Tirz Burning Poll
- Thread starter Kahtia24
- Start date
No burning stinging but progressively larger more bothersome hot red itchy ISR. This week at 5mg it was 4" around, raised welt inside 2+ inches thigh, my stomach is such a mess recovering from every 5 day ISR. I'm just hoping it's not the TZ. I will be filtering moving forward everything.
nonyabizznez
GLP-1 Specialist
I felt burnt and stung when I paid $1057 for my first box of 2.5
Feel a little sting from 9/24 Amopure L15 but 1.46/mg + ship makes it feel much better.
Feel a little sting from 9/24 Amopure L15 but 1.46/mg + ship makes it feel much better.
You may have already tried this, but a flonase type product sprayed on the skin (after alcohol wipe) right before injection can sometimes help with that type of ISR.
tangoecho311
GLP-1 Enthusiast
Compound from Salt Lake at a strength of 10mg/mL, dosage of 2.5mg: No burn
Nexa: 10mg/mL, dosage from 2.5-4mg : No Burn
QSC : 30mg/1.5mL, dosage from 4-6mg : No burn
I swab my skin with alcohol twice (letting it dry fully each time) and only pin after I have showered and used antibacterial soap. I always warm my injections in my hands before administering. And I administer into my belly. I never do a volume greater than .5mL in one injection.
I've never had any ISR. No red spots, no itching, no heat, no rash. The next morning and I can't even tell where I administered my tirz.
Nexa: 10mg/mL, dosage from 2.5-4mg : No Burn
QSC : 30mg/1.5mL, dosage from 4-6mg : No burn
I swab my skin with alcohol twice (letting it dry fully each time) and only pin after I have showered and used antibacterial soap. I always warm my injections in my hands before administering. And I administer into my belly. I never do a volume greater than .5mL in one injection.
I've never had any ISR. No red spots, no itching, no heat, no rash. The next morning and I can't even tell where I administered my tirz.
I occasionally had mild stinging for fewer than ten minutes from compound from Red Rocks at 7.5. I've had it now and again for I think every research tirz I've tried (four different vendors), sometimes along with a small itchy welt. I think I'm just sensitive to bac water. It goes away pretty quick.
I'm guessing because it's a steroid? Any OTC steroid cream would do the trick, probably?
FWIW - I absolutely DESPISE the pain rating scale. It is so subjective. I honestly don't know how to rate my pain at all. Was it like my leg was being sawed off by a rusty spoon? No. Was it enough that I couldn't sleep and it was uncomfortable AF? Yes.
I had stinging with Amo 30. It was not a dull needle - at the time was using luer-lock needles and I switched out the needle to give the injection with a new needle and NOT the one I used to draw from the vial. Was not my bac water - I did an only bac water injection and had no issues. Product still worked.
Replacement AMO 30 leaves bruising or redness at injection site which I have not had previously at all but there is no burning on injection as long as I administer slow. Product still works but am hesitant to use it.
I had stinging with Amo 30. It was not a dull needle - at the time was using luer-lock needles and I switched out the needle to give the injection with a new needle and NOT the one I used to draw from the vial. Was not my bac water - I did an only bac water injection and had no issues. Product still worked.
Replacement AMO 30 leaves bruising or redness at injection site which I have not had previously at all but there is no burning on injection as long as I administer slow. Product still works but am hesitant to use it.
katisaplot
New Member
Hallandale, Revive, Brooks - no stinging. Hallandale left a bit of bruise-feeling pain at the injection site for a few hours but no bruising was visible. Red Rock stings like crazy all through the injection and for about 10 minutes after. Coincidentally it's also the compound that's worked best for me and has had the cleanest "feel" in terms of the intended effects and the side effects.
Weird, Amo is also the only source I've ever experienced an ISR from with any kind of subq injection as well. Interesting to note it's not just me.
I also have an ISR with Aminos Research. These are the only 2 vendors I have tried. I am awaiting arrival and testing of Ronsen. I do not have an ISR with KPV or Glow just TZ.
maliaharris
New Member
I’ve been using AMO Tirz 30 since Aug 28.Never any sting，so far, so good.A+
I had a bruise from 1 injection on my stomach, but I think I had managed to hit some tiny vein or capillary or whatever. It lasted for a couple weeks and was ugly but didn’t hurt.
