Of the big 3......

Thanks! I don’t typically do a lot of hard alcohol but every two months or so enjoy a vodka martini. I guess it all comes down to awareness and moderation for me.
In my experience, it IS all about "the crave" not so much about alcohol.......alcohol just happens to fall in line with al of the other craves that the tirz helps me mitigate. Basically, tirz has curbed my crave for excess of most anything that I could put in my mouth.

In other words, if you only have a martini every month or two or even once a week (why would you want to give that up?), that is not the crave and tirz will likely have no effect on your having that glass or not.
ymmv
 
In my experience, it IS all about "the crave" not so much about alcohol.......alcohol just happens to fall in line with al of the other craves that the tirz helps me mitigate. Basically, tirz has curbed my crave for excess of most anything that I could put in my mouth.

In other words, if you only have a martini every month or two or even once a week (why would you want to give that up?), that is not the crave and tirz will likely have no effect on your having that glass or not.
ymmv
I do appreciate your comments, thank you, and I don’t have an issue with the martini every once in a while. It’s more that I’m a wine drinker (see previous post) and I’d like to not crave and drink wine every single night.
 
Ok. So i want experiences.
I have tried sema. Lost 46lbs. Have stalled. Not sure if i want to add cagri or just go to Tirz. Even reta.

I would love to all yout experiences with the 3. I've hears reta is the best, but tirz is the best at appetite suppression. I feel thats what I need since im a bored snacker. So how is reta better? Hell, I even snack when im full!

Not sure the route to take

Suggestions?
I would prefer to know how overweight you are, if you are 200lbs overweight still, it is a different issue than if you only wanted to lose another 20lbs or so. Age and how long you have been overweight are relevant as well as previous attempts to lose weight.
Obviously, especially if you are older or have other medical issues, getting a medical checkup and ideally advice on treatment would be a good idea.
The dose of sema and what side effects you had from it are relevant too. If semaglutide has been working and you are not at maximum dose of 2.4mg/week and have zero side effects then just up the dose.
Otherwise switching to reta or tirz would be fine, tiz probably has the least side effects, reta is a bit more effective and would be the best choice if you had a lot of weight you wanted to lose.
My view is that cagrilintide is best reserved for if standard maximum doses of tiz or reta have stopped causing any further weight loss, when it could be added in at low doses and very gradually increased , it is not light on side effects generally which why the low slow dose would be a good idea.
If you have been on 2.4 of sema you could go straight to 7.5 or 10 of tirzepatide, most likely you would have less side effects, but there is always a chance of worse than expected effects. For reta you could go straight to 4 or maybe 6mg, most side effects would be less but increased heart rate might be an issue jumping in at a higher dose.
In the long term weight control is going to be a problem if you snack on high calorie foods, (high fat/sugar/carbs) there really is no limit to how many calories you can get in per day eating those types of foods in that pattern, and asking appetite reduction medications to fix that on their own is maybe asking too much of them. There are very few good snack foods for losing weight, high protein and not much else is excellent like beef jerky, eggs, high protein low fat no added sugar yoghurt, or just low calorific density foods are good like fruit , a lot of fruits are about 50 kcal/100 grams or less so you can eat a very large amount and snack on them all day long and not end up eating that many calories, if you eat 2kg of fruit it is 1000 calories, but you are going to find it hard to eat that much and if you do you are unlikely to be hungry enough to eat much else that day. And if you eat 1000 kcal/day you are going to lose weight. In my opinion eating only low calorific density foods, less than 1.5kcal/gram is the easiest way to reduce calories in without too much hunger as you can eat as much as you want without too many calories - very lean meat, low fat, fruit, vegetables, low fat dairy not much else.
 
When I moved - begrudgingly - from Sema to Tirz I started T at lowest dose. After 6 weeks, I am dosing 5mg T. Loss rate is 1#/w and I am ok with that rate. I am 15# from goal and 20'ish# from my stretch goal. Is it realistic to weigh now what I weighed 19y ago? Not sure but may give it a go.

I stacked 0.2mg Cagri with Sema. No issues but also no movement on the scale. I've always - since puberty - had gut issues so the side effects have not made a dent in my willingness to continue (branded or grey).

From the period in my life when I was obese to once again being HWP, it's been a process and a helluvan education. I have to agree with @lessthanhalf, where we start and where we are in our process matters. 15# from goal, I am not going to lose at the same rate as someone morbidly obese (as I once was) just getting started. Doesn't mean all pep options work the same on everyone. Medicine is not perfect science. We're each different one to the next despite being made of the same cellular matter.

To all who walk this path, do your research, read and read some more, ask questions, find what works for you that doesn't put you in danger or compromise your good health.
 
