Question About KLOW 80mg – Is the 5 Days On, 2 Days Off Schedule Evidence-Based or Just Anecdotal?

memorex00

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I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:


“How does the ‘5 days on, 2 days off’ schedule work? This schedule provides your body with enough stimulation for healing or regeneration during the week while allowing receptors to reset and recover on weekends.” — Balanced Aesthetics Med Spa

Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?
 
Good question. I'd like to know, as well. 🫡 🤓
I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:
Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?
 
I've also seen some forums say no need to cye it 5 on, 2 off, as long as you take it for like 6-8 weeks, and then cycle off for 4-5 weeks before you start again. I think it comes down to a certain point you want to cycle off, but not sure if there is anything that is 100% set in stone. I ordered from jeep on the 6th, but haven't received it yet. Once I do I think I'm gonna do the 8 weeks on and then a month or so off.
 
5 on 2 off make a kit of KLOW80 last 5 weeks at 2mg GHK-Cu per dose, so a kit is a year supply with a two week vacation to show off the glow at the beach somewhere...
Muscles Flexing GIF by Pretty Dudes
 
I’ve been digging around the web and I can’t find any solid evidence for why the “5 days on, 2 days off” schedule is considered ideal for KLOW. Some people follow that, some people dose daily, and I found one mention here:




Does anyone here have clinical or peer-reviewed evidence for that cycling approach with KLOW, or is it purely anecdotal at this point?
Look at the single protocols for each individually and make your own dosage decision. Every body is different
 
Sorry for the wall of science answer , but you did ask.

There are no clinical trials of KLOW or GLOW in humans. Or in animals that I could find.

There have been 3 small clinical trials in humans of BPC 157 , for arthitis, cystitis and basic phase 1 toxicity test. Nearly all the research comes from a small localised set of researchers. The paper I read by them was dodgy AF. DOI: 10.3390/ph16050676 . Basically claiming it was a miracle cure, not differentiating between animal and human tests when talking about evidence and massively overstating its effectiveness compared to the evidence. No real research anywhere else. If it was as good as some of the rodent studies suggest this would not be the case.

There have been clinical trials of GHK-Cu in humans but only applied externally to the skin, not injected or oral treatment. Not being developed as a systemic treatment

There have been clinical trials of thymosin beta 4 in humans , it is currently being tested as an PCI injection (percutaneous coronary intervention), after heart attacks, and a phase 1b study iv for basic safety for use in humans

As far as I can tell KPV has never been tested in humans. It is still being researched mainly as nanoparticles with kpv attatched as a therapy for ulcerative colitis but not near human testing

There is zero doubt that these peptides do things, often quite beneficial things in the body. The problem is partly that most are not patentable so no company will pour money into researching them, only publicly funded research, and they mostly have too many effects. Drug companies generally want compounds that do a single specific thing to one receptor ( that is well studied and understood ) so it is possible to work out the effects, and there are no off target effects . So they don't spend a billion dollars on research only to find some unexpected adverse effect. Most of the peptides in KLOW have very broad effects, on many different body systems, and in general are not well understood. Trying to work out all these effects would require an enormous amount of research, before human trials could be considered, and then they would have to be huge in scale to make sure less common effects were found given the incomplete understanding of how they work.

Unfortunately just because lab and animal studies look good does not mean they will work in humans. There are dozens of treatments that prevent, treat or reverse Alzheimer's disease in rat and mouse models, but they have all failed ( to make more than a minor difference ) when tested in humans.

Going on anecdotal reports online, many people have said it has helped make healing faster, which is interesting and is a sort of evidence, unfortunately it does not prove anything. Before the scientific method people believed a lot of very weird things were effective treatments, blood letting by leeches was very popular for centuries.

The most obvious concern is that many of them significantly alter growth signals and angiogenesis, which produces reasonable concerns about the possibility of initiating or enhancing the growth of tumours, and the fact that their effects are not well understood. Most of these peptides are not likely to have further development as drugs, and I do not think any researchers would ever test klow on humans in a clinical trial due to the complexity and unpredictability of its possible effects.
 
Oh well, thanks to everyone who shared their thoughts. I figured it was mostly anecdotal and that it is a highly individualized experience. I was on the fence about doing the 5 days on 2 days off schedule since I am pretty active and want to optimize recovery while keeping inflammation down.

This is my seventh day on KLOW 80 mg so I have decided to continue with daily dosing for up to 12 weeks then take a month off. One interesting observation, maybe it is just in my head, but when I looked in the mirror last night the wrinkles on my forehead did not look as prominent as they used to. I actually did a double take because they looked slightly smoother. I know it is too early to tell but I will start taking photos to track any changes.
 
