Nexaph

[Calm Logic]

@peptideusername copied his crypto guide from PGB!

But he also steals syringes from pharmacies, so I am glad the word is getting out.

 

[Skidude]

But he also steals syringes from pharmacies, so I am glad the word is getting out.

I heard he was Santa, with his North pole selfie and Tirz bod, with beard dye to complete the disguise.

 

[DwightTheDelight]

But he also steals syringes from pharmacies, so I am glad the word is getting out.

He's actually the only person in this forum I know irl. I went to school with him. He spent most of his time in the nurse's office stealing bandaids and chapstick. Heck of a guy, but has a diabolical case of sticky fingers when medical supplies are nearby.

 

[nonyabizznez]

He's actually the only person in this forum I know irl. I went to school with him. He spent most of his time in the nurse's office stealing bandaids and chapstick. Heck of a guy, but has a diabolical case of sticky fingers when medical supplies are nearby.

You're looking too thin buddy! Hope you are well!

Also hoping your wife is well and your mistress(s) and all those "friends" at the Pink Pony and the Bada Bing and those dudes at the Floppy Rooster and Swinging Richards 😘 Oh... And the kids!

 

[nurseratchit]

The testing group I was in for the PGB NAD felt that it wasn’t actually degrading, but rather an issue with inconsistent fills. The most recent batch had a test where one vial was at over 800 mg and the lowest was 483 They tested 4 vials.

Actually there were inconsistent fills AND they were also degrading from the baseline fills. Some suspect the buffer may have contributed to degradation.

 

[Calm Logic]

Did PGB have inconsistent fills with any GLP-1s?

 

[nurseratchit]

Did PGB have inconsistent fills with any GLP-1s?

Can’t speak for all of them but AFAIK, have always been consistent and test well. They’re also more expensive but they mostly have good customer service and are trustworthy. It’s the only place I would recommend for newbies.

 

[exploitedworkerbee]

Oh oh let's start a rumor!

@peptideusername copied his crypto guide from PGB!

 

[gothpeacock]

I just received an order yesterday and it’s bad. And they are no were to be found🙁

Did you get the melted NAD too? We had 19 out of 20 vials that had chunky crystals at the bottom. Cain assures us it’s fine and was retested multiple times. He says it’s the buffering agent that caused that.

 

[zpped]

Did you get the melted NAD too? We had 19 out of 20 vials that had chunky crystals at the bottom. Cain assures us it’s fine and was retested multiple times. He says it’s the buffering agent that caused that.

It's the lack of experience that caused it. The buffering agent requires modifications to the finishing process and they fucked it up. BabaCain is once again experimenting on his customers.

 

[gothpeacock]

It's the lack of experience that caused it. The buffering agent requires modifications to the finishing process and they fucked it up. BabaCain is once again experimenting on his customers.

 

[gothpeacock]

I have an older friend that is a trainer and coach. He refuses to learn how to use crypto and I often help him facilitate orders from other vendors but I’m not always available. I sent him to Nexaph because of their willingness to accept PayPal etc. and this is what he got. Cain doesn’t seem willing to refund or replace so he’s just going to have to use it. Several others in the TG group said they had similar vials and they were fine. Just disappointing.

 

[ZippityDooDah]

I have an older friend that is a trainer and coach. He refuses to learn how to use crypto and I often help him facilitate orders from other vendors but I’m not always available. I sent him to Nexaph because of their willingness to accept PayPal etc. and this is what he got. Cain doesn’t seem willing to refund or replace so he’s just going to have to use it. Several others in the TG group said they had similar vials and they were fine. Just disappointing.

It's not so much a "willingness" to accept PayPal as it is a matter of PayPal not yet discovering the nature of his products, freezing his account and banning him from using their platform which eventually happens to anyone selling research peptides.

 

[exploitedworkerbee]

It's not so much a "willingness" to accept PayPal as it is a matter of PayPal not yet discovering the nature of his products, freezing his account and banning him from using their platform which eventually happens to anyone selling research peptides.

