As lessthanhalf laid out upthread, anyone not taking this to offset visceral fat accumulation from HIV meds is already engaging in "bro science," regardless of the number of days a week they're doing it. š¤£ And the same is true of most of the non-GLP peptides being discussed on this site.
This is quintessential bro science. The 5 days on 2 days off protocol doesn't make sense for any drug, as drugs are not salaried workers. But people working at medical spas are, which is where this protocol comes from - their offices were simply not open on the weekends, and so their patients couldn't come in to get the peptides administered.
There is no such thing as "HIV lipodystrophy." The problem Tesamorelin is solving is HIV patients taking antiretroviral HIV drugs which cause an abnormal rise in visceral fat. The significance of HIV in relation to Tesamorelin is just that the older antiretroviral HIV drugs affect visceral fat, it's not the HIV itself which affects it (other than possibly elevated chronic inflammation.)
Wow never thought about that, usually the best answer is the simplest, and this right here might be it.
Youāre spot on, a lot of this is still speculation. Iād just take it one step further.
This is great feedback. Thanks for sharing. I feel your pain on the water retention. I stated Tesa two weeks after Tirz and not only did I gain the weight I lost, I also added more weight then where I started with Tirz.
You had me worried there for a bit thinking my brain must have made the term up, but after looking through about 10 papers on it I did find a recent one that called it HIV lipodystrophy, rather than abnormal visceral and liver fat accumulation in HIV patients, so it might not be the most common term for it but at least I had not misremembered or made it up.
Maybe because the increase in GH does affect insulin sensitivity negatively, but that might be counteracted by the fact that at the same time Tesamorelin reduces visceral fat which is known to improve insulin sensitivity? Interesting stuff!
I stand corrected then. I looked it up and HIV does in fact lower GH levels, which ends up increasing fat accumulation.
I was going to ask why you werenāt at 2mg, glad you answered it. Sounds like youāre still getting good results at 1mg!
Sermorerlin is milder and would be less risky for the long-term, at least if one naturally has high-normal IGF-1 for one's age. But cost-wise, less bang for the buck with serm.
Gemini said:
Is there a typo here. It looks like your IGF-1 ended up being lower? What about your Z-Score?
No typo. The z score is -0.1. 102 to 96 is a minor difference according to AI medical experts. š¤£
I'm debating a protocol, what it one cycles between hgh, tesa and ipa? Like 2 out of hgh in the morning and 1mg and 200mcg of ipa in the night. Will it be confusing the system too much or that way the body can be at its natural state.
Was your Tesa tested? Iām no expert but I donāt think Iāve ever seen someone run 2mg of Tesa and IPA daily to have their IGF-1 drop 6 points.
Yes it was tested for Mass and purity. 11.9 mass and>99 purity. I reconstituted with 2 ml BAC for the 2mg dose at 34 units. BTW, Iām 75 and GH are not as active as a 30 year old.
138 is pretty good for a 75yo! About where I am at 30 years younger. What were the z-scores? I'm guessing 215 is >2?
54, not 75 š¤£
Lol, I mixed 2 people š
Interesting your insulin increased that much while on reta? I would think any increase due to tesamorelin would be counteracted by reta, so I asked chtgpt and it said early on reta could increase insulin levels , but after weight loss and long term use it will reduce insulin resistance and insulin levels would reduce to below starting levels. So not surprising given you have been on it a short time.
I am 54, not 70
Ya on my labcorps test it said top was 255.
High in the range, ābetter,ā depends on how you define that wordā¦. I always like to be high in the range of many things.
I guess it is better because it means the Tesamorelin is working.
