Low/non responder to GLP what’s your history?

[TurnipMate]

I am a low responder to Glp/appitite control peptides and wonder if anyone else feels to be the same. Have you just jacked your dose up? Have you experienced side effects? Have you found something that works for you? Do you have an idea what causes it? I’d like to hear from more people with the same experience!

 

[cloratheshadow]

I've seen medical professionals say that low vitamin d has been linked with non-responders. I started taking vitamin d and magnesium and I used to think I was a slow responder but now I seem to be responding really well! Worth looking into!

 

[TurnipMate]

I've seen medical professionals say that low vitamin d has been linked with non-responders. I started taking vitamin d and magnesium and I used to think I was a slow responder but now I seem to be responding really well! Worth looking into!

Thank you I was just about to add vitamin D anyway! just curious what dose were you at before you added vitamin D if you don’t mind sharing?

 

[cloratheshadow]

Thank you I was just about to add vitamin D anyway! just curious what dose were you at before you added vitamin D if you don’t mind sharing?

I was on 5 mg and didn't feel a lot of suppression, maybe for a day or two. Now I am on my 4th week of 7.5 mg and I have a hard time eating more than 800 calories a day, I've even considered lowering my dose or moving fully to Reta. I do stack about 2-3mg a week of Reta but there isn't much suppression there. I also added Cagri which is worth trying! I notice strong suppression even when I don't pin Cagri!

 

[cloratheshadow]

Thank you I was just about to add vitamin D anyway! just curious what dose were you at before you added vitamin D if you don’t mind sharing?

I also recommend using d3 + k2 because the k2 helps you absorb the d3. Also adding a magnesium supplement aids the absorption as well. Eating with a little fat is recommended as well, I just add a fish oil with it! That way you're getting the full benefits!

 

[lastresort]

I've seen medical professionals say that low vitamin d has been linked with non-responders. I started taking vitamin d and magnesium and I used to think I was a slow responder but now I seem to be responding really well! Worth looking into!

Really interesting that vitamin D is involved in so many things

 

[Kique03]

2.5mg dose didn’t do anything for me appetite wise but immediately noticed inflammation benefits. I do feel like I have to keep increasing dose to feel appetite suppression, currently on 10mg just did 2nd pin yesterday.

I am also considering microdosing Reta.

 

[TurnipMate]

2.5mg dose didn’t do anything for me appetite wise but immediately noticed inflammation benefits. I do feel like I have to keep increasing dose to feel appetite suppression, currently on 10mg just did 2nd pin yesterday.

I am also considering microdosing Reta.

how has 10 mg worked for you? i’m currently running 10 mg tirz and 10 mg reta with 1 mg cagril. I am content at my dose still able to eat and have very minimal side effects!

 

[Kique03]

how has 10 mg worked for you? i’m currently running 10 mg tirz and 10 mg reta with 1 mg cagril. I am content at my dose still able to eat and have very minimal side effects!

It's going well but I don't feel appetite is as suppressed as it was when I first started at 5mg and 7.5mg. Thankfully I do have healthier habits since I've started this journey in March. This is why I want to start on Reta now to see if it does anything for me, although I hear not too many people have appetite suppression on Reta.

Still trying to figure out this all out haha.

And wow 10mg tirz and 10mg reta? That is impressive.

 

[aepower2016]

I am currently at 5mg weekly for reta. I started at 1mg and quickly noticed I could go much longer time periods without feeling hungry. Before reta after about 3 hours from my last meal I'd get hungry or at least get the urge to eat a big meal again. On reta, I could miss a meal and still feel ok. I didn't really start to get appetite suppression up until 4mg but it was minimal. I'd still be able to at least finish up the proteins in my plate. However, now at 5mg the fullness feeling really kicks in quick. I even feel a little nauseous while eating now. The nausea stops right after I stop eating my meal so not much of a concern if at all for me.

The food noise has been a problem and to a certain extent still is at 5mg. I find at 5mg the noise is now bearable but still lingers at times. To be fair, I also stopped eating 3 hours before bed since I'm taking tesa/ipa at bedtime. You can easily make the argument I have a new found "will" to fight the noise to ensure optimization of my bedtime protocol. So it's really hard to say reta at 5mg is the primary driver at reducing my food noise at this point.

 

[TurnipMate]

It's going well but I don't feel appetite is as suppressed as it was when I first started at 5mg and 7.5mg. Thankfully I do have healthier habits since I've started this journey in March. This is why I want to start on Reta now to see if it does anything for me, although I hear not too many people have appetite suppression on Reta.

Still trying to figure out this all out haha.

And wow 10mg tirz and 10mg reta? That is impressive.

I started with reta then added tirz if you haven’t already i’d look into cagril if your only looking for more suppression. however if your adding reta for the glucagon receptor then carrol won’t help there. good luck!

