Liraglutide from Grey

[druell235]

Is it possible to get liraglutide from grey vendors. I know its not nearly as effective from a results standpoint, but just curious.

 

[Labcat]

Is it possible to get liraglutide from grey vendors. I know its not nearly as effective from a results standpoint, but just curious.

I saw it was listed on HPT

What have you heard about it not veing as effective?
Are you using brand name currently? I was prescribed it and looking for options too.

 

[miss-sanne]

liraglutide is only 5-8 % weightloss, so much less effective for that.
Also, effect on appetite varies during the day because of the short halflife.
but it's not a bad drug, it does work.

 

[Labcat]

liraglutide is only 5-8 % weightloss, so much less effective for that.
Also, effect on appetite varies during the day because of the short halflife.
but it's not a bad drug, it does work.

Ah, I misinterpreted OP as saying gray lira is worse! And was surprised 🙂

 

[miss-sanne]

Ah, I misinterpreted OP as saying gray lira is worse! And was surprised 🙂

Labcat, your user name says it, but I always misinterpret your pic. lol.
Yes I have presbyopia. But I'm still not sure if it IS a cat or ??

 

[Labcat]

Labcat, your user name says it, but I always misinterpret your pic. lol.
Yes I have presbyopia. But I'm still not sure if it IS a cat or ??

Yes, that is my extra long orange tabby looking extra extra long stretched out on the couch, looking out the window.

Now I’m a little afraid to ask… but no pain no gain… what does it look like 🤣?

 

[miss-sanne]

Yes, that is my extra long orange tabby looking extra extra long stretched out on the couch, looking out the window.

Now I’m a little afraid to ask… but no pain no gain… what does it look like 🤣?

That's a cute one !
I'm not sure, it's a bit of a blur, but my thoughts weren't entirely pure, I have to admit. lol

 

[Labcat]

That's a cute one !
I'm not sure, it's a bit of a blur, but my thoughts weren't entirely pure, I have to admit. lol

🤣

 

[miss-sanne]

🤣

First time I saw it, had to zoom in to make sure it was a lab cat lol

 

[Labcat]

First time I saw it, had to zoom in to make sure it was a lab cat lol

Well, he is more of a lap cat.

 

[Calm Logic]

I would suggest orfo instead of lira. Orfo has a short half-life (though not as short as lira) while having more efficacy in the long term. And orfo is better now for stacking than anything else, at least in theory (though reta is a stack in itself, with nothing more effective).

It seems orfo can share a GLP-1 receptor (since orfo is so small) with lira/sema/tirz/reta (which are much larger). Sooner or later, I plan to use lira and orfo together for shits and giggles.

I have used lira to avoid gaining weight while starting reta or other new things. I have also used it for stacking with no miracles to report.

In the studies, lira does great in the beginning (like the same as the other GLPs for the first 12 weeks) but tends to "poop out" earlier than the other GLPs except for maintenance:

https://www.nejm.org/doi/full/10.1056/nejmoa2302392

Phase 3 trials of liraglutide (the SCALE trial4) and semaglutide (the STEP 1 trial5) showed significant weight reduction at 56 weeks and 68 weeks, respectively, with a mean reduction of 9.2% with liraglutide and 16.9% with semaglutide. This phase 2 trial of orforglipron showed weight reduction ranging from 8.6% to 12.6% at 26 weeks and ranging from 9.4% to 14.7% at 36 weeks.

Medication	Phase	Duration	Mean Weight Loss	Approx. Plateau Point
Liraglutide	Phase 3	56 Weeks	~8.0% – 9.2%	~28–32 Weeks
Semaglutide	Phase 3	68 Weeks	~14.9% – 16.9%	~60–68 Weeks
Orforglipron	Phase 3	72 Weeks	~12.4% – 14.7%	~60+ Weeks
Tirzepatide	Phase 3	72 Weeks	~20.9% – 22.5%	~72 Weeks
Retatrutide	Phase 2	48 Weeks	~24.2%	Not yet reached

Lira is primarily used now as a "bridge" or for maintenance. Because it is a daily injection with a shorter half-life, it is much easier for doctors to "fine-tune" the dose for a patient who has already reached their goal weight and just needs enough GLP-1 activity to keep their hunger (ghrelin) in check without continuing to lose weight.

Some start on Lira because it’s cheaper or easier to manage daily. Once they hit that 28-week "poop out" point, they switch to Tirzepatide or Semaglutide.