MOTS-C is SPICY

[moonpies4misfits]

Finished a round of SS-31 and just did my first MOTS-C dose this morning. They need to put a disclaimer on all the guides and protocols that this one has some bite to it! 😂 After specifically searching for "MOTS-C burn" on various forums I saw that this is pretty common. Needless to say, I'll be including that on my searches whenever I look up new peps lol.

Is there a list for "Peps that bite back" anywhere? 😂

 

[Tomes]

I just started Mots-C this week as well, although I didn't do the SS-31 protocol beforehand. My first injection 2 days ago I had zero injection site reaction or burn, today I had a little redness, but still no burn. I put as much bac water as I could fit into the vial (3 mL) and iced the injection site after. I'm loving the intended effects so far!

Lol, Peps that Bite Back is great branding 😂
I haven't seen a full summary doc, but GHK-CU is the most infamous one for sure, though oddly I've had no issues with it, either. (And both my mots and GHK are from trusted and tested sources.)

 

[RedSkip]

I just started Mots-C this week as well, although I didn't do the SS-31 protocol beforehand. My first injection 2 days ago I had zero injection site reaction or burn, today I had a little redness, but still no burn. I put as much bac water as I could fit into the vial (3 mL) and iced the injection site after. I'm loving the intended effects so far!

Lol, Peps that Bite Back is great branding 😂
I haven't seen a full summary doc, but GHK-CU is the most infamous one for sure, though oddly I've had no issues with it, either. (And both my mots and GHK are from trusted and tested sources.)

What are the benefits of MOTS-C that you are loving?

 

[moonpies4misfits]

I just started Mots-C this week as well, although I didn't do the SS-31 protocol beforehand. My first injection 2 days ago I had zero injection site reaction or burn, today I had a little redness, but still no burn. I put as much bac water as I could fit into the vial (3 mL) and iced the injection site after. I'm loving the intended effects so far!

See, I did 1ml of water for a 10mg vial. I'll definitely be diluting my next bottle with more BAC 😂

How soon did you feel the effects? I've been stuck at a desk all day and I definitely feel more alert but sitting at a desk isn't the best way to test out my energy levels lol. Maybe I should have waited till tomorrow.

 

[Tomes]

What are the benefits of MOTS-C that you are loving?

See, I did 1ml of water for a 10mg vial. I'll definitely be diluting my next bottle with more BAC 😂

How soon did you feel the effects? I've been stuck at a desk all day and I definitely feel more alert but sitting at a desk isn't the best way to test out my energy levels lol. Maybe I should have waited till tomorrow.

For context I've been microdosing tirz for ~3 months (1.5 mg every 5 days) and even at that level the tirz fatigue has hit my hard.

When I added MOTS-C it was the first day I felt like I had real energy. For me it's been both alertness throughout the day, as well as additional energy when exercising / working out (which is what most report as the biggest effect).

For example, I did a hike at the very end of the day the first day I took it and realized after it was over that I had not at any point been tired, whereas I've been dragging myself through that hike ever since I started with tirz (it's a hike I do all the time with my dog, so it's an easy one for me to notice when I feel different). Today is only dose 2 and I have a workout later today, so hopefully it is equally effective with strength / weights!

And @moonpies4misfits hopefully adding more bac water makes the injection better!!

 

[moonpies4misfits]

For context I've been microdosing tirz for ~3 months (1.5 mg every 5 days) and even at that level the tirz fatigue has hit my hard.

When I added MOTS-C it was the first day I felt like I had real energy. For me it's been both alertness throughout the day, as well as additional energy when exercising / working out (which is what most report as the biggest effect).

For example, I did a hike at the very end of the day the first day I took it and realized after it was over that I had not at any point been tired, whereas I've been dragging myself through that hike ever since I started with tirz (it's a hike I do all the time with my dog, so it's an easy one for me to notice when I feel different). Today is only dose 2 and I have a workout later today, so hopefully it is equally effective with strength / weights!

And @moonpies4misfits hopefully adding more bac water makes the injection better!!

Well, I got off work and called my mom, them proceeded to talk her ear off while speed cleaning the kitchen, so I'd say it's working!

