What's the Best GLP-1 to purchase that has the least Side effects

Sunrise208

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I am currently on Tirz but question myself if would it be better to make a move to Retatrutide or one of the others. I have lost about 20 + and have anoth 30 to go so just asking for your experience.
 
Try a dose of sema and see how you go. 0.5mgs should be ok if you already have experience with tirz. Most ppl get sides with sema after 1mg doses.
 
Sunrise208 said:
I am currently on Tirz but question myself if would it be better to make a move to Retatrutide or one of the others. I have lost about 20 + and have anoth 30 to go so just asking for your experience.
Click to expand...
Why are you wanting to switch? Are you losing super slowly, having sides, FOMO?

I've had a lot of success with tirz that I've worked up to 15mg/week over the past year, but have dabbled with Reta and Cagri just to see if it could speed things up. So far, I've been unimpressed, but it seems to be highly variable from person to person.

Recently, I've decreased the amount of days between tirz shots, and I'm satisfied again. I'm coming off of my best month in like half a year, so I may just keep doing tirz solo for the time being.

I recommend considering the same tactic as long as tirz is working.
 
I was having good success on tirz, but swapped to reta because of the higher reduction in fatty liver deposits (My ALT is the only "bad" item on my bloodwork) and less muscle loss.

It has increased my resting heart rate by about 12, so that's fairly significant. tirz did increase my resting heart rate as well, but only by about 5.

If you don't have specific reasons to swap, and one is working for you, I wouldn't swap.
 
I think Reta is a little overblown, saw some people saying it cured their adhd which seems not likely. If you’re trying to lose a decent chunk of weight with tirz expect plateaus from time to time, can go from loss everyday to stalling for 2 weeks. I would try the approach Dewayne suggested before considering Reta
 
Start low and go slow. Treat the early side effects for comfort. Side effects really do improve with time. Severe side effects? seek medical attention.
 
glpfun said:
I think Reta is a little overblown, saw some people saying it cured their adhd which seems not likely. If you’re trying to lose a decent chunk of weight with tirz expect plateaus from time to time, can go from loss everyday to stalling for 2 weeks. I would try the approach Dewayne suggested before considering Reta
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I've seen a decent amount of people talking about GLP1s and ADHD in general, and on the surface, the science does seem to make sense.

Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol - PMC

The role of glucagon-like peptide 1 (GLP-1) in insulin-dependent signaling is well-known; GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in diabetes. GLP-1 receptors (GLP-1R) are also widely expressed in the brain, and ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

We know they have impact on the dopamine reward system. We also know that the dopamine reward system is considered dysfunctional in ADHD.

Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications - PMC

Attention-deficit/hyperactivity disorder (ADHD)—characterized by symptoms of inattention and hyperactivity-impulsivity—is the most prevalent childhood psychiatric disorder that frequently persists into adulthood, and there is increasing evidence of ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

I'm no expert here, and my understanding is that there is more to ADHD than just the dopamine stuff, but it seems feasible to my layperson understanding that GLP1s could help treat at least a portion of ADHD. If that portion is the thing that is most negatively impacting someone, it could possibly seem like a an ADHD "cure"
 
DwightTheDelight said:
Why are you wanting to switch? Are you losing super slowly, having sides, FOMO?

I've had a lot of success with tirz that I've worked up to 15mg/week over the past year, but have dabbled with Reta and Cagri just to see if it could speed things up. So far, I've been unimpressed, but it seems to be highly variable from person to person.

Recently, I've decreased the amount of days between tirz shots, and I'm satisfied again. I'm coming off of my best month in like half a year, so I may just keep doing tirz solo for the time being.

I recommend considering the same tactic as long as tirz is working.
Click to expand...

what's your current split for the 15mg?

I'm at 15mg every 6 days which is pretty much equal to 17.5mg every 7 days. im pushing tirz to the higher trial doses before stacking or switching anything else up first. already down 77lbs with tirz only so pushing a bit for science (lol) for these last 25ish pounds
 
normal said:
what's your current split for the 15mg?

I'm at 15mg every 6 days which is pretty much equal to 17.5mg every 7 days. im pushing tirz to the higher trial doses before stacking or switching anything else up first. already down 77lbs with tirz only so pushing a bit for science (lol) for these last 25ish pounds
Click to expand...

I'm on the exact same split. 15 every 6 days and it's crazy how much that has helped.

Congrats on your 77lbs btw!
 
hexagonal said:
I was having good success on tirz, but swapped to reta because of the higher reduction in fatty liver deposits (My ALT is the only "bad" item on my bloodwork) and less muscle loss.

It has increased my resting heart rate by about 12, so that's fairly significant. tirz did increase my resting heart rate as well, but only by about 5.

If you don't have specific reasons to swap, and one is working for you, I wouldn't swap.
Click to expand...
How did tirz increase your heart rate when tirz has no effect on glucagon? Glucagon yes can increase your heart rate (so reta).
 
normal said:
Thank you!! How long have you been on the 15/6 split? Any plans to push it further to 15/5 or just go straight 20mg/25mg every 7?
Click to expand...

