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My understanding is all of the immunogenicity stuff is based off of what we've seen in some animal studies specifically with hgh, e.g. https://pubmed.ncbi.nlm.nih.gov/19569057/ I don't know that there is anything resembling settled science around it for humans with hgh, much less other peptides...

I go back and forth on how much I believe what Ghoul is saying. My interpretation is that he's a fairly smart individual that has read a whole bunch of articles and papers and is now very firmly convinced he understands them very well and is an expert on them. Which, well, I've read a lot of...

Had you experienced even mild site-level reactions before? Any red welts/itchiness/etc. at all, even very mild? If so, these would be a strong indicator that you had been building up an allergic reaction. Personally, one strong reaction like this would be enough to make me discontinue use, and...

People who are active on meso often become highly allergic to cardio, though. Estimates are that up to 80% of all bodybuilders suffer from this affliction.

I popped back in to the meso qsc thread to see what was happening there and how substantiated the "it's not Tracy!!!!" stuff was. Instead I see some strange person arguing with people about how it is smart of him to take 90IU of HGH daily.

You'd be popping anavar as part of your pre workout and reading romantasy novels between sets in the gym in your quest to get jacked.

People pretty commonly report allergic reactions with these and tesa - they seem to be ones that a lot of people are susceptible to. It usually starts with localized itching and rashes,they keep injecting, progresses to the full body reactions, and people even report severe anaphylaxis if they...

I'm curious if we'll see some "biologic" multi-receptor options soon. With peptides we are capped for regulatory reasons on the number of amino acids in the chain, and I believe we're at that cap on the double/triple/etc. agonist options. But you can go higher, they just get categorized as a...

I just started using https://telyrx.com/ - US domestic telehealth provider. I just filled out my basic stats, clicked a checkbox saying I had been prescribed it before, and then it got sent to their doc for review. I never had to speak with anyone or schedule a video call or anything like that...

I do, don't have exact #s with me right now, but both dropped back down to in-range by 4 weeks after stopping, both were towards the upper middle. hba1c still 5. I did end up only doing 9 weeks because I dropped the last vial I've swapped to 3IU of HGH and increased my berberine intake. I also...

I do find her choice to be on Meso instead of here curious when you take into account the stated reasons for leaving here. I like both places, but Meso is definitely less civil. Oh well. Whatever makes her happy.

"Need" to stop using it is a strong word, but we currently have no evidence of efficacy in humans, and the mechanism we know it works on in rodents does not behave the same way in humans.

I used them over 3 phases. First third, SS-31 alone, middle third, both, last third, MOTS-C alone.

afaik egrifta is an every day thing, the 5 on 2 off is a ugl/bodybuilder cost saving thing based on how a lot of them handle hgh. A lot of the off-the-beaten-path peptide knowledge comes from the bodybuilding circles, because they've been using this stuff for far longer than those of us that...

https://thinksteroids.com/community/threads/qingdao-sigma-chemical-co-ltd-international-us-eu-canada-and-australia-domestic.134407154/page-3767#post-3438232

Tracy just posted on Meso. Says the regulation/crackdown has been tougher than expected, still some time until they're back, and that they still plan on making everyone whole for anything that needs reshipment.

10 weeks for the 10mg kits if you follow the standard 2mg/day, 5 days on 2 days off schedule. I wouldn't recommend running any longer than this either, unless your insulin and blood glucose don't see significant elevation.

Good so far, but I imagine it'll take me a while to really know. Not planning on doing additional bloodwork for them until I've been back on for another couple of months.

It took about a week from payment to get confirmation and then another day to get a tracking number from Lisa. But I'm in no rush so didn't bother me any.

I've always had trouble sleeping through the night, but on reta my RHR is up and my HRV is down, so sleep score suffers for me because of that.

They milk the snake, dilute the venom, and then inject it into (usually) horses and harvest the antibodies. Lots of people end up having allergic reactions to the antibodies, so it's kind of rough in general. They're starting to use AI/ML to design bespoke antivenoms that won't require animal...

I wasn't even aware of that DNP, but now there are more things abbreviated to DNP that I will not be using, lol. I was talking about this DNP: https://en.wikipedia.org/wiki/2,4-Dinitrophenol Some bodybuilders use it when cutting. It basically breaks your mitochondria so instead of doing what...

If you're too cold, you could always take DNP! (do no do this this is an awful idea please this is a bad joke under no circumstances should anyone be taking DNP)

https://diabetesjournals.org/diabetes/article/73/Supplement_1/266-OR/155164/266-OR-Retatrutide-an-Agonist-of-GIP-GLP-1-and...

