Reta - No Effect

[Thedooman445]

Hello,

I purchased Retatrutide and am currently going into my fifth week. I started at what’s considered the higher end of dosing and have gradually increased from there. My dosing schedule is listed below. So far, I’m honestly not feeling much of a response. I’m still able to eat normally, though I have noticed that my cravings are mostly gone and it’s been easier to eat clean. I do feel slightly fuller at times, but that’s about it. My girlfriend is following the same plan, and she has already lost 23 pounds, which makes me wonder if I might just be a non-responder. I’m feeling a bit underwhelmed and curious if anyone else has had a slower response or noticed that it took longer for things to really kick in.

Dosing schedule:

• Week 1: 2 mg
• Week 2: 3 mg
• Week 3: 3 mg
• Week 4: 3 mg
• Week 5: 4 mg

Thanks in advance for any shared experiences.

 

[Chili777]

It takes 4 weeks for Reta to reach therapeutic levels. You're also titrating up very quickly. Typical protocols show 4 weeks at each increment, also starting at 2 mg, but sometimes lower. If you're already at 4mg and tolerating any sides, I would suggest staying there for 4 weeks and then reassessing. Have you moved from Sema or Tirz to Reta? This can also cause slow response until you reach a higher dosage.

 

[Thedooman445]

It takes 4 weeks for Reta to reach therapeutic levels. You're also titrating up very quickly. Typical protocols show 4 weeks at each increment, also starting at 2 mg, but sometimes lower. If you're already at 4mg and tolerating any sides, I would suggest staying there for 4 weeks and then reassessing. Have you moved from Sema or Tirz to Reta? This can also cause slow response until you reach a higher dosage.

Thanks for the reply! I haven’t done Sema or Tirz before—this is my first GLP-1. I realize I probably moved up a bit quickly, but I plan to stay at this dose now like you suggested for the next four weeks and then reassess. It’s helpful to know it takes around four weeks to reach therapeutic levels; I think all the social media hype made it seem a lot stronger and faster-acting than it really is. I also forgot to mention that I’m on TRT, in case that plays any role with Reta. Interestingly, my girlfriend felt the effects almost immediately in the first week—so it must be doing something 😆

 

[Waclive]

Did you do any body scans beforehand? Are you do anything resistance training to go with it?

 

[gulangaloid]

i saw little to no effects until the max dose, i'd recommend to just keep titrating up if you aren't getting troublesome side effects (maybe a little more slowly) and only give up on it if you aren't seeing meaningful effects after more than a month on the max dose, then probably consider tirz

 

[Chili777]

Thanks for the reply! I haven’t done Sema or Tirz before—this is my first GLP-1. I realize I probably moved up a bit quickly, but I plan to stay at this dose now like you suggested for the next four weeks and then reassess. It’s helpful to know it takes around four weeks to reach therapeutic levels; I think all the social media hype made it seem a lot stronger and faster-acting than it really is. I also forgot to mention that I’m on TRT, in case that plays any role with Reta. Interestingly, my girlfriend felt the effects almost immediately in the first week—so it must be doing something 😆

It's possible but I haven't used TRT, so maybe someone else could provide insight there.

I do know you have to give it time to work it's magic. Everyone is different and we have different levels of response. For me, it was also the first few days, but you never really know until you start. Also, eating at a deficit, getting regular exercise and sleep habits are major factors in the outcome as well.

 

[Thedooman445]

Did you do any body scans beforehand? Are you do anything resistance training to go with it?

Did you do any body scans beforehand? - No, I did not perform any body scans.
Are you do anything resistance training to go with it? - Yes, I have been working out 5X a week for years now. My current split is Push, Pull, Leg, Rest, Upper, Lower, Rest - attempting to hit each muscle twice a week. I could probably improve on my cardio lol.

 

[Thedooman445]

It's possible but I haven't used TRT, so maybe someone else could provide insight there.

I do know you have to give it time to work it's magic. Everyone is different and we have different levels of response. For me, it was also the first few days, but you never really know until you start. Also, eating at a deficit, getting regular exercise and sleep habits are major factors in the outcome as well.

