Search results for query: fatigue mots

I have not had any issues with fatigue on Reta, neither has my wife. We both started at 2mg, and both are at 5mg. We dose twice weekly, not sure if that helps. But we also have done cycles of SS-31, MOTS-C and have been using NAD+ 3-4 times per week.

Yeah interesting, I would be curious if Mots C would be of benefit here… can you elaborate? I’m week 2 on Reta and likewise instant reaction with appetite suppression and probably for the first time really felt the strength falling in the gym yesterday. I would like to do a dexa scan before and...

5 amino 1 methylquinolinium Details: https://pep-pedia.org/peptides/5-amino-1mq It leads to epigenetic changes in adipocytes (in mice) and could erase their “memory.” https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/ I just finished a 10-day cycle at 5 mg. It eliminates the muscle fatigue...

Ya, It can be a slippery slope for sure. I went from scared of one needle a week to an 11 needle week over the course of 6 months - it's the daily Klow that really boosts the numbers though.

I was going to ask what people thought of this method. I have Cagri on order to arrive next week, but I’m also looking at mots c for just overall energy boost. But at what point am I doing too much? I def want the Cagri for occasional use to combat hunger (on 10mg Tz) as needed, but then if I...

Asterix looking for his magic potion. Funny. For brain fog: the aGLP-1s I’ve used (Lira, Tirz, and Reta) definitely have a nootropic effect. I have the cognitive acuity I had when I was 20. I completed more projects last year than in the previous five years combined, and my partners are...

I've been taking .5 about 3 days after 5mg reta and I do think it's causing some fatigue but nothing unmanageable. I like to take the cagri at night so I can sleep off the initial fatigue and then I pin MOTS-C the next morning and I feel like that helps too.

I run about 10 miles a day in the morning, pretty much every day. I haven't found that my shot schedule or dosage really affects it much. Was on reta but just switched to Tirz, so we'll see if that holds. On occasion I'll get some reflux toward the end of my run. If I take some tums beforehand...

Hi everyone, I have ME/CFS with PEM and have been reading about mitochondrial problems and energy issues in ME/CFS. I know these are not proven treatments, but I wanted to ask if anyone has tried: SS-31 MOTS-c Thymosin alpha-1 Did any of them help with: PEM / crashes after activity? Better...

As some of you know I just had surgery to remove my hardware from a tib fib fracture in preparation for total knee surgery. I am doing great! No pain after the 2nd day. I started taking glow and kpv 2 weeks before the surgery. At day 9 the staples had to be dug out because new skin started...

Not with MOTS-c. But definitely with Reta. My HbA1c was 10.5 in February. I started Reta in April, and the CGM app is projecting an HbA1c of 6.5-6.7. MOTS-c clearly cuts fatigue. I no longer wake up in the morning feeling like I've been walking all night. No significant difference between 5...

I have found this one does nothing on its own for me. Mots on it's own definitely has a positive effect. This WITH Mots has been transformational in adding it to my pre-workout routine. My workouts feel like they could go on forever, zero fatigue.

I also want to chime in with my NAD+ experience, which is similar. Nothing stimulative about it, but just a noticeable increase in baseline energy levels throughout the day. I alternate days of 2-3 mg Mots and 50 mg NAD.

How much creatine were you taking? I only take the standard 5mg a day. I'd guess that I miss that dose a few days a week to. Also, how old are you? most of the mitochondria hacks are for older people whose mitochondria are in disrepair. I've found the best hack for energy is sleep. Are your...

Doing a bit more research, maybe it was the MOTS-c helping me. Either way, I think you should do the protocol for the synergistic effects. GoalMOTS‑cNAD+ More reps⭐ Strong effectMild Delay fatigue⭐ StrongMild Increase lactate threshold⭐ StrongNone Improve mitochondrial...

40 yo female here...I just started nad+ and have noticed an increase in clean energy. Nothing over the top but no afternoon tiredness. I have ss-31 on the way. I plan to run that for a week then introduce MOTSc to go for the stack method. Im hoping to skip the fatigue. 🤞

The only thing I noticed on MOTS-c was fatigue. I do not think my mitochondria were where they needed to be to make MOTS effective. So I backed off, working on mito support, will run SS31 and then give MOTS another whirl.

I have tried nad, mots c, ss31. I'm on to semax now, seems to help some.

That’s great. The instant appetite loss as a new user of Tirz is so liberating. I take it in the evenings and by the time I wake up the next morning it’s taken effect. A bit of unsolicited advice: the scale dropping can be really exciting but be prepared to add in breaks between doses as you do...

I like it so far. I definitely had some fatigue in the the beginning but now i can feel my energy levels going back up. I think I'm going to lower my dose and see if that stops the hot flashes I've had a couple times.

I am investigating the GLOW stack for multiple reasons including a hope that BPC helps with for this, but I was told SS-31 and MOTS-C helps people with fatigue.

Time for an update Pushed my physical limits with this stack. Got what I wanted but paid the price. dropped bf% to 16% overtraining kills libido dropped ferritin due to overtraining and recovering from a surgery- stopped nad, Reta completely started pinealon and epitalon cycle for sleep...

I deal with the same. I have been on KLOW and that gave me a bump in my energy. I have been taking NAD+ and it helps even though its temporary-I take it daily at this point. I started SS31 5 days ago and it has made me more fatigued (which I’m hoping improves-I may lower my dose). I have not...

Thank you for such detailed recounting of your experiences. I am fascinated by this protocol. Seriously considering it after my current GHK-Cu cycle is over. Thank you, too, for sharing the protocol.

How many cycles do you think you will do a year? I'm still in the midst of my first cycle.

