TESOFENSINE

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BILLYD

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Hello, I’m looking to purchase this from a supplier preferably from overseas ( China)
Instead of purchasing retail in the United States, does anybody have any suggestions as far as who the best quality and pricing. Thanks.
 
Few vendors offer it for example:
Nexa - Tesofensine 500mcg/pill 120p/bottle $55/bottle
AVA - Tesofensine 500 mcg (0.5mg) x 100 tablets/bottle $15.00

not sure about others, QSC for example only sells powder.

with AVA im not sure about the quality, it seems too cheap, don't remember seeing any COA
 
BenevolentMrTang said:
I bought 5 bottles of 100 capsules, 500mcg each, for $130 plus
$40 for shipping from Tuk of ASC (plus their fee to use PayPal). Have not cracked any open yet because I still have some left over from a domestic supplier.
Click to expand...
And just an FYI, ASC requires a minumum order of 5 bottles. I wanted to buy some, but wasn't willing to buy that many bottles for something I'm not sure would work for me.
 
mopo89 said:
And just an FYI, ASC requires a minumum order of 5 bottles. I wanted to buy some, but wasn't willing to buy that many bottles for something I'm not sure would work for me.
Click to expand...
Can you provide me with their information thanks I appreciate it
 
BenevolentMrTang said:
I bought 5 bottles of 100 capsules, 500mcg each, for $130 plus
$40 for shipping from Tuk of ASC (plus their fee to use PayPal). Have not cracked any open yet because I still have some left over from a domestic supplier.
Click to expand...
Can you provide me with their information?
 
By the way,I apologize I’m not familiar with some of the abbreviated company names, can you provide me with a link, web address, or full name. What I didn’t notice as some of these have very similar names and I’m not sure which one are the legit ones. Thanks in advance thanks.
 
BILLYD said:
By the way,I apologize I’m not familiar with some of the abbreviated company names, can you provide me with a link, web address, or full name. What I didn’t notice as some of these have very similar names and I’m not sure which one are the legit ones. Thanks in advance thanks.
Click to expand...
I pm'd you the info, but FYI (and for anyone else who does not know this), you can find vendor info in the Vendor Connection forum on this site.
 
milos said:
so far it looks like its a "coke light"
Click to expand...
It’s a SNDRI. It inhibits the reuptake (removal) of serotonin, norepinephrine, and dopamine. That leaves more of those neurotransmitters freely available in your system. That’s where the effects come from.
There are no stimulants in tesofensine.
 
milos said:
first try it after let me know again! 😉
Click to expand...
Please quit the dismissive attitude. I’ve been taking teso for over a month now.

peptideusername

Teso is awesome.

This is not medical advice:

If you have GLP1 fatigue and/or anhedonia, you should read up on tesofensine. It was originally aimed at neurodegenerarive disorders such as Alzheimer’s and Parkinson’s. Some benefits include:

— Mood enhancement/improvement
— Energy increase
— Appetite suppression

Warning: do not take while on SSRI medication. This can cause serotonin syndrome.

After 8 days of ~125mcg, my own personal research reflects those beneficial outcomes. It’s been a great week and I’m looking forward to the next one!

UPDATE

Day 9 (9/15)...
  • Like
  • Love

You even commented in this thread.
 
peptideusername said:
Please quit the dismissive attitude. I’ve been taking teso for over a month now.

peptideusername

Teso is awesome.

This is not medical advice:

If you have GLP1 fatigue and/or anhedonia, you should read up on tesofensine. It was originally aimed at neurodegenerarive disorders such as Alzheimer’s and Parkinson’s. Some benefits include:

— Mood enhancement/improvement
— Energy increase
— Appetite suppression

Warning: do not take while on SSRI medication. This can cause serotonin syndrome.

After 8 days of ~125mcg, my own personal research reflects those beneficial outcomes. It’s been a great week and I’m looking forward to the next one!

