Endotoxin Warning

A vendor I used was offering a steep discount prior to this latest Jano endo release...makes me wonder if some of these vendors may have been aware of the situation prior to this very public release from the testing group, guess we'll never know, but things that make you go hmmmmm
Oh, for sure. The vendors offering deep discounts on known bad batches 100% know what they are selling, and I have no doubt some vendors knew before this latest report. It's possible/probable that a customer who doesn't access these forums did their own test and alerted their vendor long before we all found out from the testing group on these forums.
 
If a lab has stated that their method for testing is:

"Endotoxins are tested using the LAL Gel Clot sensitivity method, at a validated 1:16 dilution, looking for a result of less than 0.125 EU/mL."

Am I correct in saying that is looking for too small of an amount, and would not detect a dangerous level, such as appeared in the tirz?
 
If a lab has stated that their method for testing is:

"Endotoxins are tested using the LAL Gel Clot sensitivity method, at a validated 1:16 dilution, looking for a result of less than 0.125 EU/mL."

Am I correct in saying that is looking for too small of an amount, and would not detect a dangerous level, such as appeared in the tirz?

From what I have seen in the Janoschik lab results they write ">10 EU/Vial" and then some estimate of what it could be, but needs to be retested with a different dilution.
 
If a lab has stated that their method for testing is:

"Endotoxins are tested using the LAL Gel Clot sensitivity method, at a validated 1:16 dilution, looking for a result of less than 0.125 EU/mL."

Am I correct in saying that is looking for too small of an amount, and would not detect a dangerous level, such as appeared in the tirz?
Yes. I would not think twice about taking something that tested at 11eu/ml, for example. That is pretty far off from the tirz results, and you have no resolution in that range of 'totally fine' to 'dangerous'.
 
There was a vendor just banned from PepHub yesterday for knowingly selling the light orange cap T30 at a discount. Everyone needs to watch out for these thieves. The forum post scanner prevented me from using my first word choice.
 
There was a vendor just banned from PepHub yesterday for knowingly selling the light orange cap T30 at a discount. Everyone needs to watch out for these thieves. The forum post scanner prevented me from using my first word choice.
Is PepHub the type of site I need to use Incognito mode on? Peptides after dark. 😏
 
There was a vendor just banned from PepHub yesterday for knowingly selling the light orange cap T30 at a discount. Everyone needs to watch out for these thieves. The forum post scanner prevented me from using my first word choice.
So being unified, proactive and assertive actually works... stg booted jeep the other day. So much for the dicks saying: win some, lose some and quit bitchin these are drug deals and theres no standards.....
 
Yes.
However, being that endotoxins are released from dead bacteria, one can imply the other. It really depends on how they were introduced to begin with.
Is there a way to see this after recon? Slight color change etc.. I wonder if there is any type of “test strip” as well.
 
So being unified, proactive and assertive actually works... stg booted jeep the other day. So much for the dicks saying: win some, lose some and quit bitchin these are drug deals and theres no standards.....

Is there a way to see this after recon? Slight color change etc.. I wonder if there is any type of “test strip” as well.
No test strips or color change, there are tests available but are very expensive
 
Is there a way to see this after recon? Slight color change etc.. I wonder if there is any type of “test strip” as well.
None, no, zip. You need to have an assay of the peptide done. That requires a lab to do properly. The primary test used to determine endotoxin content in GLP-1 medications is the Limulus Amebocyte Lysate (LAL) assay, which detects lipopolysaccharides from gram-negative bacteria. And yes, I looked that up. They are extremely small particles, smaller than a filter, and invisible.
 
From what I have seen in the Janoschik lab results they write ">10 EU/Vial" and then some estimate of what it could be, but needs to be retested with a different dilution.
Thats why better send two vials to Jano and in case for retest over 10 EU it is there and not pay shipping again and loose time. Thats what I learned out of these lately.
 
