Mazdutide - 48 week study using doses as high as 16 mg

[keangkong]

In this 48 week study, mazdutide was given in different dosages. The study lasted 48 weeks. People who took 16 milligrams of mazdutide lost slightly over twice as much weight as those taking only six milligrams. Granted the people taking six milligrams actually spent the majority of their time on 3 milligrams and went to six milligrams towards the end of the study. At the highest dose, 60% of patients experienced nausea.

Hsia, et al. (Poster - Obesity Week 2025). Mazdutide (LY3305677) in Participants With Obesity or Overweight - A Phase 2 Dose-Finding Study. https://assets.ctfassets.net/mpejy6...5_HSIA_MAZDUTIDE_SYMPOSIUM_DV-037120_V4.7.pdf

Those taking the highest dosage, 16 milligrams, lost an average of 22% of their bodyweight during that time period.

That close to the 24% of weight that folks taking the maximum dose of reta lost in a similar time period. Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972.

 

[Peptidase]

Man thank you for posting these. I know everyone is "yay reta" and it's great stuff but other agents work pretty well.

 

[keangkong]

Man thank you for posting these. I know everyone is "yay reta" and it's great stuff but other agents work pretty well.

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

 

[miss-sanne]

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

thanks for this post, great reading.
keep us postet on your maz. what dose are you on now ?