Whats the quality of Chinese Tirz compared to Lilly?

[Labcat]

This is a very informative thread.
But the whole time I'm reading, I'm thinking, you know there's an exceptable amount of rat crap in your oatmeal.

It probably changes the freezing point of the oatmeal. 🤣

Your point about how we can tolerate a certain amount and also get lucky is legit. But in the days before USDA standards, there was a LOT more rat crap in everything.

My ultimate goal though is to have a reasonable expectation of the residual strength of my peptide. I’m willing to titrate to effect, but for other health reasons really want to not have a reaction by accidentally titrating up too much if it’s weak.

 

[Gr33dyOctopus]

Some of the compounding pharmacies turned out to be just buying unapproved stuff from China.

I dont doubt that for a minute

 

[Nathanologist]

Do those science guys say in the end what difference it makes, and if we can even figure out what’s being sold?
Also imma going to see what peppy’s is, any tips how to find that post you’re referring to?

If you are a member and have sufficient privileges this is the thread: https://chat.peppys.org/t/peptide-quality/42997/23

 

[Nathanologist]

I came here looking for exactly something like this comment. @joseblo How is it that we know that the counterion of the form we are receiving is acetate?
Do we know how the synthesis is purportedly done? Ie, Is it still the original solid phase synthesis using TFA then ion exchange to sub in acetate, or neutralize with NaOH and leave Na… or the hybrid solid/liqiid phase (that I known nothing about other than those words?)
I’m not actually contesting that gray Tirz works for weight, and that the salt in the correct pH solution dissociates to yield the base, but I’m wondering if we’re always receiving the base with the same counter ion or other non-peptide production molecules that might end up in the mix, yet not be visible in HPLC-mass spec purity testing. (Assuming janoshik and the like use HPLC mass spec)
Looking for someone who has looked into this to help me understand, please 🙂 I think this is very relevant to @Gr33dyOctopus’ question. Because this could make the soup that we recon a different compound. I am very interested in this because I’m in glps primarily for the less publicized benefits. Also maybe if our subcutaneous pH is not the appropriate pH to free the base, maybe it’s better to buffer the recon…

I have argued this with Jano and the other labs around in circles. They have a vested interest in telling us their RP HPLC-UV whatever test gives us all the info we need. But it doesn’t really. It probably gives us all the info we can afford, and keeps the vendors reasonable honest. I’m not convinced it’s going to confirm molecular weight and amino sequencing… among other things. No. We cannot be sure that what we are getting is the same as what EL et al are producing. I think the testing to confirm it all would be upwards of several thousand dollars IF you can find a lab capable of doing it and willing to deal B2C single test volume.

 

[Labcat]

I have argued this with Jano and the other labs around in circles. They have a vested interest in telling us their RP HPLC-UV whatever test gives us all the info we need. But it doesn’t really. It probably gives us all the info we can afford, and keeps the vendors reasonable honest. I’m not convinced it’s going to confirm molecular weight and amino sequencing… among other things. No. We cannot be sure that what we are getting is the same as what EL et al are producing. I think the testing to confirm it all would be upwards of several thousand dollars IF you can find a lab capable of doing it and willing to deal B2C single test volume.

I can see that. Arguing from most likely issues to least likely, it would imo be nice to see what residues from the actual synthesis solvents might remain, (these are washed out, and though I’m not well acquainted with the way specs are performed, why can’t they just dilute the actual product sample we provide and directly stick it in a cuvette for mass spec and see everything in the vial? That’s what we did in school decades ago. By now we certainly have software to identify peaks, and we can even tip it off as to what processes might be leaving trash behind, and then compare to a bit of EL product. And identify some known possible apecies - TFA, acetate, sodium, and so forth. We’d have to think about the pH of course. And borrow a mg from someone with meticulous technique. (I haven’t made my first purchase yet, a bit daunting with bitcoin and federal tax forms and such) This should be cheap to do.
I still have not seen assurance that we are buying the base from anyone. (Which could entirely be my own rather major ignorance, admittedly, someone please put me out of my misery!). Anyone with an academic chemistry connection?

 

[Labcat]

If you are a member and have sufficient privileges this is the thread: https://chat.peppys.org/t/peptide-quality/42997/23

Thank you!!!! Got my invite. What does it take to get privileges? I’ve just put a lot of time into getting privileges here to post in a few places 🤣, (probably the mods are tired of seeing my same themes already, but I’m happy to have gotten some awesome conversation already). Anyway this is all slow going. (Not complaining, it all makes sense, our world constantly reminds us why we can’t have nice things.)