oral steroids and rapid weight-loss is probably not a great idea without doing some blood tests since both puts stress on the liver.
I'd also like to point out that there are several steroids that would serve the purpose better, but they come with a way higher risk of side effects, which is why I haven't mentioned them.
My opinion is more biased because of personal opinions, use and experience than it is from a financial incentive - There are other places to peddle steroids that are way more suited for the purpose than this forum 🙂
The reason I lumped steroids in with peptides, is that there are quite a few peptides that can also cause quite severe harm and are still in early research stages so there are many unknowns. I often get a feeling that people tend to consider all peptides as harmless as Sema and Tirz (But I could be wrong).
The way you phrased yourself here, basically underlines that point - even if that wasn't what you intended to say. I would argue that a low dose of testosterone (trt dosages) is probably a lot safer and less problematic than some, if not all GHS peptides for example.
I don't think anyone should inject anything into their body without reading up, understanding risk/reward and preferably consulting a doctor and take the proper precautions. People are different and react differently to various medicine after all.
It's also worth mentioning that some peoples red blood cell count goes wild even on lower doses of testosterone, and more or less everyone will have an increased count - Which can increase the chance of clotting, and needs to be managed - for example by donating blood.
So yes, completely unsupervised use is not recommended at all. But under proper management I am tempted to call it harmless for the majority of people.
But I'll take what you said into account and make sure that I mention monitoring whenever I mention steroids.
Testosterone in normal doses can also worsen sleep apnea and heart failure. In obese folks it is converted to estrogen by aromatase leading to other potential cardiac risk …..and breast growth. EtcIt's a completely fair point to make, I do have a vendor tag after all 🙂 That said, I think any advice given by strangers online should be carefully considered whether they are from a vendor or not.
And I would hope that people do their own research and read up before injecting anything into their body.
Appreciate the kind words 😍
As for my motive, I would be lying if I said I'm not on here to sell products. But the products I'm selling here is weight loss peptides, not steroids - And the vendor section is the place to do that.
Other places on the board I just read and engage in order to learn and share knowledge/experience (Whether you agree with what I say or not is up to you). Long term I believe that's more beneficial than pushing products.
When it comes to steroids, they do have quite a bad rep because they are more often abused than used, usually without proper management - But that doesn't mean they don't have upsides if used correctly.
Steroid use is probably a lot more common than you think, it's just that everyone using them doesn't look like the hulk - quite few steroid users do actually.
Not saying abusing steroids for bigger muscles is a good thing, I'm no fan of the fitness industry, but it is what it is and some of us are happy to take that risk. Objectively that's a silly decision, but that can be said for a lot of things people do 🙂
I specifically mentioned a low dosage, testosterone since it's one of the safer options for maintaining muscle mass on a prolonged calorie deficit. I could argue that anavar and hgh (debatable) might serve the purpose too with a low chance of side effects - If the dosing isn't stupid.
Does that mean I think everyone should start taking testosterone?
Definitely not (well, depends - but that's off topic for this discussion)...
There are several potential complications, and overweight can increase those risks, antiatherogenic lipid profile, blood pressure, sleep apnea, aromatase and estrogen related side effects etc.
"Also testosterone is known to stimulate growth of prostate cancer in men diagnosed with the condition. Recent clinical trials, which provide more accurate information compared to observational studies, have provided some comfort around both the heart and prostate cancer risks. For men who clearly have testosterone deficiency, there is no apparent increased risk of heart attack or stroke or greater chance of developing a new prostate cancer from testosterone replacement therapy."
Is testosterone therapy safe? Take a breath before you take the plunge - Harvard Health
The marketing of therapy for low testosterone highlights the short-term benefits, like increased energy, mental sharpness, and improved sexual function. But serious concerns remain about potential ...
Oral steroids and rapid weight-loss is probably not a great idea without doing some blood tests since both puts stress on the liver.
I'd also like to point out that there are several steroids that would serve the purpose better, but they come with a way higher risk of side effects, which is why I haven't mentioned them.