Thanks for the information! Training is not a problem.. that's the easy part for me. My sleeping could probably improve though. My deficit has been better though.

 

[diamond_edge]

Body scans, rigorous testing, and an aggressive training regimen are all really important. Good luck!

 

[aRareUnicorn]

Reta was my first GLP and, like you, I haven’t felt much at either 2 mg or 4mg. It was 6mg where I definitely started seeing and feeling the effects. Stick to the schedule, stay at 4mg for a month and then, if you still don’t “feel it”, move up to 6mg.
Based on your better self control with cravings, Reta seems to be working for you, and it will work even more at the higher doses (when you finally get there), but please don’t rush the process 🙂

 

[Sasquatch]

Thanks for the reply! I haven’t done Sema or Tirz before—this is my first GLP-1. I realize I probably moved up a bit quickly, but I plan to stay at this dose now like you suggested for the next four weeks and then reassess. It’s helpful to know it takes around four weeks to reach therapeutic levels; I think all the social media hype made it seem a lot stronger and faster-acting than it really is. I also forgot to mention that I’m on TRT, in case that plays any role with Reta. Interestingly, my girlfriend felt the effects almost immediately in the first week—so it must be doing something 😆

Are you both using from the same vial? Or in other words, do you trust your juice?

 

[Thedooman445]

Are you both using from the same vial? Or in other words, do you trust your juice?

Yes, we have gone through the first vial together. We just started a new vial, but I haven't taken the new one yet. I will soon.

 

[CNCCurrency]

Are you both using from the same vial? Or in other words, do you trust your juice?

I was thinking the same, I noticed it after my first 2mg dose the next day. Currently at 8mg

 

[yrrdead]

I'm with the above 2 , did you have testing or has your batch been tested somewhere else? Not that I've seen much 0% reta (if any). But 5 weeks with nothing at those levels having never taken a glp before?? That seems odd.

Even placebo would be losing weight. Literally injecting saline.

So lets again go to the basics of ; How are you tracking your calories? Are you tracking your calories? Not that its 100% necessary but if you are wondering why you aren't losing weight , generally this is a good place to start.

 

[Airborne Daddy]

I'm not a good responder. Until I get to the higher end of dosing I get nothing .... reta nothing till I hit 8mg and lots of folks agree the appetitite suppression is lacking so I stack with 1.5 mg sema that absolutely helps..... the calorie counters too ... u think you had a turkey Sammie on low cal, high grain bread all day and forgot the 200 calorie slim Jim and 340 calorie powerade, or the half roll of wild cherry lifesavers, another 30 grams of sugar.... add to that 800 calories for a small dinner plate. Not bad but if ur like me and do 3oz of bourbon and 2 modelo negra....that's another 700 calories. Hang in there buddy. Also if you're only 40lbs overweight your likely not gonna lose the same as someone 150lbs overweight.

 

[Waclive]

Did you do any body scans beforehand? - No, I did not perform any body scans.
Are you do anything resistance training to go with it? - Yes, I have been working out 5X a week for years now. My current split is Push, Pull, Leg, Rest, Upper, Lower, Rest - attempting to hit each muscle twice a week. I could probably improve on my cardio lol.

I wouldn't add cardio if you're trying to add muscle or strength. Especially if you're not getting your protein intake on daily basis, which I don't know if you are or not.

 

[Thedooman445]

I'm with the above 2 , did you have testing or has your batch been tested somewhere else? Not that I've seen much 0% reta (if any). But 5 weeks with nothing at those levels having never taken a glp before?? That seems odd.

Even placebo would be losing weight. Literally injecting saline.

So lets again go to the basics of ; How are you tracking your calories? Are you tracking your calories? Not that its 100% necessary but if you are wondering why you aren't losing weight , generally this is a good place to start.

I didn’t personally test the Reta, but I purchased it from a vendor listed under the Vendor Connections tab on this website. They provided Janoshik lab results for their batch. I don’t believe it’s fake, especially since my spouse struggled significantly with weight loss before and is now seeing noticeable changes. As for my part, I track my calories very carefully—I weigh everything in grams and stay consistent. I’m typically eating around 1,500–1,700 calories per day and getting approximately 180–200 grams of protein daily.

