Mazdutide - 48 week study using doses as high as 16 mg

[keangkong]

In this 48 week study, mazdutide was given in different dosages. The study lasted 48 weeks. People who took 16 milligrams of mazdutide lost slightly over twice as much weight as those taking only six milligrams. Granted the people taking six milligrams actually spent the majority of their time on 3 milligrams and went to six milligrams towards the end of the study. At the highest dose, 60% of patients experienced nausea.

Hsia, et al. (Poster - Obesity Week 2025). Mazdutide (LY3305677) in Participants With Obesity or Overweight - A Phase 2 Dose-Finding Study. https://assets.ctfassets.net/mpejy6...5_HSIA_MAZDUTIDE_SYMPOSIUM_DV-037120_V4.7.pdf

Those taking the highest dosage, 16 milligrams, lost an average of 22% of their bodyweight during that time period.

That close to the 24% of weight that folks taking the maximum dose of reta lost in a similar time period. Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972.

 

[Peptidase]

Man thank you for posting these. I know everyone is "yay reta" and it's great stuff but other agents work pretty well.

 

[keangkong]

Man thank you for posting these. I know everyone is "yay reta" and it's great stuff but other agents work pretty well.

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

 

[miss-sanne]

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

thanks for this post, great reading.
keep us postet on your maz. what dose are you on now ?

 

[keangkong]

thanks for this post, great reading.
keep us postet on your maz. what dose are you on now ?

I use a quite unconventional dosing schedule. For most folks, it's overly complicated. I use an Excel sheet I found on Peppys that calculates how much mazdutide I have in the body. That figure is on the right. The figure on the left is how much I inject each day. As you can see, I ignore the hundredth column. My goal is to raise the level of mazdutide in my blood by .2 every day. Although there is a big range for the half-life of mazdutide, I used a 10 day half-life for the calculator. I read somewhere that 10 days is the average half-life of mazdutide although I don't recall which of the sources I provided states that. The figures in bold on the left are for days that haven't happened yet.


10 day

 

[geoguy78]

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

So you're using mazdutide solo? It seems almost everyone is stacking mazdutide and survodutide so not a lot of feedback available from people using them on their own. I'll be very curious how it works for you, if you're not stacking. If you are stacking, just ignore me 🤣

 

[miss-sanne]

I use a quite unconventional dosing schedule. For most folks, it's overly complicated. I use an Excel sheet I found on Peppys that calculates how much mazdutide I have in the body. That figure is on the right. The figure on the left is how much I inject each day. As you can see, I ignore the hundredth column. My goal is to raise the level of mazdutide in my blood by .2 every day. Although there is a big range for the half-life of mazdutide, I used a 10 day half-life for the calculator. I read somewhere that 10 days is the average half-life of mazdutide although I don't recall which of the sources I provided states that. The figures in bold on the left are for days that haven't happened yet.

View attachment 9794
10 day

why do you dose every day ?
that's quite thorouh ! 🙂

 

[keangkong]

So you're using mazdutide solo? It seems almost everyone is stacking mazdutide and survodutide so not a lot of feedback available from people using them on their own. I'll be very curious how it works for you, if you're not stacking. If you are stacking, just ignore me 🤣

I won't ignore you: I also take tirzepatide. I take 1.1 mg per day. I don't exceed that dose for tirzepatide because it tends to make me tired and causes GI problems when I exceed that.

 

[keangkong]

why do you dose every day ?
that's quite thorouh ! 🙂

These medicines are not tested using once per day dosing. That's a good reason not to the newer GLP-1 medicines once per day.

I take them once per day to give my body a chance to adapt. This also avoids the peaks and valleys. I believe the once per week dosing is based upon most people not wanting to inject once per day. I believe this minimizes side effects. Trials would need to be conducted to determine whether my belief turns out to be correct.

 

[miss-sanne]

I think you are right, per protocol, just easier in trials.
I do reta and cagri twice a week, and have no side effects.
I don't like the hole of food noise on day 5 and 6 if dosing weekly.
Trials needed.

 

[keangkong]

I think you are right, per protocol, just easier in trials.
I do reta and cagri twice a week, and have no side effects.
I don't like the hole of food noise on day 5 and 6 if dosing weekly.
Trials needed.

No side effects? That's great!

 

[miss-sanne]

No side effects? That's great!

I did have some annoying side effects on tirz, like sulfur burps, a bit of diahhrea, sleep trouble in the beginning. but nothing too bad.
oh, just forgot, i have the reta crazy dreams ! night mares from time to time.

 

[geoguy78]

I won't ignore you: I also take tirzepatide. I take 1.1 mg per day. I don't exceed that dose for tirzepatide because it tends to make me tired and causes GI problems when I exceed that.

Someday, somewhere, someone will post their results for stack-free mazdutide! 🤣

 

[desinr-gal]

This was the graph of previous trials compared based on weight loss percentage, but misleading because of the difference in time frames. I drew lines where they presumably would be if continued to the same 48 wk timeline as Reta. Mazdutide was almost at Reta's level, and Cagri-Sema even closer.

 

[keangkong]

This was the graph of previous trials compared based on weight loss percentage, but misleading because of the difference in time frames. I drew lines where they presumably would be if continued to the same 48 wk timeline as Reta. Mazdutide was almost at Reta's level, and Cagri-Sema even closer.View attachment 9804

Getting result that are close to those provided by reta requires using doses of 10-16 mg of mazduride. I’m going by the mazduride studies, which did not directly compare reta to maz. There was recently a 48 week trial conducted using maz at 10 and 16 mg doses.

 

[desinr-gal]

Getting result that are close to those provided by reta requires using doses of 10-16 mg of mazduride. I’m going by the mazduride studies, which did not directly compare reta to maz. There was recently a 48 week trial conducted using maz at 10 and 16 mg doses.

I don't know where this study originated, maybe you identified it in an earlier post? But it shows the 6mg dose working that well up until 24 wks. I know the loss tends to taper off. so my extensions arent truly accurate? I just assume they all taper at the same rate, but that isnt based on anything. Does the maz have less effect on the liver?
I think Andy said that glutathione is highly beneficial for liver health. Are you researching that?

 

[keangkong]

I don't know where this study originated, maybe you identified it in an earlier post? But it shows the 6mg dose working that well up until 24 wks. I know the loss tends to taper off. so my extensions arent truly accurate? I just assume they all taper at the same rate, but that isnt based on anything. Does the maz have less effect on the liver?
I think Andy said that glutathione is highly beneficial for liver health. Are you researching that?

Weight loss drugs in general will tend to reduce liver fat. However weight loss drugs that agonize (activate) the glucagon receptors (GCGR) result in a greater reduction in liver fat. Liver fat is bad. You want the level of liver fat to be low. Mazdutide and survodutide are, in part, GCGR agonists. The most well studied weight loss medicine that is a GCGR agonist is retatrutide.

I don't know anything about glutathione.

 

[desinr-gal]

Weight loss drugs in general will tend to reduce liver fat. However weight loss drugs that agonize (activate) the glucagon receptors (GCGR) result in a greater reduction in liver fat. Liver fat is bad. You want the level of liver fat to be low. Mazdutide and survodutide are, in part, GCGR agonists. The most well studied weight loss medicine that is a GCGR agonist is retatrutide.

I don't know anything about glutathione.

I thought you were the one who got higher ALT numbers and that's why you switched?
sorry if I am misremembering..