Well deserved. I went on the standard quick Zepbound titrate and that was rough once I got to 7.5. OP is doing much faster with a bigger hammer. Of course there is weight loss, but how do we know the loss wouldn’t be the same at lower doses? I guess with no sides it’s no big deal, but why run out of runway so quickly?
Is titrating up too fast unsafe?
- Thread starter Builderman
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Kyli
Recently Joined
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Okay, let's talk about the numbers:
I think this is the chart everyone knows. Let's start from the beginning, at weeks 4 and 8. Why did participants on a higher dose show greater weight loss even at week 4? I'm not buying that it was solely due to stronger appetite suppression. Or look at the 6-month mark / week 24, where the higher doses outperform the 1 mg dose, which plateaued at nearly 8.7% between 6 and 12 Month.
That's why I want to get as soon as possible to the 4mg / week. Pinning 2x a week 2mg. And the plan was to start today with 2mg. But I just increased the dose from 1.5mg to 1.75mg. To see, if everything is fine. And next time I will go up again 0.25mg.
Its a vitamin. You can get anywhere. If you don't feel like going anywhere you can always order from Amazon too 🙂
Wecandothis
GLP-1 Apprentice
appetite suppression didn’t happen for me until I got to 6, so I added a little tirz mid week
Here is a pic, there are many brands though
Attachments
when you hit the wall of GI just slow down and stick to single pin weekly
go with what your body tells you
but when you hit 6mg/8Mg stick as long you can at that dose if you get the desired effect
then titrate up only when hunger is uncontrolable
you can even pin a 2.5 tirz 4 days after your reta shot to keep the last days smooth as butter
but dont rush to 12 mg cause even at 12mg you will hit a wall of your body ajusting and you will need more
at some point GLp1 are your tools to stick to your health diet and not binge eating at night and loose all your progress not just skip eating
hit your steps and do your resistance training 3/4 days a week
its not a sprint
its a freaking long marathon of changing habits etc
Good luck on your journey
its one hell of a ride !
go with what your body tells you
but when you hit 6mg/8Mg stick as long you can at that dose if you get the desired effect
then titrate up only when hunger is uncontrolable
you can even pin a 2.5 tirz 4 days after your reta shot to keep the last days smooth as butter
but dont rush to 12 mg cause even at 12mg you will hit a wall of your body ajusting and you will need more
at some point GLp1 are your tools to stick to your health diet and not binge eating at night and loose all your progress not just skip eating
hit your steps and do your resistance training 3/4 days a week
its not a sprint
its a freaking long marathon of changing habits etc
Good luck on your journey
its one hell of a ride !
1 week on the bathroom puking from every hole
i called it the diarrheatrutide !!! 🤢💩🤢💩😱😨😰😭🤯
Tug Speedman
GLP-1 Novice
🚫No Source Discussion🚫
Question. Is there an ideal receptor concentration that subjects are trying to reach and maintain for something like reta? It's fun playing with the plotter but looking for this missing piece of information. Thanks.
headward
GLP-1 Apprentice
Starting at one then going to three after some weeks isn't too crazy imho. Main risk is temporary GI issues; severe bloating and diarrhea. Not going to die, but is not going to be fun at all. Why people just say go slowly. But 1 to 2 to 3 isn't too crazy an increase imho.
lessthanhalf
GLP-1 Specialist
There are 2 issues I see with your logic. One is that until you start taking the drug you have no idea what doses will do what in you. Effects and side effects from reta or other GLP's are really quite individual and variable, and you have to adjust dose increases based on effects and side effects, and guess at what the higher dose might or might not do based on what is happening at the current dose.
The other is that there are no plateaus anywhere on that graph, yes weight loss rates are definitely slowing down at 12 months, but the real plateau is not till well after a year on reta, and max weight loss is higher at that time 29%, not 24.2% for 12mg. Unless for some special reason you want to start losing the weight fast, I do not see any real advantage in rapid titration of doses, as it does carry higher risks of sudden severe side effects. The difference in weight loss on that graph with faster ramping of doses are at most 1-2%, so fairly small. And rapid initial weight loss can cause problems, mainly extreme fatigue and faintness, but also might make gallstones more likely.
