Weight-loss Stack Cycles

[TheTinMan]

I would like opinions on my ideas of potential weight loss stack cycles that I am considering. I have been reading up on these for a couple weeks, so greatly I appreciate info from the more experienced. Previously, I took with Sema about 4 months then shifted to Triz (12mg/week) which I have been on about 4 months currently. I have only managed to lose about 30 lbs. I need to lose another 55 lbs. I do go to the gym 4-5 days/week.

The plans on stacks is to start at the minimum dosages and titrate when required. Cycle 3 would only be required if I'm not near my goal around month 8. If it's relevant, I plan to purchase all at once and store for the future use. Thank you in advance for all of the helpful feedback!

*Cycle 1 - 4 months (Goal: weight-loss, appetite suppression, energy)
Retatrutide
Cagrilintide
Tesofensine

*Cycle 2 - 4 months (Goal: weight-loss, mitochondria, energy)
Retatrutide
MOTS-C
Tesofensine

*Cycle 3 (if necessary) - 4 months (Goal: weight-loss, mitochondria, energy)
Retatrutide
Tesamorelin or SS-31
Tesofensine

*Cycle 4 - 4 months
Glow blend

 

[rkl123]

MOTS and SS-31 don't work for most folks and in any case have nothing to do with weight. GLOW also has nothing to do with weight.Teso is likely unnecessary with everything else.

 

[Heatheranne818]

Can you switch month to month from Triz to Reta?

 

[rkl123]

Can you switch month to month from Triz to Reta?

A terrible worst of all worlds idea. It takes time to titrate up (to not hit horrific side effects). So you start to increase dose then immediately sabotage things by switching to something totally different

 

[scarywood75]

Lol what? Stop overcomplicating things, just start tirz and follow its protocol that's it

 

[Calm Logic]

If you don't have the reta on hand already, then I would certainly up the dose of the tirz to 15, before I did anything else. (One can even go up to 20+ with tirz probably.)

Normally, SS-31 is taken before MOTS-c. Though they may not help directly with weight loss at all, they may be helpful in other ways, including new, potential applications:

SS-31 markedly improved the behavioral indices and significantly mitigated the damage to the sciatic nerve

In a study in which vascular calcification was induced in rats through treatment with vitamin D3 and nicotine, subsequent treatment with MOTS-c markedly reduced blood pressure, preserved normal heart structure and decreased vascular stiffness. These findings demonstrate that MOTS-c can improve cardiovascular and vascular abnormalities caused by vascular calcification.

In theory, the GLOW blend may help at the gym with the BPC-157, TB-500, and GHK-Cu helping with recovery. And the GHK-Cu may also help with skin support during weight loss.

So, as you know, there's always a way to justify any peptide But you may be better off with a very cheap stimulant (like phentermine or very off-label clenbuterol) or other medication during a slump/slowdown compared to a non-GLP peptide.

And, of course, there are a million supplements that may provide some support like creatine, berberine, CoQ10, quercetin, etc., including cheap, subq injections of B-12 or B-complex (for potential energy or nerve support), the anti-aging antioxidant glutathione, and the more trendy NAD+.

Another option is just doing more testing, like hormone levels, A1c, glucose blood checks at home, or even continuous glucose monitoring.

 

[TheTinMan]

MOTS and SS-31 don't work for most folks and in any case have nothing to do with weight. GLOW also has nothing to do with weight.Teso is likely unnecessary with everything else.

Agreed. My intent with MOTS-C (Cycle 2) and SS-31 (Cycle 3) was for energy / mitochondria. Hopefully by GLOW (Cycle 4) I would have achieved the majority of weight-loss, so the focus would be a broader well-being.

 

[TheTinMan]

Lol what? Stop overcomplicating things, just start tirz and follow its protocol that's it

I have been taking Tirz for several months (and currently). It hasn't been real efficient for me personally.

 

[TheTinMan]

If you don't have the reta on hand already, then I would certainly up the dose of the tirz to 15, before I did anything else. (One can even go up to 20+ with tirz probably.)

Normally, SS-31 is taken before MOTS-c. Though they may not help directly with weight loss at all, they may be helpful in other ways, including new, potential applications:




In theory, the GLOW blend may help at the gym with the BPC-157, TB-500, and GHK-Cu helping with recovery. And the GHK-Cu may also help with skin support during weight loss.

So, as you know, there's always a way to justify any peptide But you may be better off with a very cheap stimulant (like phentermine or very off-label clenbuterol) or other medication during a slump/slowdown compared to a non-GLP peptide.

And, of course, there are a million supplements that may provide some support like creatine, berberine, CoQ10, quercetin, etc., including cheap, subq injections of B-12 or B-complex (for potential energy or nerve support) and the anti-aging antioxidant glutathione.

Another option is just doing more testing, like hormone levels, A1c, glucose blood checks at home, or even continuous glucose monitoring.

Thanks for the feedback!!

I plan to titrate up today, but my biggest issue with Tirz has been the lack of energy at higher dosages. I just feel drained all of the time.

I will switch the stack order for MOT-C / SS-31. Do you know why some prefer it in that order?