And very often freezing their funds for extended periods of time as they ban.

 

[ZippityDooDah]

And very often freezing their funds for extended periods of time as they ban.

💯

 

[chmuse]

And very often freezing their funds for extended periods of time as they ban.

His website already needed to find a new host. I don't know how long it's going to last at this point.

 

[exploitedworkerbee]

His website already needed to find a new host. I don't know how long it's going to last at this point.

once they lose easy payment theyll have transformed into what PGB became -- overpriced, objectively unremarkable, living on a reputation fostered when things were different.

 

[chmuse]

once they lose easy payment theyll have transformed into what PGB became -- overpriced, objectively unremarkable, living on a reputation fostered when things were different.

That or they'll rebrand somehow. Maybe a new Chinese identity.

 

[cmath]

I just received an order yesterday and it’s bad. And they are no were to be found🙁

What did you receive that was bad? They're super communicative so I would definitely reach out.

 

[AKC97]

How is it bad? Did a genie not come out to grant you three wishes?

Can someone please add the 🫢 or 🫣 emoji? I really needed them in this case. 😉

 

[Iamnew2this]

I just received an order yesterday and it’s bad. And they are no were to be found🙁

Was it NAD?

 

[Ted R]

Did you get the melted NAD too? We had 19 out of 20 vials that had chunky crystals at the bottom. Cain assures us it’s fine and was retested multiple times. He says it’s the buffering agent that caused that.

Like these beauties?

 

[Iamnew2this]

Wow, sorry. The NAD really IS bad. The vials on the bottom are awful! Did you send in pics? They shouldn't have sent them out like that.

 

[Calm Logic]

Even Google Gemini is pissed:

The most striking observation is the significant color variation among the vials. While some vials contain a powder that appears yellowish-white or off-white (which is typical for good quality NAD+ powder), others are distinctly yellowish-green, and some even appear a darker greenish-brown.

The quality of the lyophilized NAD+ powder in the image appears poor to questionable. The significant color variation, particularly the presence of yellow, green, and greenish-brown colors, is a strong indicator of degradation. The vials with darker, clumped material suggest moisture exposure.

 

[Ted R]

Wow, sorry. The NAD really IS bad. The vials on the bottom are awful! Did you send in pics?

Yes, and to Cain's benefit, he apologized that vials like these got shipped and voluntarily credited 60% of this kit, without my asking.

 

[Iamnew2this]

Yes, and to Cain's benefit, he apologized that vials like these got shipped and voluntarily credited 60% of this kit, without my asking.

Ok, that's better. I'm seeing that people are trying to get in touch with him and he's not available. He's usually responsive. I like their products. I'll skip on the NAD, though. I'm happy that Cain made things a better for you👍

 

[Ted R]

The NAD overall is probably fine in general, but the stability of their buffered solution during the lyophilization process is still flawed. I did get 2 other kits which were as perfect looking as this one was ugly. I am most interested to see how this batch as a whole tests out.

 

[Calm Logic]

As an alternative to NAD+, oral supplementation with NMNH:

NMNH Raises NAD+ Substantially More than NMN

An NMN molecule with an added hydrogen atom, NMNH, boosts blood NAD+ about twice as much as NMN and significantly elevates NAD+ in tissues where NMN does not—muscle, the heart, and the brain—in mice.

www.nmn.com

"An NMN molecule with an added hydrogen atom, NMNH, boosts blood NAD+ about twice as much as NMN and significantly elevates NAD+ in tissues where NMN does not—muscle, the heart, and the brain—in mice."

I am most interested to see how this batch as a whole tests out.