UPDATE

Day 9 (9/15)...
  • Like
  • Love

You even commented in this thread.
Click to expand...
no need to bite, your teeth are scary enough! 😉 I understand your ego is inflated like on coke, since you take the teso ... 😎😈
but my post was obviously not so serious, c'mon....
I was just reffering to other member reported about "tweeking" like effects while others reported stimulation and insomnia ... and also its from Phenyltropane family of medications - you can google it (Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine.), after that, when you consider all info I just write, you will hopefully understand my comment
☮️
 
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milos said:
no need to bite, your teeth are scary enough! 😉 I understand your ego is inflated like on coke, since you take the teso ... 😎😈
but my post was obviously not so serious, c'mon....
I was just reffering to other member reported about "tweeking" like effects while others reported stimulation and insomnia ... and also its from Phenyltropane family of medications - you can google it (Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine.), after that, when you consider all info I just write, you will hopefully understand my comment
☮️
Click to expand...
Cool, I can copy and paste from google results too.
I can’t read your level of “seriousness”, but when you start telling me I have an “inflated ego” and “scary teeth” I have to assume you’re just trying to ad hominem attack me into an argument. It’s insufferable.
 
Those responses are pretty uncharacteristic for Milos. He's not wrong about some chemical similarities, but he's also being a bit tone-deaf.

If you've ever tried the two, you'd know they're not similar in effects at all.

Milos, do you go around telling people who need to take morphine that they're on "heroin light"? Those are even closer chemically.
 
Dee X said:
Those responses are pretty uncharacteristic for Milos. He's not wrong about some chemical similarities, but he's also being a bit tone-deaf.

If you've ever tried the two, you'd know they're not similar in effects at all.

Milos, do you go around telling people who need to take morphine that they're on "heroin light"? Those are even closer chemically.
Click to expand...
As The Dude once said: “You’re not wrong, Walter. You’re just an asshole.”
 
Dee X said:
Those responses are pretty uncharacteristic for Milos. He's not wrong about some chemical similarities, but he's also being a bit tone-deaf.

If you've ever tried the two, you'd know they're not similar in effects at all.

Milos, do you go around telling people who need to take morphine that they're on "heroin light"? Those are even closer chemically.
Click to expand...
c'mon guys I didn't say anything so bad, to be for instance even close to Tracy's everyday language, why are you so sensitive?
I really just tried to be little bit funny based on the fact the compound is in fact from the same family as cocaine, so that I just call it "coke light" is not far from the truth and absolutely not any personal attack against anyone. Seriously c'mon, whats the issue here?
 
milos said:
c'mon guys I didn't say anything so bad, to be for instance even close to Tracy's everyday language, why are you so sensitive?
I really just tried to be little bit funny based on the fact the compound is in fact from the same family as cocaine, so that I just call it "coke light" is not far from the truth and absolutely not any personal attack against anyone. Seriously c'mon, whats the issue here?
Click to expand...
Tracy is known for being an asshole, you're better than that. We respect you more.
 
I check back my original post wasn't even answer to @peptideusername
never mind, not worth my time creating some new drama around total nonsense
 
milos said:
I check back my original post wasn't even answer to @peptideusername
never mind, not worth my time creating some new drama around total nonsense
Click to expand...
How to identify when someone has realized they are wrong. Minimize, negate, deflect.

It’s like a Platonic perfect form… it’s really quite beautiful.
 
peptideusername said:
“we” is a stretch here.
Click to expand...
i don't think so. She's talking about the forum in general. He has a lot of knowledge and helps out a lot.

Edit: I don't mean to get in the middle of this, but milos caught me overdosing myself by 10x ( i know....i'm an idiot) so i have some firsthand experience and am grateful for his presence.
 
Last edited:
raw_oyster_eater said:
i don't think so. She's talking about the forum in general. He has a lot of knowledge and helps out a lot.

Edit: I don't mean to get in the middle of this, but milos caught me overdosing myself by 10x ( i know....i'm an idiot) so i have some firsthand experience and am grateful for his presence.
Click to expand...
support from @raw_oyster_eater means a lot to me! it wasn't easy to gain respect and trust from him! but seriously we have more important things to discuss than creating some new dramas
☮️
 
BeardedGuy said:
So but wait… is Tesofesine going to be addicting? Physically or mentally?
Click to expand...
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
 
Dee X said:
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
Click to expand...
Understood much better now, thanks. Love this forum.
 