I haven't noticed any fatigue on Tirz yet, but I'm early on in my journey (6 weeks in) and I've had crazy fatigue for a while so it's been hard to tell if it was just my normal fatigue or the Tirz.

I've also just recently found out I have one of the MTHFR gene mutations that screws up your body's ability to process B12 efficiently, so I plan on switching from Cyano B12 to Methyl B12 to see if that helps. I may ask my doctor for B12 injections next time I'm there.

 

[MarisWinter]

Well, I got off work and called my mom, them proceeded to talk her ear off while speed cleaning the kitchen, so I'd say it's working!

I haven't noticed any fatigue on Tirz yet, but I'm early on in my journey (6 weeks in) and I've had crazy fatigue for a while so it's been hard to tell if it was just my normal fatigue or the Tirz.

I've also just recently found out I have one of the MTHFR gene mutations that screws up your body's ability to process B12 efficiently, so I plan on switching from Cyano B12 to Methyl B12 to see if that helps. I may ask my doctor for B12 injections next time I'm there.

Hi, MOTS-C affects some people like that. Wish it would work like that for me. Still waiting…🤩

 

[moonpies4misfits]

Hi, MOTS-C affects some people like that. Wish it would work like that for me. Still waiting…🤩

Did you prime with a round of SS-31 first? I heard lots of people got energy from that one too but I didn't really feel anything on that one.

 

[moonpies4misfits]

Update: I doubled the dilution for a total of 2mg bac for a 10mg vial. Then I massaged the area after pinning and applied an ice pack for about 10 minutes. Injection site reaction is significantly less angry, red, and painful.

My first dose stung for about 4 hours, not incredibly bad, but enough discomfort to be super annoying.

 

[Drexeldragon216]

Update: I doubled the dilution for a total of 2mg bac for a 10mg vial. Then I massaged the area after pinning and applied an ice pack for about 10 minutes. Injection site reaction is significantly less angry, red, and painful.

My first dose stung for about 4 hours, not incredibly bad, but enough discomfort to be super annoying.

What’s your dosing and schedule like so far? I am super interested in MOTs-C.

 

[moonpies4misfits]

What’s your dosing and schedule like so far? I am super interested in MOTs-C.

I decided to try 2mg every 3 days for 20 days, but after my 2nd dose today I crashed super hard halfway through the day and ended up needing to nap, and it was a pretty intense nap.

I think I'm gonna put it on hold for a bit while I research this gene mutation that I have that could be making it less effective. Something to do with methylation donors, homocysteine levels, and my bodies ability to metabolize B12. This is all super new to me and I don't really know jack shit about genetics, but from my limited understanding its possible it's all related. I have a LOT more reading to do to. The short of it is that I may need supplement with Betaine TMG and/or Methyl-B12, but I wanna discuss it with my doctor and see if we can get some testing done before I proceed.

 

[Drexeldragon216]

I decided to try 2mg every 3 days for 20 days, but after my 2nd dose today I crashed super hard halfway through the day and ended up needing to nap, and it was a pretty intense nap.

I think I'm gonna put it on hold for a bit while I research this gene mutation that I have that could be making it less effective. Something to do with methylation donors, homocysteine levels, and my bodies ability to metabolize B12. This is all super new to me and I don't really know jack shit about genetics, but from my limited understanding its possible it's all related. I have a LOT more reading to do to. The short of it is that I may need supplement with Betaine TMG and/or Methyl-B12, but I wanna discuss it with my doctor and see if we can get some testing done before I proceed.

Taking a break sounds like a good idea while you figure the rest out. I hope your doc can help you along! I’ve seen some doing 5mg every 5 days, some recommending smaller dosing but 3x a week. I’ll keep reading before doing anything. Will probably still order so try the sales going on though 🤣

 

[vond4]

I just started Mots-C this week as well, although I didn't do the SS-31 protocol beforehand. My first injection 2 days ago I had zero injection site reaction or burn, today I had a little redness, but still no burn. I put as much bac water as I could fit into the vial (3 mL) and iced the injection site after. I'm loving the intended effects so far!

Lol, Peps that Bite Back is great branding 😂
I haven't seen a full summary doc, but GHK-CU is the most infamous one for sure, though oddly I've had no issues with it, either. (And both my mots and GHK are from trusted and tested sources.)

