Bigdog0628
GLP-1 Apprentice
I’m new here and with that didn’t know you could stack Tirz with Reta. Can someone tell me what the benefit is of using both?
What dose did you really start noticing its working? Also those that stack?
- Thread starter WLBLD
- Start date
There's a lot of conflicting information about it tbh. Lots of people seem to be doing it but I think the general consensus is it's not a great idea. Having said that I've just started reta having been on Tirz for 7 months and while I'm increasing my reta dose over the next month I'll be reducing and coming off Tirz. So I'll be overlapping a stack for a short period . From what I've seen many people use the tirz to help with food noise as reta doesn't give the same food noise control as tirz. But you are doubling up on glp using both which is why I've decided to wean off the tirz completely when I get up to dose of reta that does the job in terms of weight control. I'm mainly going to be using it for maintenance though. So all that probably doesn't help you much but tbh we could all do with more information - but as reta isn't even released yet I don't imagine that will be forthcoming any time soon.
I started on tirz & then I changed my mind to go to reta but after I stopped the tirz I noticed that I hadn't realized tirz helped my pain, so decided to add that back as well.
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Bigdog0628
GLP-1 Apprentice
Yea I didn’t know if there was a benefit to having less of the glucagon receptor and more of the other 2.
woundcarping
GLP-1 Specialist
My loss has been consistent across the doses and reduced weight, not really a given tipping point of efficacy.
chewonmysac
GLP-1 Enthusiast
I will be taking shot 52 tomorrow. One year. All Tirz with a mix of peps at the 6-month mark. 15mg. Down 97lbs and 34.6% total weight loss. The Tirz did the majority of the weight loss by month 9.
Never did Reta. Bought a couple of R24 kits and threw them in the freezer. Mostly a novelty purchase, but I convinced myself at the time of purchase that I might need to stack the two. That is becoming increasingly unlikely.
The plan for the next year is to add muscle and complete the body composition. Legs and butt took quite a beating. Leg day is now twice a week. The lower abdomen still needs work to remove the remaining 1 inch of SQ fat. I expect this to take some time. I have never been this focused on self-care in my life.
Never did Reta. Bought a couple of R24 kits and threw them in the freezer. Mostly a novelty purchase, but I convinced myself at the time of purchase that I might need to stack the two. That is becoming increasingly unlikely.
The plan for the next year is to add muscle and complete the body composition. Legs and butt took quite a beating. Leg day is now twice a week. The lower abdomen still needs work to remove the remaining 1 inch of SQ fat. I expect this to take some time. I have never been this focused on self-care in my life.
Thats so Amazing!! I wish I was having as great of results. The past few weeks (even though adding more exercise & been eating less bc no appetite going up) the scale is stuck 🙁
I started my 2nd cartridge of Tirz last week & I think I might have taken 5mg bc I forgot I added 1.5ml instead of 2ml. I planned on 5mg this week anyway, so, ha ha. But I still didn't lose 🙁
You're really having great results!! Congratulations!! Did you stall & that's why you increased?
woundcarping
GLP-1 Specialist
I haven’t stalled, I’ve moved my dose up based on tolerability of symptoms and metrics.
My main bumps that lasted more than a few days are primarily related to TRT causing water retention which resolves, and most recently, starting taking creatine which retains water that doesn’t resolve unless you stop taking it.
I was wondering since you went up so high if it stopped working each time so you keep going up?
I think thats what I need to do, just keep going up, ha ha
woundcarping
GLP-1 Specialist
Do you see points where I had meaningful plateaus? I don’t.
If you’ve got substantial weight to drop, low and slow seems to be a waste of time. The expensive trials titrated based on time and gave predictable results for the general population.
I’m well above trial dosing, but I expect to pull it back considerably to find my maintenance equilibrium point.
Not at all 🙂 What makes you decide when you want to move up?
I have 40lbs more to lose. That's substantial to me! I'm usually sensitive to medications so I've been moving up slow. I need to be able to function, ha ha. Up to the 5 on Tirz & this week will be 3 Reta split
Do you have any side effects?
Bigdog0628
GLP-1 Apprentice
This is an amazing chart. How are your energy levels for this duration? Congrats on the journey
woundcarping
GLP-1 Specialist
I’m not losing weight too quickly vs sides and metrics suggest escalation isn’t overly taxing. I’ve lost no days of work from sides.
