Side Effect: Diarrhoea

[Der Erlkasper]

So I'm still on the 2mg dose, and got strong watery diarrhoea last week that slowly subsided.
I'm not sure if this was perhaps some unclean vegetable, or indeed caused by Reta, because it felt so much like food poisoning.

Anyone else experienced this? Does this pattern match the known side effects? Should I lower my dose, or perhaps skip a week?

 

[miss-sanne]

This is a normal known side effect. If it starts after your dose, it's very likely reta. I would try to go down to 1 mg.

 

[Der Erlkasper]

This is a normal known side effect. If it starts after your dose, it's very likely reta. I would try to go down to 1 mg.

It happened in week 3. Weekly 2mg doses so far.

 

[miss-sanne]

It happened in week 3. Weekly 2mg doses so far.

I would suspect Reta. It buildts up in your system.

 

[lessthanhalf]

The effects on gut motility do not make perfect sense in that it can cause constipation or diarrhoea. At a consistent dose, peak levels are reached at 4 weeks, so blood levels should peak a day or so after each dose and be slightly higher each week. The https://glp1plotter.com/ site is useful for visualising this as it is so different to just about any other drug in terms of its slow absorption and week long half life. Side effects correlate with peak blood levels.
I would agree with dropping the dose to 1mg for a while and then going up more slowly , to 1.5mg next time. In general gastrointestinal side effects are usually worst at about months 1 to 3 and then slowly settle in most people, going up in dose more slowly is the best way to minimise this.

 

[AxlBundy]

I’ve been on Reta for 18 weeks, recently upped the dose from 3mg e5D to 5mg e5d and have had the explosions since. Also switched to Jeep Reta when I upped the dose. Couple theories, but Imodium seems to help. Hopefully just a short term adaptation

 

[Calm Logic]

Some bathroom reading material:

Normal side effects?

I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach...

glp1forum.com

Anyone else get a good bit of undigested food in stool as a triz side?

Maybe its also due to diet change as I am eating more veg and salads and stuff, but its a bit wierd to be shitting out leaves and bits of carrot and crap. Especally 2 days out from a dose, for some reason. For some reason the triz sides hit @ 48 hours out from a dose.

glp1forum.com

Lower starting doses

So should people start on 1.0 mg of tirz? I don't think so. There's always exceptions, but almost no one does that. The 2.5 mg dose is considered the lowest, initiation dose for tirz, with a current maximum of 15 mg that is six times that. I think part of the confusion is because people lose...

glp1forum.com

Might retrutide work better for me

I have been taking tirzepatide for a little over three months and have ran into problems that are stopping me from getting to an effective dose. I worked my way up to a dose of 5 mg of tirz once weekly. About three days into the week, I got debilitating diarrhea and bothersome insomnia...

glp1forum.com

What I don't see enough of: People using
telehealth to manage GI symptoms. A person could even schedule weekly telehealth appointments with a board-certified internist. Or just use Amazon telehealth as needed. But the microdosers, to be consistent, may want to microdose GI meds too, haha.

 

[randompersonrandom]

Some bathroom reading material:

Normal side effects?

I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach...

glp1forum.com

Anyone else get a good bit of undigested food in stool as a triz side?

Maybe its also due to diet change as I am eating more veg and salads and stuff, but its a bit wierd to be shitting out leaves and bits of carrot and crap. Especally 2 days out from a dose, for some reason. For some reason the triz sides hit @ 48 hours out from a dose.

glp1forum.com

Lower starting doses

So should people start on 1.0 mg of tirz? I don't think so. There's always exceptions, but almost no one does that. The 2.5 mg dose is considered the lowest, initiation dose for tirz, with a current maximum of 15 mg that is six times that. I think part of the confusion is because people lose...

glp1forum.com

Might retrutide work better for me

I have been taking tirzepatide for a little over three months and have ran into problems that are stopping me from getting to an effective dose. I worked my way up to a dose of 5 mg of tirz once weekly. About three days into the week, I got debilitating diarrhea and bothersome insomnia...

glp1forum.com

What is up with the way humans just LOVE to tell poop stories. I feel like across all cultures and all timelines, there is always a gaggle of humans who's here to tell you all about their pooping.

 

[MFGamesta]

It happened to me my 2nd week of tirzapatide and again the 2nd week of retatrutide. Only happened once. I while try to stick it out for another week to see if it fades.

 

[Minkster]

I had it in the beginning for a few days and maybe a day after a dose increase but mostly constipation is my issue.

 

[Calm Logic]

Soluble fiber supplements may also help, though it may seem counterintuitive since they are also used for constipation.

In addition to probiotics like Florastor Advanced, the controversial supplement kratom is another long-term option (due to the mild opiod-like effects slowing down the lower GI system).

What is up with the way humans just LOVE to tell poop stories. I feel like across all cultures and all timelines, there is always a gaggle of humans who's here to tell you all about their pooping.

Diarrhea is the side effect my pharmacist warned me the most of, as far as why people stop taking tirz completely. For many on GLPs, this is the worst diarrhea they will have in their entire lives, especially if they had IBS-D before.

 

[Dogmandu]

It happened in week 3. Weekly 2mg doses so far.

This is not unusual, as week 4 after first shot as that's when the reta level begins to peak and plateau. So, expect some additional troubles this week and next.

You have options:
1) go back to 1 mg or 1.5 mg and stay there for a month. As your body gets used to that dose, go up slowly to 2 mg. Your escalation may have to be slower to allow your body time to adjust.

2) stay the course and deal with it (not my preference) and hope your digestive system adapts sooner than later.

3) pay attention to what type of foods triggered the issue. When I started, fatty or oily foods would cause problems. You may be able to stay at 2 mg as long as you avoid triggering foods.

Of course, it is also entirely possible that you got a case of food poisoning, but I doubt it.