Which GLP-1 drugs most strongly affect the GLP-1 system?

[keangkong]

Which GLP-1 drugs most strongly affect the GLP-1 system? I know between tirzepatide, retatrutide, and semaglutide, semaglutide is the strongest. My FEELZ test says that tirzepatide more strongly affects the GLP-1 system than retatrutide but that's not based on reading anything scientific. What I think might not be true. Where does mazdutide fit in the mix? I'm only able to get up to about 7.5 mg of tirzepatide per week because at that point my stomach begins to get knotted up so that eating becomes uncomfortable though I'm still hungry.

I can't currently take retatrutide because it's a possible cause of my severely elevated liver enzymes (10 times the upper limit of normal).

 

[miss-sanne]

I think this is from an animal model, but i'm not sure.
Low number means the peptide affects the receptor the most.
As you can see of tirz, sema and reta, Sema hits the receptor strongest, then comes tirz, then Reta. Most people have bad appetite suppression from Reta, especially if you have been on another GLP-1.
Hope, it answered you question.

 

[Pipsko]

Anyone trial >12 mg Reta or stalled on high dose reta?

Hey all, For some background, I've been on GLPs for >1.5 yrs. Started on Tirz, maxed out and stalled at 15mg. Switched to reta about 3 months ago and am currently at Reta 10mg. On my switch I regained about 10 lbs but reduced 3 of those lbs on reta so far. So net -7 lbs. Just wondering how...

glp1forum.com

 

[miss-sanne]

I think this is from an animal model, but i'm not sure.
Low number means the peptide affects the receptor the most.
As you can see of tirz, sema and reta, Sema hits the receptor strongest, then comes tirz, then Reta. Most people have bad appetite suppression from Reta, especially if you have been on another GLP-1.
Hope, it answered you question.

Oh, btw, I would like to research survo at some point, I don't think, Maz will do anything for me.
I'm currently on reta and need to stack cagri, because I have no appetite suppression fro reta.
me too, couldn't go high i Tirz, no more than 7-8, because I got depressed.
But loved Tirz as an appetite suppresionl
Sema did nothing for me.
Maybe you can research survo, hope it won't affect your liver enzymes.

 

[keangkong]

I think this is from an animal model, but i'm not sure.
Low number means the peptide affects the receptor the most.
As you can see of tirz, sema and reta, Sema hits the receptor strongest, then comes tirz, then Reta. Most people have bad appetite suppression from Reta, especially if you have been on another GLP-1.
Hope, it answered you question.

I

I think this is from an animal model, but i'm not sure.
Low number means the peptide affects the receptor the most.
As you can see of tirz, sema and reta, Sema hits the receptor strongest, then comes tirz, then Reta. Most people have bad appetite suppression from Reta, especially if you have been on another GLP-1.
Hope, it answered you question.

Am I reading this correctly as meaning the mazdutide has quite weak GLP-1 effects? I hope that's what it means because I'm stacking with tirzepatide and the GLP-1 effects of it keep me from raising the dose.

 

[Batscout]

Which GLP-1 drugs most strongly affect the GLP-1 system? I know between tirzepatide, retatrutide, and semaglutide, semaglutide is the strongest. My FEELZ test says that tirzepatide more strongly affects the GLP-1 system than retatrutide but that's not based on reading anything scientific. What I think might not be true. Where does mazdutide fit in the mix? I'm only able to get up to about 7.5 mg of tirzepatide per week because at that point my stomach begins to get knotted up so that eating becomes uncomfortable though I'm still hungry.

I can't currently take retatrutide because it's a possible cause of my severely elevated liver enzymes (10 times the upper limit of normal).

I think I am a super responder to all of it, however I find Tirz to be the best for appetite control and food noise.

 

[miss-sanne]

I

Am I reading this correctly as meaning the mazdutide has quite weak GLP-1 effects? I hope that's what it means because I'm stacking with tirzepatide and the GLP-1 effects of it keep me from raising the dose.

Yes that's what it says.
But I think, it will affect more on high doses = you will feel it more.