Whats the quality of Chinese Tirz compared to Lilly?

[Labcat]

This is a very informative thread.
But the whole time I'm reading, I'm thinking, you know there's an exceptable amount of rat crap in your oatmeal.

It probably changes the freezing point of the oatmeal. 🤣

Your point about how we can tolerate a certain amount and also get lucky is legit. But in the days before USDA standards, there was a LOT more rat crap in everything.

My ultimate goal though is to have a reasonable expectation of the residual strength of my peptide. I’m willing to titrate to effect, but for other health reasons really want to not have a reaction by accidentally titrating up too much if it’s weak.

 

[Gr33dyOctopus]

Some of the compounding pharmacies turned out to be just buying unapproved stuff from China.

I dont doubt that for a minute

 

[Nathanologist]

Do those science guys say in the end what difference it makes, and if we can even figure out what’s being sold?
Also imma going to see what peppy’s is, any tips how to find that post you’re referring to?

If you are a member and have sufficient privileges this is the thread: https://chat.peppys.org/t/peptide-quality/42997/23

 

[Nathanologist]

I came here looking for exactly something like this comment. @joseblo How is it that we know that the counterion of the form we are receiving is acetate?
Do we know how the synthesis is purportedly done? Ie, Is it still the original solid phase synthesis using TFA then ion exchange to sub in acetate, or neutralize with NaOH and leave Na… or the hybrid solid/liqiid phase (that I known nothing about other than those words?)
I’m not actually contesting that gray Tirz works for weight, and that the salt in the correct pH solution dissociates to yield the base, but I’m wondering if we’re always receiving the base with the same counter ion or other non-peptide production molecules that might end up in the mix, yet not be visible in HPLC-mass spec purity testing. (Assuming janoshik and the like use HPLC mass spec)
Looking for someone who has looked into this to help me understand, please 🙂 I think this is very relevant to @Gr33dyOctopus’ question. Because this could make the soup that we recon a different compound. I am very interested in this because I’m in glps primarily for the less publicized benefits. Also maybe if our subcutaneous pH is not the appropriate pH to free the base, maybe it’s better to buffer the recon…

I have argued this with Jano and the other labs around in circles. They have a vested interest in telling us their RP HPLC-UV whatever test gives us all the info we need. But it doesn’t really. It probably gives us all the info we can afford, and keeps the vendors reasonable honest. I’m not convinced it’s going to confirm molecular weight and amino sequencing… among other things. No. We cannot be sure that what we are getting is the same as what EL et al are producing. I think the testing to confirm it all would be upwards of several thousand dollars IF you can find a lab capable of doing it and willing to deal B2C single test volume.

 

[Labcat]

I have argued this with Jano and the other labs around in circles. They have a vested interest in telling us their RP HPLC-UV whatever test gives us all the info we need. But it doesn’t really. It probably gives us all the info we can afford, and keeps the vendors reasonable honest. I’m not convinced it’s going to confirm molecular weight and amino sequencing… among other things. No. We cannot be sure that what we are getting is the same as what EL et al are producing. I think the testing to confirm it all would be upwards of several thousand dollars IF you can find a lab capable of doing it and willing to deal B2C single test volume.

I can see that. Arguing from most likely issues to least likely, it would imo be nice to see what residues from the actual synthesis solvents might remain, (these are washed out, and though I’m not well acquainted with the way specs are performed, why can’t they just dilute the actual product sample we provide and directly stick it in a cuvette for mass spec and see everything in the vial? That’s what we did in school decades ago. By now we certainly have software to identify peaks, and we can even tip it off as to what processes might be leaving trash behind, and then compare to a bit of EL product. And identify some known possible apecies - TFA, acetate, sodium, and so forth. We’d have to think about the pH of course. And borrow a mg from someone with meticulous technique. (I haven’t made my first purchase yet, a bit daunting with bitcoin and federal tax forms and such) This should be cheap to do.
I still have not seen assurance that we are buying the base from anyone. (Which could entirely be my own rather major ignorance, admittedly, someone please put me out of my misery!). Anyone with an academic chemistry connection?

 

[Labcat]

If you are a member and have sufficient privileges this is the thread: https://chat.peppys.org/t/peptide-quality/42997/23

Thank you!!!! Got my invite. What does it take to get privileges? I’ve just put a lot of time into getting privileges here to post in a few places 🤣, (probably the mods are tired of seeing my same themes already, but I’m happy to have gotten some awesome conversation already). Anyway this is all slow going. (Not complaining, it all makes sense, our world constantly reminds us why we can’t have nice things.)