Hey can I ask what was tested? purity or for residual solvents, metals, etc?

 

[Tomes]

Hey can I ask what was tested? purity or for residual solvents, metals, etc?

Only for purity and quantity, not tested for heavy metals (which I think is pretty uncommon to run because would be a pretty unlikely contaminant) or TAMC / TYMC bacterial tests. I'm not aware of a gray market test for residual solvents, but would be interested to know if it exists.

 

[vond4]

Only for purity and quantity, not tested for heavy metals (which I think is pretty uncommon to run because would be a pretty unlikely contaminant) or TAMC / TYMC bacterial tests. I'm not aware of a gray market test for residual solvents, but would be interested to know if it exists.

I've confirmed that Jano offers GCMS testing (it's actually on the website, just alllllll the way down the page), which would pick up the residual solvents by comparing with NIST library standards (I think). It's odd to me that no one does it. People seem to think a good purity test result means an absence of anything harmful

 

[Tomes]

I've confirmed that Jano offers GCMS testing (it's actually on the website, just alllllll the way down the page), which would pick up the residual solvents by comparing with NIST library standards (I think). It's odd to me that no one does it. People seem to think a good purity test result means an absence of anything harmful

Ah, good to know. There's been much discussion of late on what a 'pass' on TAMC/TYMC actually means, to your point it does not exonerate the peptide from anything harmful and i think that was the basic interpretation for a long time (from myself included, til people started to ask questions and understand more about the specifics). Of course, a failed TAMC/TYMC almost definitely tells you something.

ETA: I thought I remembered Janoshik commenting on GC/MS and it's lack of suitability for peptide testing, so I just went to check and confirm this. It's part of the full Q&A published on Peppys.

 

[Chizikitide-1977]

Just wanted to share my experience with MOTS-C: First took this a couple of months back, just a 10 mg vial from Skye. I broke that into 3 doses. No injection site reaction, but I did notice the energy boost many report.

After that I wanted to try a more thorough cycling of the peptide to get the full benefit. I ordered a 30 mg vial from Skye. This time I did notice an injection site reaction, a first for me for any peptide. Not that bad though, and it cleared up in an hour or so.

For my last dose, to avoid the reaction and to minimize the number of injections I figured I’d mix the mots-c with my weekly dose of sema and cagri. I vaguely recalled reading somewhere that this type of mixing was not advisable, but against my better judgment I said fuck it and went ahead anyway. Well, the mix turned cloudy and thick, so I passed. Lesson learned, don’t mix MOTS-C with GLP-1s in the same syringe. 5 mg mots-c, 2.5 mg sema and .75 mg cagri down the drain.

 

[RedSkip]

Just wanted to share my experience with MOTS-C: First took this a couple of months back, just a 10 mg vial from Skye. I broke that into 3 doses. No injection site reaction, but I did notice the energy boost many report.

After that I wanted to try a more thorough cycling of the peptide to get the full benefit. I ordered a 30 mg vial from Skye. This time I did notice an injection site reaction, a first for me for any peptide. Not that bad though, and it cleared up in an hour or so.

For my last dose, to avoid the reaction and to minimize the number of injections I figured I’d mix the mots-c with my weekly dose of sema and cagri. I vaguely recalled reading somewhere that this type of mixing was not advisable, but against my better judgment I said fuck it and went ahead anyway. Well, the mix turned cloudy and thick, so I passed. Lesson learned, don’t mix MOTS-C with GLP-1s in the same syringe. 5 mg mots-c, 2.5 mg sema and .75 mg cagri down the drain.

How long have you been stacking Cagri? Are you handling it well, I’ve read that a lot of folks start off at 0.1mg.

 

[Chizikitide-1977]

How long have you been stacking Cagri? Are you handling it well, I’ve read that a lot of folks start off at 0.1mg.

There was a thread where I was talking about my cagri experiences along with a few other folks but it's gone. Not sure what happened to it.

Anyway, I stacked for 9 weeks. Started at .25, then .25 up per week until with minimal effects until I hit 1mg. That dose hit me hard, and I had the worst gastrointestinal side effects from these types of meds to date. Stuck to .75 from that point on, which provided good appetite suppression and minimal gastrointestinal distress. I did eventually notice it was making me very tired though. I'm taking a break from it for a while for that reason.

