This is not medical advice:
If you have GLP1 fatigue and/or anhedonia, you should read up on tesofensine. It was originally aimed at neurodegenerarive disorders such as Alzheimer’s and Parkinson’s. Some benefits include:
— Mood enhancement/improvement
— Energy increase
— Appetite suppression
Warning: do not take while on SSRI medication. This can cause serotonin syndrome.
After 8 days of ~125mcg, my own personal research reflects those beneficial outcomes. It’s been a great week and I’m looking forward to the next one!
UPDATE
Day 9 (9/15):
At 1/4 tab (~125mcg) daily for the first 8 days, RS reports that the effects were stronger at first but have “leveled out”, which is a good thing.
Starting today, I’m going to research 1/2 tab, as 250mcg was the lowest amount used for clinical trials.
Day 13 (9/19):
As previously reported, on day 9 my RS was bumped up to 1/2 tab. It was too much for my RS. That dose only lasted one day, so back down to 1/4 tab on day 10, although the effects seemed to build over the next few days.
Day 12 was not great for my RS. With the extra bump in dose for that one day, the effects seem to have built to a point that was uncomfortable for my RS by day 12. Given its 9-day half life, I will be changing my RS’s protocol to 1/4 tab every other day. RS skipped day 13 and reported feeling more evened out.
I will say that looking back, I think it would’ve been wiser to wait that full 9 days, or maybe longer, before considering an increased protocol. RS also barely ate on day 12, likely due to those effects, which just compounded the yuck.