WARNING -- FOX04 OR FOX04-DRI

AlexSilver

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After much searching and speaking with reps, I am convinced that most of the vendors here do not carry FOX04-DRI. They only carry FOX04. You don't want FOX04.

The distinction is critical because they have the opposite effect.

FOX04 helps maintain the viability of senescent cells by inhibiting apoptosis, which can contribute to aging and age-related diseases while FOXO4-DRI is engineered to promote the death of senescent cells, offering potential therapeutic benefits in aging and cancer treatment.

So if you took FOX04 and think it didn't have the effect you've been reading about, that's because IT WASN'T FOX04-DRI.
 
After much searching and speaking with reps, I am convinced that most of the vendors here do not carry FOX04-DRI. They only carry FOX04. You don't want FOX04.

The distinction is critical because they have the opposite effect.

FOX04 helps maintain the viability of senescent cells by inhibiting apoptosis, which can contribute to aging and age-related diseases while FOXO4-DRI is engineered to promote the death of senescent cells, offering potential therapeutic benefits in aging and cancer treatment.

So if you took FOX04 and think it didn't have the effect you've been reading about, that's because IT WASN'T FOX04-DRI.
GOOD catch !!! I found this online if it helps. but fantastic info !!! I was looking to buy this so Thank for the heads up. on top of it FOX04 is not a cheap peptide.

  • An unmodified FOXO4 peptide (the short L-amino acid sequence mimicking the p53-binding domain, without DRI modifications) exists in theory but is not used for senolytic purposes because:
    • It would act more like the natural protein: potentially promoting senescent cell survival (by binding p53 and shielding it from apoptosis), rather than killing them.
    • Unmodified L-peptides have poor stability: Short half-life (minutes to hours), rapid enzymatic breakdown, limited cell penetration, and low potency.
    • Studies show the unmodified sequence doesn't disrupt the FOXO4-p53 interaction effectively enough to induce apoptosis in senescent cells—it's too weak and short-lived.
In essence: Taking unmodified FOXO4 (or a non-DRI peptide version) would likely do nothing useful for anti-aging or senescent cell clearance—or could theoretically counterproductive by mimicking the protective role of natural FOXO4 in zombie cells.
 

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After much searching and speaking with reps, I am convinced that most of the vendors here do not carry FOX04-DRI. They only carry FOX04. You don't want FOX04.

The distinction is critical because they have the opposite effect.

FOX04 helps maintain the viability of senescent cells by inhibiting apoptosis, which can contribute to aging and age-related diseases while FOXO4-DRI is engineered to promote the death of senescent cells, offering potential therapeutic benefits in aging and cancer treatment.

So if you took FOX04 and think it didn't have the effect you've been reading about, that's because IT WASN'T FOX04-DRI.
Get it tested by Janoshik to make sure you have the right foxo4.
 
does Uther have a site where they offer better prices on kits? the regular site with single vials is incredibly expensive.
 
You have a no source discussion banner so I’m not going to state the real site, but be aware that Uther doesn’t sell singles.
my bad, thats a new addition i guess and because i'm still considered a noob because of lower post count i guess. been gone from here a few weeks as i've been going through and digesting the massive amount of info over at peppy's.

i'm not sure how i'm supposed to seek clarity on this situation or find out where i'm going wrong checking on what i thought was this well know and often mentioned vendors site if i can't discuss sources at all.

@ZippityDooDah could you possibly drop in and offer me some guidance/clarity on the source discussion overall?
 
Could you DM me on it?
It’s searchable within the forum. Calm Logic has posted it a few times. (The website is for their US promos. For everything else, going to their TG group is the most direct and complete. Just be aware of fake groups. Again, there are screenshots of the real group that have been recently posted that a search will ping.) Also like Calm pointed out, it’s frequently more cost-effective to get Uther from groups.

Not trying to be difficult or overly gatekeeping. Just trying to respect the forum rules. (A DM to you as an apprentice would be fine, but I don’t want to start a whole series of DM comments on the thread when the info is posted on the forum already.)

Cheers and happy pepping! 👍
 
my bad, thats a new addition i guess and because i'm still considered a noob because of lower post count i guess. been gone from here a few weeks as i've been going through and digesting the massive amount of info over at peppy's.

i'm not sure how i'm supposed to seek clarity on this situation or find out where i'm going wrong checking on what i thought was this well know and often mentioned vendors site if i can't discuss sources at all.

@ZippityDooDah could you possibly drop in and offer me some guidance/clarity on the source discussion overall?
What part of this do you find confusing?

