Mazdutide - 48 week study using doses as high as 16 mg

[keangkong]

In this 48 week study, mazdutide was given in different dosages. The study lasted 48 weeks. People who took 16 milligrams of mazdutide lost slightly over twice as much weight as those taking only six milligrams. Granted the people taking six milligrams actually spent the majority of their time on 3 milligrams and went to six milligrams towards the end of the study. At the highest dose, 60% of patients experienced nausea.

Hsia, et al. (Poster - Obesity Week 2025). Mazdutide (LY3305677) in Participants With Obesity or Overweight - A Phase 2 Dose-Finding Study. https://assets.ctfassets.net/mpejy6...5_HSIA_MAZDUTIDE_SYMPOSIUM_DV-037120_V4.7.pdf

Those taking the highest dosage, 16 milligrams, lost an average of 22% of their bodyweight during that time period.

That close to the 24% of weight that folks taking the maximum dose of reta lost in a similar time period. Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972.

 

[Peptidase]

Man thank you for posting these. I know everyone is "yay reta" and it's great stuff but other agents work pretty well.

 

[keangkong]

Man thank you for posting these. I know everyone is "yay reta" and it's great stuff but other agents work pretty well.

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

 

[miss-sanne]

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

thanks for this post, great reading.
keep us postet on your maz. what dose are you on now ?

 

[keangkong]

thanks for this post, great reading.
keep us postet on your maz. what dose are you on now ?

I use a quite unconventional dosing schedule. For most folks, it's overly complicated. I use an Excel sheet I found on Peppys that calculates how much mazdutide I have in the body. That figure is on the right. The figure on the left is how much I inject each day. As you can see, I ignore the hundredth column. My goal is to raise the level of mazdutide in my blood by .2 every day. Although there is a big range for the half-life of mazdutide, I used a 10 day half-life for the calculator. I read somewhere that 10 days is the average half-life of mazdutide although I don't recall which of the sources I provided states that. The figures in bold on the left are for days that haven't happened yet.


10 day

 

[geoguy78]

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

So you're using mazdutide solo? It seems almost everyone is stacking mazdutide and survodutide so not a lot of feedback available from people using them on their own. I'll be very curious how it works for you, if you're not stacking. If you are stacking, just ignore me 🤣

 

[miss-sanne]

I use a quite unconventional dosing schedule. For most folks, it's overly complicated. I use an Excel sheet I found on Peppys that calculates how much mazdutide I have in the body. That figure is on the right. The figure on the left is how much I inject each day. As you can see, I ignore the hundredth column. My goal is to raise the level of mazdutide in my blood by .2 every day. Although there is a big range for the half-life of mazdutide, I used a 10 day half-life for the calculator. I read somewhere that 10 days is the average half-life of mazdutide although I don't recall which of the sources I provided states that. The figures in bold on the left are for days that haven't happened yet.

View attachment 9794
10 day

why do you dose every day ?
that's quite thorouh ! 🙂

 

[keangkong]

So you're using mazdutide solo? It seems almost everyone is stacking mazdutide and survodutide so not a lot of feedback available from people using them on their own. I'll be very curious how it works for you, if you're not stacking. If you are stacking, just ignore me 🤣

I won't ignore you: I also take tirzepatide. I take 1.1 mg per day. I don't exceed that dose for tirzepatide because it tends to make me tired and causes GI problems when I exceed that.

 

[keangkong]

why do you dose every day ?
that's quite thorouh ! 🙂

These medicines are not tested using once per day dosing. That's a good reason not to the newer GLP-1 medicines once per day.

I take them once per day to give my body a chance to adapt. This also avoids the peaks and valleys. I believe the once per week dosing is based upon most people not wanting to inject once per day. I believe this minimizes side effects. Trials would need to be conducted to determine whether my belief turns out to be correct.

 

[miss-sanne]

I think you are right, per protocol, just easier in trials.
I do reta and cagri twice a week, and have no side effects.
I don't like the hole of food noise on day 5 and 6 if dosing weekly.
Trials needed.