Incidentally, to test one's own blood for NAD levels, I see at-home tests for $200, though I don't know how helpful or accurate they are, especially for women:

Association of Human Whole Blood NAD+ Contents With Aging - PMC

NAD+, nicotinamide adenine dinucleotide, is mostly described to associate with the aging process. We aimed to investigate the association between human whole blood NAD+ contents and aging in a relative large-scale community-based population and ...

pmc.ncbi.nlm.nih.gov

"The loss of blood NAD+ with aging only was observed in males, especially in the male middle-aged population. It is crucial to consider the gender difference in further NAD+ related studies in the future."

Regarding the potential value of NAD level tests, once more is known:

Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies - PMC

Precursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main boosters of NAD+. Increasing public awareness and interest in anti-ageing ...

pmc.ncbi.nlm.nih.gov

"The use of NAD+ boosters when cellular NAD+ levels are already/still adequate may thus be unwise [96]. Therefore, we need to establish the normal/healthy NAD+ levels and how to measure them. The age-related reference intervals for NAD+ levels should be determined in future clinical trials."

 

[Iamnew2this]

The NAD overall is probably fine in general, but the stability of their buffered solution during the lyophilization process is still flawed. I did get 2 other kits which were as perfect looking as this one was ugly. I am most interested to see how this batch as a whole tests out.

It probably is fine. That would be great if you can keep us posted.

 

[Ted R]

It probably is fine. That would be great if you can keep us posted.

Will do.

 

[exploitedworkerbee]

Like these beauties?

lol I can’t believe they shipped that. Poor babacain is gonna have to issue yet another assurance that product integrity is their highest priority just a week after the last time he had to 🤣 I’m starting to wonder if that’s just hollow damage control marketing speak.

 

[raw_oyster_eater]

I checked over there to see if he put it up as "ugly NAD"

not yet. always looking for bargains.

I'll buy anybody's bum stuff for a buck or two a vial.

 

[Calm Logic]

but the stability of their buffered solution during the lyophilization process is still flawed. I did get 2 other kits which were as perfect looking as this one was ugly. I am most interested to see how this batch as a whole tests out.

The first person who posted about "bad" NAD+ had vials that looked perfect as well (before the picture was deleted).

So to make sense of the madness, I had to ask what else may be at play:

Reasons for Differential Degradation in Lyophilized Vials:

Even with seemingly identical vials of freeze-dried powder, variations in storage or processing can lead to some degrading more than others:

1. Residual Moisture Content: This is arguably the most critical factor for lyophilized products.
   • Incomplete Drying: If some vials didn't undergo complete drying during the lyophilization process, they would have higher residual moisture. Even a tiny amount of water can significantly accelerate degradation of NAD+.
     
     
   • Moisture Ingress: A compromised vial seal (even a microscopic defect) can allow ambient humidity to slowly ingress into the vial, rehydrating the powder and triggering degradation. This can happen during storage or shipping.
2. Temperature Excursions:While lyophilized powder is more robust than solution, extreme or prolonged heat can still cause degradation.
   • Localized Hot Spots: During shipping or storage, some vials might have been exposed to warmer temperatures for longer periods or to higher peak temperatures within a batch.
     
     
   • Fluctuations: Repeated temperature cycling (even if within recommended storage ranges) can stress the powder and potentially exacerbate degradation.
3. Light Exposure: NAD+ is generally sensitive to light, especially UV light. If some vials were exposed to light more than others, it could contribute to their degradation, though this is usually secondary to moisture and temperature.
   
   
4. Oxygen Exposure / Seal Integrity: Oxygen can also contribute to NAD+ degradation. If a vial's seal is not perfectly hermetic, it could allow oxygen in, leading to oxidation and degradation.
   
   
5. Initial Purity and Consistency:
   • Raw Material Quality: While unlikely from reputable suppliers, slight variations in the initial purity of the NAD+ used for different vials could influence their long-term stability.
     