 

[Sackett]

For context I've been microdosing tirz for ~3 months (1.5 mg every 5 days) and even at that level the tirz fatigue has hit my hard.

When I added MOTS-C it was the first day I felt like I had real energy. For me it's been both alertness throughout the day, as well as additional energy when exercising / working out (which is what most report as the biggest effect).

For example, I did a hike at the very end of the day the first day I took it and realized after it was over that I had not at any point been tired, whereas I've been dragging myself through that hike ever since I started with tirz (it's a hike I do all the time with my dog, so it's an easy one for me to notice when I feel different). Today is only dose 2 and I have a workout later today, so hopefully it is equally effective with strength / weights!

And @moonpies4misfits hopefully adding more bac water makes the injection better!!

If this helps with energy with triz then sign me up. I have been in a slump. Even C4 work out powder doesn't give me energy. Check the PH on the mot c it would he interesting to see. Also I wonder if you could add sodium bicarbonate. 0.5ml to buffer. I use it to cut lidocaine before injection.

 

[RedSkip]

If this helps with energy with triz then sign me up. I have been in a slump. Even C4 work out powder doesn't give me energy. Check the PH on the mot c it would he interesting to see. Also I wonder if you could add sodium bicarbonate. 0.5ml to buffer. I use it to cut lidocaine before injection.

How are you determining how much Sodium BiCarb to add? Using a calculator or just a Rule of Thumb which led you to 0.5mL?

 

[Sackett]

How are you determining how much Sodium BiCarb to add? Using a calculator or just a Rule of Thumb which led you to 0.5mL?

I cut 2% xylocaine 1:100,000 parts of epi with 8.4% sodium bicarbonate. 5ml of sodium bicarbonate to 50 mL of xylocaine. That is the ratio I use for minor procedures but it shortens the life of the bottle. I use regular Bac for all peptides. So do some research and ph test. But the ratio should be the dame 1/10

 

[RedSkip]

I cut 2% xylocaine 1:100,000 parts of epi with
8.4% sodium bicarbonate. 5ml of sodium bicarbonate to 50 mL of xylocaine. That is the ratio I use for minor procedures. So do some research and ph test

Interesting. Appreciate the response, I don’t have much understanding of those products. I’ll need read up on those more.

 

[Sackett]

Interesting. Appreciate the response, I don’t have much understanding of those products. I’ll need read up on those more.

That's a numbing agent used for minor procedures. Definitely no expert on peptides or a pharmaceutical expert. Just my personal experience

 

[Tomes]

If this helps with energy with triz then sign me up. I have been in a slump. Even C4 work out powder doesn't give me energy. Check the PH on the mot c it would he interesting to see. Also I wonder if you could add sodium bicarbonate. 0.5ml to buffer. I use it to cut lidocaine before injection.

Still doing great for me for energy! I tried reta for a moment and really didn't like it (although was noticeably less tired than tirz), so I've hopped back to tirz + mots-c and I am not anywhere near as tired as I used to be with tirz. I'm about to start a cycle of SS-31 plus MOTS-C and see if that amplifies energy even more. I still don't have much, if any, stinging with the MOTS.

 

[Sackett]

Still doing great for me for energy! I tried reta for a moment and really didn't like it (although was noticeably less tired than tirz), so I've hopped back to tirz + mots-c and I am not anywhere near as tired as I used to be with tirz. I'm about to start a cycle of SS-31 plus MOTS-C and see if that amplifies energy even more. I still don't have much, if any, stinging with the MOTS.

This is great. I wanted to try this before tesofensine due to the stim affect of teso. Which vendors did you look at for the mots-c? I mean did you stay with US or overseas providers? I

 

[Tomes]

This is great. I wanted to try this before tesofensine due to the stim affect of teso. Which vendors did you look at for the mots-c? I mean did you stay with US or overseas providers? I

I'm pretty much down to only purchasing through PGB which uses a vendor not accessible to individuals (for all peptides, not just MOTS). If you're on Peppys there is a lot of good vendor info and you could definitely ask around on there for recs!