My opinion is more biased because of personal opinions, use and experience than it is from a financial incentive - There are other places to peddle steroids that are way more suited for the purpose than this forum 🙂
The reason I lumped steroids in with peptides, is that there are quite a few peptides that can also cause quite severe harm and are still in early research stages so there are many unknowns. I often get a feeling that people tend to consider all peptides as harmless as Sema and Tirz (But I could be wrong).
The way you phrased yourself here, basically underlines that point - even if that wasn't what you intended to say. I would argue that a low dose of testosterone (trt dosages) is probably a lot safer and less problematic than some, if not all GHS peptides for example.
I don't think anyone should inject anything into their body without reading up, understanding risk/reward and preferably consulting a doctor and take the proper precautions. People are different and react differently to various medicine after all.
It's also worth mentioning that some peoples red blood cell count goes wild even on lower doses of testosterone, and more or less everyone will have an increased count - Which can increase the chance of clotting, and needs to be managed - for example by donating blood.
So yes, completely unsupervised use is not recommended at all. But under proper management I am tempted to call it harmless for the majority of people.
But I'll take what you said into account and make sure that I mention monitoring whenever I mention steroids.
A quick disclaimer: I'm not trying to say steroids are harmless, they most definitely are not. And the risks increase significantly with increased BMI, but that does not mean that they can't serve a purpose. I simply stated that it is a way to retain muscle mass when losing weight, and it can be managed quite safely (In most cases).
There are studies that indicate positive effects treating obesity with trt. I would consider them inconclusive for now, but it does give me enough reason to question whether trt is a bad idea for an obese man with low T.
Effectiveness of testosterone therapy in obese men with low testosterone levels, for losing weight, controlling obesity complications, and preventing cardiovascular events: Protocol of a systematic review of randomized controlled trials - PMC
Supplemental Digital Content is available in the text Keywords: low testosterone, metabolic syndrome, obesity, testosterone therapy, type 2 diabetes mellitus, weight loss
www.ncbi.nlm.nih.gov
https://endocrinenews.endocrine.org...ical disorder,common in men with hypogonadism. (Unsure about this source to be fair)
Heart failure:
Show me a conclusive study backing up your claim of heart failure. The observational studies you are most likely referring to are not solid enough, and over 10 years old.
There are also studies showing that the risk is increased by a low baseline level of testosterone and can potentially be amended by trt.
Some recent studies shows no difference in the risk of adverse cardiovascular events in men taking the therapy versus those not taking it. Arrhythmia risk may be slightly higher while on testosterone replacement though.
Basically, it's inconclusive.
Testosterone and the Heart - PMC
Testosterone (T) has a number of important effects on the cardiovascular system. In men, T levels begin to decrease after age 40, and this decrease has been associated with an increase in all-cause mortality and cardiovascular (CV) risk. Low T ...
www.ncbi.nlm.nih.gov
Heart health: Low testosterone associated with higher mortality risk
Researchers say low testosterone levels in men can increase mortality risk and very low levels of testosterone can increase the risk of cardiovascular-related death
www.medicalnewstoday.com
The Effect of Testosterone on Cardiovascular Disease and Cardiovascular Risk Factors in Men: A Review of Clinical and Preclinical Data - PMC
Cardiovascular disease (CVD) is the leading cause of death worldwide. The effects of testosterone, the primary male sex hormone, on cardiovascular risk have been of special interest due to the increased risk of CVD in men. Although it is well ...
www.ncbi.nlm.nih.gov
How Low Testosterone Affects the Heart
Low sex drive and declining muscle mass aren't the only reasons to prevent low T.
www.houstonmethodist.org
Sleep apnea caused by testosterone is quite individual and random, and risk increases with dosage. But yes, obesity will increase this risk.
Estrogen/Aromatase:
All people turn testosterone into estrogen via aromatase, not just obese folks - An increase of aromatase is associated with the inflammatory response in adipose tissue caused by obesity.
You can manage aromatase with an AI. Though in some cases obesity, due to aromatase-mediated androgen conversion into estradiol in the peripheral adipose tissue, might impair AI inhibitory capacity.
It's worth to mention that this risk would be present with or without exogenous testosterone. But might be slightly increased by testosterone if left unmanaged, I'm unsure if there are any studies on that specifically.