Oh well, thanks to everyone who shared their thoughts. I figured it was mostly anecdotal and that it is a highly individualized experience. I was on the fence about doing the 5 days on 2 days off schedule since I am pretty active and want to optimize recovery while keeping inflammation down.

This is my seventh day on KLOW 80 mg so I have decided to continue with daily dosing for up to 12 weeks then take a month off. One interesting observation, maybe it is just in my head, but when I looked in the mirror last night the wrinkles on my forehead did not look as prominent as they used to. I actually did a double take because they looked slightly smoother. I know it is too early to tell but I will start taking photos to track any changes.
cough placebo! cough 🤣
 
cough placebo! cough 🤣
It's probably not; a ton of people have noted that when you first start klow, there's a kind of puffiness effect in the skin in the first week. It's not a permanent improvement, and it's not strong; more like how when you use hyaluronic acid in a serum, you get a temporary puffiness that makes wrinkles look less.

It's definitely not the same as collagen and elastin being improved/rebuilt/whatever in your skin, which is one of klow's longer-term claims, but it's a nice little first-week boost.
 
A typical "cycle" of GHK-CU is six weeks on, three weeks off to give the RS a break from the copper in GHK-CU.

Does this mean only for GHK-CU peptide itself or does this apply to GLOW/KLOW too?
 
Pure speculation with no basis in anything meaningful.
Do you know of anything less speculative that says something different? I don't mean that in the snotty way, I'd be happy if I came across something convincing that says you don't have to cycle it.
 
Do you know of anything less speculative that says something different? I don't mean that in the snotty way, I'd be happy if I came across something convincing that says you don't have to cycle it.
There is a plausible reason to cycle it. Copper build up in the blood.

But I took 2mg a day of ghk-cu for months with no noticeable effect on copper through weekly testing. I don't take bpc/tb with it though. I save those for acute injuries with higher doses over a shorter periods.
 
There is a plausible reason to cycle it. Copper build up in the blood.

But I took 2mg a day of ghk-cu for months with no noticeable effect on copper through weekly testing. I don't take bpc/tb with it though. I save those for acute injuries with higher doses over a shorter periods.
You know, the bpc/tb unsettles me JUST enough that I think when I use up both my klow kits, if I'm still into this by then, maybe I'll just do a mix of GHK-CU and KPV and call it good
 
cough placebo! cough 🤣
🙂 Here's the thing about the placebo effect (I did a few major metanalysis of the placebo effect in psychotherapy in college for my professor).... it can be highly effective. In fact, in the case of psychotherapy, it has been shown to actually and often be more effective than treatment. Just throwin' that out there for flamingly fun ongoing discussion.
🙂
 
🙂 Here's the thing about the placebo effect (I did a few major metanalysis of the placebo effect in psychotherapy in college for my professor).... it can be highly effective. In fact, in the case of psychotherapy, it has been shown to actually and often be more effective than treatment. Just throwin' that out there for flamingly fun ongoing discussion.
🙂
Agreed. Somebody sell me some straight up lyophilized mannitol for cheap and tell me it’ll make me a highly intelligent super hero please!
 
It has actually been researched, placebos still work surprisingly well even if you tell people it is a placebo.
Naming something the wolverine stack is designed to maximise placebo responses.
The placebo response to KLOW might be part of why people seem to think it works, but it does have very significant biological effects, it is just that they are poorly understood for most of the individual components, let alone the combination.
 
u/DoctordUP2 on Reddit is the creator of the Anela protocols. This is what she has to say about the 5 on 2 off cycling.
There's no particular reason to believe that Anela has any real understanding of what she is talking about, and plenty that she doesn't. Anyone can put together a peptide blend and talk it up on social media. I wouldn't suggest a 5 day on 2 day off schedule either, but the idea that doing so makes you "miss out on all the benefits" just doesn't make much sense. What is happening that you're not getting any impact from the other 5 days? If two days off is enough to reverse all the positive impact from 5 days on, why wouldn't going off of it reverse everything in a similarly quick fashion, too?

And as for GLOW/KLOW - what about all of the other compounds in the blend besides Ghk-Cu? They're not inactive ingredients - KPV, BPC, TB are all pharmacological active ingredients too.

There's a whole bunch of stuff in this hobby (and I'm really going to argue that peptides beyond the GLP-1 stuff really is more hobby than anything else) that is basically taken on gospel because people started saying it relatively early on in the hobby's lifespan on social media and people have just all picked it up and run with it based entirely on anecdotes. Basically everything not backed by clinical trials is just a bunch of assholes on the internet shouting their opinions based on personal anecdotes. Myself included.
 
Nou ja, bedankt aan iedereen die zijn of haar gedachten heeft gedeeld. Ik dacht dat het vooral anekdotisch was en dat het een zeer individuele ervaring is. Ik twijfelde of ik het schema van 5 dagen op en 2 dagen af moest doen, omdat ik behoorlijk actief ben en mijn herstel wil optimaliseren en tegelijkertijd de ontstekingen wil beperken.