 

[semisweet]

I was coming here to search about this very thing with Mots! It is spicy. My first injection was on Saturday and it left a welt the size of a quarter at the injection site. Burned like a mother trucker. This morning I went to inject again, had a dull pin (wtf?) so it didn't pierce the skin nicely, so I redrew with a new syringe. Well that tiny amount that went in my skin left a small welt like I was bit by a bug. I didn't reinject with the new syringe. I got scared lol.

This is normal for people to have a site reaction like this?

I don't react with tirz.

 

[moonpies4misfits]

This is normal for people to have a site reaction like this?

I don't react with tirz.

I don't know if it's "normal" per se but it's definitely not a rare occurrence. Some peptides are known to burn or leave an ISR. What I found helped was diluting with more bac and applying pressure to injection site for about 10 minutes, preferably with a cold pack. I still had a red spot after but it wasn't as pronounced and didn't hurt as bad after. The discomfort also didn't last as long when I did the above.

 

[semisweet]

I don't know if it's "normal" per se but it's definitely not a rare occurrence. Some peptides are known to burn or leave an ISR. What I found helped was diluting with more bac and applying pressure to injection site for about 10 minutes, preferably with a cold pack. I still had a red spot after but it wasn't as pronounced and didn't hurt as bad after. The discomfort also didn't last as long when I did the above.

I'll try your suggestions. Thank you! I used 2ml of BAC, maybe next time I'll do 3. Saw one site recommend 4ml and that baffled me. Maybe this is why lol

 

[Tomes]

I'll try your suggestions. Thank you! I used 2ml of BAC, maybe next time I'll do 3. Saw one site recommend 4ml and that baffled me. Maybe this is why lol

You could also check the pH, I'm curious if different types of buffers may influence the pH of MOTSC and potentially explain the ISRs.

I used MOTSC this morning with only 1mL to dilute the 10mg (I previously said I was using 3mL) and I got only the smallest sting. I do get a small red reaction (like 1 cm diameter) sometimes, but it goes away in less than an hour. I'm using XYX (the anonymous vendor through the PGB group buy) and haven't tried any other vendors for this pep yet, what is your source?

 

[semisweet]

You could also check the pH, I'm curious if different types of buffers may influence the pH of MOTSC and potentially explain the ISRs.

I used MOTSC this morning with only 1mL to dilute the 10mg (I previously said I was using 3mL) and I got only the smallest sting. I do get a small red reaction (like 1 cm diameter) sometimes, but it goes away in less than an hour. I'm using XYX (the anonymous vendor through the PGB group buy) and haven't tried any other vendors for this pep yet, what is your source?

I purchased mine from Peptide Crafters.

 

[QueenP]

Finished a round of SS-31 and just did my first MOTS-C dose this morning. They need to put a disclaimer on all the guides and protocols that this one has some bite to it! 😂 After specifically searching for "MOTS-C burn" on various forums I saw that this is pretty common. Needless to say, I'll be including that on my searches whenever I look up new peps lol.

Is there a list for "Peps that bite back" anywhere? 😂

 

[QueenP]

You could also check the pH, I'm curious if different types of buffers may influence the pH of MOTSC and potentially explain the ISRs.

I used MOTSC this morning with only 1mL to dilute the 10mg (I previously said I was using 3mL) and I got only the smallest sting. I do get a small red reaction (like 1 cm diameter) sometimes, but it goes away in less than an hour. I'm using XYX (the anonymous vendor through the PGB group buy) and haven't tried any other vendors for this pep yet, what is your source?

The bite is not even the worst part about it. In my experience, it leaves a little lump that takes forever to go away.

 

[HUNTBHAM]

There was a thread where I was talking about my cagri experiences along with a few other folks but it's gone. Not sure what happened to it.

Anyway, I stacked for 9 weeks. Started at .25, then .25 up per week until with minimal effects until I hit 1mg. That dose hit me hard, and I had the worst gastrointestinal side effects from these types of meds to date. Stuck to .75 from that point on, which provided good appetite suppression and minimal gastrointestinal distress. I did eventually notice it was making me very tired though. I'm taking a break from it for a while for that reason.

This was helpful for me. I put cargi with sema and it was way too much. It blocked me up. balance in dosages is very important.