Thats why better send two vials to Jano and in case for retest over 10 EU it is there and not pay shipping again and loose time. Thats what I learned out of these lately.
It's much better to send one and ask for the 10-1000EU range. Who cares if it's 9.9 or 0EU? And if over 1000 I already know I'm not using it so no need to test higher again.
 
Anybody else notice about 3 - 4 vendors are currently posting/offering/highlighting 75$ - 85$ T30 kits? Those vendors appear to offer COA's for nearly all their on-sale products, INCLUDING T20 and T60....but no T30 COA. Call me cynical, but I suspect they are not offering the T30 COAs with these amazing T30 deals because the COA would show the top/cap color of the tested vial....WHICH IS MOST LIKELY ORANGE!

I would regard ANY current "great deal" on T30, without a COA to verify the cap color, HIGHLY SUSPICIOUS. At the very least, if you are considering taking advantage of the deal, reach out to the vendor and verify that it is NOT the orange cap.
 
Anybody else notice about 3 - 4 vendors are currently posting/offering/highlighting 75$ - 85$ T30 kits? Those vendors appear to offer COA's for nearly all their on-sale products, INCLUDING T20 and T60....but no T30 COA. Call me cynical, but I suspect they are not offering the T30 COAs with these amazing T30 deals because the COA would show the top/cap color of the tested vial....WHICH IS MOST LIKELY ORANGE!

I would regard ANY current "great deal" on T30, without a COA to verify the cap color, HIGHLY SUSPICIOUS. At the very least, if you are considering taking advantage of the deal, reach out to the vendor and verify that it is NOT the orange cap.
Post the vendor names here.
 
Post the vendor names here.
My only hesitation is that I might be wrong and I don't want to unjustly point fingers. I think my warning is fair though, and people can watch out for themselves as they peruse the specials/promotions 🙂

The main point: I may or may not be paranoid about this, just everyone be careful and alert. We KNOW there are bad orange cap T30s out there....so if you are seeing a GREAT deal for T30, VERIFY it is not orange top.

EDIT: I will name THIS vendor as it appears they may be selling the orange tops according to the COA they provide on this thread (https://glp1forum.com/threads/7-day-limited-promotioncollisionbig-discount.14507/#post-150974). This is their COA: https://janoshik.com/tests/92825-T30_VA44NTI97VK7

I am colorblind so I don't see shades/differences in colors, so i may be wrong. If I am please, tell me and i will REMOVE this section of my post.
 
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It's much better to send one and ask for the 10-1000EU range. Who cares if it's 9.9 or 0EU? And if over 1000 I already know I'm not using it so no need to test higher again.
This. 10-1000 is a great range for this test. I consider >1000 clearly not usable, and if it's below 10 I don't care.
 
Anybody else notice about 3 - 4 vendors are currently posting/offering/highlighting 75$ - 85$ T30 kits? Those vendors appear to offer COA's for nearly all their on-sale products, INCLUDING T20 and T60....but no T30 COA. Call me cynical, but I suspect they are not offering the T30 COAs with these amazing T30 deals because the COA would show the top/cap color of the tested vial....WHICH IS MOST LIKELY ORANGE!

I would regard ANY current "great deal" on T30, without a COA to verify the cap color, HIGHLY SUSPICIOUS. At the very least, if you are considering taking advantage of the deal, reach out to the vendor and verify that it is NOT the orange cap.
The problem is that even if they provide the COA for the light orange caps it looks good. It's only the Endo test that shows the danger, which the scammers won't provide. Also, LS is testing the solid orange caps, and the black caps that replaced the solid orange cap batch. No word on that testing yet, that I've seen, and it's up to them as to when they provide it.
 
The problem is that even if they provide the COA for the light orange caps it looks good. It's only the Endo test that shows the danger, which the scammers won't provide. Also, LS is testing the solid orange caps, and the black caps that replaced the solid orange cap batch. No word on that testing yet, that I've seen, and it's up to them as to when they provide it.
Yes, that is true. But we should assume ALL of the "orange cap" vials of T30 come from the same manufacturer and therefore all orange cap vials are contaminated with high endo. We should also assume that vendors selling the orange cap T30 at a significant discount are trying to offload a known bunk product. So....checking the COA can, at the very least, tell you if they are selling an orange cap OR some other type (which would need testing for endos as well).

