Question about weight loss on Reta / GLP-1

[Kyli]

Hey Everyone,

I need a little bit help. Long story short (the long story you can find in my introduction), I'm 178 and my SW was about 145kg. CW is 140kg. Currently I'm in my third week with Reta. I was taking 1mg 2x a Week and the last two injections I increased to 1.5mg, the last injection was 2 days ago. And according to my calculation, the active amount of Reta is currently 3mg.

And with Reta I'm taking 5-Amino-1MQ and SS-31.

Now to my question. On 1mg I sometimes got hunger again. Now on 1.5mg everything seems to be fine. But what I don't understand is the effect of Reta. How people loose wight. Because if something is tasty it's pure will power not to eat it.

What I don't understand is, people say to titrate slowly. But why? If according to the studies most patients started to lose weight in the 2nd or even 3rd month. As far as I understand, even the Glucagon Recepterors are not triggered at a dose below about 4mg, because Reta can dock to the receptors but it's not enough to get the liver start working and cleaning the fat from it.

You know, I compared to the SW I now lost about 5kg. But I'm sure most of it was water, because of the inflammations that are now mostly gone. I'm sure it wasn't fat, that melted.

And currently I'm some kind of stuck. I read everything I can get my hand on. But I don't understand, why in the studies people start loosing the weight, when they were at 4-6-8mg a week. So around 5-10mg on active substance in Body. Than I saw here in the forum, that people are stacking Cagri on top. But according to my research it can cause Gastroparesis.

You know, I started very motivated in the journey. Bur currently I'm some kind confused. I want more in a shorter period of time.

 

[FLglpguy]

It's a marathon, not a race. You will make yourself very sick if you up the dose too soon. As far as will power...you won't have the desire to eat the foods you liked before starting this journey. It won't take any will power at all. Stay the course. Titrate up as scheduled and don't overthink it or overdo it.

I'm on week 5 of Tirz. I have lost 26lbs and feel GREAT! No food noise, inflammation is gone, my skin is clearer, I'm better focused at work and my joint pain has even lessened.

I also take B12, Magnesium Malate, Whey, Casein protein powder and have been eating soups, raw veggies and fresh fruits, nuts, fiber and nut bars and salads. Loving the new foods and not missing the fried junk that clogged me up from head to toe. I don't even think of burgers, or meat filled meals or sweats or treats and none of these foods are even in my home.

 

[Rezwalker]

First thing first its not a miracle weight loss drug (but almost )
You still need to train and diet
reta will help with binge eating at night and usually over eat at every meal
you will get full quicker and stay full longer

but you wont lose 50 pound in 3 months unless your 300lbs + and stop eating drasticly

you need to eat in a deficit and train and do your 12k steps

GLP1 will help mitigate your bing eating thats it
forget the glucacon etc
dont split dose reta you will only get used to it faster
single dose will do more appetite suppresion vs split

Even if its the tastiest treat in front of you reta will help the urge to eat it
always remember the prize and the end
Slim and healthy
if you dont train and eat you will look like Hollywood star atm ultra skelleton slim and look like your about the die

 

[rmhla]

Retatrutide sides can be awful to some like
Aladonia which is basically "goosebumps" cold feeling down your legs, arms, etc. While some like that or dont mind it many hate it.
Then there rapid increase in heart beat (not blood pressure)
So...
By taking your time titrating up you see what you are capable of. Why take 8mg if it works at 3mg... right... but yes most notice more of a difference at 8mg spilt into 4mg shots 2 x weekly.

Also by using other peptides at the same time, you dont actually know which ones working best. Food for thought here..

Like other posters here above its not a race, you spent how many years pigging out with no worries, so why rush losing it all so fast you end up needing a grocery cart to carry your extra skin behind... yup happens allot..

Healthy is 1.2lb to 2lb month as it will stay off then as too rapid weight loss almost always comes back.

Dont keep up with the Jones, do your own thing be patient and just because the scale isnt moving doesnt mean it isn't working...

As for food noise you can drop the other peptides your taking for example and look into Cagrilintide for example..

Also remeber higher doses of Retatrutide come with loss of muscle though not 100% proven in everyone theres more and.morw studies coming out to this effect.


Lastly just because Glps make it easy, its mucb better to excersie even if atleast walking deliberately not counting day to day bill payments or grocery stores runs. Actually out walking for 30mins to an hour.
Eatting also plays a big role reta hates to much fat and you'll feel it, often not talked about.

 

[quicksilver80]

Going too fast can lock up your gastric. Either none at all or everything all the time. I had constipation but some of my friends could have pooped through a screen door and left it spotless. Then comes the whole pancreatitis and other secondary issues from that. Yeah. Be careful buddy.

 

[Kyli]

Thank you for your advice, everyone.
The idea behind stacking the SS-31 and 5-Amino-1MQ was on one hand to fix broken mitochondria and increase the energy level.