Well, I have been actively trying to lose weight for the past year. February 2025 I weighed in at 429.5 at a doctor's visit and he had a sit down with me to discuss everything I already knew but was too lazy, stubborn, weak to do anything about. Dieting was always a rollercoaster on the scales and I inevitably always gained more back that I started with. From February to early July I was counting calories and choosing to take the stairs instead of the elevator, parking in the back of lot, etc to try and reduce the burden. I was able to lose about 20ish pounds in that 20 weeks, doctor preached slow and steady. Well, I wasn't satisfied, went down the glp1 rabbit hole and ended up here.

I joined in July, created my 'about me' in August, and started Reta in September. I started at 2mg and am now up to 8mg and doing pretty good. Yesterday, my weight was 357.7 so that's 50ish pounds in 5 months with very little exercise added in and admittedly bad tracking of total calories. I am more focused on consuming proteins since I just don't feel like eating half the time or we go out to eat and I can only eat a third of the meal.

Interesting, my scale thinks I have added 7.2lb of muscle mass. Which obviously isn't going to be accurate.
50lbs in 5 months with Reta? Wow that is crazy! Any side effects? Great story-thanks for that!
 
I thought about food all the time. If I started a bag of chips I couldn't stop. Taking Reta I have zero interest in food. I struggle to want to make dinner for the hubs. Nothing sounds good. Now if I start to eat something really tasty I could def eat it but I just don't keep it in the house. I'm just focusing on getting my protein in. And it completely turned me off of any alcohol, which I miss a little.🤣
It has curbed my drinking a good bit but I can still enjoy a night time whiskey before bed. I kind of wish it had a better effect on my booze, I know no booze would be greatly beneficial. Maybe when I get my dose above 3.5 it will kick in.
 
50lbs in 5 months with Reta? Wow that is crazy! Any side effects? Great story-thanks for that!
Nothing other than the expected slower digestion and slower emptying. I have been at the same weight for the past 10 days or so, but I am not overly concerned as my hunger/satiety hasn't really changed. I just keep plugging away. My wife, after my lack of sides, decided to join in the research as well. She is down from 215 to about 180 and never got higher than 6mg. We are discussing lowering her dose and she could focus on recomp if she wants, but she doesn't really want to weight much less since she is just under 5'10". Especially since she was averaging a couple pounds per week.
 
I won't underestimate the power of retatrutide. I reached me goal and switched to retatrutide. My appetite went up but I kept losing weight on maintenance dose. Burns the fat off for me regardless of appetite.
That's amazing. What is it about Reta that gets the fat burning? Or are you much more fit now and the muscle is doing its work to increase RMR?
 
I am eating a little better but I believe it's the GIP and Glucagon part of the retatrutide. My exercise habits haven't really changed. Note that I only wanted to get down from 202 to 170.
 
I won't underestimate the power of retatrutide. I reached me goal and switched to retatrutide. My appetite went up but I kept losing weight on maintenance dose. Burns the fat off for me regardless of appetite.
When you switched to reta, what dose did you start with?
 
Ok. So i want experiences.
I have tried sema. Lost 46lbs. Have stalled. Not sure if i want to add cagri or just go to Tirz. Even reta.

I would love to all yout experiences with the 3. I've hears reta is the best, but tirz is the best at appetite suppression. I feel thats what I need since im a bored snacker. So how is reta better? Hell, I even snack when im full!

Not sure the route to take

Suggestions?
I have moved from Tirz to Reta. The Tirz does have very strong appetite suppression (stronger than Reta), however it also came ROARING back when I lowered my Tirz dose to start Reta. I wanted to be on Reta because I think it's a more balanced med, and has reported ancillary benefits (anti inflammatory, heart health and others) that aren't present in Tirz. If it were me, I'd switch to Reta and slowly titrate up. Be aware that Reta seems to take longer to work when you've been on another GLP1, it can take 4 weeks to achieve steady state blood concentration, which is when you should start to feel/see results. Of course everyone is different, and it could work right away at lower doses...so "mileage may vary".
 
When you switched to reta, what dose did you start with?
While I was on Zepbound, I stayed on weekly 2.5mg the whole 3 months I went from 202 to 170 (my goal). 13% body fat according to InBody at gym. I then went cold-turkey to reta at weekly 2mg and gained about 5 lbs in 2 weeks and upped it to 4mg after 4 weeks.

Appetite didn't change and I started losing weight agin. I'm definitely eating more after the switch but the reta doesn't seem to care. Something with the 4mg told my body to burn more and I do have more energy as well. I can barely keep up and may drop back down to 3 or 2mg weekly.

I was already on testosterone, CJC-1297/Ipamorelin, and GLOW during the whole Zepbound phase and still use these.