Yeah, I think even going with the party line might be enough. Especially since I doubt Amazon wants to invest a bunch of time figuring out what is and isn't the line from the pharma companies. Easier to just nuke anything from KDP that touches on it. Though my understanding is you can basically...

Doing some googling and digging around the KDP subreddit, it sounds like anything that includes medical claims tends to get removed. I'd guess this treads too closely to that line.

I have no context - who is this dude and what is this book?

I would take time off. I posted my ipa/tesa bloodwork in https://glp1forum.com/threads/8-week-ipa-tesa-stack-bloodwork.2258/ along with dexa results. I saw solid response to my IGF-1 levels, reaching the supraphysiological range for my age, but I also saw significant increases in blood glucose...

Gary Wittert, who led the studies on AOD in humans while funded by the company developing it, has publicly stated multiple times that the studies showed no useful effect in humans. https://www.smh.com.au/sport/much-ado-about-nothing-the-peptide-they-say-never-worked-20130802-2r4ug.html...

From a practical perspective, I wouldn't. 5mg might make sense if you respond well to 1mg/day, but yeah, I'd only buy 10mg. I've just swapped to regular ol HGH though.

2mg is what they used in the egrifta trials for HIV patients, and why it is sort of the de-facto dose. The 5 days on 2 days off is just to make it work nicely with 10mg vials for that dosage. Some people run at 1mg. You can always get your IGF-1 levels tested before and after starting to take...

I'm glad the group exists. I've got zero desire to be a part of it because my level of risk tolerance to laziness ratio has meant I've never gone and tested any of the substances I've ever gotten from drug dealers over the past decades of my life, plus it all sounds quite pretentious to me, but...

I think there's an untapped market of people wanting to buy from great apes. The world is your oyster

A lot of the AAS UGLs on other sites have people with well defined abs in their avatars and sell peptides too. Granted, closer to Skye prices than QSC, but, if all you want is some abs to look at while putting in your order...

On the titrating up, I'd say give it even more than a couple of weeks on a stall. I've been on 8mg of reta for a while now and sometimes I'll spend a 2-3 weeks with the scale fluctuating a few pounds back and forth and never seeming to really go anywhere, and then the next week it'll drop 5lb...

Zippity disappeared Tracy disappeared Has anyone seen Zippity and Tracy in the same room at the same time?

only 7 posts per day on average not that bad by internet standards

One thing about all of this is even if food noise and cravings come back, if before you were eating hyper-palatable calorie-dense food, and you just swap to eating high protein, high fiber, etc., you'll almost certainly get full faster than you were eating stuff with tons of refined sugar...

The world is inherently political and in this case the politics directly intersect with the purpose of this forum. These are all politically motivated policies - how can we discuss them without allowing politics to intersect?

This mess is directly tied to the sourcing of peptides.

Unsuspended already https://www.cnn.com/2025/02/04/business/us-postal-service-suspends-parcels-china-intl-hnk/index.html

I think you stuck it instead of locking it

Not even a guarantee there. The de minimis stuff was started by Biden, and even if the next admin is more friendly, it will take time to unwind it all.

They can't comply with the de minimis exception being removed. Don't have the infrastructure or people power to do it. This is their only option if they want to comply with the latest EO. CBP does the actual inspection, etc., but USPS is responsible for all duty payments on the goods. They...

FWIW, set point theory is not universally accepted, particularly in how applicable it is to humans. It's quite possible it is true, but it's also possible that it isn't. Lots of things in animal studies carry over to humans, but even more do not.

Muji, Daiso, Kinokuniya stores should have you covered on your Japanese stationery needs, at least.

Depends on how big the appetite suppression/food noise reduction is. A decent amount of people just stop getting hungry on 2.5mg of tirz and just can't eat the level of food that they did before, and instead just eat a third of whatever they get instead of the full meal.

Sure, but we're also talking to a lot of people here that have no understanding of what "hard" vs. "too hard" is. In a past life, and once again more recently, I've helped a lot of friends and co-workers get their start with lifting weights. The overwhelming majority have been far more likely...

There have been entire call centers in the US dedicated to defrauding people. There have been entire huge corporations. There are a billion MLM pyramid schemes. No, calling an entire population of people "predatory thieves" is not better than calling them "scammy." Nor is calling an entire...

Yes, we should instead just make blanket statements about 1.4 billion people being scammy. That's obviously a good way to handle things. No, of course we shouldn't do that, what the fuck.