And yes, I'm doing sport. I have three dogs. So I walk every day for about 2 hours + the training with the dog. And I also start weightlifting.

I already looked into Cagrilintide. But I don't get it's meaning in combination with Reta. Why it should be better to stack it on top instead of increasing the dosage?

I'm on week 5 of Tirz. I have lost 26lbs and feel GREAT! No food noise, inflammation is gone, my skin is clearer, I'm better focused at work and my joint pain has even lessened.

May I ask, with what kind of dose you are currently in Week 5?

forget the glucacon etc

Why? As I understand, this is the factor, what makes the difference to Trizapetide. It's increasing the total energy, and prevent the metabolism adaptation to a lower callory level.

 

[FLglpguy]

Thank you for your advice, everyone.
The idea behind stacking the SS-31 and 5-Amino-1MQ was on one hand to fix broken mitochondria and increase the energy level.

And yes, I'm doing sport. I have three dogs. So I walk every day for about 2 hours + the training with the dog. And I also start weightlifting.

I already looked into Cagrilintide. But I don't get it's meaning in combination with Reta. Why it should be better to stack it on top instead of increasing the dosage?


May I ask, with what kind of dose you are currently in Week 5?


Why? As I understand, this is the factor, what makes the difference to Trizapetide. It's increasing the total energy, and prevent the metabolism adaptation to a lower callory level.

I'm currently at .50 dose of Tirz. It titrates up every 4wks. I just took shot 6 on Wednesday. I chose Tirz because I want the best appetite suppression. I started at 386lbs. - I'm at 360lbs right now and I'm 6'2" and 55yrs old. I have a long road in front of me to get to my GW of 215lbs, so I wanted as much appetite suppression as possible.

 

[Rezwalker]

Thank you for your advice, everyone.
The idea behind stacking the SS-31 and 5-Amino-1MQ was on one hand to fix broken mitochondria and increase the energy level.

And yes, I'm doing sport. I have three dogs. So I walk every day for about 2 hours + the training with the dog. And I also start weightlifting.

I already looked into Cagrilintide. But I don't get it's meaning in combination with Reta. Why it should be better to stack it on top instead of increasing the dosage?


May I ask, with what kind of dose you are currently in Week 5?


Why? As I understand, this is the factor, what makes the difference to Trizapetide. It's increasing the total energy, and prevent the metabolism adaptation to a lower callory level.

all that mather is how can you hold your diet without binging its there the reta/tirz/sema/etc that shine
steady diet will win over everything or any compound
you will get the glucagon over time but you can acheive fatloss with it
its just a +

 

[NagChamp]

When I was making decisions about which route to choose (GLP vs Reta) I went with GLP (Tirz) because my main aim was to quash food noise, knowing that positive results would flow from this. Reta is known for not managing food noise as effectively as Tirz. You might want to consider either switching or stacking both if food noise is an issue for you.

That said, FLglpguy is right, this is a marathon and not a sprint. Don't let the BS you've seen on Reddit forums trick you into thinking that you can get ripped in 3 months.

 

[gimmeshelter]

You want food intake or eating adherence meaning reta will allow you to be indifferent about most food like wasted cals of snacks and sugar drinks. You don't want to feel sick. I'm 6 5' started at 240lbs. Did .5ml for a month , now on week 10 on 1.8ml. BUT.......

I weigh food to the gram / hard cardio 3 times a week / high protein diet / gym 4 days a week.

I feel normal w my reta dose I can eat w the family I can also skip a meal if I want or eat more getting ready for cardio .

 

[Kyli]

Hey everyone, I have another question about my current "condition". My last food intake was yesterday at 18:00. Some meat and fish as protein and fat source and a pear and a half apple to have something sweet. Today I had to do a few things in the city. And normally I fast 18 hours. So the next time, I was planing to eat at about 12:00. But at 10:00 I suddenly felt that my stomach is growling. And that I have to burp. It was some kind of strange feeling. Like I'm hungry but on the other hand, that I'm not hungry. And I think from this feeling I now think, that I'm hungry.

Shouldn't this stomach growling also be suppressed by GLP-1? (or Cagrilintide - I'm not taking it. Just a question). My next injection would be tomorrow in the morning.

PS: And after my breakfast / lunch this feeling was gone.

 

[lessthanhalf]

The reason to not increase doses fast is to reduce the risk of being hit like a ton of bricks with severe nausea and vomiting. This is by far the most common fairly serious problem that happens with these drugs while starting and increasing doses, and maybe 1% or so need hospital treatment as a result with IV fluids to fix the dehydration that results. Going faster than standard makes that risk higher, but nearly 50% will get some degree of nausea or vomiting at some point, so not at all uncommon. And there was a poor guy who got weeks of hiccoughs after his first dose of reta, not fun.