Dustycotton
New Member
Regarding rating pain on 1-10 scale, I agree it's not very helpful unless patients rating their pain have the same understanding of what the numbers mean. Just asking for a number from 1-10 without definitions means everyone correlates the pain they are experiencing to the scale differently.
It is intended to apply to how your pain interrupts your ability to carry on your daily activities. Below is only one example of how the pain scale is broken up into mild, moderate, severe, and descriptions for each. What is always going to be subjective about any pain rating is how each individual experiences pain for similar events. However, if one persion can't get out of bed and is or is almost incoherent and delirious due to their pain and they say 10; and another person is able to still do daily activities but can feel pain while going about their day and also says 10, then that is due to different interpretations of what a 10 on the pain scale actually means when applied to daily activities.
Measuring Your Pain
The pain scale breaks up pain into levels from 1 to 10, which describe just how much your pain affects your daily activity. These levels are grouped together into Mild, Moderate, and Severe pain.
Mild pain may be annoying and noticeable, but it doesn’t keep you from performing normal activity. Specifically:
It is intended to apply to how your pain interrupts your ability to carry on your daily activities. Below is only one example of how the pain scale is broken up into mild, moderate, severe, and descriptions for each. What is always going to be subjective about any pain rating is how each individual experiences pain for similar events. However, if one persion can't get out of bed and is or is almost incoherent and delirious due to their pain and they say 10; and another person is able to still do daily activities but can feel pain while going about their day and also says 10, then that is due to different interpretations of what a 10 on the pain scale actually means when applied to daily activities.
Measuring Your Pain
The pain scale breaks up pain into levels from 1 to 10, which describe just how much your pain affects your daily activity. These levels are grouped together into Mild, Moderate, and Severe pain.
Mild pain may be annoying and noticeable, but it doesn’t keep you from performing normal activity. Specifically:
- At level 1, pain may be barely noticeable and easily ignored.
- Level 2 pain is annoying and may flare into occasional stronger twinges.
- Pain at level 3 is distracting, but you can learn to adapt to it.
- You may be able to push level 4 pain aside for periods while involved in a task, but it is still very distracting.
- Level 5 pain can’t be ignored for more than a few minutes, but you can push through it with effort.
- At level 6, the pain may make it hard for you to concentrate on regular tasks.
- At level 7, the pain demands your attention and prevents you from performing tasks. It may even interfere with your sleep.
- Level 8 pain is intense, limiting your physical activity and even making conversation difficult. Sleep is usually disrupted.
- Pain at level 9 leaves you unable to talk at all. You may just be moaning or crying uncontrollably.
- The greatest pain, level 10, leaves you bedridden, incoherent and even delirious.
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moonpies4misfits
GLP-1 Specialist
Never had burning from Skye or Amo, but I have on occasion gotten red welts from both.
Pr0digalSun
New Member
I’m using the scale and rating Amo L15 an 7 out of 10. I’ll use 10 being the most painful inj I’ve ever had.
I would rate trstosterone and hcg subQ inj a 1, ozempic a 1, trimix injections a 4, syphilis prophylactic injections a 5, getting an IV started a 8, and spinal tap a 10
But I paid $1.6/mg incl shipping, so like someone else said it’s worth it, bc of the results
I’m clarifying this is not a post-injection reaction caused by an immune or allergic response, I have no redness, itching, or inflammation after. It’s an immediate sting that goes away after 30-45 mins
Also I draw with one needle the switch to a new smaller needle, so not a dullness issue. The pain doesn’t start until the push of the solution, not the skin puncture, which is completely painless with a 31g new needle.
I would rate trstosterone and hcg subQ inj a 1, ozempic a 1, trimix injections a 4, syphilis prophylactic injections a 5, getting an IV started a 8, and spinal tap a 10
But I paid $1.6/mg incl shipping, so like someone else said it’s worth it, bc of the results
I’m clarifying this is not a post-injection reaction caused by an immune or allergic response, I have no redness, itching, or inflammation after. It’s an immediate sting that goes away after 30-45 mins
Also I draw with one needle the switch to a new smaller needle, so not a dullness issue. The pain doesn’t start until the push of the solution, not the skin puncture, which is completely painless with a 31g new needle.