 

[Nathanologist]

I can see that. Arguing from most likely issues to least likely, it would imo be nice to see what residues from the actual synthesis solvents might remain, (these are washed out, and though I’m not well acquainted with the way specs are performed, why can’t they just dilute the actual product sample we provide and directly stick it in a cuvette for mass spec and see everything in the vial? That’s what we did in school decades ago. By now we certainly have software to identify peaks, and we can even tip it off as to what processes might be leaving trash behind, and then compare to a bit of EL product. And identify some known possible apecies - TFA, acetate, sodium, and so forth. We’d have to think about the pH of course. And borrow a mg from someone with meticulous technique. (I haven’t made my first purchase yet, a bit daunting with bitcoin and federal tax forms and such) This should be cheap to do.
I still have not seen assurance that we are buying the base from anyone. (Which could entirely be my own rather major ignorance, admittedly, someone please put me out of my misery!). Anyone with an academic chemistry connection?

As long as you don't sell crypto for fiat currency I don't think you create a taxable event. Like, buy crypto, spend it, -poof- gone. it's when you buy it and then sell it you create a capital gain or loss, and they're MOSTLY interested in your gains. But what do I know, I've only been studying taxes my whole life...

 

[Labcat]

As long as you don't sell crypto for fiat currency I don't think you create a taxable event. Like, buy crypto, spend it, -poof- gone. it's when you buy it and then sell it you create a capital gain or loss, and they're MOSTLY interested in your gains. But what do I know, I've only been studying taxes my whole life...

Well of it’s your actual WHOLE life 🤣.
So spending and seeking is different?
And if i have any left over that I didn’t spend due to some counting error, (like wise is always gonna have that leftover lol)… is that of interest to the tax people who only tax us stupid wage earners?
Anything else I need to know, sir?
Really, thank you so much for this advice. Too.

 

[Nathanologist]

Well of it’s your actual WHOLE life 🤣.
So spending and seeking is different?
And if i have any left over that I didn’t spend due to some counting error, (like wise is always gonna have that leftover lol)… is that of interest to the tax people who only tax us stupid wage earners?
Anything else I need to know, sir?
Really, thank you so much for this advice. Too.

I don't think having it left over is a problem. Just leave it in the wallet. You aren't paying me for advice however, and it's worth every penny you spent on it.... I'm a tax guy... but I'm not YOUR tax guy!

 

[Labcat]

I don't think having it left over is a problem. Just leave it in the wallet. You aren't paying me for advice however, and it's worth every penny you spent on it.... I'm a tax guy... but I'm not YOUR tax guy!

And I’m a biologist, but not your biologist! 🙂. (Though I could be, we don’t really seem to carry legal risk from that. Shh don’t tell the lawyers.)
You’re still a thousand times more accurate than any google or AI. search. Thank you, for the general wisdom that is not advice! I didn’t even know about it.
I don’t have a tax guy, alas, he’d have to work for a share of debt 😜. Or medical issues, i got a lot of that too.

 

[keangkong]

As long as you don't sell crypto for fiat currency I don't think you create a taxable event. Like, buy crypto, spend it, -poof- gone. it's when you buy it and then sell it you create a capital gain or loss, and they're MOSTLY interested in your gains. But what do I know, I've only been studying taxes my whole life...

Are you sure? That's not how I read IRS Publication 544. https://www.irs.gov/pub/irs-pdf/p544.pdf. That publication states, in part: "Amount realized. The amount you realize from a sale or exchange is the total of all the money you receive plus the FMV (defined below) of all property or services you receive."

 

[Labcat]

Are you sure? That's not how I read IRS Publication 544. https://www.irs.gov/pub/irs-pdf/p544.pdf. That publication states, in part: "Amount realized. The amount you realize from a sale or exchange is the total of all the money you receive plus the FMV (defined below) of all property or services you receive."

Thank you for weighing in also! I’m completely ignorant… but is this referring to the monetary value received by a seller (businesman) rather than the consumer? Or are both sides of a transaction taxed?

 

[MsGizmo]

As long as you don't sell crypto for fiat currency I don't think you create a taxable event. Like, buy crypto, spend it, -poof- gone. it's when you buy it and then sell it you create a capital gain or loss, and they're MOSTLY interested in your gains. But what do I know, I've only been studying taxes my whole life...

If you realize a profit when you spend crypto then you ARE creating a taxable event. Just because you aren't caught because the dollar amounts are to low for the IRS to be bothered with doesn't mean that tax laws haven't been broken.

 

[Labcat]

If you realize a profit when you spend crypto then you ARE creating a taxable event. Just because you aren't caught because the dollar amounts are to low for the IRS to be bothered with doesn't mean that tax laws haven't been broken.

Does realizing a profit apply to getting a good deal? Isn’t a simple purchase of a noninvestment object net zero? Like buying groceries, even with crypto. Or am I too naive

 

[Nathanologist]

Are you sure? That's not how I read IRS Publication 544. https://www.irs.gov/pub/irs-pdf/p544.pdf. That publication states, in part: "Amount realized. The amount you realize from a sale or exchange is the total of all the money you receive plus the FMV (defined below) of all property or services you receive."

