Cagri (still) nothing, in fact the opposite ???

Captconundrum

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So far I have done 0.2mg last Monday then 3 days later another 0.3mg then about 8 hrs ago 0.75mg (I did not dare go straight to 1mg week 2 on this). In between I did my T6mg/5day. With C's longer half life I should by now be allergic to food, but weirdly the opposite is true. The net effect: greater sensitivity to cold (T effect but heightened) and greater hunger than I would normally feel on T alone. I am totally baffled frankly, given how many people have had huge responses to C on much lower doses. This batch is from Nexa and I am certain tests out well (theirs is quality), and in fact was slightly over-filled so if anything I (and my appetite) should be on our knees by now. I cannot fathom how my response is so at odds with everyone else. I am going to give it another week, and I suppose I could go past 1mg this week but that is not the intention here and I never intended to race up Cagri. Might recon a new vial from a different second batch just to see (got 2 because I expected to be on this for a little while). Meanwhile I am wondering if anyone has 'gone backwards' in appetite on T + C? Anyone gone backwards then 'forwards' (to suppression) doing this stack? Very weird...
 
Well, I just posted something similar in another post, but these peptides are working on hormone reception. Maybe your problem has nothing to do with amylin, but with glucagon or GLP-1. I believe the folks who respond to Cargri suffer from reduced amilyn reception.

I think most of us with weight problems suffer from GLP-1 reception issues. A Danish study showed BEFORE diabetes or obesity manifest our GLP-1 reception drops 20-25%. So most of this group responds to GLP-1s, but sometimes it's more than GLP-1. Sometimes it’s GIP, amylin, and/or glucagon too. Lord only knows what other receptor correctors they will find down the road! 😂
 
Any improvement? I started cagri at .25 and now am at .5. No effect. I was wondering if I got a bunk batch from Tracy and got some from a different source. Still doesn’t work on me. I’ll go up to .75 next week and see
 
Well I tested yesterday at 0,170 mg stacking with 5 mg reta.

Today even water makes me full. I have to eat very small portions or I feel nauseous.

This is super potent. Maybe I don't need for now.

Massive headache as well even do I am hidrated and took electrolytes
 
codered said:
Well I tested yesterday at 0,170 mg stacking with 5 mg reta.

Today even water makes me full. I have to eat very small portions or I feel nauseous.

This is super potent. Maybe I don't need for now.

Massive headache as well even do I am hidrated and took electrolytes
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0.170 ??? Really low dose, look at the clinical study doses
 
GLP1Pharmacist said:
0.170 ??? Really low dose, look at the clinical study doses
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If I did I would be throwing up my guts.

Since I'm already at 5 mg reta I started slowly and I am so glad I did it.

Besides it's more than 50% on trials initial dosage. I see reta started at 0,5 mg when initial trial dosages where 2 mg and people saying it works.
 
I think you have missunderstood what I wrote.
I started at 0,17 to test and it hit me like a truck. I have trouble drinking water without feeling like I am about to explode..

What I meant is that while Reta for me needed to start at 2 mg on Cagri I responded too much.

I think I don't even need so much supression.
 
Captconundrum said:
So far I have done 0.2mg last Monday then 3 days later another 0.3mg then about 8 hrs ago 0.75mg (I did not dare go straight to 1mg week 2 on this). In between I did my T6mg/5day. With C's longer half life I should by now be allergic to food, but weirdly the opposite is true. The net effect: greater sensitivity to cold (T effect but heightened) and greater hunger than I would normally feel on T alone. I am totally baffled frankly, given how many people have had huge responses to C on much lower doses. This batch is from Nexa and I am certain tests out well (theirs is quality), and in fact was slightly over-filled so if anything I (and my appetite) should be on our knees by now. I cannot fathom how my response is so at odds with everyone else. I am going to give it another week, and I suppose I could go past 1mg this week but that is not the intention here and I never intended to race up Cagri. Might recon a new vial from a different second batch just to see (got 2 because I expected to be on this for a little while). Meanwhile I am wondering if anyone has 'gone backwards' in appetite on T + C? Anyone gone backwards then 'forwards' (to suppression) doing this stack? Very weird...
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Thought I was losing it, but cagri also made me feel more hungry. And also sleep for a whole day.

Also, mine was also from Nexaph
 
I started 4 days ago, 0.1 mg each day, felt nothing till day 3. Have 0.4mg onboard now. I think a good weekly dose might be around 0.5 mg. I wanted to ease into it. I'm also using nexa.
 
codered said:
If I did I would be throwing up my guts.

Since I'm already at 5 mg reta I started slowly and I am so glad I did it.

Besides it's more than 50% on trials initial dosage. I see reta started at 0,5 mg when initial trial dosages where 2 mg and people saying it works.
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We are in the same boat Ive seen significant suppression at ~.15 or 150mcg
 
luc-k said:
I'm thinking about adding 0.25 of cagri, because I'm on tirz 15mg and I still feel hungry.
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I was on equivalent of 10.75 Tirz/week. Added .25 Cagri week 1 and .50 Cagri week 2 and had to back my Tirz down to 6 mg./week because the Cagri was so effective (PGB Cagri FWIW).
 
luc-k said:
no, I haven't lost weight for 2 months.
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ouch. After 6 months on Tirz, reaching 10mg/w, I began to stall (no loss for two weeks). Added Cagri 0.3mg/w and got 100% food noise suppression (and quite nauseous, and many smells became intolerable). Started to loose again. A few months later, stalling again and added Reta 1mg (Tirz/Cagri and Reta). Same pattern, a few months later, less weight loss, so I cranked Tirz to 15mg. This was over a year period, loosing weekly average of 1.33lbs. I recently stopped Cagri after 6 months (was at 0.9mg/w) , up Tirz slowly to 17mg/w and increased Reta. For me, Cagri was real effective. My suggestion is to stack/increase glp1 dosage slowly but react within a few weeks if weight is not coming off. GLP1 changes can take a few weeks to kick in, so should be working within a month, imo. Maybe cut carbs and add protein shake. Not everybody react the same way to glp1. Maybe add Sema.
 
This week, I took two shots of Cagri at 0.125mg and didn't notice any hunger suppression. I'm going to try 0.25mg tomorrow.
 
I'm suprised your not impressed with cagri. I'm about 4 weeks in now 0.25mg stacking it on top of tirz 10mg and it's been really good for appetite suppression.. if I take it in the morning I can feel it by dinner time where as tirz on its own the suppression comes and goes. It did exactly what I wanted it to but I think it does make me really tired
 
I did 0.25mg Cag on Saturday to stack with my Reta. No fatigue. It did seem to help with hunger, and I don't feel like I need to increase it next week. Low and slow.
 
zpped said:
Units are a volume measurement. That doesn't tell us anything about how much cag is in that volume. That would be measured in milligra
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zpped said:
Units are a volume measurement. That doesn't tell us anything about how much cag is in that volume. That would be measured in milligrams.
Click to expand...
In my case, I reconstituted 5 mg with 2 mL bacteriostatic water, so each unit equals 0.025 mg. I draw 30 units, which is 0.75 mg of Cagrilintide.
 
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