Anyone with tesamorelin experience?
- Thread starter ScarFace
- Start date
latviantower
GLP-1 Enthusiast
I’ve had better luck with tesamorelin than ipamorelin/cjc1295. Following some extensive reading about the clinical trials of Egrifta (brand name), I’m almost through a 26 week run of tesa- 2 mg daily, 5 on, 2 off. Between the tesa and tirz, melted off a ton of both visceral and subq fat. I recon 10 mg tesa with 2.5 ml BAC, pin 50 units (2 mg) before bed Mon-Fri.
Good luck!
Good luck!
I have been pinning tessa/ipmorelin for about 4 weeks. I am on 20 mg of tirz. I want to avoid more muscle loss from the weight loss. The first week I just used tesa by itself. I noticed a definite increase in my resting pulse rate. I noticed I fall asleep faster but I woke up a little more often than normal during the night. I stopped losing noticable muscle mass after starting. I am a little more hungry from the ipmorelin. I am getting close to my final weight goal. I am hoping to turn the visceral fat weight to muscle. So far I am happy with it although the pulse increase scared me a little.
At the moment I am just on Reta but even on this I have noticed a slight loss in muscle mass not enough to be seen visually but I do measure myself and have lost almost half a inch on my biceps which is why I’m wondering if switching to tesamorelin could be better and also help get rid of the last bit of stubborn belly fat that’s left. My plan was to stack Reta with CJC no dac + ipamorelin for muscle retention and TB 500 for muscle recovery as I do quite physical work + working out and was going to throw GHKCU in there aswell just for better skin not sure if you know much about stacking but does this sound like a good stack for what I’m trying to do?
latviantower
GLP-1 Enthusiast
Yes that was my gripe with ipa - food noise started coming back (on 15 mg tirz) and I stopped losing.
We have very simular situations. I have a very physical job as well. I swim and work out quite a bit also. From everything I read tesa is better than CJC. Mixing with Ipamorelin supposedly makes tesa work much better. I have only been using it for about a month but I believe it's definitely working at keeping me from losing muscle mass. My strength seems to be increasing also. About 3 weeks ago I started ghk-cu and bpc. I just added kpv and tb500. Old injuries seem to be getting better. Less pain might allow me to lift heavier weight. Or it could just be the tessa/ip. I am probably adding Peps too fast but so far it has been great.
That’s good news then that means I can get it out the freezer and give it a whirl.
I was also concerned about adding in peps too fast and too many at a time just out of curiosity what is your pinning routine?
Nice thanks for the insight really appreciate it wishing you the best of luck mate
Tesamorelin, Ipamorelin, CJC-1295, all did zero for me. I don’t think any of them can make a measurable difference. How old are you, and do you have any health issues that would prevent you from taking regular, proven HGH rather than wasting money on a bunch of ineffective secretagogues of GHRH analogous?
I’m 26 and don’t have any health issues what would you suggest?
You are so young that you probably produce a good amount of GH on your own and don’t really need any of it. You would probably see benefits in your skin, and burn some visceral fat with 1 to 2iu HGH daily about an hour before bed on an empty stomach. If you are you trying to build serious muscle, then maybe 3-4iu. I would never go above 4iu at 26 years of age.
Calm Logic
GLP-1 Specialist
If you are curious, I would get blood tested for IGF-1 to see where you are at. I did that even at my age of 48. Fitomics (which has direct-to-consumer lab ordering) was the cheapest for IGF-1 testing, even with their membership fee. Most guys are curious at least about their testosterone level, and primary care is used to ordering that.
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latviantower
GLP-1 Enthusiast
Personally I give the credit for reduced pain, healing and better workout recovery to BPC and TB500, with GHK and KPV assisting. I started those first and got relief. Speedier workout recovery especially noteworthy. I only added the ipa and tesa later for fat burning.
Tesa and ip are used to get your body to make more hgh. Of course pinning hgh will work much better. I am 63 and Im sure I can benefit from hgh because your body decreases production as you get older. Right now I am mostly concentrating on losing weight. I do plan on adding muscle building substances eventually. When I do I will take the suggested blood tests to insure safety. You are lucky, I think you reside in a country where posession of hgh is legal. You are smart to learn from the fine people on this forum about their experience with these substances.
Calm Logic
GLP-1 Specialist
Personally, my baseline was being clinically low for testosterone but above average for my age for IGF-1. So though I like everything under the sun including HGH, I like TRT a lot more.
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Mr. Blonde
GLP-1 Apprentice
I got a kit of tesamorelin and can't wait to start pinning. Hopefully, I get the sleep benefits that others rave about. I did cjc1295/ipa in the past for 8weeks and it wrecked my sleep from night 1.
Fingers crossed
Fingers crossed
Another side effect of Tesa/ip I forgot to mention earlier is it causes me to retain water. I pin it from Monday through Friday. I take a break Saturday and Sunday. From last night to this morning I lost about 9 pounds of water weight. I guess it takes a couple of days for the water weight to start comming off. (Peeing like crazy!!) I wonder if it is a side effect of the tesa/ip or hgh itself. Does anyone taking hgh have that side effect?
