2boxers
Recently Joined
My wife has no energy on Tirezepatide is there something she can take to help with this
No energy
- Thread starter 2boxers
- Start date
Nikki nik
GLP-1 Specialist
Make sure she's not deficient of any vitamins. I take MOTS C. I no longer feel tired from tirz.
How long did it take you to notice the effects?
geoguy78
GLP-1 Specialist
Is she eating? Many of us end up in (over)extreme caloric deficit and as much as we would like to, our bodies won't let us run at full speed on just our reserves.
2boxers
Recently Joined
Yep! It's only on the end of week two so hopefully she'll adjust
2boxers
Recently Joined
2boxers
Recently Joined
Thanks I'll look into it.
Sounds basic, but Vitamin C IM injection. I took 250mg and it blew my mind!
stickfigure
GLP-1 Enthusiast
You may be able to compensate for it with some supplements or peptides, but it is normal - the body is using more energy than it is getting from food, so it's in energy deficit. That's how weight loss without amphetamines works.
Nikki nik
GLP-1 Specialist
ASAP
Sunflower
GLP-1 Member
I’ve had the same issue. Has she had her free Test, free T3, and other hormones checked? If she is already hormonally optimized, alternating or switching to Reta may help. I’m doing 50/50 Tirz/Reta and feel less lethargic.
2boxers
Recently Joined
She's almost 50, I told her she should get those checked.
keangkong
A Not So Fat Dude
- Joined
- Sep 2, 2024
- Posts
- 1,287
- Like Points
- 3,443
- CIty/State
- Ryongsong Residence, Pyongyang, North Korea
I've tried amphetamines. I lose weight quickly. A month or two later, the weight comes back. By the way, I take the amphetamines for ADHD. Twenty-four years after I began taking them, my Adderall still works great . . . for ADHD.
keangkong
A Not So Fat Dude
- Joined
- Sep 2, 2024
- Posts
- 1,287
- Like Points
- 3,443
- CIty/State
- Ryongsong Residence, Pyongyang, North Korea
A small minority of people, including me, experience a great deal of fatigue on tirzepatide. I thought I was sick; so did the doctors. Eventually the fatigue largely went away. I also reduced the dose. I don't take anything to help with fatigue. However, I am adding retatrutide, which I believe is less likely to cause fatigue.
Sunflower
GLP-1 Member
I had the same issue with Tirz, which helped somewhat when adding/ alternating Reta. I just got some Pinealon from PGB which might help the mental fatigue, possibly. I’ve also got Test cyp on the way to see if that helps energy and motivation. If either are “magical,” I’ll post an update on the forum.
Valerie
GLP-1 Member
@2boxers
2 weeks isn't very long, but I do recommend she get a full blood panel if she hasn't to check for any and all deficiencies (vit D, iron) as well as full conversation about her hormone levels. Is she in menopause? Post menopause?
Taking HRT?
I'm in her age range and I am taking supplements to help with fatigue due to menopause because I am not taking hormones. I was feeling tired before starting tirz due to meno.
Tirz specifically:: I split dose and that was a game changer for me recently. I'm in maintenance and instead of once a week I'm now Friday / Monday. I also agree less is more with Tirz -- of course I have noticed there are variances depending on the source.
Meat_Peterson
GLP-1 Novice
Has she had any labs done before starting ? There are companies you can contact directly for lab work, it's all out of pocket , but can be done. I had chronically low vitamin D. This, with Triz, had me feeling pretty lethargic. Also, dehydration and an extreme caloric shortage, as others have said, can cause it. I definitely still feel some fatigue during specific parts of the day. But since balancing my diet and correcting what I can after my labs has helped extremely.
keangkong
A Not So Fat Dude
- Joined
- Sep 2, 2024
- Posts
- 1,287
- Like Points
- 3,443
- CIty/State
- Ryongsong Residence, Pyongyang, North Korea
I also felt no energy on tirzepatide. It's a side effects that's not nearly as universal as the experiencing gastrointestinal distress at some point, but it's still common.
keangkong
A Not So Fat Dude
- Joined
- Sep 2, 2024
- Posts
- 1,287
- Like Points
- 3,443
- CIty/State
- Ryongsong Residence, Pyongyang, North Korea
I believe we're in a minority in the grey GLP-1 community: I also dose twice per week.
Valerie
GLP-1 Member
I like the steady lower level. I was getting tirz fatigue 48 hrs after shot day because the levels were to high in my system. I literally had to plan for a tirz fatigue day ... now -- that's all gone as is tirz fatigue ..🥹😌 I feel like I get the benefits without the side effects. It's nice.
Last edited:
Meat_Peterson
GLP-1 Novice
I'm running 5mg of tirz, currently. I've noticed a little lethargy. But it's been pretty minimal. My BM have changed, I'm lucky to see one every 2-3 days. Early on I did have some Constipation. Just really working to hit 100% of my fiber intake and extra magnesium . It's helped. Wondering how the fatigue will be once I hit 7.5 / 10mg.
chmuse
Public Nuisance 🦜🐧🦅🦚🦃🦢🐓🦆🦉
I think a lot of people do it every 4-5 days to skip the food noise on day 6-7.
GimmeABreak
Rabbit-hole Explorer
I switched to 5 day dosing at the same equivalent 7 day dose for a month or two trying to lower the fatigue by making the highs a little lower, and the lows a little higher compared to 7 day dosing. I always feel the most fatigue on day three after my shot. What I found with this dosing is my weight loss was about the same but with more shots per month, I ended up having more fatigue days per month. Switched back to 7 day for a few weeks and now added Reta and quickly titrating down Tirz for a soft landing into maintenance.
So far reta is helping with the fatigue but I have only had one 2mg dose (four-days ago), so we'll see.
Valerie
GLP-1 Member
Magnesium Citrate gummies 2 in the morning 2 before bed were my best friends.
