Not to come roaring in with TMI, but I've had microscopic colitis, confirmed by biopsy, since my late twenties. (It's pretty much like IBS.) There was no great way to manage it except being very careful about what I ate, maintaining my dignity by never daring to combine anything that involved a meal and being far from a restroom after, just in case, and not making any plans before 10 am, or if I did, getting up VERY early so that my stomach had settled by the time it was time to be around any people. I've had flare-ups put me in the hospital twice over the years, when I lost water faster than I could get it in until I finally just fainted where I was and someone drove me to the ER.
Tirzepatide ENDED that. If it stopped working for weight loss tomorrow, I'd STILL keep taking it forever, because oh my god, it is no longer a great deal of work to never be embarrassed and keep my medical issues to myself. I can even stay overnight while out and about if I want to, because I will be fine in the morning, EVERY morning.