Is 4mg+ really the key?

[cujet]

I'm not going to mess with the 4/weeks 2mg stats, I lost a bunch, but likely water weight. I lost 11lbs in 6 weeks on 4mg. I lost 10lbs in 6 weeks on 6mg, but later in the 6mg is when my sleep issues started. Lost 13lbs in 6 weeks on 8mg. Currently on the second week on 9mg and close to 2lbs down. Down 52lbs since 1/9/26.

Retatrutide absolutely affects my sleep. I've found a few things that help. Going to bed on time is a big one. Eating prior to bed helps a bit, as does magnesium glycinate. But the bottom line is that it's 50-50 as to whether I will get a full night's sleep or not.

 

[woundcarping]

Who doesn't like a chart?

I started Tirz on 12/12/25, Reta on 1/10/26. The chart starts at 1/10/26, the weight loss stats start at 12/12/25.

I started supplementing creatine on 5/1/26, which stagnated the loss trajectory temporarily.

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Who doesn’t like a linear update? Down 70lb in 200 days.

 

[RetCurious]

Who doesn’t like a linear update? Down 70lb in 200 days.

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That's a sweet graphic, good work on both accounts.

 

[GLP1Pharmacist]

I’ve seen a lot of back and forth on whether or not 4mg or more is where you truly get the benefits of Retatrutide compared to Trizepitide. To my understanding the argument supports that the Glucogon agonist doesn’t really get activated until you hit the 4mg+ a week. I’ve titrated up from .5mg to 4mg over a course of an couple of months and have been cruising there for about 3 weeks and haven’t really noticed anything different effect wise (Other than the continuous benefits of Reta obviously lol). Can anyone share their own experience?

6mg to feel it and 8mg to really make a difference for me.

 

[bogardbilla]

So yeah, n=1 here but 4mg is definitely the sweet spot, I don't have any side effects at all it's perfect I'm going to stay on this indefinitely.

Same here side effect-wise on 7.5mg. My only worry is that I've started believing that I'm finally cured and that things (appetite, inflammation, etc.) would generally stay the same even if I titrated off Reta 🙂