Tirzepatide higher doses

I split my dose to half on a Wednesday and half on a Sunday. That means I don't get the highest peak levels I would injecting 15mg, but I also don't get the lows the days before it is due again. My levels stay at a nice consistent level and that's really helped. If I need to, I'll move up slightly. I know there are trials being done by Eli Lilly on dosing at 20 and 25mg right now so I can't imagine it's much of an issue.
 
Summer48 said:
Anyone taken a higher dose than the 15mg recommended? Been at 15mg for a few months but last week absolutely starving and just had to eat so much. So last jab I’ve done 17mg and back to feeling satisfied with what I’m eating
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I have been doing 7.5 mg every 3 days for since Nov 24/25. Loss has slowed as only 1.8 frontal and I am trying to increase calories. Have lost 72 lbs since June 16
 
Summer48 said:
Anyone taken a higher dose than the 15mg recommended? Been at 15mg for a few months but last week absolutely starving and just had to eat so much. So last jab I’ve done 17mg and back to feeling satisfied with what I’m eating
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New trials are going to at least 25mg. Most people shouldn't go that high but some people are lower responders.
 
Summer48 said:
Anyone taken a higher dose than the 15mg recommended? Been at 15mg for a few months but last week absolutely starving and just had to eat so much. So last jab I’ve done 17mg and back to feeling satisfied with what I’m eating
Click to expand...

I take about 17mg to 18mg weekly and have good reduction of food noise and appetite. I’ve been on that level for about 2 months. My plan was to keep increasing up to 20 or 25 mg to goal, but I started a sema stack on day 3 about six weeks ago. I’m up to 1mg of sema. The “plan” was to cut back on the tirzepatide as I increased the sema, but really haven’t felt the need.
 
I was taking 20 mg every 5 days for several months till I hit my target weight. I had no side effects. My current maintenance dosage is 10 mg per week. I stack it with 2.5 mg Mazdutide once per week.
 
Grogu said:
I take about 17mg to 18mg weekly and have good reduction of food noise and appetite. I’ve been on that level for about 2 months. My plan was to keep increasing up to 20 or 25 mg to goal, but I started a sema stack on day 3 about six weeks ago. I’m up to 1mg of sema. The “plan” was to cut back on the tirzepatide as I increased the sema, but really haven’t felt the need.
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Has adding the Sema helped your weight loss progress? I am thinking about supplementing it with my weekly Reta.
 
CMA Pooky said:
Has adding the Sema helped your weight loss progress? I am thinking about supplementing it with my weekly Reta.
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Yes, had some really good results adding sema. For the 3 months of Sept, Oct and November I only lost 10 pounds, so my weightloss had definitely slowed. Prior to September I was losing about 8 or 9 pounds a month.

I started stacking Sema in early December and in December/January I've lost 18 pounds, and even lost weight during the Christmas/New Years week. I hit 100lbs lost since January last year this morning.

I actually really like the feel of Sema on shot day and the few day after. I think I almost like it better than tirz and I love trizepatide. So glad I tried stacking with sema. People suggested I stack with Reta, but I'm saving the big guns if I don't lose these last 20 or 30 pounds.
 
Congratulations, 100 pounds lost is a big accomplishment. I also averaged 9 pounds a month during my first 2 months, but the past week+ I have stalled and gained almost 2 pounds. I Plan to up my Reta from 4mg to 5mg next dose and then add Sema at .25mg or .50mg weekly to my Reta in February.
 
CMA Pooky said:
Congratulations, 100 pounds lost is a big accomplishment. I also averaged 9 pounds a month during my first 2 months, but the past week+ I have stalled and gained almost 2 pounds. I Plan to up my Reta from 4mg to 5mg next dose and then add Sema at .25mg or .50mg weekly to my Reta in February.
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I’ve gained weight from week to week. And even day to day. When people track their weight using an app that provides a graph you’ll often see ups and downs. I think it’s just part of the normal fluctuations in weight and probably not a stall or weight gain.

Just out of curiosity, why stack with sema and not just keeping increasing your reta dose.
 
zpped said:
New trials are going to at least 25mg. Most people shouldn't go that high but some people are lower responders.
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I was reading up on this a week or so ago - I'm currently taking 15mg.
Still paying begrudgingly for the monthly pens until I find a vendor and fully confident I know what I'm doing!
I am definitely thinking of going a slightly higher dose - my guess would be 17.5 and see how it goes.
15mg is a little up and down for me which annoys me. Some weeks it's zero food noise and others, I just want to launch all the chocolate and crisps down my throat!
 
woundcarping said:
I asked the same thing in his thread, I can’t make sense of it.
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Yup, it's a little confusing, but it's the wild wild west out there. Lots of people on low doses of tirz and complaining about lack of weight loss or food noise 🤔, especially in reddit. I'm like really....
 