     
   • Manufacturing Variability: Even with strict GMP (Good Manufacturing Practice) standards, minor inconsistencies during the lyophilization process (e.g., slight differences in freezing rate, vacuum levels, or drying time for individual vials) could result in subtle differences in the final powder structure and stability.
6. Static Electricity/Handling: In rare cases, electrostatic charges or excessive agitation during handling could potentially contribute to subtle changes in the powder's physical structure, making it slightly more susceptible to moisture or other degradation pathways, though this is less likely to cause significant visual degradation.

 

[Divide By Zero]

I was sent vials of NAD+ that suffer from straight-up meltback... not crystallization. Confirmed by an actual (retired) chemist, not a vendor (Cain) that just seems bent on gaslighting everyone. Meltback is definitely a problem, and I find it laughable Cain tries to say it "tested" fine when he has kits of widely varying quality and condition being sent out sight-unseen. It is also laughable that he likes to posture himself as some "stand up guy," offering refunds for bad kits, when he turns right around and arbitrarily decides "that's good to go.. it's just crystallization." Partial refunds are also a joke; he should be refunding people in full and abandoning this entire product until whoever is manufacturing it gets their crap together. There seems to be a very large set of people (disciples) hellbent on refusing to believe Cain (cult leader) is not perfect and very much want to believe everything he says. Cain relies on people's ignorance in situations like this and selectively refunds those he thinks will run the most "interference" defending his... uh... honor (cough). The need to believe is very strong with this guy. He should have just cut his losses, admitted it's crap, refunded everyone, and taken up all complaints with his source. I shouldn't have to even know what "meltback" is... unfortunately due to Cain, I do now.

 

[Calm Logic]

Does anyone do NAD right, consistently? There are complaints here about PGB too over NAD.

 

[chmuse]

I was sent vials of NAD+ that suffer from straight-up meltback... not crystallization. Confirmed by an actual (retired) chemist, not a vendor (Cain) that just seems bent on gaslighting everyone. Meltback is definitely a problem, and I find it laughable Cain tries to say it "tested" fine when he has kits of widely varying quality and condition being sent out sight-unseen. It is also laughable that he likes to posture himself as some "stand up guy," offering refunds for bad kits, when he turns right around and arbitrarily decides "that's good to go.. it's just crystallization." Partial refunds are also a joke; he should be refunding people in full and abandoning this entire product until whoever is manufacturing it gets their crap together. There seems to be a very large set of people (disciples) hellbent on refusing to believe Cain (cult leader) is not perfect and very much want to believe everything he says. Cain relies on people's ignorance in situations like this and selectively refunds those he thinks will run the most "interference" defending his... uh... honor (cough). The need to believe is very strong with this guy. He should have just cut his losses, admitted it's crap, refunded everyone, and taken up all complaints with his source. I shouldn't have to even know what "meltback" is... unfortunately due to Cain, I do now.

Yeah, until now I'd been using him as a 'I need something fast I'll just pay the premium' but I'm not sure he can come back from this one in my eyes. These kits should have never been sent out, especially not at his usual mark up.

 

[Peloma]

Bristaxx said that unbuffered Nad+ is the way to go because what you see in those previous pics is the result of the buffer separation. The buffer also adds a level of instability that degrades the Nad faster.

Buffer your own as needed with sodium bicarbonate, and ugly Nad shouldn't be an issue.

 

[Ted R]

Bristaxx said that unbuffered Nad+ is the way to go because what you see in those previous pics is the result of the buffer separation. The buffer also adds a level of instability that degrades the Nad faster.

Buffer your own as needed with sodium bicarbonate, and ugly Nad shouldn't be an issue.