 

[Chizikitide-1977]

I've used every peptide on your list except for SS31. The only note I have is about Cagri. It seems like you want to loose weight while mataining energy to keep working out. Cagri can make you very lethargic (much more so than Sema or Tirz), but in my experience offers the strongest appetite suppression of any of the incretin mimetics. Perhaps this is by design and your first round is focused on "cutting", just be aware your workouts may take a hit during that first cycle.

Not sure if you've taken MOTS-C yet, but that has to be my favorite peptide. The energy it provides is unlike anything else I've taken. It doesn't feel like a stimulant, its more of an endurance thing and makes exercise enjoyable. Not everyone responds at the lower doses. I've done as much as 20 mg per week personally. If you want to better prioritize energy that first cycle, you might consider taking MOTS-C at the same time as the Cagri to counteract the lethargic effects. If you just want to prioritize weight loss that first cycle, your approach is likely fine as is.

 

[Calm Logic]

I will switch the stack order for MOT-C / SS-31. Do you know why some prefer it in that order?

Google Gemini:

The recommendation to use SS-31 before MOTS-c often stems from the idea of preparing the mitochondrial environment for MOTS-c's metabolic effects.

If you are looking for oral supplements to support mitochondrial health before considering MOTS-c (and if SS-31 is not an option or is being complemented), MitoQ and Lipoic Acid might be the most logical choices due to their direct antioxidant effects within the mitochondria. Additionally, ensuring adequate levels of CoQ10, NAC, B vitamins, and Magnesium can provide a good foundation for overall mitochondrial function.

 

[TheTinMan]

I've used every peptide on your list except for SS31. The only note I have is about Cagri. It seems like you want to loose weight while mataining energy to keep working out. Cagri can make you very lethargic (much more so than Sema or Tirz), but in my experience offers the strongest appetite suppression of any of the incretin mimetics. Perhaps this is by design and your first round is focused on "cutting", just be aware your workouts may take a hit during that first cycle.

Not sure if you've taken MOTS-C yet, but that has to be my favorite peptide. The energy it provides is unlike anything else I've taken. It doesn't feel like a stimulant, its more of an endurance thing and makes exercise enjoyable. Not everyone responds at the lower doses. I've done as much as 20 mg per week personally. If you want to better prioritize energy that first cycle, you might consider taking MOTS-C at the same time as the Cagri to counteract the lethargic effects. If you just want to prioritize weight loss that first cycle, your approach is likely fine as is.

Correct; that first cycle is heavy emphasis on the weight-loss. I've read much of the same on Cagri. I plan to use this at the lowest effective dosages. My worry is that I will not have the appetite suppression with solely Reta. Historically, I had pretty good suppression on Sema, but minimal on Tirz.

 

[Brdss]

I would like opinions on my ideas of potential weight loss stack cycles that I am considering. I have been reading up on these for a couple weeks, so greatly I appreciate info from the more experienced. Previously, I took with Sema about 4 months then shifted to Triz (12mg/week) which I have been on about 4 months currently. I have only managed to lose about 30 lbs. I need to lose another 55 lbs. I do go to the gym 4-5 days/week.

The plans on stacks is to start at the minimum dosages and titrate when required. Cycle 3 would only be required if I'm not near my goal around month 8. If it's relevant, I plan to purchase all at once and store for the future use. Thank you in advance for all of the helpful feedback!

*Cycle 1 - 4 months (Goal: weight-loss, appetite suppression, energy)
Retatrutide
Cagrilintide
Tesofensine

*Cycle 2 - 4 months (Goal: weight-loss, mitochondria, energy)
Retatrutide
MOTS-C
Tesofensine

*Cycle 3 (if necessary) - 4 months (Goal: weight-loss, mitochondria, energy)
Retatrutide
Tesamorelin or SS-31
Tesofensine

*Cycle 4 - 4 months
Glow blend

Maybe look into adding a short run of tesamorelin in one of your later cycles?

 

[Chizikitide-1977]

Correct; that first cycle is heavy emphasis on the weight-loss. I've read much of the same on Cagri. I plan to use this at the lowest effective dosages. My worry is that I will not have the appetite suppression with solely Reta. Historically, I had pretty good suppression on Sema, but minimal on Tirz.

The decreased appetite suppression is a valid concern. In my experience the decrease from tirz to reta was similar to the decrease from sema to tirz.

 

[EsSquared]

It's super easy to get caught up by the reta cagri vortex...it's sexy, it's Stage 3 and cagri will never be combined with reta unless you do it yourself.

However, almost everyone would be best suited by just going with tirz. known side effects, cheaper, and really effective for most people, but especially effective if you know how to eat and train.

 

[Calm Logic]

cagri will never be combined with reta unless you do it yourself.

I wonder why none of kit vendors sell kits with half of one GLP-1 and half of the other.

 

[Skidude]

I wonder why none of kit vendors sell kits with half of one GLP-1 and half of the other.

I have seen this many times, not sure on accuracy but suggests never to mix GLPs:

 

[TheTinMan]

It's super easy to get caught up by the reta cagri vortex...it's sexy, it's Stage 3 and cagri will never be combined with reta unless you do it yourself.

However, almost everyone would be best suited by just going with tirz. known side effects, cheaper, and really effective for most people, but especially effective if you know how to eat and train.

I like the idea. I really wished that I had more positive results on Tirz. I'm going to continue taking it for at least the next 6 weeks. That's what I have left from the compound pharmacy.