From https://glp1forum.com/help/new-member-posting/

1772296713655.webp
 
It’s searchable within the forum. Calm Logic has posted it a few times. (The website is for their US promos. For everything else, going to their TG group is the most direct and complete. Just be aware of fake groups. Again, there are screenshots of the real group that have been recently posted that a search will ping.) Also like Calm pointed out, it’s frequently more cost-effective to get Uther from groups.

Not trying to be difficult or overly gatekeeping. Just trying to respect the forum rules. (A DM to you as an apprentice would be fine, but I don’t want to start a whole series of DM comments on the thread when the info is posted on the forum already.)

Cheers and happy pepping! 👍
It's fake groups that have me concerned. That's all.
 
the entire section seems to be in regard to people getting here and starting threads and such or jumping into random threads and asking for sources.

i haven't been here oodles of time but not brand new, and while i'm not the most prolific poster i have engaged in the community without doing any of the things outlined in the 3.5 months i've been here. my post in this thread was to ask for clarification on an ongoing discussion about a seller, specifically someone mentioned a seller and linked a jano report on which the website of the seller is listed where single vials are on offer. the response that this seller doesn't sell singles is even more confusing. (edit - not sure what i was looking at but guessing i wound up on a site from someone who uses the same name but is not actually the seller, but tbh i have no idea)

i understand the intent of the rules is largely so stop spam and manipulation, as well as to stop people joining and peppering the forum with source requests. i don't believe i or my question here fits either of those. i'm guessing you disagree.
 
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the entire section seems to be in regard to people getting here and starting threads and such or jumping into random threads and asking for sources.

i haven't been here oodles of time but not brand new, and while i'm not the most prolific poster i have engaged in the community without doing any of the things outlined in the 3.5 months i've been here. my post in this thread was to ask for clarification on an ongoing discussion about a seller, specifically someone mentioned a seller and linked a jano report on which the website of the seller is listed where single vials are on offer. the response that this seller doesn't sell singles is even more confusing.

i understand the intent of the rules is largely so stop spam and manipulation, as well as to stop people joining and peppering the forum with source requests. i don't believe i or my question here fits either of those. i'm guessing you disagree.
I'm not sure that I can make this any clearer, but I'm going to try because apparently my limitations due to being bilingual are creating an endless reading comprehension problem.

The user level displayed under your forum name is "GLP-1 Novice", and carries the recent additional badge of "No Source Discussion" to further clarify things and remove confusion (yet, here I am...).

The information on the new member page clearly states that new members are prohibited from discussing sources until reaching the "GLP-1 Apprentice" user level. In hierarchical orders, Novice is BELOW Apprentice; now combined with the additional "No Source Discussion" badge for anyone who might not be familiar with hierarchical titles.

How long someone has been a member is only one of about six metrics by which members advance up the user level ladder. It doesn't matter if someone joined on August 1, 2023; if they haven't participated meaningfully in enough discussions, received enough "likes", viewed enough threads, avoided violating forum rules (like the no source discussion rule), etc. then they are no different than someone who joined yesterday.

For the vast majority of active members, the time it takes to reach "GLP-1 Apprentice" averages around 3 to 4 weeks. Everyone's time eventually comes. Ironically, it's the impatient people complaining about not being able to discuss sources who invariably take longer.

There are over 36,000 members of this forum. While you and some others may believe you have attained sufficient knowledge, experience, and reputation to move up to the next user level, the rules were created to treat everyone equally because we don't have the time nor resources to individually analyze the merits of every single member to make that determination. We rely on the integrated automations to do it based on an established set of parameters (no, I'm not going to tell anyone what they are) which have been finely-tuned over the past two and a half years.

Ultimately, it comes down to the "respect is earned, not given" maxim. Respecting the rules is an important aspect of keeping the forum civil and meaningful, and those who do earn respect in return and become positive members of our forum community. The saddest irony is, I fucking hate rules and I hate that we even have to have any here. If the world wasn't full of so many shitty humans, I would be happy just to let things roll on however they may. Unfortunately, reality is a harsh punch in the balls, so here we are.

I don't even know what you have been trying to discuss in this thread, and—frankly—I don't care. The rules are the rules and apply to everyone equally. Other helpful members have pointed out your "No Source Discussion" badge. Instead of questioning it, if you had taken a little time to pause, reflect, research and read up via the countless previous threads and posts here to understand how it all works, you probably would have already reached the Apprentice level by now.
 
For what its worth, I found some from QSC. I tried to order a 5mg kit, sent BTC, and everything was going well, until I got an email explaining that they didn't have 5mg and only had 10mg kits. Being my first transaction with the notorious Tracy, I was sketched out and asked for a refund instead. They promptly returned my money.
 

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