One might also consider if they wish to do business with a vendor trying to quickly offload bunk peptides at a tantalizing discount for those who don't know better.
 
regarding testing, this is what Canadian Testides responded:

Here are our current testing services and pricing (as of March 7, 2026):

What each standard test includes (per sample / per lot):

1. ID: Molecular identity confirmation (RT match vs internal reference standard).

2. Purity (HPLC-UV/DAD): % area normalization; chromatogram included in every report.

3. Quantification: Content per vial (mg) from a calibration curve; fill-accuracy reported as %.

4. Report Artifacts: Sample photo, Testides logo watermark, unique report ID with on-site verification. *We can also add your watermark and make a watermarked test directly available on our website.

Add-Ons (Optional):
  • Endotoxin (LAL)
  • Heavy metals ICP-MS screen (As, Cd, Hg, Pb) or expanded panel on request.
  • Antimicrobial testing
Pricing (CAD):
  • Standard panel (ID + Purity + Quant + Chromatogram): $280 per sample; $250 per sample for 3 or more.
  • LAL endotoxin: $100 per sample.
  • Heavy metals (4-metal screen As, Cd, Pb, Hg): $100 per sample. (2-3 week lead time.)
  • Heavy metals (Extended panel Ni, Cr, Co, Cu, Fe, Zn, Mo, V, Pd, Pt, Rh, Ru (customizable): $300-$500
  • Antimicrobial
  • Total Aerobic Microbial Count (TAMC) $65
  • Total Yeast and Molds Count (TYMC) $65
  • (TAMC + TYMC) $100
Turnaround: 7–10 business days from receipt unless stated otherwise.


So they are asking $350 CAD for a standard test + LAL endotoxin. But i don't know what LAL endotoxin testing actually means.
 
regarding testing, this is what Canadian Testides responded:

Here are our current testing services and pricing (as of March 7, 2026):

What each standard test includes (per sample / per lot):

1. ID: Molecular identity confirmation (RT match vs internal reference standard).

2. Purity (HPLC-UV/DAD): % area normalization; chromatogram included in every report.

3. Quantification: Content per vial (mg) from a calibration curve; fill-accuracy reported as %.

4. Report Artifacts: Sample photo, Testides logo watermark, unique report ID with on-site verification. *We can also add your watermark and make a watermarked test directly available on our website.

Add-Ons (Optional):
  • Endotoxin (LAL)
  • Heavy metals ICP-MS screen (As, Cd, Hg, Pb) or expanded panel on request.
  • Antimicrobial testing
Pricing (CAD):
  • Standard panel (ID + Purity + Quant + Chromatogram): $280 per sample; $250 per sample for 3 or more.
  • LAL endotoxin: $100 per sample.
  • Heavy metals (4-metal screen As, Cd, Pb, Hg): $100 per sample. (2-3 week lead time.)
  • Heavy metals (Extended panel Ni, Cr, Co, Cu, Fe, Zn, Mo, V, Pd, Pt, Rh, Ru (customizable): $300-$500
  • Antimicrobial
  • Total Aerobic Microbial Count (TAMC) $65
  • Total Yeast and Molds Count (TYMC) $65
  • (TAMC + TYMC) $100
Turnaround: 7–10 business days from receipt unless stated otherwise.


So they are asking $350 CAD for a standard test + LAL endotoxin. But i don't know what LAL endotoxin testing actually means.

LAL is the endotoxin assay test: The primary test used to determine endotoxin content in GLP-1 medications is the Limulus Amebocyte Lysate (LAL) assay, which detects lipopolysaccharides from gram-negative bacteria. And yes, I looked that up.
 
Yes, that is true. But we should assume ALL of the "orange cap" vials of T30 come from the same manufacturer and therefore all orange cap vials are contaminated with high endo. We should also assume that vendors selling the orange cap T30 at a significant discount are trying to offload a known bunk product. So....checking the COA can, at the very least, tell you if they are selling an orange cap OR some other type (which would need testing for endos as well).

