Liraglutide from Grey

[druell235]

Is it possible to get liraglutide from grey vendors. I know its not nearly as effective from a results standpoint, but just curious.

 

[Labcat]

Is it possible to get liraglutide from grey vendors. I know its not nearly as effective from a results standpoint, but just curious.

I saw it was listed on HPT

What have you heard about it not veing as effective?
Are you using brand name currently? I was prescribed it and looking for options too.

 

[miss-sanne]

liraglutide is only 5-8 % weightloss, so much less effective for that.
Also, effect on appetite varies during the day because of the short halflife.
but it's not a bad drug, it does work.

 

[Labcat]

liraglutide is only 5-8 % weightloss, so much less effective for that.
Also, effect on appetite varies during the day because of the short halflife.
but it's not a bad drug, it does work.

Ah, I misinterpreted OP as saying gray lira is worse! And was surprised 🙂

 

[miss-sanne]

Ah, I misinterpreted OP as saying gray lira is worse! And was surprised 🙂

Labcat, your user name says it, but I always misinterpret your pic. lol.
Yes I have presbyopia. But I'm still not sure if it IS a cat or ??

 

[Labcat]

Labcat, your user name says it, but I always misinterpret your pic. lol.
Yes I have presbyopia. But I'm still not sure if it IS a cat or ??

Yes, that is my extra long orange tabby looking extra extra long stretched out on the couch, looking out the window.

Now I’m a little afraid to ask… but no pain no gain… what does it look like 🤣?

 

[miss-sanne]

Yes, that is my extra long orange tabby looking extra extra long stretched out on the couch, looking out the window.

Now I’m a little afraid to ask… but no pain no gain… what does it look like 🤣?

That's a cute one !
I'm not sure, it's a bit of a blur, but my thoughts weren't entirely pure, I have to admit. lol

 

[Labcat]

That's a cute one !
I'm not sure, it's a bit of a blur, but my thoughts weren't entirely pure, I have to admit. lol

🤣

 

[miss-sanne]

🤣

First time I saw it, had to zoom in to make sure it was a lab cat lol

 

[Labcat]

First time I saw it, had to zoom in to make sure it was a lab cat lol

Well, he is more of a lap cat.

 

[Calm Logic]

I would suggest orfo instead of lira. Orfo has a short half-life (though not as short as lira) while having more efficacy in the long term.

And orfo may be better for stacking, at least in theory. It seems orfo can share a GLP-1 receptor (since orfo is so small) with lira/sema/tirz/reta (which are much larger). But reta would still be better in the long term. Sooner or later, I plan to use lira and orfo together for shits and giggles.

I have used lira to avoid gaining weight while starting reta or other new things. I have also used it for stacking with no miracles to report. In the studies, lira does great in the beginning (like the same as the other GLPs for the first 12 weeks) but tends to "poop out" earlier than the other GLPs except for maintenance:

https://www.nejm.org/doi/full/10.1056/nejmoa2302392

Phase 3 trials of liraglutide (the SCALE trial4) and semaglutide (the STEP 1 trial5) showed significant weight reduction at 56 weeks and 68 weeks, respectively, with a mean reduction of 9.2% with liraglutide and 16.9% with semaglutide. This phase 2 trial of orforglipron showed weight reduction ranging from 8.6% to 12.6% at 26 weeks and ranging from 9.4% to 14.7% at 36 weeks.

Medication	Phase	Duration	Mean Weight Loss	Approx. Plateau Point
Liraglutide	Phase 3	56 Weeks	~8.0% – 9.2%	~28–32 Weeks
Semaglutide	Phase 3	68 Weeks	~14.9% – 16.9%	~60–68 Weeks
Orforglipron	Phase 3	72 Weeks	~12.4% – 14.7%	~60+ Weeks
Tirzepatide	Phase 3	72 Weeks	~20.9% – 22.5%	~72 Weeks
Retatrutide	Phase 2	48 Weeks	~24.2%	Not yet reached

Lira is primarily used now as a "bridge" or for maintenance. Because it is a daily injection with a shorter half-life, it is much easier for doctors to "fine-tune" the dose for a patient who has already reached their goal weight and just needs enough GLP-1 activity to keep their hunger (ghrelin) in check without continuing to lose weight.

Some start on Lira because it’s cheaper or easier to manage daily. Once they hit that 28-week "poop out" point, they switch to Tirzepatide or Semaglutide.

 

[tubby]

Actually, some may choose liraglutide specifically because of the short half-life.