Just started Tesa last week, and I too can feel the water weight. Prior to the GLP1 adventure, I have been taking hydrochlorothiazide for years as a first-line blood pressure treatment, and when I would forget to take it, the biggest sign would be edema in my ankles. With Tesa, it feels very different, I can tell the water retention is in my core. Subtle but weird feeling.
Anyway, first few days I would have to piss very frequently, peaking every 30min for a while, and no longer than 4hrs at night. It seems to have settled out to 3-5hrs but that's still pretty bothersome. OTOH I can tell the fat metabolism from Tirz/Reta is continuing by the color and smell, so... yeah, bad water out....
(FWIW, Tesamorelin 2mg + 0.2mg CJC1295noDAC + 0.2mg Ipamorelin, nightly a few hours after last food. Aiming for reduction in visceral fat/too much torso stuffing in the bear. I can feel bodily conditions changing, but it'll be a few weeks before I have some sense of the effect, and can connect the sensations to the outcomes. Weird to watch and wait.)
Anyway, first few days I would have to piss very frequently, peaking every 30min for a while, and no longer than 4hrs at night. It seems to have settled out to 3-5hrs but that's still pretty bothersome. OTOH I can tell the fat metabolism from Tirz/Reta is continuing by the color and smell, so... yeah, bad water out....
(FWIW, Tesamorelin 2mg + 0.2mg CJC1295noDAC + 0.2mg Ipamorelin, nightly a few hours after last food. Aiming for reduction in visceral fat/too much torso stuffing in the bear. I can feel bodily conditions changing, but it'll be a few weeks before I have some sense of the effect, and can connect the sensations to the outcomes. Weird to watch and wait.)
Woah didn’t expect 9lb… do you have to pin it Monday to Friday or can you do it every other day and see if that makes a difference?
That is a good question. It did take 2 days off before it was peed away so I don't think 1 day off would do much. It was strange. I started thinking the tirz was stalled. I started thinking about stacking cag or surv. I was greatly relieved after peeing out 9 lbs. That brought my weight down to a new record low by 2 pounds like normal. What a relief. The tesa/ip is just temporary till I lose visceral weight and protect muscle mass. So far it seems to be working as intended.
Okay appreciate the insight sounds like it could be a good option for me temporarily as a alternative to HGH for presentation purposes
Calm Logic
GLP-1 Specialist
Bumping this thread with Google Gemini:
"What HGH does that Tesamorelin doesn't is provide a direct, exogenous source of the hormone. Because of this, HGH can have a broader and potentially more powerful effect on overall growth, tissue repair, and metabolism, which can be both a benefit and a source of more significant side effects. Tesamorelin is more targeted, specifically for its effects on fat reduction, and works by leveraging the body's own systems."
OTOH, from the Seeds book:
"What HGH does that Tesamorelin doesn't is provide a direct, exogenous source of the hormone. Because of this, HGH can have a broader and potentially more powerful effect on overall growth, tissue repair, and metabolism, which can be both a benefit and a source of more significant side effects. Tesamorelin is more targeted, specifically for its effects on fat reduction, and works by leveraging the body's own systems."
OTOH, from the Seeds book:
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Calm Logic
GLP-1 Specialist
From 2017, a signification reduction in cholesterol, in a 12-week study of tesa, given 2 mg daily (vs 1 mg or none) in T2D patients (≥50 years of age):
journals.plos.org
Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial
Objective Use of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or control of diabetes. Design A 12-week...
journals.plos.org
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latviantower
GLP-1 Enthusiast
That’s great to know - thanks for sharing. Getting updated lab work tomorrow to see if new statin dose lowered my LDL - if it’s down I can always credit the tesamorelin!From 2017, a signification reduction in cholesterol, in a 12-week study of tesa, given 2 mg daily (vs 1 mg or none) in TD2 patients (≥50 years of age):
Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial
Objective Use of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or control of diabetes. Design A 12-week...
I had a similar experience. Started taking Tesa/Ipa a few weeks ago. At first 1MG/day, 5 days a week. All was good. But last week I increased to 1.5MG/day and could tell I retaining water. I actually added a pound of weight during the week and I started thinking the Tirz had stalled. But then I rested this past Saturday and Sunday and my weight this morning, Tuesday, was 5 lbs lighter than it was on Saturday.
In week four now, Tesamorelin 2mg + 0.2mg CJC1295noDAC + 0.2mg Ipamorelin, nightly 7days/week. This is on top of the GLP1.
Yep, it set me back 7-8lbs of water weight, and it definitely blunts the food noise supression of the GLP1. Tesamorelin is a finicky bastard to reconstitute, and one batch/kit just won't stop gelling even with low-pH water. But the good batch reconstitutes ok, mixes well w CJIPA, and the results are two more notches on the belt. Changes in body geometry/dimension are surprising even if the scale readings have slowed down ...and the biggest change is being able to go on a 1.5hr hike on Friday without getting winded. Two months ago I woulda started wheezing at 10min. Will continue.
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