I was sent vials of NAD+ that suffer from straight-up meltback... not crystallization. Confirmed by an actual (retired) chemist, not a vendor (Cain) that just seems bent on gaslighting everyone. Meltback is definitely a problem, and I find it laughable Cain tries to say it "tested" fine when he has kits of widely varying quality and condition being sent out sight-unseen. It is also laughable that he likes to posture himself as some "stand up guy," offering refunds for bad kits, when he turns right around and arbitrarily decides "that's good to go.. it's just crystallization." Partial refunds are also a joke; he should be refunding people in full and abandoning this entire product until whoever is manufacturing it gets their crap together. There seems to be a very large set of people (disciples) hellbent on refusing to believe Cain (cult leader) is not perfect and very much want to believe everything he says. Cain relies on people's ignorance in situations like this and selectively refunds those he thinks will run the most "interference" defending his... uh... honor (cough). The need to believe is very strong with this guy. He should have just cut his losses, admitted it's crap, refunded everyone, and taken up all complaints with his source. I shouldn't have to even know what "meltback" is... unfortunately due to Cain, I do now.

Here is Janoshik's vendor supplied test report for this batch. Note the attached pics (scroll all the way to the last pics) that show most if not all have at least some degree of melting and they still tested from ~495 to ~584. Definitely he has some work to do to improve the puck quality but all in all not too bad.

Janoshik Analytical

 

[Calm Logic]

I would be filtering (as always):

When the lyophilized NAD+ melts, it re-enters a liquid state. This immediately increases the risk of microbial growth for several reasons:

• Reabsorption of Moisture: The melting implies moisture re-entry, creating an aqueous environment that many microorganisms need to thrive.
  
  
• Exposure to Environment: Unless the melting occurred within a completely sterile, sealed, and undamaged vial, there's a risk of environmental contamination. Even microscopic cracks in the stopper or vial, or improper handling during storage, could allow airborne microbes or those from surfaces to enter the now-liquid product.
  
  
• Breach of Aseptic Seal: The integrity of the vial's seal (stopper, crimp) is crucial for maintaining sterility. Melting and subsequent re-solidification (if it happens) can stress the stopper and potentially compromise the seal, allowing ingress of contaminants.
  
  
• Nutrient Availability: NAD+ itself, or any excipients in the formulation (like sugars or buffers), can serve as nutrients for microbial growth if contamination occurs.

 

[zpped]

Here is Janoshik's vendor supplied test report for this batch. Note the attached pics (scroll all the way to the last pics) that show most if not all have at least some degree of melting and they still tested from ~495 to ~584. Definitely he has some work to do to improve the puck quality but all in all not too bad.

Janoshik Analytical

Any issue is almost certainly going to manifest as premature degradation. What's it going to test like in 6 months? Or how is it going to compare to other NAD 1-2 weeks after reconstitution?

 

[ironbull]

Just ordered from nexaph to Canada
Cleared customs within an hour.. delivery was 3 days from ordering. Impressive

 

[ironbull]

Not sure what is bad but properly buffered NAD+ is light yellow. If it's dark yellow then it's oxidized. I brew my own NAD+ and have messed up many batches. Even with it oxidized it will still give some benifits and the oxidized portion just converts to NADH. Not exactly what we are looking for but it will still give some benifits.

I just buy bulk nmn and that boosts nad levels very well

 

[Calm Logic]

I am planning on using oral NMNH (which seems better than NMN at raising NAD levels in the body as a whole, at least in mice). But I'm sure I will try NAD subq at some point.

 

[ironbull]

I am planning on using oral NMNH (which seems better than NMN at raising NAD levels in the body as a whole, at least in mice). But I'm sure I will try NAD subq at some point.

this must be newer.. i havent seen this listed for sale yet on some of the main sources for NMN... NMN works great already.. I'm taking a gram of NMN daily .. do you have to take as much in that form to get the same results?

 

[Calm Logic]

Yes, the same amount of NMNH (like the kind sold at Amazon), to provide superior results if anything, especially to other tissues and not just the bloodstream.

1.5 grams may be even better:

https://www.nmn.com/news/nmnh-substantially-raises-nad-levels-more-than-nmn

"The dosages used in these mice were 250 mg/kg injections or about 1.5 grams for adults weighing about 165 pounds. These results suggest that NMNH more effectively increases blood NAD+ compared to NMN."