Pr0digalSun
New Member
This chart skips 5 and has two 3’s lol
I keep seeing two different phenomena getting mixed up. The first is an allergic reaction that happens hours or a day after a shot. It's an itchy red welt that lasts a while. The second is an immediate painful stinging response that seems unique to amopure. Would be nice to have two different terms instead of grouping them together as 'ISR". Maybe ISR and AISR (Amopure ISR)? Or Amopure Stinging Sensation?
So, ASS? 😆
I suspect you are correct as long as it is a corticosteroid. I picked up the flonase trick on an HRT board for patch reaction. Cream probably wouldn't work for that since the patch needs to stick (waiting for the spray to dry is a bit of a pain in the tuchas, but it does work).
Have you asked them to reship? They've agreed to other users to resend a new batch and typically just ask you to send pics of the stinging set smashed up
Pr0digalSun
New Member
To their credit, they were very fast in responding and offering to replace with a new batch, which I haven’t gotten yet but will update on how it feels. I gave one vial to a friend of mine who is going to test it next week to see if it stings him too.
I ordered ph strips that will get here tomorrow, just out of curiosity. I have a background in chemistry, and wonder if it was ph balanced with NaOH, which could cause the burn. If the ph is really high that might be a good hypothesis. Or maybe not, lol but I’m just curious.
Pr0digalSun
New Member
Yes they are definately two different issues. ISR is a reaction caused by either antibodies forming (which happened in trials), or a histamine/allergic reaction, and both of those are redness swelling or itching, that like you said take some time. And a corticosteroid would help. Or antibiotics if it’s infected, but that would take at least 24 hrs to show up.
The stinging isn’t really a reaction by the immune system; it’s immediate then goes away (for me at least).
Some fun reading:
Understanding and Minimising Injection-Site Pain Following Subcutaneous Administration of Biologics: A Narrative Review
Injection-site pain (ISP) is a subjective side effect that is commonly reported with the subcutaneous administration of biological agents, yet it may only be a concern to some. Multiple factors related to the product formulation, such as pH, volume and ...
www.ncbi.nlm.nih.gov
SmokeySquid
GLP-1 Enthusiast
Out of the 4 ish months that I have been using Tirz, I recently had some burning (amo T60) that lasted for a few minutes. I am pretty sure I hit some scar tissue though as I was trying a new spot on my stomach 😅
That was the one and only time though. Every other time has been a breeze thankfully.
That was the one and only time though. Every other time has been a breeze thankfully.
Can we pin this chart somewhere? I keep hearing people claim they experience over an 11.
3 subjects and no reports of any adverse injection effects. Tried brand names Mounjaro and Zepbound, compound from Red Rock. Domestic from Aminos research and CN from Amo. I personally have had tried them all and have the least amount of side effects. To me the Amo seems to not be doing anything for me yet gave someone else their typical headache and "moonwalking" feeling. The Mounjaro pen also did nothing for me either. I may need to look into alternatives or maybe it is because I have very little weight left to lose even though I still have a chubby belly. Waiting on some SRY and if that doesnt help I will have to look into maybe stacking with sema or reta.
Dustycotton
New Member
I didn't make the chart but the second 3 looks to be a typo and is your missing 5. Deductive reasoning!
ETA I found a corrected chart and switched it out on my post.
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No stinging with L20 that I bought on 10/3 and received 3 days later from the US warehouse. Used new BAC, reconstituted 2 days before using. Injected cold (not leaving filled syringe to warm up). Felt it a tiny bit more than my usual compound but no burning or stinging.
Valerie
GLP-1 Enthusiast
Haven’t received my research Tirz. Using compound from Red Rock. 12.5mg. No noticeable stinging; only if my alcohol rub hasn’t dried yet.
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Valerie
GLP-1 Enthusiast
I used Hallandale and RR. I agree that RR best results with minimal to no side effects, but no sting for me. Interesting. I inject top of thigh and pinch the skin pretty hard tho to distract from the needle, but even afterwards … no noticeable sting or discomfort. Edit:: clean is a great adjective for RR. I agree.