One might also consider if they wish to do business with a vendor trying to quickly offload bunk peptides at a tantalizing discount for those who don't know better.
I would agree that any orange T30 "on sale" right now is a warning flag, until further testing sorts it out.
 
regarding testing, this is what Canadian Testides responded:

Here are our current testing services and pricing (as of March 7, 2026):

What each standard test includes (per sample / per lot):

1. ID: Molecular identity confirmation (RT match vs internal reference standard).

2. Purity (HPLC-UV/DAD): % area normalization; chromatogram included in every report.

3. Quantification: Content per vial (mg) from a calibration curve; fill-accuracy reported as %.

4. Report Artifacts: Sample photo, Testides logo watermark, unique report ID with on-site verification. *We can also add your watermark and make a watermarked test directly available on our website.

Add-Ons (Optional):
  • Endotoxin (LAL)
  • Heavy metals ICP-MS screen (As, Cd, Hg, Pb) or expanded panel on request.
  • Antimicrobial testing
Pricing (CAD):
  • Standard panel (ID + Purity + Quant + Chromatogram): $280 per sample; $250 per sample for 3 or more.
  • LAL endotoxin: $100 per sample.
  • Heavy metals (4-metal screen As, Cd, Pb, Hg): $100 per sample. (2-3 week lead time.)
  • Heavy metals (Extended panel Ni, Cr, Co, Cu, Fe, Zn, Mo, V, Pd, Pt, Rh, Ru (customizable): $300-$500
  • Antimicrobial
  • Total Aerobic Microbial Count (TAMC) $65
  • Total Yeast and Molds Count (TYMC) $65
  • (TAMC + TYMC) $100
Turnaround: 7–10 business days from receipt unless stated otherwise.


So they are asking $350 CAD for a standard test + LAL endotoxin. But i don't know what LAL endotoxin testing actually means.
their extra sample pricing kills it vs most others.

1000$ for 4 samples ? jano is 500
 
LAL is the endotoxin assay test: The primary test used to determine endotoxin content in GLP-1 medications is the Limulus Amebocyte Lysate (LAL) assay, which detects lipopolysaccharides from gram-negative bacteria. And yes, I looked that up.
well, for a $100CAD, it's really not a big deal to get done.
 
their extra sample pricing kills it vs most others.

1000$ for 4 samples ? jano is 500
*note also that the inquiry was for FOXO4-DRI and I think Janoshik is pricey for that compound.
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this is Janoshik's table. I didn't see the extra vial tests. $380 USD not $280 CAD.

that 380 USD = 520 CAD, almost double the price.

Anyhow, if I ever do track down a reliable source for foxo4-dri, I will send it to testides (since it's here in Canada, no border bs).
 
Thats why better send two vials to Jano and in case for retest over 10 EU it is there and not pay shipping again and loose time. Thats what I learned out of these lately.
Do they really need to use the whole vial??
 
That question is only part of the endo problem. I just listened to an old podcast of Huberman's a few days ago where he addressed endo's. I certainly don't always agree with him on everything, but he made a valid point here: Endo's, at an acceptable level, are handled routinely by the body and eliminated. That capacity is how the FDA and other standard-setting agencies consider what is acceptable and set limits. What that doesn't really take into consideration is lipopolysaccharides (endo's) can have an additive and cumulative effect if they are ingested faster than the body can eliminate them, and if the levels rise too quickly, it can reduce the body's ability to eliminate them. Tirz or Reta with acceptable levels, administered every 6 or 7 days, is generally fine. But a lot of people use other peps (mitochondria protocols, inflamatory protocols, GLOW, KLOW, NAD+, bioregulators, Gluta,, etc,etc) any and all with "acceptable levels, and when those levels start adding up, that has the potential to become problematic.
This is an important addition to the endotoxins problem. What if we are getting them from multiple doses of peptides. Best be testing everything!
 

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