 

[Thedooman445]

I wouldn't add cardio if you're trying to add muscle or strength. Especially if you're not getting your protein intake on daily basis, which I don't know if you are or not.

I am definitely getting my daily protein in! You can see my last message reply above, I am getting around 180-200 grams of protein a day.

 

[eyfm!]

Have you thought about adding cagrilintide? I was a complete non-responder to tirzepatide: I titrated Zepbound (aka Tirzapetide) all the way up to 15 mg/week (the max dose) and lost only about 1 lb over 8 months.

I then switched to reta. Initially I noticed some changes to appetite supression, but nothing dramatic. I started at doses similar to yours (around 2 mg) and titrated fairly quickly as well since I had essentially no side effects.

After about three weeks on reta, I added cagrilintide, and that’s when the weight really started coming off. I’m now four months in and down almost 48 lbs. Cagrilintide works through a completely different pathway than GLP-based drugs and has extremely strong appetite suppression, which might be the missing piece for you.

You could start by trying just a single vial to see whether you respond (they typically sell in 5mg or 10mg vials). I personally felt the appetite suppression on day one. If it works, stacking reta + cagri has been very effective for me and many others. For reference, I started cagrilintide at 0.5 mg/week (0.5 — not 5). My current dose is 2mg/week (this is significantly higher that most people, most start at 0.25 and titrate to 0.5 or 1mg every week)

 

[eyfm!]

Another thing worth experimenting with is dosing frequency, for example, whether you’re taking a single weekly dose or splitting it across the week. People respond very differently to this. I initially pinned three times per week, but eventually switched to once weekly. I personally feel a stronger effect with once-weekly dosing, though some people report better appetite suppression with two or three injections per week.

Diet and hydration also matter more than they get credit for. Are you eating enough protein and drinking enough water? I know these sound like the usual annoying doctor questions, but they genuinely make a noticeable difference in how well these compounds work.

Also, don’t give up if reta doesn’t seem to be doing much yet. All of these drugs act on different pathways, and they affect those pathways to different degrees. For example, even though retatrutide targets three pathways (including the two targeted by tirzepatide), it isn’t necessarily as strong on those two as tirzepatide itself. The key is figuring out which pathway your body responds to and adjusting your stack accordingly. This is still very experimental territory.

Finally, keep in mind that in the retatrutide Phase II trial there were no true non-responders, everyone lost weight, even if some did so very slowly. That’s very different from tirzepatide, where some people see almost no weight loss at all. I totally get how frustrating it is to watch others take the same doses and drop weight effortlessly, but try to focus on your own progress, and be happy that your girlfriend happened to find a combo that works well for her.

 

[yrrdead]

I didn’t personally test the Reta, but I purchased it from a vendor listed under the Vendor Connections tab on this website. They provided Janoshik lab results for their batch. I don’t believe it’s fake, especially since my spouse struggled significantly with weight loss before and is now seeing noticeable changes. As for my part, I track my calories very carefully—I weigh everything in grams and stay consistent. I’m typically eating around 1,500–1,700 calories per day and getting approximately 180–200 grams of protein daily.

I don't know then. 15-17 is already pretty low. Unless you are already pretty small and lean. Even with zero drugs I would expect you to be losing weight.

Did you just recently start TRT? I wouldn't normally expect it to impact much unless you just started and/or you are blasting.

The only things that make sense to me is that for some reason 15-17 is maintenance which sounds unlikely unless again you are already pretty lean. Or you are retaining a bunch of water for some reason.

 

[miss-sanne]

Maybe you won't respond until the higher doses 8-12 mg. Increase your dose, but not too fast.
It's not that uncommon to not respond to the lower doses. You are not at non-responder on the lower dose 4 mg.

Also consider if something else is going on, - did you have a full blood test panel before you started ? It's a good idea to have a baseline. If you have some metabolic issues, the drugs often need to be in higher doses to loose weight. You are only on 4 mg now. The medicine needs time to work.

And you don't say how much you need to loose, how high are you and what weight ?