If the primary goal is weight loss, I have lots of sides or secondary effects. None are adverse and pronounced to the point of causing an issue in the time frame I’m expecting to be done cutting.
RHR is elevated, roughly 8bpm currently.
HRV can take a hit with escalation, but nothing meaningful to me.
No upper GI issues period, perhaps less lower GI issues than the baseline from before I started.
Sleep can take a hit, although that is likely multifactorial and my tracking hasn’t shown my sleep debt exceed 5 hours at the worst (DSIP by itself was counterproductive, maybe neutral stacked with Epi).
I too have ~40lb left to lose.
Aside from being tired from sleep (I’ve noticed I’m more sensitive to sleep debt than before, but still entirely functional) my energy level is fine. I was going to the gym every day until March, need to get back on that routine.
salt'n papa
Recently Joined
🚫No Source Discussion🚫
I'm a 205 lbs guy, Tirz at 2.5mg and Reta at 2mg. and things really got going 2 weeks ago. I'm pretty physically active, and after a 3 hour bike ride I finally broke through my plateau> It took over 2 months without the peps to get down from 210 to 202 on diet alone...but my dietician was a real nag... I'm now effortlessly losing 2 lbs a week. Maybe more...but it took a breakthough effort to crack the plateau. Perhaps something like this or maybe a big "true" fast day would work? I've also realized how much my "liquid" diet effected me. Too many beers...Good luck!
Not thinking too quickly at all. You're having great success (losing more than half what you want already).
Knock on wood, my sides are not really much if anything. Don't know what my RHR was before now in the 70s.
I'm having the same less GI issues than prior as well (certain foods used to give me some issues but not really anymore)
My sleep was horrible before. I think I'm a bit better now on & off (able to get my mind to be quiet a bit easier)
Same 40lbs! I'm sure you will succeed way before I do at the rate you're going. I hope I can get there too, ha ha. My prob wasn't how much I are (prob too little) its whatever is going on inside that is telling my body F-U & no Dr can figure out, haha. Some women just have a harder time. I have no clue & Yes I am tired too 😉
woundcarping
GLP-1 Specialist
On the speed, that's how I judged increasing my dose... I don't want to lose (sustained) more than ~1.1% week over week.
My thinking is if I'm wanting to drop 32-35% of my weight, I'll likely be at a higher dose. 24% of Reta participants lost 30% or more. My general theory is my cutting dose ≠ maintenance dose, maintenance dose is more of an equilibrium point between the dose and my body's "set point" weight wise. I don't think cutting dose heavily influences the future maintenance dose but I suppose/hope I'll see.
My RHR is in the high 60s to low 70s. Low enough I'm not particularly worried about it.
Good luck with managing it if you can't get it figured out!
I took a ~90 minute nap, hopefully not too late to mess up my sleep tonight.
Turnus
GLP-1 Apprentice
Started on Reta at 2MG and responded very well. After about 5 weeks bumped up to 3MG and then at 11 weeks bumpted it up to 4MG where I'm currently at. Seem to responded very well and will plan on riding out at 4MG for another 4 or 5 weeks and reassess
I would like to pick up the speed (from nothing/stalled) so I have to keep going up I guess haha. I just dont want to be at a point where I feel like total garbage or any issues
Thank you, I hope so!!
Wow, a nap? I hope you enjoyed that!! I can never let myself do it (unless sick in bed, ha ha). I hope you were able to get good sleep last night too!!
Is that really the "general consensus" though?
If we're thinking about safety (or even efficacy) and your concern is combining the content of GLP-1 for both tirzepatide and retatrutide, consider this:
Doses of Wegovy at 7.2mg are FDA-approved
That means they've done the clinical trials, they've done the safety studies and they've given that the green light.
What's the equivalent dose of tirzepatide that roughly equates to 7.2mg of semaglutide? I've seen suggestions that it's around 53-55mg. Yeah. Not a typo.
We also know that they're currently running high-dose tirzepatide trials that are testing doses of 20mg, 25mg and possibly 30mg. They would have already halted those if there were safety issues.
So in terms of combining both and worrying about the GLP-1 content of that combo? I really don't think it should be a worry.
