Reta seems to be not working any more???

Thos

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Been on Reta for 22 weeks and the last few weeks weight loss has stalled big time and appetite has come back especially at night, am down 47 kg , was on 15 mg a week but bumped it up to 20 mg a week and no difference !!!!
 
Not working would mean weight regain, not weight loss stalling.

What’s your current weight? There is a practical limit to most things. It may be time to stack.
 
Am down from 203 kg to 156


First thoughts are be to attack the numbers/math.

Consistent daily weigh in timing, calorie counting, exercise tracking.

Losing 2+kg/week is exceptionally aggressive, but relative to your starting weight it’s closer to the realm of reasonable. My personal goal is 1% reduction week/week.
 
First thoughts are be to attack the numbers/math.

Consistent daily weigh in timing, calorie counting, exercise tracking.

Losing 2+kg/week is exceptionally aggressive, but relative to your starting weight it’s closer to the realm of reasonable. My personal goal is 1% reduction week/week.
I have everything recorded, weekly weigh in and strict calorie intake of 1000 calories a day but I must admit no real excercise apart from a daily 30 min walk ,
Appreciate your input
 
I have everything recorded, weekly weigh in and strict calorie intake of 1000 calories a day but I must admit no real excercise apart from a daily 30 min walk ,
Appreciate your input
Been on 15 mg a week since mid February
 
15-20mg per week is nuts! I have never heard of someone taking that amount. I would look into where you're getting your reta first and make sure its legit.
And I have a few friends taking the same stuff but on very low dosage and works well for them
 
I have everything recorded, weekly weigh in and strict calorie intake of 1000 calories a day but I must admit no real excercise apart from a daily 30 min walk ,
Appreciate your input
This is probably your issue. Up your calories and get in the gym. 1000 calories just is not enough in a day to keep your body healthy. The weight loss stall may be your body going into defense mode because you aren’t eating enough and it feel it needs to retain all nutrients it is taking in.
 
This is probably your issue. Up your calories and get in the gym. 1000 calories just is not enough in a day to keep your body healthy. The weight loss stall may be your body going into defense mode because you aren’t eating enough and it feel it needs to retain all nutrients it is taking in.
Not sure if that would actually fix it but 1000 calories does seem extremely low for the weight stated above. Could double it and still be in a deficit
 
Not sure if that would actually fix it but 1000 calories does seem extremely low for the weight stated above. Could double it and still be in a deficit
Exactly. And you may be right, that may not be the sole issue. But even at 2000 calories you are almost certainly in a deficit. That is just the first place I would start.
 
15-20mg per week is nuts! I have never heard of someone taking that amount. I would look into where you're getting your reta first and make sure its legit.
I’ve known a couple people taking reta in the mid-20s. It’s stronger than 12 but not dramatically so, there’s diminishing returns with GLP-1s.
 
Been on Reta for 22 weeks and the last few weeks weight loss has stalled big time and appetite has come back especially at night, am down 47 kg , was on 15 mg a week but bumped it up to 20 mg a week and no difference !!!!
Given where you started and the loss of 47 kilos, the reta has worked a bit less well than average, but not much, so about 25% loss rather than 29% plus that is the average from 12mg of reta over a year. Higher doses of reta have never been studied in humans yet so it is hard to say what to expect from doses higher than 12mg, on average you would expect some extra weight loss, but you are getting into diminishing returns territory where higher doses will not cause much extra weight loss, but might cause worse side effects.

The important thing to realise is that it is still working and stopping you from putting the weight back on, Even if getting to 150kg from 200 is less than you hoped it is still enough to make a lot of difference to long term health, and keeping it off is as important as anything.

But I would second adding in elora ( or cagri ) , no good human studies yet apart from semaglutide with cagrilintide. Cagri is probably a bit less effective and has more side effects than elora but is cheaper . Elora has literally only been available for a few weeks. There are very good reasons to believe you could get a fair bit of extra weight loss out of reta plus cagri or reta plus elora. And much more likely to work than increasing reta more or adding in tirz. But starting at very low doses of cagri is important 0.25mg and increase slowly, or if elora maybe 1mg and also go slow. The way I see it is the adverse effects of combos of GLP drugs are mostly unknown, but given how severe the health risks are of severe obesity it is very unlikely they are worse.

I think a fair bit of the advice above is not taking into account the issues of hitting the gym at 150 kg plus, if you can great, but if not, waiting till weight gets down a bit more might be more practical and safer. I know I could not even start walking much till I got down from 145 kg to 115kg and even then a 5 minute walk was really quite painful. But from there I was able to gradually build it up.

The 1000 kcal/day is not impossible in the context of long term low calorie metabolic adaptation, but even then is pretty low for that weight. It might be worth trying to get a more precise estimate by weighing everything you eat and writing it down for a week and I found chatgpt was pretty good at calculating calories / protein / carbs etc from the foods and amounts, or even a professional dietitian appointment might not hurt.
 

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