 

[Tomes]

This was helpful for me. I put cargi with sema and it was way too much. It blocked me up. balance in dosages is very important.

I'm now stacking 1.5mg tirz 1x/week with 100mcg cagri 2x/week though I think even this may be too much for me and will drop down to 1x100mcg next week. Cagri is very strong for me. The downside is I will never make it all the way through a vial.

With the MOTSC, I don't have issues with fatigue on this stack.

 

[moonpies4misfits]

Cagri is very strong for me. The downside is I will never make it all the way through a vial.

I just started it and didn't feel much from 300mcg. I'll give it a few weeks though. I do wish more places sold it in 5mg though. Most of what I've seen is 10mg.

 

[AndyPanda]

I'm now stacking 1.5mg tirz 1x/week with 100mcg cagri 2x/week though I think even this may be too much for me and will drop down to 1x100mcg next week. Cagri is very strong for me. The downside is I will never make it all the way through a vial.

With the MOTSC, I don't have issues with fatigue on this stack.

Cagri has a minimum half-life of 6.5 days. You could probably cut that to one dose.

 

[Tomes]

I just started it and didn't feel much from 300mcg. I'll give it a few weeks though. I do wish more places sold it in 5mg though. Most of what I've seen is 10mg.

Ahh as usual, it's all dependent on the researcher. I don't think I'd be able to eat if I took 300mcg at one. Are you stacking or taking it on its own?

I see a lot of 5mg actually, and yet I wish places sold it in 2mg! I'm lobbying vendors to consider this. If you need additional 5mg sources let me know.

 

[Tomes]

Cagri has a minimum half-life of 6.5 days. You could probably cut that to one dose.

Thanks! I'm aware the half life, but I was splitting the dose I wanted to take into two injections, which is fairly common. Now I've learned my target weekly dose should be lower, for now at least!

 

[moonpies4misfits]

Sta

Ahh as usual, it's all dependent on the researcher. I don't think I'd be able to eat if I took 300mcg at one. Are you stacking or taking it on its own?

Stacking with Tirz

 

[Chizikitide-1977]

Has anyone noticed an increase in appetite when taking MOTS-C? It's not a side effect I've seen reported but I do seem to have more of an appetite when cycling on than off.

For more context I've been at 2.5 mg sema weekly and have cycled 4 mg mots-c 4 days on 3 days off per week, 2 weeks on then 2 weeks off.

 

[Tomes]

Has anyone noticed an increase in appetite when taking MOTS-C? It's not a side effect I've seen reported but I do seem to have more of an appetite when cycling on than off.

For more context I've been at 2.5 mg sema weekly and have cycled 4 mg mots-c 4 days on 3 days off per week, 2 weeks on then 2 weeks off.

I haven't personally noticed this. I've been doing 10mg/week for about 6 weeks now, split in 2-3 doses. I'm also currently on 1.5mg tirz and 100mcg cagri per week.

Could it be that you're able to work out more / harder and that may as a result be increasing appetite?

 

[Chizikitide-1977]

I haven't personally noticed this. I've been doing 10mg/week for about 6 weeks now, split in 2-3 doses. I'm also currently on 1.5mg tirz and 100mcg cagri per week.

Could it be that you're able to work out more / harder and that may as a result be increasing appetite?

Thanks for chiming in. That may be a contributing factor, though I've been doing the same bike ride for my regular cardio regardless of the mots-c. Probably has something to do with the effects of sema diminishing after months at the top dose as well.

 

[George Bailey]

Where can I find an effective SS-31 and Mots-C protocol?

 

[Lullabytreehugger]

Finished a round of SS-31 and just did my first MOTS-C dose this morning. They need to put a disclaimer on all the guides and protocols that this one has some bite to it! 😂 After specifically searching for "MOTS-C burn" on various forums I saw that this is pretty common. Needless to say, I'll be including that on my searches whenever I look up new peps lol.

Is there a list for "Peps that bite back" anywhere? 😂

What is the recommended dosage for ss31?

With motsc i used to do 5mg x 3 injections per week. A total weekly dose of 15mgs.

I always got ISR. MotsC always made me sleepy. Not only me but my more mature friend who takes it gets the same sleepy tired feeling afterwards.