Dit is mijn zevende dag op KLOW 80 mg, dus ik heb besloten om de dagelijkse dosering tot 12 weken vol te houden en daarna een maand te stoppen. Een interessante observatie, misschien is het alleen maar in mijn hoofd, maar toen ik gisteravond in de spiegel keek, leken de rimpels op mijn voorhoofd niet meer zo prominent als voorheen. Ik keek zelfs nog een keer, want ze zagen er iets gladder uit. Ik weet dat het nog te vroeg is om te zeggen, maar ik ga foto's maken om eventuele veranderingen bij te houden.
Wat is jou dagelijkse dosis als ik vragen mag?
 
There's no particular reason to believe that Anela has any real understanding of what she is talking about, and plenty that she doesn't.
And she says so herself, her word is not gospel and that there are different routes to finding what works best. She's simply offering her opinions based on her experience "following hundreds of research subjects over the years". She makes no claims about having any sort of credentials in the matter and nothing she says is medical advice. Basically, she's just someone who's been in the hobby for a long time and has some opinions to share based on that time.

Her stance on the GHKCu 6-week cycle is that it takes 6 weeks of consistent, daily use to reap the full benefits of GHKCu. She added BPC-157 to help lessen the ISRs from GHKCu. TB500 and KPV were added by other people to make the GLOW and KLOW.

I do agree with you that so much of the peptide hobby is just anecdotes and opinions because there are no human clinical trials to back them up. Even the studies that showed success in rats are not guaranteed to be successful in humans.

Anyway, my main reason reason for sharing what I shared about Anela's opinion on 5 day cycling was to offer OP an explanation on why medspas are perpetuating the idea. No medspa would tell you that you need to take it daily to reap the benefits because they're not open daily. Anela said "the typical cycle is 6 weeks", but she has also stated that many people take GHKCu daily indefinitely with no issues. She does recommend zinc supplementation to be taken at a different time of the day when doing GHKCu daily. And yes - she has also cautioned on the potential for BPC-157 and TB500 to accelerate cancer cell growth. Again, whatever she says about GHKCu cycling/scheduling/dosing is her opinion based on experience and observations. She doesn't make any claims about any of it being backed by clinical trials.
 
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🙂 Here's the thing about the placebo effect (I did a few major metanalysis of the placebo effect in psychotherapy in college for my professor).... it can be highly effective. In fact, in the case of psychotherapy, it has been shown to actually and often be more effective than treatment. Just throwin' that out there for flamingly fun ongoing discussion.
🙂
Personally, if placebo works just just as well as treatment, then take all my money! I'll take placebo over a treatment that might not work for me or give me a bunch of side effects. Unless it costs substantially more than the actual treatment, who's to say it's wrong if it's working?
 
Wat is jou dagelijkse dosis als ik vragen mag?

My KLOW 80 mg kit is interesting. The Janoshik report shows it being overfilled by about 1 to 3 mg, so I have to factor that in. I reconstituted it with 3 ml of bac water, and I started at 8 units, which I estimated to be roughly 2,667 mcg give or take. Now I am at 10 units, which is close to 3,000 mcg.

Since I am running this for a full twelve weeks, I am keeping the dose at 10 units for the first month. I may titrate up to 12 to 15 units during the second month and a bit more in the third month before taking a month off. The plan is to monitor how my body responds and see what kind of progress I get.

Mijn KLOW 80 mg injectieflacon is interessant. Het Janoshik-rapport laat zien dat het met ongeveer 1 tot 3 mg wordt gevuld, dus ik moet daar rekening mee houden. Ik heb het gereconstitueerd met 3 ml bac-water en ik ben begonnen met 8 eenheden, die naar schatting ongeveer 2.667 mcg geven of nemen. Nu zit ik op 10 eenheden, wat bijna 3.000 mcg is. Aangezien ik dit een volle twaalf weken gebruik, houd ik de dosis de eerste maand op 10 eenheden. Ik mag in de tweede maand tot 12 tot 15 eenheden titreren en iets meer in de derde maand voordat ik een maand vrij neem. Het plan is om te controleren hoe mijn lichaam reageert en te zien wat voor vooruitgang ik krijg.
 
I take it daily through a cycle. Just figure out how long you want to take it (I'd recommend not more than 6 weeks) and then take at least a month off of it. Word has it that you can develop an allergy to BPC-157 with continuous use.
 
I take it daily through a cycle. Just figure out how long you want to take it (I'd recommend not more than 6 weeks) and then take at least a month off of it. Word has it that you can develop an allergy to BPC-157 with continuous use.

It is all anecdotal at this point, which is why I decided on twelve weeks and will let my body speak for itself.
 
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