Valerie
GLP-1 Enthusiast
Help with what ISR and amopure mean. Is there a glossary section s/ ? 😀
Injection site reaction. Amopure is a bad vendor that has infiltrated this forum with shills.
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highlowwegot
New Member
Slight burning/pain. It was more like a 2-inch red oval that itched like a mosquito bite. Three different manufacturers, all with the same results. No cream, ointment, lotion, or Benadryl-type medication (pills or ointment) would stop it. The slight pain and itch lasted for 4 days. By the time the next shot was due, the redness was 95% gone. The dose size didn’t seem to matter, except the red oval would get slightly larger, maybe by 1/8th of an inch, with higher dosages. I started taking tirzepatide at 1,250 mg for 6 weeks, then moved to 2,500 mg for 6 weeks (it was the first GLP I had ever used), and it worked great.
Things we did to try to eliminate the problem: three different brands (Skye, Peptide Sciences, and one China source) — all caused the same reaction. We tried different injection sites (stomach, thighs, love handles, and butt), but all had the same results. Injecting 1 ml of straight Hospira bacteriostatic water into two different locations caused no pain or irritation, so we ruled out the water as the issue. All vials were reconstituted with new Hospira bacteriostatic water bought from a medical supply store, and all were stored in the fridge. We even tried running it through a .22-micron filter, but it made zero difference.
When we switched to semaglutide, there was no redness, no itching, and no problem. Those were my wife’s results. Interestingly, I used the exact same vials from all three vendors and experienced no redness, pain, or itching. My wife has used melanotan 1 and BPC-157 with zero reactions, so I don’t think it’s the filler (mannitol) used in the peptide mix. I would assume the issue must be with the tirzepatide chemical itself.
Things we did to try to eliminate the problem: three different brands (Skye, Peptide Sciences, and one China source) — all caused the same reaction. We tried different injection sites (stomach, thighs, love handles, and butt), but all had the same results. Injecting 1 ml of straight Hospira bacteriostatic water into two different locations caused no pain or irritation, so we ruled out the water as the issue. All vials were reconstituted with new Hospira bacteriostatic water bought from a medical supply store, and all were stored in the fridge. We even tried running it through a .22-micron filter, but it made zero difference.
When we switched to semaglutide, there was no redness, no itching, and no problem. Those were my wife’s results. Interestingly, I used the exact same vials from all three vendors and experienced no redness, pain, or itching. My wife has used melanotan 1 and BPC-157 with zero reactions, so I don’t think it’s the filler (mannitol) used in the peptide mix. I would assume the issue must be with the tirzepatide chemical itself.
moonpies4misfits
GLP-1 Specialist
I hope you meant mcg 😅
SmokeySquid
GLP-1 Enthusiast
I have seen a few people post about allergic reactions with tirz now and it seems to be something that some people experience. What's crazy to me is that I have only heard about it with tirz and not sema and that seems to line up with your wife's experience. Hopefully Lilly can figure out how to work around that moving forward.
On another note, the manufacture, Pfizer, recommends keeping the BAC water out of the refrigerator as the colder temperature speeds up the deterioration of the alcohol in the solution.
highlowwegot
New Member
maybe that explains the pain and itch....yes mcg..
I've posted this before, but this is the perfect thread to record this for future reference.
Just to be clear. THIS IS NOT ABOUT AMOPURE TIRZEPATIDE. This about my experience with Tirzepatide through Valhalla Vitality.
I've been using pharmacy compounded tirz for a few months and I experienced stinging/burning on 3 occasions, where I had to ice the area for about 1/2 an hour after injection.
Here's the interesting part, I share the tirz vial. Other person has never experienced stinging/burning and we take the shot at the same time. Other person takes a higher dose than me. I did not experience the stinging/burning for the first few weeks, but maybe started happening at my 7th and 8th shot (stinging/burning was consecutive for 3 times after), and I haven't experienced sting/burn ever since then.
Also, I took Ozempic prescription shot before starting tirz. I was only on it for 4 weeks. I developed a round welt at injection site using Ozempic pen at my 3rd shot and also had to ice it.
One more thing, I've bruised easily with no sting in the past, but not all the time. Other person has never bruised.
Now I'll share my AmoPure tirzepatide experience. I used L60 purchased early September two days ago - I'm happy to report, absolutely no sting or burn.
