Tirz Burning Poll
- Thread starter Kahtia24
- Start date
No burning stinging but progressively larger more bothersome hot red itchy ISR. This week at 5mg it was 4" around, raised welt inside 2+ inches thigh, my stomach is such a mess recovering from every 5 day ISR. I'm just hoping it's not the TZ. I will be filtering moving forward everything.
nonyabizznez
GLP-1 Specialist
I felt burnt and stung when I paid $1057 for my first box of 2.5
Feel a little sting from 9/24 Amopure L15 but 1.46/mg + ship makes it feel much better.
Feel a little sting from 9/24 Amopure L15 but 1.46/mg + ship makes it feel much better.
You may have already tried this, but a flonase type product sprayed on the skin (after alcohol wipe) right before injection can sometimes help with that type of ISR.
tangoecho311
GLP-1 Apprentice
Compound from Salt Lake at a strength of 10mg/mL, dosage of 2.5mg: No burn
Nexa: 10mg/mL, dosage from 2.5-4mg : No Burn
QSC : 30mg/1.5mL, dosage from 4-6mg : No burn
I swab my skin with alcohol twice (letting it dry fully each time) and only pin after I have showered and used antibacterial soap. I always warm my injections in my hands before administering. And I administer into my belly. I never do a volume greater than .5mL in one injection.
I've never had any ISR. No red spots, no itching, no heat, no rash. The next morning and I can't even tell where I administered my tirz.
Nexa: 10mg/mL, dosage from 2.5-4mg : No Burn
QSC : 30mg/1.5mL, dosage from 4-6mg : No burn
I swab my skin with alcohol twice (letting it dry fully each time) and only pin after I have showered and used antibacterial soap. I always warm my injections in my hands before administering. And I administer into my belly. I never do a volume greater than .5mL in one injection.
I've never had any ISR. No red spots, no itching, no heat, no rash. The next morning and I can't even tell where I administered my tirz.
I occasionally had mild stinging for fewer than ten minutes from compound from Red Rocks at 7.5. I've had it now and again for I think every research tirz I've tried (four different vendors), sometimes along with a small itchy welt. I think I'm just sensitive to bac water. It goes away pretty quick.
I'm guessing because it's a steroid? Any OTC steroid cream would do the trick, probably?
FWIW - I absolutely DESPISE the pain rating scale. It is so subjective. I honestly don't know how to rate my pain at all. Was it like my leg was being sawed off by a rusty spoon? No. Was it enough that I couldn't sleep and it was uncomfortable AF? Yes.
I had stinging with Amo 30. It was not a dull needle - at the time was using luer-lock needles and I switched out the needle to give the injection with a new needle and NOT the one I used to draw from the vial. Was not my bac water - I did an only bac water injection and had no issues. Product still worked.
Replacement AMO 30 leaves bruising or redness at injection site which I have not had previously at all but there is no burning on injection as long as I administer slow. Product still works but am hesitant to use it.
I had stinging with Amo 30. It was not a dull needle - at the time was using luer-lock needles and I switched out the needle to give the injection with a new needle and NOT the one I used to draw from the vial. Was not my bac water - I did an only bac water injection and had no issues. Product still worked.
Replacement AMO 30 leaves bruising or redness at injection site which I have not had previously at all but there is no burning on injection as long as I administer slow. Product still works but am hesitant to use it.
katisaplot
Recently Joined
Hallandale, Revive, Brooks - no stinging. Hallandale left a bit of bruise-feeling pain at the injection site for a few hours but no bruising was visible. Red Rock stings like crazy all through the injection and for about 10 minutes after. Coincidentally it's also the compound that's worked best for me and has had the cleanest "feel" in terms of the intended effects and the side effects.
Weird, Amo is also the only source I've ever experienced an ISR from with any kind of subq injection as well. Interesting to note it's not just me.
I also have an ISR with Aminos Research. These are the only 2 vendors I have tried. I am awaiting arrival and testing of Ronsen. I do not have an ISR with KPV or Glow just TZ.
maliaharris
Recently Joined
I’ve been using AMO Tirz 30 since Aug 28.Never any sting，so far, so good.A+
I had a bruise from 1 injection on my stomach, but I think I had managed to hit some tiny vein or capillary or whatever. It lasted for a couple weeks and was ugly but didn’t hurt.
Dustycotton
GLP-1 Apprentice
Regarding rating pain on 1-10 scale, I agree it's not very helpful unless patients rating their pain have the same understanding of what the numbers mean. Just asking for a number from 1-10 without definitions means everyone correlates the pain they are experiencing to the scale differently.
It is intended to apply to how your pain interrupts your ability to carry on your daily activities. Below is only one example of how the pain scale is broken up into mild, moderate, severe, and descriptions for each. What is always going to be subjective about any pain rating is how each individual experiences pain for similar events. However, if one persion can't get out of bed and is or is almost incoherent and delirious due to their pain and they say 10; and another person is able to still do daily activities but can feel pain while going about their day and also says 10, then that is due to different interpretations of what a 10 on the pain scale actually means when applied to daily activities.
Measuring Your Pain
The pain scale breaks up pain into levels from 1 to 10, which describe just how much your pain affects your daily activity. These levels are grouped together into Mild, Moderate, and Severe pain.
Mild pain may be annoying and noticeable, but it doesn’t keep you from performing normal activity. Specifically:
It is intended to apply to how your pain interrupts your ability to carry on your daily activities. Below is only one example of how the pain scale is broken up into mild, moderate, severe, and descriptions for each. What is always going to be subjective about any pain rating is how each individual experiences pain for similar events. However, if one persion can't get out of bed and is or is almost incoherent and delirious due to their pain and they say 10; and another person is able to still do daily activities but can feel pain while going about their day and also says 10, then that is due to different interpretations of what a 10 on the pain scale actually means when applied to daily activities.
