Question About KLOW 80mg – Is the 5 Days On, 2 Days Off Schedule Evidence-Based or Just Anecdotal?

memorex00

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I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:


“How does the ‘5 days on, 2 days off’ schedule work? This schedule provides your body with enough stimulation for healing or regeneration during the week while allowing receptors to reset and recover on weekends.” — Balanced Aesthetics Med Spa

Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?
 
Good question. I'd like to know, as well. 🫡 🤓
I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:
Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?
 
I've also seen some forums say no need to cye it 5 on, 2 off, as long as you take it for like 6-8 weeks, and then cycle off for 4-5 weeks before you start again. I think it comes down to a certain point you want to cycle off, but not sure if there is anything that is 100% set in stone. I ordered from jeep on the 6th, but haven't received it yet. Once I do I think I'm gonna do the 8 weeks on and then a month or so off.
 
Common knowledge says that the 5 on 2 off schedule is for med spas that don't want to open on the weekends. Many users on this forum pin daily for months at a time with very good results and no discernible side effects.
 
5 on 2 off make a kit of KLOW80 last 5 weeks at 2mg GHK-Cu per dose, so a kit is a year supply with a two week vacation to show off the glow at the beach somewhere...
Muscles Flexing GIF by Pretty Dudes
 
I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:




Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?
Look at the single protocols for each individually and make your own dosage decision. Every body is different
 
Sorry for the wall of science answer , but you did ask.

There are no clinical trials of KLOW or GLOW in humans. Or in animals that I could find.

There have been 3 small clinical trials in humans of BPC 157 , for arthitis, cystitis and basic phase 1 toxicity test. Nearly all the research comes from a small localised set of researchers. The paper I read by them was dodgy AF. DOI: 10.3390/ph16050676 . Basically claiming it was a miracle cure, not differentiating between animal and human tests when talking about evidence and massively overstating its effectiveness compared to the evidence. No real research anywhere else. If it was as good as some of the rodent studies suggest this would not be the case.

There have been clinical trials of GHK-Cu in humans but only applied externally to the skin, not injected or oral treatment. Not being developed as a systemic treatment

There have been clinical trials of thymosin beta 4 in humans , it is currently being tested as an PCI injection (percutaneous coronary intervention), after heart attacks, and a phase 1b study iv for basic safety for use in humans

As far as I can tell KPV has never been tested in humans. It is still being researched mainly as nanoparticles with kpv attatched as a therapy for ulcerative colitis but not near human testing

There is zero doubt that these peptides do things, often quite beneficial things in the body. The problem is partly that most are not patentable so no company will pour money into researching them, only publicly funded research, and they mostly have too many effects. Drug companies generally want compounds that do a single specific thing to one receptor ( that is well studied and understood ) so it is possible to work out the effects, and there are no off target effects . So they don't spend a billion dollars on research only to find some unexpected adverse effect. Most of the peptides in KLOW have very broad effects, on many different body systems, and in general are not well understood. Trying to work out all these effects would require an enormous amount of research, before human trials could be considered, and then they would have to be huge in scale to make sure less common effects were found given the incomplete understanding of how they work.

Unfortunately just because lab and animal studies look good does not mean they will work in humans. There are dozens of treatments that prevent, treat or reverse Alzheimer's disease in rat and mouse models, but they have all failed ( to make more than a minor difference ) when tested in humans.

Going on anecdotal reports online, many people have said it has helped make healing faster, which is interesting and is a sort of evidence, unfortunately it does not prove anything. Before the scientific method people believed a lot of very weird things were effective treatments, blood letting by leeches was very popular for centuries.

The most obvious concern is that many of them significantly alter growth signals and angiogenesis, which produces reasonable concerns about the possibility of initiating or enhancing the growth of tumours, and the fact that their effects are not well understood. Most of these peptides are not likely to have further development as drugs, and I do not think any researchers would ever test klow on humans in a clinical trial due to the complexity and unpredictability of its possible effects.
 
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