Nothing in life is sure, except that fear is overpriced. Technically, yes you are converting an asset. Practically, no I don’t treat it like that personally or for my clients and am comfortable defending the position to the IRS. (…and have successfully.) Similarly, what if you fix a friends car and in return they install a window in your house? Do you report the income on the exchange? Technically, yes; practically no. There is of course a point where the action becomes so frequent or so large that it is material and will need to be handled differently. You cannot avoid all taxes by functioning only on the barter system. Do you realize a profit when you buy food and consume it? What if you do so using barter at the farmer’s market? Do you drive 10mph over the speed limit on the freeway? Especially with stable coins and small transactions it is a non-issue.

Like I said, however, I am a licensed tax professional but I’m not YOUR licensed tax professional. Hire one for yourself and they will take your money, advise you the same or differently, and then if you get audited take your money again to defend you; all the while having no actual liability! It’s a great field to work in, almost as good as law. The good ones know what’s a red flag and what’s water under the bridge. I believe I am one of the good ones, as do my clients, but you may have a different opinion.

 

[Labcat]

Nothing in life is sure, except that fear is overpriced. Technically, yes you are converting an asset. Practically, no I don’t treat it like that personally or for my clients and am comfortable defending the position to the IRS. (…and have successfully.) Similarly, what if you fix a friends car and in return they install a window in your house? Do you report the income on the exchange? Technically, yes; practically no. There is of course a point where the action becomes so frequent or so large that it is material and will need to be handled differently. You cannot avoid all taxes by functioning only on the barter system. Do you realize a profit when you buy food and consume it? What if you do so using barter at the farmer’s market? Do you drive 10mph over the speed limit on the freeway? Especially with stable coins and small transactions it is a non-issue.

Like I said, however, I am a licensed tax professional but I’m not YOUR licensed tax professional. Hire one for yourself and they will take your money, advise you the same or differently, and then if you get audited take your money again to defend you; all the while having no actual liability! It’s a great field to work in, almost as good as law. The good ones know what’s a red flag and what’s water under the bridge. I believe I am one of the good ones, as do my clients, but you may have a different opinion.

Wait, so buying groceries counts as realizing a profit?

 

[Nathanologist]

If you realize a profit when you spend crypto then you ARE creating a taxable event. Just because you aren't caught because the dollar amounts are too low for the IRS to be bothered with doesn't mean that tax laws haven't been broken.

I find it amusing how concerned we all get about breaking the laws in an inconsequential way… some might cry hypocrisy! Have you ever bought and sold a car? Yard sale? Clothes on consignment? It is the same. What about importing illegal, counterfeit, and/or non-approved pharmaceuticals? 🤣🤣🤣🙄

 

[Nathanologist]

Does realizing a profit apply to getting a good deal? Isn’t a simple purchase of a noninvestment object net zero? Like buying groceries, even with crypto. Or am I too naive

No. You are very practical. You probably drive 80 in a 65 zone, never questioned reporting your credit card rewards as income (legit non-taxable) and maybe just maybe even bought some questionable pharmaceuticals on the internet. You’ll live.

 

[Labcat]

I find it amusing how concerned we all get about breaking the laws in an inconsequential way… some might cry hypocrisy! Have you ever bought and sold a car? Yard sale? Clothes on consignment? It is the same. What about importing illegal, counterfeit, and/or non-approved pharmaceuticals? 🤣🤣🤣🙄

See, some of us didn’t know that was technically an issue.
Some of us are not touting the pharm purchases, but crypto is on our name

 

[Nathanologist]

See, some of us didn’t know that was technically an issue.
Some of us are not touting the pharm purchases, but crypto is on our name

It’s all on our names, unless we paid cash. Most of what we are doing is simply flying under the radar, or traveling 10mph over the limit depending on your preferred analogy.

 

[Labcat]

It’s all on our names, unless we paid cash. Most of what we are doing is simply flying under the radar, or traveling 10mph over the limit depending on your preferred analogy.

I think that’s what I mean, garage sale - petty cash. Crypto - name and taxes. Flying under the radar. It seems different somehownin the age of AI. Trying to come to terms with it, not at all opposing what you’re saying

 

[keangkong]

Nothing in life is sure, except that fear is overpriced. Technically, yes you are converting an asset. Practically, no I don’t treat it like that personally or for my clients and am comfortable defending the position to the IRS. (…and have successfully.) Similarly, what if you fix a friends car and in return they install a window in your house? Do you report the income on the exchange? Technically, yes; practically no. There is of course a point where the action becomes so frequent or so large that it is material and will need to be handled differently. You cannot avoid all taxes by functioning only on the barter system. Do you realize a profit when you buy food and consume it? What if you do so using barter at the farmer’s market? Do you drive 10mph over the speed limit on the freeway? Especially with stable coins and small transactions it is a non-issue.

Like I said, however, I am a licensed tax professional but I’m not YOUR licensed tax professional. Hire one for yourself and they will take your money, advise you the same or differently, and then if you get audited take your money again to defend you; all the while having no actual liability! It’s a great field to work in, almost as good as law. The good ones know what’s a red flag and what’s water under the bridge. I believe I am one of the good ones, as do my clients, but you may have a different opinion.

Thanks for the explanation.