Going at the standard start rate is designed to keep those risks reasonably low. But not zero. You should have a play with glp plotter so you can see what the drug does over time on a graph. The way they work is very different to most drugs, it takes about 24 hours to reach peak blood levels after a dose, and then it takes 6 days for levels to drop to half that peak, so that if intolerable side effects happen it can take a week for them to get better. And the amount in your system builds up over 4 weeks at the same dose, so side effects can happen weeks after a dose increase. This is one of the problems with grey GLP's, hopefully anyone being prescribed them by a competent doctor would have at least some warnings and advice about side effects before starting.

You are already using the one safeish strategy to increase doses faster, smaller more frequent doses. I would not really recommend any speed up strategy to someone who has not been on glp drugs before. But you are doing twice weekly doses, so the advantage of that is simply if you do get side effects that are a problem, it will not take as long for them to settle down after a smaller twice weekly dose than after a weekly dose that is twice as large. As a week of puking is not fun, and this is what you need to aim to avoid. ( not the only side effect, but the only one with a decent chance of putting you in hospital ) Even using twice weekly doses you still need to base any decision to keep increasing doses on effects and side effects. if you start getting a bit of appetite suppression at 1mg /2x a week or a bit of nausea it is a good bet it will get worse if you increase the dose, so you need to listen to your body's response before increasing doses, and make sure you stop increasing quickly once effects start happening. Bumping up doses by 1mg a week is probably fairly safe doing twice weekly doses, but there is never a guarantee of anything, and effects and side effects do not always make perfect sense. But smaller bump ups in dose will hopefully give you a heads up about future side effects so you can slow down.

In the end for more severe obesity I see these as lifetime treatments, so losing a few weeks to start more slowly is not a disaster, and will reduce the odds of unexpected severe side effects, even if it does not change the dose at which they might or might not happen in you. The advantage of looking at them as long term treatments is that unlike every other diet nearly everyone has been on where you put the weight back on later, hopefully with GLP drugs you only need to lose the weight once, so long as you keep taking them to maintain the weight loss.

 

[lessthanhalf]

In response to the last post , I have had a lot of time taking ozempic that made me feel slightly ill and mildly nauseous for a year even at tiny doses, but did also reduce hunger, and I was trying not to regain the 70 kilos I had lost. So getting sensations that are somewhere in between stomach discomfort and mild nausea and hunger and it being very hard to tell the difference is something I had about a year of. And sometimes I had to eat a tiny bit of something like dark chocolate or ginger to stop the nausea. Thankfully tirz plus reta cause me less side effects than the ozempic did.

Sound like it might be starting to work. Not all the gut sensations they can cause will be pleasant.

The effects on reducing appetite and food noise and making you feel full after eating much less food will happen. The dose at which this starts to be obvious varies a lot, everyone's responses to these drugs is a bit different, but in general with no special effort to eat less, people lost an average of 29% of their weight on 12mg of reta over a year. So it works, probably better than any drug ever for weight loss.

 

[Kyli]

@lessthanhalf Thank you for your answer and honesty.

Well, I my current plan is not to take GLPs forever, but to loose weight and then be able to hold it even without any kind of medication. I hope, it's going to work out, but this is the second step. The first is to loose the fat.

I build something like the GLP plotter, you mentioned above, myself to know exactly, what amount is currently working in my body. So I'm aware of the half life and the concentration over time.

So far, the side effects were Ok, for me. After my first injection I had a light nausea. And after another one, I had a headache. I think, it was the 3rd injection of 1mg. And another side effect was constipation. But honestly, I have no idea, what caused it. If I was just not eating enough. Or if Reta caused it? No idea. But when I'm taking Magnesium in the morning, I can pool without a problem.

And another thing, that happened is, that I can't see myself naked in the mirror. I want to have all the fat off... And at a time with overwhelming instant gratification it's hard to go the entire journey. And just as I write it, I had to think about the "Click" movie with Adam Sandler.

 

[rmhla]

Going too fast can lock up your gastric. Either none at all or everything all the time. I had constipation but some of my friends could have pooped through a screen door and left it spotless. Then comes the whole pancreatitis and other secondary issues from that. Yeah. Be careful buddy.

Nice analogy haha "pop through a screen door and not leave a mark" hahaa

 

[eidos]

I was trying not to regain the 70 kilos I had lost.

When I lose my keys, part of me wants to find them.
Just a little trick: replace that way of thinking with something like "the weight I've gotten rid of" or "the kilos that have disappeared." or something else that really makes it clear to you that it's in the past and has no chance of coming back. These sentences may seem to say the same thing, but they have a completely different impact on unconscious processes, beliefs, and motivation.

And among the wonderful things to inject, I take 5 mg/day of 5-amino-1-mq. It cuts through fatigue, and most importantly, it might erase the epigenetic memory of adipocytes to prevent them from returning to their previous (large) size. but I will really know in two or three years wether it worked.