Breast growth:
Adolescent gynecomastia is associated with a high incidence of obesity, dysglycemia, and family background of diabetes mellitus - PMC
Gynecomastia during adolescence is common though etiology is not clear. We studied the clinical and hormonal profile of adolescent patients with gynecomastia. Patients who had onset of breast development between age 10 and 20 years were included in ...
www.ncbi.nlm.nih.gov
Sleep apnea:
Having low testosterone leads to lower muscle mass and a higher BMI, both of which are risk factors for sleep apnea. However, the reverse is also true. High testosterone levels are also correlated with an increased risk of sleep apnea.
_______________________________________________________
It's not like I'm saying he should take testosterone. I just mentioned that it is a potential solution to a concern he has. If you know what you're doing (or preferably consult a specialist), it may or may not be manageable depending on your situation.
According to your knowledge I should be dead 5-10 years ago 🙂
But all my health checkups are perfectly fine - that includes long term heart rate monitoring.
I also attended a study a couple years ago where they did god knows how many tests, from cognitive tests to mri, contrast agent, bloodwork and so on and so on. Perfectly healthy, and the list of stuff I have injected in my body (some in stupid amounts when young and dumb) is long.
That does NOT mean that there are no risks, not by a long shot. And higher doses do not have any upsides except big muscles - but there are more colors than black and white.
To be fair, you are probably better off health wise by not taking ANY kind of medication you don't need. But if you look around, that isn't really what happens in practice.
If you dive down the rabbit hole, there are actually quite a few health benefits from trt (depending on situation and dosage). Most of those could probably be achieved with a clean and healthy diet and exercise though, depending slightly on age and genetics.
zpped
Moderator
No, I'm making sure people know what they are reading. I didn't say he was lying about anything, just that he has an obvious bias.
Oyster has posted all over the internet what he's doing and it's obviously wreckless. Steroids *can* be used responsibly but even then they carry a lot of tradeoffs. Oyster is already abusing peptides, suggesting he look into steroids is like offering fent to supplement someone's pot habit.
Aromatase activity is greatly increased in obesity. A large amount of the injected testosterone will convert to estrogen. Estrogen - estradiol increase causes gynecomastia directly. Also prostate enlargement... Smarter to use an aromatase inhibitor . Also most obese folks have low total testosterone. So every research study will have a low total testosterone patient if obese. A total testosterone means nothing in an obese patient . A free/ bioavailable is better. Low total testosterone in the obese doesn’t mean they need replacement. The sleep apnea risk isn’t just from lack of muscle tone but also enlargement of tongue plays a role. Testosterone increase fluid retention and that is bad for the heart…if you have cardiac problems . Many obese do and don’t know it. Just been prescribing it for 15 years or so and have seen the many, many troubles with improperA quick disclaimer: I'm not trying to say steroids are harmless, they most definitely are not. And the risks increase significantly with increased BMI, but that does not mean that they can't serve a purpose. I simply stated that it is a way to retain muscle mass when losing weight, and it can be managed quite safely (In most cases).
There are studies that indicate positive effects treating obesity with trt. I would consider them inconclusive for now, but it does give me enough reason to question whether trt is a bad idea for an obese man with low T.
Effectiveness of testosterone therapy in obese men with low testosterone levels, for losing weight, controlling obesity complications, and preventing cardiovascular events: Protocol of a systematic review of randomized controlled trials - PMC
Supplemental Digital Content is available in the text Keywords: low testosterone, metabolic syndrome, obesity, testosterone therapy, type 2 diabetes mellitus, weight loss
https://endocrinenews.endocrine.org/the-long-haul-treating-men-with-obesity-with-testosterone/#:~:text=A study presented at ENDO,mortality or major cardiovascular incidents.&text=Obesity – a complex physiological disorder,common in men with hypogonadism. (Unsure about this source to be fair)
Heart failure:
Show me a conclusive study backing up your claim of heart failure. The observational studies you are most likely referring to are not solid enough, and over 10 years old.
There are also studies showing that the risk is increased by a low baseline level of testosterone and can potentially be amended by trt.
Some recent studies shows no difference in the risk of adverse cardiovascular events in men taking the therapy versus those not taking it. Arrhythmia risk may be slightly higher while on testosterone replacement though.
