Tirz Freezing/Defrosting

[Jack brown]

I have several vials of tirz (not reconstituted) in the freezer. I want to take them out for about a day to travel, before refreezing them.

I heard that freezing then defrosting degrades the Tirz, is this true?

What would you guys reccommend?

 

[PurpleCatFur]

Do you have a nordic ice pack or something similar? I would wrap them in an insulated bin as close to the nordic as as possible. Maybe some dry ice but I think that would be overkill.

I would just try to keep the variartion as low as possible.

 

[indolent]

I have several vials of tirz (not reconstituted) in the freezer. I want to take them out for about a day to travel, before refreezing them.

I heard that freezing then defrosting degrades the Tirz, is this true?

What would you guys reccommend?

Unreconstituted Tirz is very hardy. Don't inconvenience yourself too much.

 

[Skidude]

I have several vials of tirz (not reconstituted) in the freezer. I want to take them out for about a day to travel, before refreezing them.

I heard that freezing then defrosting degrades the Tirz, is this true?

What would you guys reccommend?

I have some of our members describe Tirz as the cockroach of peps... I have seen Jano quotes stating it can last years in a garage with minor degradation.. I would feel real comfortable personally, tossing it in a cooler. My understanding is significant temperature swings can be detrimental.

 

[AndyPanda]

I’ve heard that Tirz is the most resilient of all the GLP-1s. Just keep it from opposing extremes and don’t freeze it after recon and I think you’ll be fine.

 

[indolent]

don’t freeze it after recon

disproved via Janos study

 

[lissybeme]

Is it best to freeze in a padded carrying case or as it was delivered?? I have to drive from Reno to SEA it will probably take me 2 days..
I have not yet received my package and o leave in a month.. or would it be better to just not freez until I get to my final destination??

 

[PurpleCatFur]

For a few weeks I would keep out of freezer and at a decent controlled temperature till you leave and while traveling, if you want maybe bring it in with you overnight or keep in a place in you vehicle that will stay mostly the same temperature. Jano would probably say it will be fine if you just throw it on your dash

 

[lissybeme]

For a few weeks I would keep out of freezer and at a decent controlled temperature till you leave and while traveling, if you want maybe bring it in with you overnight or keep in a place in you vehicle that will stay mostly the same temperature. Jano would probably say it will be fine if you just throw it on your dash

Thank you. I really appreciate it!

 

[TooBigtoFail]

Recommended to not refreeze due to risk of breaking the seal and allowing air/moisture in. Should be fine in frigo for 6+ months if lyophilized (Studies are all over the place on this). I would not travel by air with an ice pack of any sort or a vial with 'white powder'.

I travel with reconstituted Tirz, enough to cover my trip. Good for 21 days at room temperature.

 

[New2pepz]

Recommended to not refreeze due to risk of breaking the seal and allowing air/moisture in. Should be fine in frigo for 6+ months if lyophilized (Studies are all over the place on this). I would not travel by air with an ice pack of any sort or a vial with 'white powder'.

I travel with reconstituted Tirz, enough to cover my trip. Good for 21 days at room temperature.

So it shouldn’t go in freezer for storage before recon?

 

[Iamnew2this]

Recommended to not refreeze due to risk of breaking the seal and allowing air/moisture in. Should be fine in frigo for 6+ months if lyophilized (Studies are all over the place on this). I would not travel by air with an ice pack of any sort or a vial with 'white powder'.

I travel with reconstituted Tirz, enough to cover my trip. Good for 21 days at room

disproved via Janos study

I totally agree with this. Funny thing, I popped up to see what's going on on reddit yesterday. The new talk with compound tirz from what I read, is freezing it and then rethawing it in order to save their stockpiles. I guess if you have tirz and are cutting it close to the BUDs. They say in the sub that it still works fine. I don't know if I would do that with my reconstituted vials myself. I just thought that was interesting.

 

[indolent]

I totally agree with this. Funny thing, I popped up to see what's going on on reddit yesterday. The new talk with compound tirz from what I read, is freezing it and then rethawing it in order to save their stockpiles. I guess if you have tirz and are cutting it close to the BUDs. They say in the sub that it still works fine. I don't know if I would do that with my reconstituted vials myself. I just thought that was interesting.

Hereon, I'll be reconstituting/freezing the whole tirz kit at once, and thawing each vial when its turn comes.

Honestly, some of these soft-drugs "never" superstitions are as nonsensical as Italian national food rules. Like Italian Food Rule numbers 267/268: never let foreigners know that we don't actually only drink espressos after 10am, and never tell them about the existence of the caffé macchiato. Your risk profile may vary.

 

[Iamnew2this]

Hereon, I'll be reconstituting/freezing the whole tirz kit at once, and thawing each vial when its turn comes.

Honestly, some of these soft-drugs "never" superstitions are as nonsensical as Italian national food rules. Like Italian Food Rule numbers 267/268: never let foreigners know that we don't actually only drink espressos after 10am, and never tell them about the existence of the café macchiato. Your risk profile may vary.

Great analogy!

