keangkong
GLP-1 Specialist
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In this 48 week study, mazdutide was given in different dosages. The study lasted 48 weeks. People who took 16 milligrams of mazdutide lost slightly over twice as much weight as those taking only six milligrams. Granted the people taking six milligrams actually spent the majority of their time on 3 milligrams and went to six milligrams towards the end of the study. At the highest dose, 60% of patients experienced nausea.
Hsia, et al. (Poster - Obesity Week 2025). Mazdutide (LY3305677) in Participants With Obesity or Overweight - A Phase 2 Dose-Finding Study. https://assets.ctfassets.net/mpejy6...5_HSIA_MAZDUTIDE_SYMPOSIUM_DV-037120_V4.7.pdf
Those taking the highest dosage, 16 milligrams, lost an average of 22% of their bodyweight during that time period.
That close to the 24% of weight that folks taking the maximum dose of reta lost in a similar time period. Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972.
Hsia, et al. (Poster - Obesity Week 2025). Mazdutide (LY3305677) in Participants With Obesity or Overweight - A Phase 2 Dose-Finding Study. https://assets.ctfassets.net/mpejy6...5_HSIA_MAZDUTIDE_SYMPOSIUM_DV-037120_V4.7.pdf
Those taking the highest dosage, 16 milligrams, lost an average of 22% of their bodyweight during that time period.
That close to the 24% of weight that folks taking the maximum dose of reta lost in a similar time period. Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972.