I just finished the following NAD, SS31, Mots-C protocol. I took my last MOTS-C shot. Yay!!!!! I was able to answer most of my questions: 1. I guess my mitochondria needed repair because the protocol helped me. 2. ... 3. My swim times did not improve. 4. I am stronger but I think it is...

This is some good info. I ran a cycle of MOTS-c and SS-31 for about a month, I'm giving it a break then I was going to start it back up. How long did you run it ie all 7 days or did you take a break on the weekends? I'm on a cycle of CJC no DAC and just got some Ipamorelin showing up today.

When I was losing my last 10 lbs, I was on 20 mg tirz every 5 days. I wanted to stop losing muscle. I added Tesa/Ipamorelin 1mg/150 mcg right after workouts. 5 days on 2 off. It was a game changer. I actually started gaining muscle and continued to lose weight. I still cycle it : 12 weeks on...

I love hearing this had such a profound effect for you! Out of curiosity, have you run the full 14 week NAD+, ss-31, mots-c protocol, that's so popular on the internet these day? If so, what was your take on it? If not, are you considering it?

I would only do oral SLUPP. It is only dissolvable in DMSO at 1mg per 0.1mL of DMSO and it is recommended to keep DMSO level <= 5%. The remainder of the oil carriers can be PEG400, PG, etc. Mixing it without first using DMSO has resulted in cloudy suspensions and not clear solutions. And...

I’ve been reading through a lot of the discussion on whether it’s better to run MOTS-c first vs SLU-PP-322 first, and from what I can tell a lot of the disagreement seems less about biology and more about practicality/finance. The way I understand it (correct me if I’m wrong): MOTS-c is more...

Two severe anaphylactic reactions in July of last year: https://lifespan.io/news/two-people-almost-died-at-raadfest-we-went-to-the-experts/ I do not know if those injections were by IM or subq, and we don't know which peptides (or combinations) were used with the two women. A table by Gemini...

I started with caffeine pills a month or two ago to combat fatigue and I swear by them now. Just basic 100mg Nutricost ones from Amazon, I keep them by the bed and take 2-3 when I wake up with some L-Theanine. I used to have cabinet/fridge stacked with energy drinks of different kinds for...

-- I am not a doctor and have had ZERO formal medical training beyond simple first aid and CPR. Treat anything I say accordingly -- On the surface I want to say no. The only thing that any of these peptides have in relation to known epilepsy triggers is fatigue. But we also don't know how any...

Hey all, I have been researching for a bit and am all in on Reta. Getting older (50+) and am keen to focus on mitochondrial health given recent advances in bio-tech. I have a lot of interest in MOTS-c and SLU-PP-332 as a potential stack and I have heard/read some conflicting perspectives on...

Update: I’ve done 5-6 weeks of SS-31 10mg/day alone, then a few weeks of MOTS-C 5mg/2 days alternating with SS-31 10mg/2 days, and I’ve finally noticed increased energy. But today is different: for the first time I increased MOTS-C to 7mg yesterday, and today I’m sweating a lot for no reason at...

💥 Hair Regrowth & Anti-Aging Repair Stack GHK-Cu + TB-500 + MOTS-c Hair thinning, inflammation, and poor skin recovery are signs of cellular decline. This powerful 3-peptide protocol supports hair follicle health, collagen regeneration, and deep mitochondrial repair — all in one cycle...

I stack tirz with Survo and like it VERY much. I feel like my tirz fatigue/anhedonia (it may have only been one or the other, since the two would have had the same result for me) is almost entirely gone. That said, I was REALLY unscientific about it; the fact that I was also doing a cycle of...

💥 Hair Regrowth & Anti-Aging Repair Stack GHK-Cu + TB-500 + MOTS-c Hair thinning, inflammation, and poor skin recovery are signs of cellular decline. This powerful 3-peptide protocol supports hair follicle health, collagen regeneration, and deep mitochondrial repair — all in one cycle...

This is incredible! Thanks for posting.

Update on Peptides and Health 12/20/25 A brief update now that I'm a week back on peps! I am currently taking reta, MOTS-C, KLOW, CJC/Ipamorelin, and Semax. Additionally, I've gotten on LDN- Low Dose Naltrexone; it's an opiod BLOCKER that encourages production of natural endo-opiods, which help...

I've been noodling on a concept related to running peptide protocols alongside specific training blocks to get the most out of my training. This is just an intellectual experiment because there's no reason a person couldn't run multiple peptide protocols at once, but if I had to choose, here's...

Update on Peptides and Health - 12/13/2025 Hello everyone! I am back, but certainly not better than ever. It's been about a month since my last check-in. Last update, I confirmed that I was getting off my peptides for the next month to rule out if they were contributing to my symptomology. In...

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how many units are you pinning?

Took me about 2 months for the fatigue to pass lol

I got more energy when I titrated up. When the glukagon part came more and more to the party. But you need to eat the minimum, you will be depressed from low bloodsugar etc and it won’t help on your energy levels. Emotional eating, well I ‘missed’ that a lot in the beginning. I did a lot of...

I was on trt first. Probably the first 2 weeks I was good and then fatigue set in. That next month I really struggled with fatigue. Probably the 2 mths mark it went away. I did start on HGH as well, so I’m not sure that affected the fatigue going away.. but I feel great now! My dosages went...

I just started out on reta. The first week I only took 1mg, just to make sure I wasn't allergic or had any adverse effects. I also stack it with tirz 7.5 (which hasn't made much of a difference for me in terms of appetite suppression, KLOW, and MOTS-C). This week I took 2mg of reta...

yes--I'm really happy so far. I have high hopes for the MOTS-C, because I'm pretty bored of having ANY fatigue. I'd tolerate it for the rest of my life if it came to that, I can breathe when I'm sleeping again, I look and feel hot, and I'm out of my mind with happiness; if that comes with...