Measuring Your Pain
The pain scale breaks up pain into levels from 1 to 10, which describe just how much your pain affects your daily activity. These levels are grouped together into Mild, Moderate, and Severe pain.
Mild pain may be annoying and noticeable, but it doesn’t keep you from performing normal activity. Specifically:
- At level 1, pain may be barely noticeable and easily ignored.
- Level 2 pain is annoying and may flare into occasional stronger twinges.
- Pain at level 3 is distracting, but you can learn to adapt to it.
- You may be able to push level 4 pain aside for periods while involved in a task, but it is still very distracting.
- Level 5 pain can’t be ignored for more than a few minutes, but you can push through it with effort.
- At level 6, the pain may make it hard for you to concentrate on regular tasks.
- At level 7, the pain demands your attention and prevents you from performing tasks. It may even interfere with your sleep.
- Level 8 pain is intense, limiting your physical activity and even making conversation difficult. Sleep is usually disrupted.
- Pain at level 9 leaves you unable to talk at all. You may just be moaning or crying uncontrollably.
- The greatest pain, level 10, leaves you bedridden, incoherent and even delirious.
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moonpies4misfits
GLP-1 Specialist
Never had burning from Skye or Amo, but I have on occasion gotten red welts from both.
Pr0digalSun
GLP-1 Novice
I’m using the scale and rating Amo L15 an 7 out of 10. I’ll use 10 being the most painful inj I’ve ever had.
I would rate trstosterone and hcg subQ inj a 1, ozempic a 1, trimix injections a 4, syphilis prophylactic injections a 5, getting an IV started a 8, and spinal tap a 10
But I paid $1.6/mg incl shipping, so like someone else said it’s worth it, bc of the results
I’m clarifying this is not a post-injection reaction caused by an immune or allergic response, I have no redness, itching, or inflammation after. It’s an immediate sting that goes away after 30-45 mins
Also I draw with one needle the switch to a new smaller needle, so not a dullness issue. The pain doesn’t start until the push of the solution, not the skin puncture, which is completely painless with a 31g new needle.
I would rate trstosterone and hcg subQ inj a 1, ozempic a 1, trimix injections a 4, syphilis prophylactic injections a 5, getting an IV started a 8, and spinal tap a 10
But I paid $1.6/mg incl shipping, so like someone else said it’s worth it, bc of the results
I’m clarifying this is not a post-injection reaction caused by an immune or allergic response, I have no redness, itching, or inflammation after. It’s an immediate sting that goes away after 30-45 mins
Also I draw with one needle the switch to a new smaller needle, so not a dullness issue. The pain doesn’t start until the push of the solution, not the skin puncture, which is completely painless with a 31g new needle.
Pr0digalSun
GLP-1 Novice
This chart skips 5 and has two 3’s lol
I keep seeing two different phenomena getting mixed up. The first is an allergic reaction that happens hours or a day after a shot. It's an itchy red welt that lasts a while. The second is an immediate painful stinging response that seems unique to amopure. Would be nice to have two different terms instead of grouping them together as 'ISR". Maybe ISR and AISR (Amopure ISR)? Or Amopure Stinging Sensation?
So, ASS? 😆
I suspect you are correct as long as it is a corticosteroid. I picked up the flonase trick on an HRT board for patch reaction. Cream probably wouldn't work for that since the patch needs to stick (waiting for the spray to dry is a bit of a pain in the tuchas, but it does work).
Have you asked them to reship? They've agreed to other users to resend a new batch and typically just ask you to send pics of the stinging set smashed up
Pr0digalSun
GLP-1 Novice
To their credit, they were very fast in responding and offering to replace with a new batch, which I haven’t gotten yet but will update on how it feels. I gave one vial to a friend of mine who is going to test it next week to see if it stings him too.
I ordered ph strips that will get here tomorrow, just out of curiosity. I have a background in chemistry, and wonder if it was ph balanced with NaOH, which could cause the burn. If the ph is really high that might be a good hypothesis. Or maybe not, lol but I’m just curious.
Pr0digalSun
GLP-1 Novice
Yes they are definately two different issues. ISR is a reaction caused by either antibodies forming (which happened in trials), or a histamine/allergic reaction, and both of those are redness swelling or itching, that like you said take some time. And a corticosteroid would help. Or antibiotics if it’s infected, but that would take at least 24 hrs to show up.
The stinging isn’t really a reaction by the immune system; it’s immediate then goes away (for me at least).
Some fun reading:
Understanding and Minimising Injection-Site Pain Following Subcutaneous Administration of Biologics: A Narrative Review
Injection-site pain (ISP) is a subjective side effect that is commonly reported with the subcutaneous administration of biological agents, yet it may only be a concern to some. Multiple factors related to the product formulation, such as pH, volume and ...
www.ncbi.nlm.nih.gov
SmokeySquid
GLP-1 Enthusiast
Out of the 4 ish months that I have been using Tirz, I recently had some burning (amo T60) that lasted for a few minutes. I am pretty sure I hit some scar tissue though as I was trying a new spot on my stomach 😅
That was the one and only time though. Every other time has been a breeze thankfully.
That was the one and only time though. Every other time has been a breeze thankfully.
Can we pin this chart somewhere? I keep hearing people claim they experience over an 11.