It is worth knowing that significant side effects starting and increasing doses are very common with any GLP, At least 50% get nausea and vomiting, and there is also constipation diarrhoea, and with reta increased heart rate and weird skin sensory symptoms.
Despite that your dose increase scheme is actually pretty safeish, mainly as you are doing twice weekly dosing, as each smaller dose is less of a jump up , blood level rises are less dramatic, and it should only take half a week for levels to drop to pre dose levels, compared to a whole week if dosing is weekly , so if unpleasant side effects happen, they won't last as long. And the more graduated build up in doses is more likely to give you a better indication of what is likely to happen next time you increase the dose, which makes it easier to determine if it is a good idea or not. But there is still the build up of blood levels over 4 weeks at the same weekly dose, so side effects can still be unpredictable. And using glp plotter is always a good idea.
Kyli
Recently Joined
🚫No Source Discussion🚫
I've done a lot of research—read studies, looked into the medical data and science, and also gathered user experiences alongside my own observations. For me, a dosage of around 4 mg/week (or 2 mg twice a week) seems like a nice sweet spot to escalate to, and then to maintain for as long as possible—possibly even combined with cagrilintide or low-dose triz.
The 4 mg/week mark seems to be a good spot where people lose weight, fat, and liver fat at a reasonable pace—not too slow, but not too fast either. And from there, there's plenty of room to escalate to 5, 6, 7, 8, or 9 mg/week if the effects start to flatten out, as well as room to combine it with other peptides like the ones I mentioned.
bogardbilla
GLP-1 Apprentice
Doesn't the fact that so many people are combining GLP-1s tell us that they're underdosing their original GLP-1?
Kyli
Recently Joined
🚫No Source Discussion🚫
I would not phrase it that way. Well, I never saw some one combining Semaglutide with something else. Why? Because on Semaglutide you have the maximal appetite suppression. Reta triggers the same receptors at a much lower rate. So the hunger suppression on Reta is much less.
For some people it might be enough, for others maybe not. Some people might be comfortable with having hunger. Other know that when they enter a supermarket, they will buy some stupid things.
From this point of view, it just makes sense to create your own individual medicine with a combination that suits the personal situation.
Builderman
Recently Joined
🚫No Source Discussion🚫
Reta is different from other glp- the people I see stacking them typically are using reta for the weight loss and triz for the appetite suppression it seems.
Wecandothis
GLP-1 Apprentice
Yes! As you really can’t increase Reta quickly, and tirz has benefits of appetite suppression and decreased inflammation.
I see a risk that you could fatigue your receptors faster than desired and it could quit working sooner than for most people.
Bioexplorer
GLP-1 Apprentice
I keep seeing these claims that Tirz has a greater effect on inflammation than Reta. Is this mainly anecdotal or is there some hard evidence supporting this?
Google and various AI queries mainly answer with 'inconclusive' because Reta studies are still underway. But overall, Reta is expected to have a stronger effect on inflammation than Tirz. Especially when liver and kidney inflammation is included. Am I missing some key info?
Builderman
Recently Joined
🚫No Source Discussion🚫
Interesting. I hadn’t thought of it from this perspective. Actually makes a lot of sense though.
lessthanhalf
GLP-1 Specialist
Not trying to be excessively critical here, but this just is not how receptors work, and not how these drugs work.
People on this forum do sometimes add low dose sema to a higher dose of reta for a bit extra GLP-1 agonism, and it can work. Adding cagri makes more sense as it works on a different receptor system, amylin.
All three receptors - GLP-1, GIP and Glucagon affect hunger or appetite, not just GLP-1, and the effects are not on or off , even at maximum doses not all receptors are maximally stimulated, but it is getting close. The effect on reducing hunger is generally proportional to dose with higher doses reducing hunger more, and having more side effects, the maximum doses chosen by the drug companies are on average around the point where higher doses cause little extra weight loss for a lot more side effects in most people.
The effects on the different receptors is far more complex than which one is more potent, and in terms of maximal downstream effects from GLP activation it probably goes sema>tirz>reta, but allowing for differences in dosing it is most likely tirz>reta>sema. Tirz has a complex mode of action on GLP-1 with biased agonism on the receptor that alters the downstream effects, and makes it work better with less side effects.