 

[jusmypullup]

It's going well but I don't feel appetite is as suppressed as it was when I first started at 5mg and 7.5mg. Thankfully I do have healthier habits since I've started this journey in March. This is why I want to start on Reta now to see if it does anything for me, although I hear not too many people have appetite suppression on Reta.

Still trying to figure out this all out haha.

And wow 10mg tirz and 10mg reta? That is impressive.

I was on 5 mg and didn't feel a lot of suppression, maybe for a day or two. Now I am on my 4th week of 7.5 mg and I have a hard time eating more than 800 calories a day, I've even considered lowering my dose or moving fully to Reta. I do stack about 2-3mg a week of Reta but there isn't much suppression there. I also added Cagri which is worth trying! I notice strong suppression even when I don't pin Cagri!

do u feel like you get the metabolism increase from reta even if u don’t get crazy appetite suppression?I just recently started and have not had much suppression on 3 mg and hope i wont need an unholy amount to feel anything

 

[AngieHolmes]

2.5mg dose didn’t do anything for me appetite wise but immediately noticed inflammation benefits. I do feel like I have to keep increasing dose to feel appetite suppression, currently on 10mg just did 2nd pin yesterday.

I am also considering microdosing Reta.

I'm curious about your idea to microdose reta, even though your appetite didn't respond to a normal dose of tirz. Do you think reta uses a different mechanism? Or?

 

[Kique03]

I'm curious about your idea to microdose reta, even though your appetite didn't respond to a normal dose of tirz. Do you think reta uses a different mechanism? Or?

I'm looking to improve metabolic health alongside the diet and exercise I am doing. Thankfully my eating habits have significantly improved and I do experience some appetite suppression on Tirz, just not as much as others imo.

Where Reta comes in for me is the glucagon receptor, it will help increase fat loss (thermogenesis) which is what I am trying to do.

Increasing muscle mass while trying to achieve fat loss in my experience is slowing the weight loss. So I am looking at Reta to jump start the fat loss. Also trying to focus on lean mass when on the scale instead of lbs, but I'm a Woman who can't help but notice the weight loss slowing down 🤷🏽‍♀️

 

[miameow]

I am a low responder to Glp/appitite control peptides and wonder if anyone else feels to be the same. Have you just jacked your dose up? Have you experienced side effects? Have you found something that works for you? Do you have an idea what causes it? I’d like to hear from more people with the same experience!

I’m really glad you started this thread, because every time I mention that reta did not work for me, I get the reta police asking about my source and my inability to control my food intake.

To answer your questions:

Have you just jacked your dose up?
Yes, but over a six-month period. I titrated steadily by 1 mg every 4 weeks. I did jump from 6 mg to 8 mg in the last month because I thought, YOLO.

Have you experienced side effects?
Severe side effects. The gastrointestinal issues were the worst and persisted throughout the entire 6 months. I also had insane hunger like I’ve never experienced in my entire life, along with incessant daydreaming about food.

Have you found something that works for you?
Not a GLP. I even tried Cagri for one week, but that was unbearable too, so I’ve stopped and am waiting for my Elora.

Do you have an idea what causes it?
Not really. I can only assume it’s some sort of insulin resistance. I’m not diabetic, but my entire family has blood sugar control issues. I’m the only one who is relatively normal because I have the discipline of a German soldier. If I were to let my desires run wild, I would be dead by now, as others in my family have already passed away from complications, some even before the age of 40.

 

[TurnipMate]

Interesting I personally get very mild side effects which made me think low responders also responded low to side effects. I have a buddy who I share a kit with and he’s wiped out by 3 mg of reta a week, if he goes higher he can’t keep any food down. I have a pretty long history of successful natural dieting but now that I don’t weigh all my food I have found i need pretty high doses to not over eat. I haven’t heard of Elora before what does it do? I eventually found the right combination and doses of peptides that gets me enough suppression but I imagine it would wipe any normal person out with the side effects.

 

[diplomat]

Interesting I personally get very mild side effects which made me think low responders also responded low to side effects. ....

Low responder here, but with a different history - heard about the GLP1s a while ago, but only decided to dive in last year.
Skipped the Sema/Tirz 'old school' and went right for the shiny/new Reta. Gently eased up to 12mg over 16 weeks.

Immediate effects were a full feeling in the stomach and awful acid reflux. Unfortunately I had ZERO appetite suppression, I was starving hungry. Not even 'food noise' - I was ravenous!
The reflux was 24/7 and worse when (trying to) sleep. No food 8 hours before bed, no difference. My poor guts were not happy and I had lost a total of 4 pounds from starting weight.

Cut way back on the Reta and added 2mg of Cagri, for it's (alleged) appetite effects....Two months of that put an end to that myth too.

Currently up to 4mg of Survodutide. Two months in, I am down 9 pounds with zero reflux, wonderful sleep and mostly normal heartbeat.

Obviously a whole different effect than yours, TurnipGuy, as all I got was side effects!