In the future, if it does sting or burn, I will not be quick to blame it on AmoPure because of my personal history/experience with regular Tirzepatide/GLP1s. I did filter the AmoPure with the recommended size from PeptideTest, transferred to sterile vial, and used Hospira Bac to reconstitute. I did notice some "gel" sticking to side of vial when adding BAC, but that went away and reconstituted completely clear with no impurities seen to visible to the eye.
Just to be clear. THIS IS NOT ABOUT AMOPURE TIRZEPATIDE. This about my experience with Tirzepatide through Valhalla Vitality.
I've been using pharmacy compounded tirz for a few months and I experienced stinging/burning on 3 occasions, where I had to ice the area for about 1/2 an hour after injection.
Here's the interesting part, I share the tirz vial. Other person has never experienced stinging/burning and we take the shot at the same time. Other person takes a higher dose than me. I did not experience the stinging/burning for the first few weeks, but maybe started happening at my 7th and 8th shot (stinging/burning was consecutive for 3 times after), and I haven't experienced sting/burn ever since then.
Also, I took Ozempic prescription shot before starting tirz. I was only on it for 4 weeks. I developed a round welt at injection site using Ozempic pen at my 3rd shot and also had to ice it.
One more thing, I've bruised easily with no sting in the past, but not all the time. Other person has never bruised.
Now I'll share my AmoPure tirzepatide experience. I used L60 purchased early September two days ago - I'm happy to report, absolutely no sting or burn.
In the future, if it does sting or burn, I will not be quick to blame it on AmoPure because of my personal history/experience with regular Tirzepatide/GLP1s. I did filter the AmoPure with the recommended size from PeptideTest, transferred to sterile vial, and used Hospira Bac to reconstitute. I did notice some "gel" sticking to side of vial when adding BAC, but that went away and reconstituted completely clear with no impurities seen to visible to the eye.
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Oh, thank you for that information about BAC water storage. I currently have my opened BAC vial in the fridge, I'll take it out tonight. My unopened BAC is stored outside of the fridge.
TheNorthernDude
New Member
I had what would be a 4/10 from name brand Zepbound. First three weeks were fine. Last week of my first box had significant burning that lasted almost 30 minutes. Since then have gone to LSH, which one stung once for five minutes at about a 3 and then eventually Amopure L30 which after a month have not stung or burned. I have started letting my syringe warm to room temp after I draw it up, which I think helps.
this seems like an overreaction. the problem with accusing people of being shills is where does it end? go to reddit, facebook groups just for name brand tirz products and there are plenty of folks who report stinging or effects that vary from injection to injection with the pens. same carries to compounded. are all of those people amopure shills as well?
DwightTheDelight
GLP-1 Enthusiast
^^ just another 1 comment user coming in to defend a company ^^ nothing to see here
No, those cases really don't exist, or are SUPER rare from what I can tell. What isn't rare is the plethora of amopure users complaining about post injection stinging in this forum though. Hopefully, it's a thing of the past moving forward. We will have to see.
I mean... I think it's kind of an overreaction too. I think Amo has an effective product and I've personally had no problems with it. I admittedly took the plunge with their product before the reports of stinging were coming in, so I'm not recommending it to people because of the ISRs but it's a bit of a stretch to say that if we buy and use their products that we're shills. To me, it's very obvious that whatever filler they're using commonly causes a reaction and so people should buy at their own risk. Maybe it's just because I grew up with a pharmacist in the family, so I know how common it is for people to react to fillers, so it doesn't bother me, idk. I react poorly to name-brand Tylenol because of their fillers (and it's a fairly common reaction) but I don't think anyone who recommends Tylenol is a shill. Just seems a little silly.
But I do hope that new people coming in here think long and hard about whether they want to potentially deal with an ISR for the next 50+ injections. If they prioritize ease of ordering and having a website then maybe they don't have a problem with it. As long as they order it having all of the information.
DwightTheDelight
GLP-1 Enthusiast
I don't necessarily disagree with you or agree with the shills statement. I'm just going to call out every new user I see coming in with a definitive statement about a complex issue, whether they are defending a company or accusatory. I just feel like a quarter of the users who pop up in here are fake.