I eat one full meal a day that focuses on protein and veggies but there a carbs too...pasta, rice, whatever sugars are in the dishes. And I snack on things like meat sticks and protein shakes once or twice a day. Not the healthiest diet but it's not ben and jerry's every night.

I do play tennis 3-5 times a week and run/lift 3-5 times a week so I'm very active.

The only reason I went on this diet was because at 60 and being 200lbs, it affected my tennis mobility. Not to mention the 27% body fat and approaching insulin resistance pretty quickly.
 
While I was on Zepbound, I stayed on weekly 2.5mg the whole 3 months I went from 202 to 170 (my goal). 13% body fat according to InBody at gym. I then went cold-turkey to reta at weekly 2mg and gained about 5 lbs in 2 weeks and upped it to 4mg after 4 weeks.

Appetite didn't change and I started losing weight agin. I'm definitely eating more after the switch but the reta doesn't seem to care. Something with the 4mg told my body to burn more and I do have more energy as well. I can barely keep up and may drop back down to 3 or 2mg weekly.

I was already on testosterone, CJC-1297/Ipamorelin, and GLOW during the whole Zepbound phase and still use these.

I eat one full meal a day that focuses on protein and veggies but there a carbs too...pasta, rice, whatever sugars are in the dishes. And I snack on things like meat sticks and protein shakes once or twice a day. Not the healthiest diet but it's not ben and jerry's every night.

I do play tennis 3-5 times a week and run/lift 3-5 times a week so I'm very active.

The only reason I went on this diet was because at 60 and being 200lbs, it affected my tennis mobility. Not to mention the 27% body fat and approaching insulin resistance pretty quickly.
Thank you for the detailed response. Exactly what I needed. My story is similar and investingating the idea of reta for similar reasons. I've been stacking survo on tirz for months and have been at gw for 3 months and am wondering if I can get away with a single injection of reta per week rather than the double of tirz and survo and also if the energy level might be different although my tirz/survo stack has delivered very, very well for me. I also use BPC, TB, & KPV. Just seperately. Also CJC/Ipa. Also for strength training and cardio. I'm 62 and went from 240 to my current 185 since last June. Takes dedication and consistency as I am sure you know. Totally worth it. Congrats!
 
Ok. So i want experiences.
I have tried sema. Lost 46lbs. Have stalled. Not sure if i want to add cagri or just go to Tirz. Even reta.

I would love to all yout experiences with the 3. I've hears reta is the best, but tirz is the best at appetite suppression. I feel thats what I need since im a bored snacker. So how is reta better? Hell, I even snack when im full!

Not sure the route to take

Suggestions?
I have found Reta to be really good at stopping food noise and although it doesn't entirely shut down the ability to eat, I'm not sure total food suppression is a good goal. I started at 2mg of Reta weekly, then titrated to 4mg and now the food chatter is gone but I can still eat when I need to. What I can't do is stuff myself, I have no interest in crappy food, and I want to be able to eat good, clean food and hit my macros so that I can maintain muscle mass as best I can. This is what Reta does perfectly.
I think if you get to your therapeutic dose with reta and you are exercising and eating clean, it's the best of all possible worlds. I am convinced having used semaglutide and tirzepitide that Reta is the healthiest choice. But that's just me!
 
You know with all the talk of Reta vs. Tirz for less muscle loss; I wonder how much of it has to do with the indivisuals diet. Like, if you eat the right amount of protein and change nothing about your workout routine, isnt it safe to assume you'll maintain the same amount of muslce regardless of which GLP you go with?
 
You know with all the talk of Reta vs. Tirz for less muscle loss; I wonder how much of it has to do with the indivisuals diet. Like, if you eat the right amount of protein and change nothing about your workout routine, isnt it safe to assume you'll maintain the same amount of muslce regardless of which GLP you go with?
They’re finding there’s little to no difference in muscle sparing between reta and tirz:

1772507809816.webp
 
Never tried sema. I did briefly try the pills, rybelsus for a couple months, rybelsus didn't really do much for me. Ive been on tirz now for 7 weeks tomorrow....this stuff is great. I was the type to snack all day long..almost hourly. A handful of this..hand full of that...etc. now I can barely even remember to eat, and often forget. Definitely no more snacking here. Started at 178, not at 147. 31 pounds down on my third shot of 5mg tomorrow. I love that im no longer thinking of food all day long. So much more space in my brain to think of other things.

Haven't tried reta, and wont likely, as im very happy with tirz.
 

Trending Topics

Forum Statistics

Threads
17,632
Posts
182,936
Members
59,300
Newest
Glamtheory1
Back
Top Bottom