Dee X said:
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
Click to expand...
pubmed.ncbi.nlm.nih.gov

Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users - PubMed

Tesofensine is a (triple) reuptake inhibitor of noradrenaline, dopamine, and serotonin that is in development for the treatment of obesity. The abuse potential of triple reuptake inhibitors is not yet known, and so this study was undertaken to evaluate the potential abuse-related effects of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Yeah, not apparently addictive… good news.
 
I looked at adding Teso to my trial research but I am concerned with the heart rate increase (adding to the impact of the Tirz HR increase I already have) and the potential for variations in tablet strength.

From what I have read many start on 125mcg (which I would start with) which means cutting the pill in quarters. My concern is dosing/strength inconsistency from one tablet to the next and even within each 1/4 tablet. Similar to many of the people ODing on fentanyl tablets. One user is fine and the next user OD's from the same batch. If you have ever tried to mix salt and pepper (perfect for smoking a brisket) it is very difficult to get the mix to come out evenly. This is what I imagine happening in the UGL's making these tabs (or capsules). I may still give it a shot though, maybe when I am in maintenance.

Does anyone get several tabs tested from each bottle/batch? Janoshik was the only lab that I found that offers it.
 
Dee X said:
No, not according to any clinical trials. The mechanisms are completely different. It also does not get you high, and it lasts in your system for a long time.

You can probably misuse it if you try hard enough since it affects dopamine, just like anything else that affects dopamine, but you're going to have a bad time.

For short read: https://en.m.wikipedia.org/wiki/Tesofensine

For long reads, look at PubMed and the patents.

This is actually why I was so against calling it "coke light".

(Disclaimer: we haven't seen phase 3 trials data. Though, my RSs have not experienced anything like that)
Click to expand...
pubmed.ncbi.nlm.nih.gov

Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users - PubMed

Tesofensine is a (triple) reuptake inhibitor of noradrenaline, dopamine, and serotonin that is in development for the treatment of obesity. The abuse potential of triple reuptake inhibitors is not yet known, and so this study was undertaken to evaluate the potential abuse-related effects of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
EDIT: @BeardedGuy found it first, no it will not be addictive any more compared to antidepressants
 
GimmeABreak said:
I looked at adding Teso to my trial research but I am concerned with the heart rate increase (adding to the impact of the Tirz HR increase I already have) and the potential for variations in tablet strength.

From what I have read many start on 125mcg (which I would start with) which means cutting the pill in quarters. My concern is dosing/strength inconsistency from one tablet to the next and even within each 1/4 tablet. Similar to many of the people ODing on fentanyl tablets. One user is fine and the next user OD's from the same batch. If you have ever tried to mix salt and pepper (perfect for smoking a brisket) it is very difficult to get the mix to come out evenly. This is what I imagine happening in the UGL's making these tabs (or capsules). I may still give it a shot though, maybe when I am in maintenance.

Does anyone get several tabs tested from each bottle/batch? Janoshik was the only lab that I found that offers it.
Click to expand...
Here is an example of a recent Janoshik test of four 500mg tablets from Wuhan presumably from the same batch (all four were listed on the same test):

1729520877438.png


This seems like a huge variation from one tablet to the next and also doesn't account for the potential variation within each tab when you split it in four.

Does this dose variation impact your research results or does the long half-life sort of even it all out?
 
I would to research tesofensine. I see biopep mentioned but I can’t find them. Can someone provide more information?
 
divisible1830 said:
I would to research tesofensine. I see biopep mentioned but I can’t find them. Can someone provide more information?
Click to expand...
on the 1st page of this thread I list down some vendors who sell it, the cheapest looks like is Ava.
I suggest you compare the vendors first. Ava has at least some history and reviews here on the forum.
 
milos said:
on the 1st page of this thread I list down some vendors who sell it, the cheapest looks like is Ava.
I suggest you compare the vendors first. Ava has at least some history and reviews here on the forum.
Click to expand...
Thank you.
 
BenevolentMrTang said:
I bought 5 bottles of 100 capsules, 500mcg each, for $130 plus
$40 for shipping from Tuk of ASC (plus their fee to use PayPal). Have not cracked any open yet because I still have some left over from a domestic supplier.
Click to expand...
Let us know how they are, please...
 
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