Basically, it's inconclusive.
Testosterone and the Heart - PMC
Testosterone (T) has a number of important effects on the cardiovascular system. In men, T levels begin to decrease after age 40, and this decrease has been associated with an increase in all-cause mortality and cardiovascular (CV) risk. Low T ...
Heart health: Low testosterone associated with higher mortality risk
Researchers say low testosterone levels in men can increase mortality risk and very low levels of testosterone can increase the risk of cardiovascular-related death
The Effect of Testosterone on Cardiovascular Disease and Cardiovascular Risk Factors in Men: A Review of Clinical and Preclinical Data - PMC
Cardiovascular disease (CVD) is the leading cause of death worldwide. The effects of testosterone, the primary male sex hormone, on cardiovascular risk have been of special interest due to the increased risk of CVD in men. Although it is well ...
How Low Testosterone Affects the Heart
Low sex drive and declining muscle mass aren't the only reasons to prevent low T.www.houstonmethodist.org
Sleep apnea caused by testosterone is quite individual and random, and risk increases with dosage. But yes, obesity will increase this risk.
Estrogen/Aromatase:
All people turn testosterone into estrogen via aromatase, not just obese folks - An increase of aromatase is associated with the inflammatory response in adipose tissue caused by obesity.
You can manage aromatase with an AI. Though in some cases obesity, due to aromatase-mediated androgen conversion into estradiol in the peripheral adipose tissue, might impair AI inhibitory capacity.
It's worth to mention that this risk would be present with or without exogenous testosterone. But might be slightly increased by testosterone if left unmanaged, I'm unsure if there are any studies on that specifically.
Breast growth:
Again, still a risk without trt, probably marginally increased by trt, again unsure if there are studies on the topic.Adolescent gynecomastia is associated with a high incidence of obesity, dysglycemia, and family background of diabetes mellitus - PMC
Gynecomastia during adolescence is common though etiology is not clear. We studied the clinical and hormonal profile of adolescent patients with gynecomastia. Patients who had onset of breast development between age 10 and 20 years were included in ...
Sleep apnea:
Having low testosterone leads to lower muscle mass and a higher BMI, both of which are risk factors for sleep apnea. However, the reverse is also true. High testosterone levels are also correlated with an increased risk of sleep apnea.
_______________________________________________________
It's not like I'm saying he should take testosterone. I just mentioned that it is a potential solution to a concern he has. If you know what you're doing (or preferably consult a specialist), it may or may not be manageable depending on your situation.
According to your knowledge I should be dead 5-10 years ago 🙂
But all my health checkups are perfectly fine - that includes long term heart rate monitoring.
I also attended a study a couple years ago where they did god knows how many tests, from cognitive tests to mri, contrast agent, bloodwork and so on and so on. Perfectly healthy, and the list of stuff I have injected in my body (some in stupid amounts when young and dumb) is long.
That does NOT mean that there are no risks, not by a long shot. And higher doses do not have any upsides except big muscles - but there are more colors than black and white.
To be fair, you are probably better off health wise by not taking ANY kind of medication you don't need. But if you look around, that isn't really what happens in practice.
If you dive down the rabbit hole, there are actually quite a few health benefits from trt (depending on situation and dosage). Most of those could probably be achieved with a clean and healthy diet and exercise though, depending slightly on age and genetics.
I can't argue when it's phrased like that 🙂 Would like the post twice if I could.
raw_oyster_eater
lemon bottle brewer
maybe. not too bad.
peptide log:
6/27 0.25 script zepbound
7/4 0.25 script zepbound
7/11 0.25 nuscience triz
7/21 1.0 peptide sciences reta
7/24 1.0 peptide sciences reta
7/26 2.0 peptide sciences reta
7/29 5.0 nuscience triz
8/1 2.0 peptide science reta
8/5 5.0 nuscience triz
8/7 1.0 acpeptides reta
8/8 3.0 acpeptides reta
8/15 2.0 acpeptides reta
8/17 2.0 acpeptides reta
8/20 0.5 amopure reta
8/21 1.0 amopure reta
8/22 1.0 amopure reta
8/23 0.10 amopure cagri
8/26 0.10 amopure cagri
8/28 0.20 amopure cagri
8/29 0.20 amopure cagri
9/1 0.25 amopure cagri
9/3 4.4 acpeptides reta
zpped
Moderator
Not necessarily in what you're taking but in how you're treating it. (although just completely jumping way ahead in dosing schedules and mixing glp1s isn't great) But you're using them to enable an abysmal diet and blow off everyone who told you it was bad idea. Not focusing on muscle retention isn't unique to you however. A lot of people aren't taking that serious enough.
