My experience (note: I started DSIP at the same time and changed ROA) , so this obviously isn’t a controlled experiment😉):
I initially started at 10 mg, sub q, taken about 30 minutes before bed, after what I believed was a reasonable amount of research. I ran that dose for three nights.
The results weren’t great:
- Sleep quality was poor
- Significant next day grogginess
- Mild headache-like feeling
- Overall, not restorative sleep
During that phase, my sleep score averaged around 50.
I then switched to 1 mg/day intranasal, and I’m currently on day 4 of that approach.
The difference has been noticeable.
- I’m not sleeping longer, but I’m waking up far less (maybe once per night vs. 6–7 times previously)
- Deep sleep is up ~25%
- Sleep scores have been 96–99% consistently
This has been some of the best sleep I’ve had in a long time.
Random thoughts....
Lower dosing and intranasal delivery may result in more favorable central nervous system signaling and less spillover into pathways that cause next day sedation or headaches. It’s also possible the higher dose was simply excessive for me. DSIP may be contributing as well.
Takeaway: In my case, more was not better. Lower dose + route of administration mattered far more than I expected.