I've been doing it for a month now. I'll be open to increasing the dose further if it's needed, hopefully I can hang out at 15/6 days for a while though
 
normal said:
Thank you!! How long have you been on the 15/6 split? Any plans to push it further to 15/5 or just go straight 20mg/25mg every 7?
Click to expand...
It would be interesting to find out later down the track if they will trial the same thing with reta or not? Currently max weekly accepted dose is 12mg a week. I wonder if they may bum it up to like 16mg a week? In terms of strength and this is my personal opinion, reta is stronger than tirz. Sema is stronger than them both. I was not able to tolerate 1.5mgs of sema without severe sides. My max dose is 1mg even that I dont prefer. I can have 0.8 comfortably. With tirz I pushed 5 then 7.5 then 10 then even 12.5 but with no sides other than a bit of fatigue the day after injection. Reta I had racy thoughts as my main sides but pushed 2mgs then 4 then 6 then 8mgs. Still does not compare with Sema max dose my body likes of 0.8-1mg max before I start violently throwing up and non stop diarrhoea. Sema is one powerful drug man …
 
Lullabytreehugger said:
How did tirz increase your heart rate when tirz has no effect on glucagon? Glucagon yes can increase your heart rate (so reta).
Click to expand...

The Cardiovascular Effect of Tirzepatide: A Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Dual Agonist - PMC

Glucagon-like peptide-1 (GLP-1) receptor agonists have been used extensively in the clinic and have an established safety profile in cardiovascular disease settings. For the treatment of peptide-secreting enteroendocrine cells, most research has ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

It is consistently reported in studies that tirzepatide can increase RHR.
 
RHR elevation during 4 weeks period of 1.25mg tirzepatide every 4 days:
 

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I’ve had really good results with Reta. I had Gastro issues with both Sema and Tirz, as well as some low energy days. Worst still I had persistent Gout outbreaks which went from 1-2 times per year to every 2 weeks.

I took a chance on Reta having read that it helped with fatty liver which I suspected was the root cause for some of my issues. 10 weeks in I am down 27 lbs, no gout, no gastrointestinal issues and good energy levels. The skin tags i had (fatty liver symptom) were gone a month in.
 
ruisenor said:
I’ve had really good results with Reta. I had Gastro issues with both Sema and Tirz, as well as some low energy days. Worst still I had persistent Gout outbreaks which went from 1-2 times per year to every 2 weeks.

I took a chance on Reta having read that it helped with fatty liver which I suspected was the root cause for some of my issues. 10 weeks in I am down 27 lbs, no gout, no gastrointestinal issues and good energy levels. The skin tags i had (fatty liver symptom) were gone a month in.
Click to expand...

Now that you mention it, I'm just realizing all of my skin tags have vanished too.

Was all of that weight loss from Reta or did you have some initial loss from the sema and tirz?

Congrats on your progress btw!
 
DwightTheDelight said:
Now that you mention it, I'm just realizing all of my skin tags have vanished too.

Was all of that weight loss from Reta or did you have some initial loss from the sema and tirz?

Congrats on your progress btw!
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Thanks- it was all on Reta, tried Sema and Tirz last year.
 
To say that it’s super individualized is an understatement. I took brand name Ozempic for 5 months and lost no weight while feeling like complete garbage for the whole 5 months. Then I switched to grey market tirz for 4 months and felt better but didn’t lose any weight until I added phentermine for appetite suppression.

I stopped the tirz because it wasn’t working and switched to Contrave over some blood pressure concerns. I had crazy side effects to contrave AND gained weight on it so I decided to order some Reta and use up the last bottle of tirz that I ordered last year just to get back into the swing of things. For some bizarre reason, I’m having fantastic appetite suppression without phentermine on this bottle of tirz; it only starts to wear off on day 6/7.

Now a month later I have 400mg of Reta in hand and I’m wishing I had ordered tirz instead because I’m down 5lbs this month. So here’s to hoping that Reta works well for me and I don’t need to keep my appointment with my doc next month to get more phentermine.
 
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CallieKat said:
Start low and go slow. Treat the early side effects for comfort. Side effects really do improve with time. Severe side effects? seek medical attention.
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I'm brand new to all of this so please forgive my ignorance. I'm on my 2nd week of tirz & have had zero side effects. Is that typical? Thanks in advance for any info
 
AreYouSureorNo said:
I'm brand new to all of this so please forgive my ignorance. I'm on my 2nd week of tirz & have had zero side effects. Is that typical? Thanks in advance for any info
Click to expand...
Lots of people have no (or minimal) side effects. I had a little bit of constipation but I resolved it pretty easily by upping my fiber intake and drinking more water. (Both of which I needed to do anyway, really.) Also a bit of a resting heart rate increase, but not a ton. Larger increase on reta.
 
AreYouSureorNo said:
I'm brand new to all of this so please forgive my ignorance. I'm on my 2nd week of tirz & have had zero side effects. Is that typical? Thanks in advance for any info
Click to expand...
Some people have very little side effects, some have a ton. Some people respond very strongly immediately, some people need to titrate up. Keep an eye on what you eat and the scale. You may need to go up, or you may react well to a small dose and lose weight without side effects. Go slow and see what happens. If there isn't much difference by your fourth week, go up in dose.

I started with sema and had zero side effects with the minimum dose and all the benefits. I eventually moved to every 5-6 days instead of 7, then half the minimum dose 2-3 times a week based on how I felt. The benefit of grey is you're completely in control of your doses and schedule. Smaller doses more frequently makes me have the benefits with almost no side effects at all.
 
Anyone noticed a change in their blood pressure from Tirz? Either higher or lower?

I have major white coat syndrome and my home device isn't the most reliable, so curious what y'all have experienced.
 
YoYoFat said:
Anyone noticed a change in their blood pressure from Tirz? Either higher or lower?

I have major white coat syndrome and my home device isn't the most reliable, so curious what y'all have experienced.
Click to expand...
Major blood pressure drop within a month of starting, but in my case it took me from the danger zone to completely normal and it's stayed there ever since.
 
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