Of course I am an NP might be biased
Biased or not, it’s a very sane point of view 🙂
I have a bias in the opposite direction, which can definitely be unfortunate if someone decides to make a decision based on what I say without taking proper precautions and getting the necessary tests
raw_oyster_eater
lemon bottle brewer
you've lost 100 in 8 months but I'm reckless for trying to do the same thing? Please share what you have done so everyone can learn. That's amazing. I don't expect to reach my goal but just something i'm shooting for. I just had a CBC and metabolic panel done last week. Creatinine is a little high.
I think people are kidding themselves with the weightlifting. You weightlift when you're gaining weight. Bodybuilders go thru a constant cycle of eating like crazy and lifting then cutting expecting to lose muscle. I've got plenty of muscle.
I just got my tesamorelin kit and look forward to mixing it up and dosing ASAP.
MrsRoper_1977
GLP-1 Specialist
That’s impressive. Congratulations on your success!!
Blood in urine and low kidney function not good….. you are dehydrated too. Gonna get referred to nephrology? Could be from dehydration …… it is considered grade 3 chronic kidney disease …. Unless it is acute from a drug or dehydration……..
I have lost 100 lbs since January but eat 1200 calories a day. 85 since starting tirz. It can be done safely under proper supervision
How many calories do you eat a day. I use myfitness pal to track calories and macros
How do you know if it’s even working? It takes 3-4 weeks before the system is properly dosed.
moonpies4misfits
GLP-1 Specialist
FYI for those using MFP and like to use the barcode scanner: If you switch your location to UK then you can use the scanner without premium. I did that for a little bit but I ditched MFP because it got too bogged down with ads on the free version and it's not worth $20 a month to me. Switched to MyNetDiary, premium is only $9, and liking it so far.
So
we are similar except protein around 75-80 grams a day, b12 shots twice a month, vitamin … stopped fish oil due to a fib risk … yeah saw the new cgm for 99 a month … was thinking about it too , using a glucometer. Fasting glucose went from 160’s to 90’s so far…. I need to increase fiber
Im that case, doctor even suspected I got a blood cancer!!! (he didn't know I self medicate with TRT)
solution is simple - aspirin and donate blood every 3 months
but yeah, steroids are risky, its not for everyone, however same can be said about research peptides, especially those very new
What indicates dehydration?
The urine specific gravity
his blood in urine is the most alarming + other markers detected, it indicates he needs more tests
edit: I overlook his kidney test, well all together it doesn't look good
That's what I thought but it seems borderline.
Yes, agree. That plus the high creatinine is a no bueno sign for kidneys, though potentially could indicate an infection.
Many things should be addressed …..well a gfr of 45 is concerning…. something is attacking the kidneys ……. Ketones can be from dehydration or fasting ……. Leukocyte est 2 plus can be from inflammation or infection …… might be smart to have a urine culture done too.
Some labs urine specific gravity ends at 1.030 so you don’t know if higher
I think we all agree he needs more investigation, there will be some issue with kidneys for sure
raw_oyster_eater
lemon bottle brewer
i'm going to the urologist soon. I have a 100+ gram prostate (4x normal size) and i think the pressure backs up the kidneys a bit (Hydronephrosis). Urine was coffee color when i had the test done. It'll do that for a day then clear up. And it started way before i did any peptides.
issue like this is probably not related to any peptides, but it could worsen it (dehydrated)
its obvious you are having some kidney issue + maybe some ongoing infection, prostate can be easily involved too (prostatitis etc.) , but infection by itself cant explain all the elevated markers
your doctor didn't comment on the lab test findings?