 

[lissybeme]

Hereon, I'll be reconstituting/freezing the whole tirz kit at once, and thawing each vial when its turn comes.

Honestly, some of these soft-drugs "never" superstitions are as nonsensical as Italian national food rules. Like Italian Food Rule numbers 267/268: never let foreigners know that we don't actually only drink espressos after 10am, and never tell them about the existence of the caffé macchiato. Your risk profile may vary.

Wait, wait, wait.. you reconstitute then freeze??????

 

[Iamnew2this]

Usually not. Freeze the dry pucks not the reconstituted peptide.

 

[indolent]

Wait, wait, wait.. you reconstitute then freeze??????

Yes, *I* do. Literally everyone else's mileage does vary.

I find it more convenient, and it's also God's Will: A 30mL bac vial is intelligently-designed to serve a kit of 10 3mL vials (although actually I use less than 3mL of bac per each, according to what the reverse calculator commands). I'm an atheist.

A Czech laboratory study of three reconned peptides found that tirz held up very well with freeze/thaw, hGH not as well, and something or another (non-GLP1) had terrible degradation.

What I won't do is extrapolate the tirz finding to anything else; not even similar GLP-1 drugs.

 

[Iamnew2this]

Yes, *I* do. Literally everyone else's mileage does vary.

I find it more convenient, and it's also God's Will: A 30mL bac vial is intelligently-designed to serve a kit of 10 3mL vials (although actually I use less than 3mL of bac per each, according to what the reverse calculator commands). I'm an atheist.

A Czech laboratory study of three reconned peptides found that tirz held up very well with freeze/thaw, hGH not as well, and something or another (non-GLP1) had terrible degradation.

What I won't do is extrapolate the tirz finding to anything else; not even similar GLP-1 drugs.

I know I jumped on quick, but I didn't want to confuse @lissybeme. I know that she/you wasn't directing the conversation to me, but to you @indolent. I'm sorry if I stepped on toes or confused you @lissybeme

 

[TooBigtoFail]

So it shouldn’t go in freezer for storage before recon?

For Tirz, is your call: to freeze or not to freeze. Like many, I have a lot of vials of various peps and I have a good freezer where the temp is -8F (-22c), +/- 2 degrees (my Blink camera inside says so). I freeze all my lyophilized peps. According to studies and Jano, refrigeration is sufficient for many, many months. Extremes are bad: above 120 degrees, light, will diminish efficacy/potency.

Tirz is in a category by itself. QSC had done studies, like Jano (long term), and professionals. Very robust pep. Worst case I read is a 10% deterioration in efficacy after 1 year, under bad conditions. Not so bad negligence over one month: 1-2% loss. The most recent report from E. Lilly is that at 30C for 6 months, the Tirz recon deterioration was 7%. 3% after 3 months. No deterioration at 5C for the same period.

My suggestion is to read up on the basics learned by Registered Nurses, and understand the scientific papers. Not all peps are as robust. And not all recons are effective/safe for 60 days: Thymosin alpha1 (ZADAXIN) is ok up to a week.

Please note that because you are not supervised by a doctor, you are a lab rat, and must learn to summarized a lot of anecdotal data, research papers, etc. My line of work is far away from the medical field so be warned. But as an engineer, I learned do the best I can, with the little info/money I have, and to play it on the safe side.

 

[Rolefun]

I have a small cooler bag, given to me by my daughter. I use this to put my unconstituted vials in the deep freezer, along with a refreezeable ice pack….our lights go out at the thought of a breeze. So far, so good.

 

[Jack brown]

What about getting past airport security with vials with white powder in them... how you guys explain that?

 

[Calm Logic]

That would be a big no for me. For TSA, people will use reusable pens, normally sold for insulin, that are filled with the peptide solution in the pen's cartridge.

 

[Iamnew2this]

Why couldn't you place your reconstituted vials in a zip lock bag with your toiletries?

 

[AndyPanda]

I’m traveling to Italy, Switzerland, France, Germany and Amsterdam for 13 days in a couple of months. I’m going to try to take one lyopholized vial of Tirz and a 3ml ampule of McKesson sterile water, in my checked bag. I will let you know.

 

[Calm Logic]

Why couldn't you place your reconstituted vials in a zip lock bag with your toiletries?

Another vote for your idea (and a downvote for Andy's):

Post in thread 'Should we store our peptides in the freezer in powdered form?'

Nov 25, 2024

From what I have read lyophilized peps (powder) will last for months stored in a room temperature, dark place with minimal loss. If you are traveling, just take what you will need out of the freezer and throw it in your bag.

Depending upon the country that you wish to travel to; it would be in your best interest to reconstitute and then take it with you. Yes your peptides will probably deteriorate but at least you will still have it with you during your trip!

Don’t believe me? Try going into Dubai or Singapore or Australia with some “white powder in a vial” and see what will...

• Lullabytreehugger

• 

The only problem to me then is that the vial is still unlabeled, which may be a problem if the checked bag is randomly or otherwise inspected. (So, for the sufficiently paranoid, maybe using an insulin-labeled vial in a diabetic-looking travel case would help, for either checked or carry-on.)