Grogu said:
I take about 17mg to 18mg weekly and have good reduction of food noise and appetite. I’ve been on that level for about 2 months. My plan was to keep increasing up to 20 or 25 mg to goal, but I started a sema stack on day 3 about six weeks ago. I’m up to 1mg of sema. The “plan” was to cut back on the tirzepatide as I increased the sema, but really haven’t felt the need.
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Any side effects, or just the usual to expect? I've been lucky that I haven't had any side effects whilst increasing to 15mg. Other than when I ate a slice of pizza (but I wont go into the aftermath of that!) 🤣🤣 NEVER AGAIN!
 
Grogu said:
Yup, it's a little confusing, but it's the wild wild west out there. Lots of people on low doses of tirz and complaining about lack of weight loss or food noise 🤔, especially in reddit. I'm like really....
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Ive noticed that too. I split dose tirz and reta and have zero food noise or hunger, so ok with that until I get to goal and bulk back up with more muscle
 
Phoenix_Vixen said:
Any side effects, or just the usual to expect? I've been lucky that I haven't had any side effects whilst increasing to 15mg. Other than when I ate a slice of pizza (but I wont go into the aftermath of that!) 🤣🤣 NEVER AGAIN!
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I’ve also been pretty lucky with not too many side effects, so going past 15mg really didn’t feel any different. I don’t think I would have advanced past 15mg if I had had significant side effects at lower doses. I also was prepared to go as high as 20mg or 25mg if I needed that to reach goal, but decided on the sema stack instead.
 
Yes, please do and I’ll continue to do the same.

You’re getting hungry mid week, 4mg “isn’t working”, gained two pins, don’t want to get above 6 mg/week (bottom edge of therapeutic dosage), YouTuber says something about receptor burnout, so what does the forum suggest your starting dose of Sema should be.

Response:
Consider split dosing for mid week control. Consider increasing your Reta exposure towards therapeutic levels vs stacking your GLP receptors with Sema, especially if you’re worried about burnout.

I can see how trackable logic and defensible decision making has that air of superiority that makes you feel some way.
 
CMA Pooky said:
You sound like one of the I know what's best people. Let people do what they want to do, it's their bodies. Don't reply to anymore of my future posts, you will be ignored from now on.
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No one can stop you from doing whatever you want. But that won't stop them from saying what you're doing is dumb.

There is no such thing as receptor burnout. And mixing glp1 medications when you have huge amounts of runway to increase your dose is dumb.
 
zpped said:
No one can stop you from doing whatever you want. But that won't stop them from saying what you're doing is dumb.

There is no such thing as receptor burnout. And mixing glp1 medications when you have huge amounts of runway to increase your dose is dumb.
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Interesting take on receptors… if receptors don’t fatigue, why is dose escalation typically required to maintain efficacy?

My thought is he’s 50-100% below a therapeutic dose of Reta. Reta has roughly 1/10th the glp exposure as sema. Getting to a therapeutic dose of Reta would give him the benefits of glucagon, with approximately appropriate glp exposure. Split dosing would reduce the peak exposure while maintaining the average exposure. Without getting the benefit of typically therapeutic levels of glucagon, why take Reta over Tirz?
 
woundcarping said:
Interesting take on receptors… if receptors don’t fatigue, why is dose escalation typically required to maintain efficacy?

My thought is he’s 50-100% below a therapeutic dose of Reta. Reta has roughly 1/10th the glp exposure as sema. Getting to a therapeutic dose of Reta would give him the benefits of glucagon, with approximately appropriate glp exposure. Split dosing would reduce the peak exposure while maintaining the average exposure. Without getting the benefit of typically therapeutic levels of glucagon, why take Reta over Tirz?
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Requiring higher doses to get higher weight loss isn't receptor burnout, its the maximum effect for a given dose. If the receptors were burned out you'd eventually gain back all the weight on the same dose and that doesn't happen.

The therapeutic dose is the dose that is working. It's different for everyone. Splitting your dose is something to possibly consider when the side effects are troublesome. Otherwise stick to what works. There is good reason to believe (especially with reta) that split dosing could be less effective. But that's not proven in any way.
 
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