Let's say you reach your goal weight on a weekly-injectable GLP1 and are curious what kind of battle you'd be in for if you went "cold turkey." If you stop taking the weekly drug, that's not really cold turkey because (thanks to the long half-life) it's going to be over a month until it's really out of your system. A better indication of what cold turkey would be like would be to switch from the weekly GLP1 to a daily GLP1 (e.g. liraglutide) for a month and then to try stopping that.

There's also a question of if having the GLP1 receptors in your gut continually maxed out could prove to be bad for your health long-term (we have no way of knowing that just yet). With weekly injectables, you're never giving them a break. As a hypothetical, let's say we discover that it turns out some cancer is 30% more common on GLP1 users because some aspect of autophagy is hindered by continually elevated GLP1 levels. A daily shot like liraglutide could mitigate that risk, since GLP1 would be allowed to fall overnight. I'm not saying that's actually the case, just saying it's theoretically possible.

 

[Calm Logic]

Daily lira is a pain though compared to popping a pill. And orfo has a short enough half life, based my own experience as well.

 

[druell235]

I would suggest orfo instead of lira. Orfo has a short half-life (though not as short as lira) while having more efficacy in the long term.

And orfo may be better for stacking, at least in theory. It seems orfo can share a GLP-1 receptor (since orfo is so small) with lira/sema/tirz/reta (which are much larger). But reta would still be better in the long term. Sooner or later, I plan to use lira and orfo together for shits and giggles.

I have used lira to avoid gaining weight while starting reta or other new things. I have also used it for stacking with no miracles to report. In the studies, lira does great in the beginning (like the same as the other GLPs for the first 12 weeks) but tends to "poop out" earlier than the other GLPs except for maintenance:

I have two bottles of orfo. I have used a few pills at the end of the week and can confirm it does work. I was just curious if you could even get Liraglutide through grey vendors, given the popularity and effectiveness of sema, tirz, and reta.

 

[Calm Logic]

Lira is a cool GLP, even though unpopular. I have three lira pens now, one from India and two from a friend who no longer needed them (the brand name).

A generic lira pen from India is less than $30. But the shipping fee of $30 and seizure risk is there (with shipments from India getting more heat than China).

The lira pens are somewhat less flexible for doing since 3 mg would require two shots (1.8 mg and 1.2 mg). But the pens are themselves convenient, especially for dosing up to 1.8 mg.

 

[Calm Logic]

Half-lives per Gemini:

Medication	Half-Life	Short-Term Efficacy (12-16w)	Long-Term Efficacy (40-72w)	Reference Link
Liraglutide (Lira)	~13 hours	~5% loss	~8.0% loss (56w)	PMC 11642516
Orforglipron (Orfo)	~30–50 hours	~8-9% loss	~12.4% loss (72w)	ATTAIN-1 (2025)
Tirzepatide (Tirz)	~5 days	~12-15% loss	~20.2%–22.5% loss (72w)	SURMOUNT-5
Survodutide (Survo)	~6 days	~8.7% loss (16w)	~14.9%–18.7% loss (46w)	AJMC Phase 2
Retatrutide (Reta)	~6 days	~10% loss (12w)	~24.2%–28.7% loss (48-68w)	NEJM Ph 2 / TRIUMPH
Semaglutide (Sema)	~7 days	~6% loss	~14.9%–17.0% loss (68w)	STEP 1 Trial
Mazdutide (Maz)	~7–10 days	~5.2%–10.9% loss (12w)	~18.6%–21.0% loss (24w+)	PMC 12515780

 

[tubby]

The only hesitation I might have about orforglipron is that although it accomplishes the same thing as GLP-1RA peptides, it is fundamentally different in that it's a drug designed to accomplish the same effect. Novo's pill is just a novel delivery mechanism to get a peptide from the stomach to the gut, so theoretically should have a similar risk profile to semaglutide. You can't really say the same thing about orforglipron. Although, I guess one could level the same critique about the newest peptides that add glucagon agonism too.

 

[Calm Logic]

The only hesitation I might have about orforglipron is that although it accomplishes the same thing as GLP-1RA peptides, it is fundamentally different in that it's a drug designed to accomplish the same effect. Novo's pill is just a novel delivery mechanism to get a peptide from the stomach to the gut, so theoretically should have a similar risk profile to semaglutide. You can't really say the same thing about orforglipron. Although, I guess one could level the same critique about the newest peptides that add glucagon agonism too.

All the more exciting for us living on the edge, needing new feelz, haha. But so far, it seems like the other GLPs subjectively, as in the studies, just a shorter time frame.