Reaction to Tirzepatide

JAYB820

GLP-1 Novice
Member Since
May 21, 2025
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From
Philadelphia PA
Anyone else have any reactions to tirzepatide. Mine started after week 3. Now on week 4 and my injection site is warm, red, sore and itchy. Swelling much bigger than a mosquito bite. Usually starts to fade away 48-72 hours after injection.

Any tips on how to stop this? Been using Benadryl cream…
 
What brand of bacteriostatic water are you using? How many Mg's per injection, and how much water per injection? Most reactions that I have seen locally have been due to water from amazon or ebay. One lady that I help gets warm spots from time to time after injections if she does them in her stomach. Switched her to upper quad and shoulders and for whatever reason helped with that issue ( she was using Hospira water).
 
Could definitely be the water like someone else mentioned. Is it all from the same vial of Tirz where it’s been sitting in the same BAC water, or have you reconned a new vial? Could be so many things.

When I was having ISR from GLOW I went to a longer needle and it helped.
 
It could be what you're reconstituting it with. What is your strength in the vial and how much bac water are you mixing it with? I ask this because you can either add, more bac water to your jabs, or take a Benadryl the day that you're going to pin, and rub some Benadryl or cortisone cream on the injection site, also.
 
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