There really is no good evidence that reta suppresses hunger less than tirz or sema, just internet talk, the fact that it causes more weight loss pretty much makes it impossible for that to be true, even allowing 1-200 kcal of extra energy expenditure from the glucagon agonism. I would regard the appetite suppressing effects as reta and tirz about the same, maybe tirz is marginally stronger and sema a long way behind.
Sema is different to reta and tirz in that it lacks the GIP agonism, GIP also suppresses hunger , but more usefully also counteracts some of the adverse effects of GLP-1 agonism, mainly nausea, vomiting, malaise and food aversion, it is these stronger side effects of GLP-1 agonism that make sema look like it is stronger, but it causes less weight loss than tirz or reta due to suppressing appetite less. I put up with a year of taking low dose sema with malaise, nausea and hunger, before I discovered other options, and had much better hunger control and a lot less side effects on 15mg tirz plus 5 of reta compared with 0.8mg of sema.
The total effect of these drugs is a complex sum of all the different receptor effects, and their interactions as they are often present on the same cells, the downstream secondary responses of those cells and the body's adaptive responses to these effects. There are no doses where effects start or stop . I do not disagree that going by the numbers in the studies 4mg of reta looks like a good balance between most of the weight loss with a fairly low rate of side effects, but until you get there there is no way to know if you will respond the same as the study averages, as from my experience and on this forum, effects and side effects at different doses vary a lot between individuals. And adjusting doses to get a reasonable amount of appetite reduction with the least side effects is usually the best approach.
Bioexplorer
GLP-1 Apprentice
And to quantify "a reasonable amount of appetite suppression", is it safe to say a dose that provides around 0.5 to 1% weight loss per week on average? That seems to be the most common recommendation for safe weight loss without excessive lean mass loss.
dolph
GLP-1 Novice
🚫No Source Discussion🚫
bogardbilla
GLP-1 Apprentice
Fortune favors the brave!
BNLFL
GLP-1 Specialist
17hrs isn't shit, give it time. It's not like coke or other drugs.
dolph
GLP-1 Novice
🚫No Source Discussion🚫
Peak circulation is about 24hr after injection. If I don't feel anything peculiar in a few hours, I'm claiming victory this week.
joseblo
GLP-1 Enthusiast
My peak sides and appetite suppression is 48-72hr for Reta.
I don't typically feel much at all at 24hr. Your colon could be building bowling balls, about to blowout... or both! Give it a few days.
dolph
GLP-1 Novice
🚫No Source Discussion🚫
Ahhh, the poops. Yes, they've been perfectly normal so far so I forget constipation could be a side effect. I'm mostly concerned with nausea, vomiting and overall junky feeling.
When the original Tirz research began, the day after the first two doses the RS felt like hot garbage. Fortunately, that hasn't happened since.
I'll add some Colon Blow to the ole Amazon cart just in case.
When the original Tirz research began, the day after the first two doses the RS felt like hot garbage. Fortunately, that hasn't happened since.
I'll add some Colon Blow to the ole Amazon cart just in case.
Cluni0n
GLP-1 Novice
🚫No Source Discussion🚫
I’ve just had my canon event; I’m in my third week: 0.5, 1.0, 1.0, and last night I thought, ‘Hmm, well, I haven’t had that many side effects, so maybe I could inject another 0.5, so my dose would be 1,5mg per week…’
Guess who was feeling super bloated at 3 pm today and threw up everything in her stomach🫠
Guess who was feeling super bloated at 3 pm today and threw up everything in her stomach🫠
tendency
GLP-1 Enthusiast
My wife lost 35lb in 4.5 months never going above 2.5mg every 6 days. She started at 1mg for the first 4 weeks and we bumped .5mg every 4 weeks after that.
Start low and go slow - some people really respond aggressively.
Start low and go slow - some people really respond aggressively.
BNLFL
GLP-1 Specialist
Yes, we have a new Smiter!
dolph
GLP-1 Novice
🚫No Source Discussion🚫
Me? Should I go find a corner with my new box of cereal?
